{
	"name":"aaus03016",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P"
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors"
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"EP12_04475 CCA-adding protein\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonuclease complex"
			},
			{
				"name":"tRNA splicing ligase complex"
			},
			{
				"name":"Other tRNA splicing factors"
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			},
			{
				"name":"tRNA import factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"EP12_13510 proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				},
				{
					"name":"EP12_09360 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"EP12_12495 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"EP12_09810 glutamate--tRNA ligase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"EP12_06555 aspartyl-tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"EP12_05475 alanyl-tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"EP12_07105 asparaginyl-tRNA synthetase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				},
				{
					"name":"EP12_08210 thrS; threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"EP12_11105 seryl-tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"EP12_15885 valyl-tRNA synthetase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"EP12_13570 histidinol dehydrogenase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"EP12_08355 phenylalanine--tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"EP12_08360 pheT; phenylalanine--tRNA ligase\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"EP12_15680 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"EP12_02305 tryptophanyl-tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"EP12_17775 D-tyrosyl-tRNA(Tyr) deacylase\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				}
				]
			},
			{
				"name":"AARS associated factors",
				"children":[
				{
					"name":"EP12_03575 zinc-binding protein\tK02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases"
			},
			{
				"name":"Dihydorouridine synthases"
			},
			{
				"name":"Methylthiotransferase",
				"children":[
				{
					"name":"EP12_07620 (dimethylallyl)adenosine tRNA methylthiotransferase\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"EP12_01335 tRNA (guanine-N7)-methyltransferase\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"EP12_13505 hypothetical protein\tK22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"EP12_12610 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"EP12_08885 pseudouridine synthase\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"EP12_03060 pseudouridine synthase\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"EP12_13635 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Elongator complex"
			},
			{
				"name":"Elongator related proteins"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"EP12_00125 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"EP12_18305 tRNA dimethylallyltransferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"EP12_20115 trmE; tRNA modification GTPase TrmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"EP12_20095 gidA; tRNA uridine 5-carboxymethylaminomethyl modification protein\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"TRAMP complex"
			},
			{
				"name":"Rapid tRNA decay (RTD) pathway factors",
				"children":[
				{
					"name":"EP12_06250 3'-5'-bisphosphate nucleotidase\tK01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]"
				}
				]
			},
			{
				"name":"Other tRNA degradation factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"5'processing factors",
			"children":[
			{
				"name":"Ribonucrease P",
				"children":[
				{
					"name":"EP12_20130 ribonuclease P\tK03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]"
				},
				{
					"name":"EP12_20145 bacterial RNase P\tK01978 rnpB; RNase P catalytic RNA component"
				}
				]
			}
			]
		},
		{
			"name":"3'processing and CCA adding factors",
			"children":[
			{
				"name":"3'processing factors",
				"children":[
				{
					"name":"EP12_06005 ribonuclease T\tK03683 rnt; ribonuclease T [EC:3.1.13.-]"
				},
				{
					"name":"EP12_12810 ribonuclease D\tK03684 rnd; ribonuclease D [EC:3.1.13.5]"
				}
				]
			},
			{
				"name":"CCA adding factors",
				"children":[
				{
					"name":"EP12_04475 CCA-adding protein\tK00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA spricing factors",
			"children":[
			{
				"name":"tRNA splicing endonucleases"
			},
			{
				"name":"tRNA splicing ligases"
			},
			{
				"name":"Other tRNA splicing factors",
				"children":[
				{
					"name":"EP12_02145 2'-5' RNA ligase\tK01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA transport factors",
			"children":[
			{
				"name":"tRNA export factors"
			}
			]
		},
		{
			"name":"Aminoacyl-tRNA synthetases (AARSs)",
			"children":[
			{
				"name":"Multi-aminoacyl-tRNA synthetase complex (MSC)",
				"children":[
				{
					"name":"EP12_09360 leuS; leucine--tRNA ligase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"EP12_13510 proline--tRNA ligase\tK01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]"
				}
				]
			},
			{
				"name":"Other AARSs",
				"children":[
				{
					"name":"EP12_15680 tyrosine--tRNA ligase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"EP12_02305 tryptophanyl-tRNA synthetase\tK01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]"
				},
				{
					"name":"EP12_08210 thrS; threonine--tRNA ligase\tK01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]"
				},
				{
					"name":"EP12_05475 alanyl-tRNA synthetase\tK01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]"
				},
				{
					"name":"EP12_15885 valyl-tRNA synthetase\tK01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]"
				},
				{
					"name":"EP12_12495 metG; methionine--tRNA ligase\tK01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]"
				},
				{
					"name":"EP12_11105 seryl-tRNA synthetase\tK01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]"
				},
				{
					"name":"EP12_06555 aspartyl-tRNA synthetase\tK01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]"
				},
				{
					"name":"EP12_00035 glycyl-tRNA synthetase\tK01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]"
				},
				{
					"name":"EP12_00030 glyS; glycyl-tRNA ligase\tK01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]"
				},
				{
					"name":"EP12_09810 glutamate--tRNA ligase\tK01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]"
				},
				{
					"name":"EP12_08355 phenylalanine--tRNA ligase alpha subunit\tK01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]"
				},
				{
					"name":"EP12_08360 pheT; phenylalanine--tRNA ligase\tK01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]"
				},
				{
					"name":"EP12_13570 histidinol dehydrogenase\tK01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]"
				},
				{
					"name":"EP12_07105 asparaginyl-tRNA synthetase\tK01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]"
				}
				]
			},
			{
				"name":"Trans-editing factors",
				"children":[
				{
					"name":"EP12_17775 D-tyrosyl-tRNA(Tyr) deacylase\tK07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]"
				},
				{
					"name":"EP12_08375 hypothetical protein\tK03976 ybaK; Cys-tRNA(Pro)\/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"tRNA modification factors",
			"children":[
			{
				"name":"Deaminases",
				"children":[
				{
					"name":"EP12_04930 cytidine deaminase\tK11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]"
				}
				]
			},
			{
				"name":"Dihydorouridine synthases",
				"children":[
				{
					"name":"EP12_16600 tRNA-dihydrouridine synthase A\tK05539 dusA; tRNA-dihydrouridine synthase A [EC:1.-.-.-]"
				},
				{
					"name":"EP12_07280 tRNA-dihydrouridine synthase C\tK05541 dusC; tRNA-dihydrouridine synthase C [EC:1.-.-.-]"
				}
				]
			},
			{
				"name":"Methylthiotransferases",
				"children":[
				{
					"name":"EP12_07620 (dimethylallyl)adenosine tRNA methylthiotransferase\tK06168 CDK5RAP1; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]"
				}
				]
			},
			{
				"name":"Methyltransferases",
				"children":[
				{
					"name":"EP12_11385 tRNA methyltransferase\tK15256 cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"EP12_09845 SAM-dependent methyltransferase\tK06219 smtA; tRNA 5-carboxymethoxyuridine methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"EP12_16510 tRNA (uracil-5-)-methyltransferase\tK00557 trmA; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]"
				},
				{
					"name":"EP12_01335 tRNA (guanine-N7)-methyltransferase\tK03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]"
				},
				{
					"name":"EP12_06460 trmD; tRNA (guanine-N1)-methyltransferase\tK00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]"
				},
				{
					"name":"EP12_20115 trmE; tRNA modification GTPase TrmE\tK03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]"
				},
				{
					"name":"EP12_00660 tRNA guanosine-2'-O-methyltransferase\tK00556 trmH; tRNA (guanosine-2'-O-)-methyltransferase [EC:2.1.1.34]"
				},
				{
					"name":"EP12_13650 tRNA (cytidine\/uridine-2'-O-)-methyltransferase\tK15396 trmJ; tRNA (cytidine32\/uridine32-2'-O)-methyltransferase [EC:2.1.1.200]"
				},
				{
					"name":"EP12_02490 rRNA methylase\tK03216 trmL; tRNA (cytidine\/uridine-2'-O-)-methyltransferase [EC:2.1.1.207]"
				},
				{
					"name":"EP12_13505 hypothetical protein\tK22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]"
				},
				{
					"name":"EP12_16760 hypothetical protein\tK15460 yfiC; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]"
				},
				{
					"name":"EP12_14085 rRNA methyltransferase\tK03437 spoU; RNA methyltransferase, TrmH family"
				}
				]
			},
			{
				"name":"Psudouridine synthases",
				"children":[
				{
					"name":"EP12_12610 truA; tRNA pseudouridine synthase A\tK06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]"
				},
				{
					"name":"EP12_08885 pseudouridine synthase\tK03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]"
				},
				{
					"name":"EP12_04805 pseudouridine synthase\tK06175 truC; tRNA pseudouridine65 synthase [EC:5.4.99.26]"
				},
				{
					"name":"EP12_03060 pseudouridine synthase\tK06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]"
				},
				{
					"name":"EP12_03195 pseudouridine synthase\tK06177 rluA; tRNA pseudouridine32 synthase \/ 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]"
				}
				]
			},
			{
				"name":"Thiolation factors",
				"children":[
				{
					"name":"EP12_09210 mnmA; tRNA 2-thiouridylase\tK00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]"
				},
				{
					"name":"EP12_10880 tRNA 2-thiocytidine biosynthesis protein TtcA\tK14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA"
				},
				{
					"name":"EP12_19800 sulfurtransferase\tK04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]"
				},
				{
					"name":"EP12_11070 sulfur reduction protein DsrE\tK07236 tusC; tRNA 2-thiouridine synthesizing protein C"
				},
				{
					"name":"EP12_11065 sulfur transfer complex subunit TusD\tK07235 tusD; tRNA 2-thiouridine synthesizing protein D [EC:2.8.1.-]"
				},
				{
					"name":"EP12_11080 sulfur transfer protein TusE\tK11179 tusE; tRNA 2-thiouridine synthesizing protein E [EC:2.8.1.-]"
				},
				{
					"name":"EP12_13610 ATPase\tK13628 iscA; iron-sulfur cluster assembly protein"
				},
				{
					"name":"EP12_13635 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"EP12_13305 glycine cleavage system protein T\tK06980 ygfZ; tRNA-modifying protein YgfZ"
				}
				]
			},
			{
				"name":"KEOPS\/EKC complex"
			},
			{
				"name":"Other tRNA modification factors",
				"children":[
				{
					"name":"EP12_20095 gidA; tRNA uridine 5-carboxymethylaminomethyl modification protein\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"EP12_18305 tRNA dimethylallyltransferase\tK00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]"
				},
				{
					"name":"EP12_12575 tRNA hydroxylase\tK06169 miaE; tRNA 2-(methylsulfanyl)-N6-isopentenyladenosine37 hydroxylase [EC:1.14.99.69]"
				},
				{
					"name":"EP12_13690 S-adenosylmethionine tRNA ribosyltransferase\tK07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]"
				},
				{
					"name":"EP12_06200 7-cyano-7-deazaguanine synthase\tK06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]"
				},
				{
					"name":"EP12_06205 pyrroloquinoline quinone biosynthesis protein\tK10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]"
				},
				{
					"name":"EP12_04720 queF; 7-cyano-7-deazaguanine reductase\tK06879 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]"
				},
				{
					"name":"EP12_18330 [Fe-S]-binding protein\tK18979 queG; epoxyqueuosine reductase [EC:1.17.99.6]"
				},
				{
					"name":"EP12_13685 tgt; queuine tRNA-ribosyltransferase\tK00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]"
				},
				{
					"name":"EP12_05650 hypothetical protein\tK06957 tmcA; tRNA(Met) cytidine acetyltransferase [EC:2.3.1.193]"
				},
				{
					"name":"EP12_12835 hypothetical protein\tK14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB"
				},
				{
					"name":"EP12_00125 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein\tK07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]"
				},
				{
					"name":"EP12_03550 UGMP family protein\tK25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]"
				},
				{
					"name":"EP12_18320 ATPase\tK06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE"
				},
				{
					"name":"EP12_09685 sulfur acceptor protein CsdL\tK22132 tcdA; tRNA threonylcarbamoyladenosine dehydratase"
				}
				]
			}
			]
		},
		{
			"name":"tRNA degradation factors",
			"children":[
			{
				"name":"EP12_09490 polynucleotide phosphorylase\/polyadenylase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
			}
			]
		}
		]
	}
	]
}