{
	"name":"acha01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"KYT87_12395 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]"
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"KYT87_24595 HAMP domain-containing protein\tK18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]"
				},
				{
					"name":"KYT87_24600 response regulator\tK18073 parR; two-component system, OmpR family, response regulator ParR"
				},
				{
					"name":"KYT87_02120 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KYT87_05060 Cu(+)\/Ag(+) sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KYT87_27570 heavy metal sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"KYT87_02125 heavy metal response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KYT87_05065 heavy metal response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KYT87_11890 response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KYT87_27565 heavy metal response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"KYT87_27575 heavy metal response regulator transcription factor\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]"
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"KYT87_02695 D-alanine--poly(phosphoribitol) ligase\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				},
				{
					"name":"KYT87_02690 membrane-bound O-acyltransferase\tK03739 dltB; membrane protein involved in D-alanine export"
				},
				{
					"name":"KYT87_02675 acyl carrier protein\tK14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]"
				},
				{
					"name":"KYT87_02680 D-alanyl-lipoteichoic acid biosynthesis protein DltD\tK03740 dltD; D-alanine transfer protein"
				},
				{
					"name":"KYT87_22800 D-alanyl-lipoteichoic acid biosynthesis protein DltD\tK03740 dltD; D-alanine transfer protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"KYT87_02995 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KYT87_10990 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KYT87_18390 efflux RND transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KYT87_03000 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KYT87_10995 efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KYT87_18385 multidrug efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"KYT87_01215 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_02325 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_08830 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_11000 adeC; (GenBank) AdeC\/AdeK\/OprM family multidrug efflux complex outer membrane factor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_18380 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_19030 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]",
				"children":[
				{
					"name":"KYT87_12720 TetR\/AcrR family transcriptional regulator\tK18294 nfxB; TetR\/AcrR family transcriptional regulator, mexCD-oprJ operon repressor"
				},
				{
					"name":"KYT87_12725 efflux RND transporter periplasmic adaptor subunit\tK18295 mexC; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KYT87_12730 multidrug efflux RND transporter permease subunit\tK18296 mexD; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"KYT87_06045 efflux RND transporter periplasmic adaptor subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KYT87_06040 efflux RND transporter permease subunit\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"KYT87_01215 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_02325 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_08830 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_11000 adeC; (GenBank) AdeC\/AdeK\/OprM family multidrug efflux complex outer membrane factor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_18380 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_19030 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"KYT87_01215 TolC family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_02325 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_08830 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_11000 adeC; (GenBank) AdeC\/AdeK\/OprM family multidrug efflux complex outer membrane factor\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_18380 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"KYT87_19030 efflux transporter outer membrane subunit\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"KYT87_13275 cueR; (GenBank) Cu(I)-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"KYT87_02170 TolC family outer membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"KYT87_02170 TolC family outer membrane protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"KYT87_17705 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KYT87_24655 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KYT87_26565 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KYT87_26570 efflux RND transporter periplasmic adaptor subunit\tK18901 bpeE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"KYT87_26575 efflux RND transporter permease subunit\tK18902 bpeF; multidrug efflux pump"
				},
				{
					"name":"KYT87_26580 efflux transporter outer membrane subunit\tK18903 oprC; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"KYT87_12395 MFS transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}