{
	"name":"acie03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins"
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family",
				"children":[
				{
					"name":"KIP84_08115 feaR; transcriptional regulator FeaR\tK14063 feaR; AraC family transcriptional regulator, positive regulator of tynA and feaB"
				},
				{
					"name":"KIP84_09355 AraC family transcriptional regulator\tK21747 alkR; AraC family transcriptional regulator, alkane utilization regulator"
				},
				{
					"name":"KIP84_09030 helix-turn-helix domain-containing protein\tK07506 K07506; AraC family transcriptional regulator"
				},
				{
					"name":"KIP84_17020 methylated-DNA--[protein]-cysteine S-methyltransferase\tK10778 ada; AraC family transcriptional regulator, regulatory protein of adaptative response \/ methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"LysR family",
				"children":[
				{
					"name":"KIP84_09175 LysR family transcriptional regulator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"KIP84_06715 LysR family transcriptional regulator\tK03576 metR; LysR family transcriptional regulator, regulator for metE and metH"
				},
				{
					"name":"KIP84_13530 LysR family transcriptional regulator\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator"
				},
				{
					"name":"KIP84_13225 LysR family transcriptional regulator ArgP\tK05596 argP; LysR family transcriptional regulator, arginine and lysine transport system\/DNA replication regulator"
				},
				{
					"name":"KIP84_08205 hcaR; DNA-binding transcriptional regulator HcaR\tK05817 hcaR; LysR family transcriptional regulator, hca operon transcriptional activator"
				},
				{
					"name":"KIP84_08250 LysR family transcriptional regulator\tK05817 hcaR; LysR family transcriptional regulator, hca operon transcriptional activator"
				},
				{
					"name":"KIP84_16540 hcaR; DNA-binding transcriptional regulator HcaR\tK05817 hcaR; LysR family transcriptional regulator, hca operon transcriptional activator"
				},
				{
					"name":"KIP84_04730 CysB family HTH-type transcriptional regulator\tK13635 cbl; LysR family transcriptional regulator, cys regulon transcriptional activator"
				},
				{
					"name":"KIP84_14930 LysR family transcriptional regulator\tK13794 tcuR; LysR family transcriptional regulator, regulatory protein for tcuABC"
				},
				{
					"name":"KIP84_14945 LysR family transcriptional regulator\tK13794 tcuR; LysR family transcriptional regulator, regulatory protein for tcuABC"
				},
				{
					"name":"KIP84_10330 LysR family transcriptional regulator\tK13928 mdcR; LysR family transcriptional regulator, malonate utilization transcriptional regulator"
				},
				{
					"name":"KIP84_12795 LysR family transcriptional regulator\tK16135 dmlR; LysR family transcriptional regulator, transcriptional activator for dmlA"
				},
				{
					"name":"KIP84_14300 LysR family transcriptional regulator\tK16135 dmlR; LysR family transcriptional regulator, transcriptional activator for dmlA"
				},
				{
					"name":"KIP84_08965 LysR family transcriptional regulator\tK17737 dhcR; LysR family transcriptional regulator, carnitine catabolism transcriptional activator"
				},
				{
					"name":"KIP84_05755 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KIP84_10425 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KIP84_11415 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"KIP84_01955 LysR family transcriptional regulator\tK21645 hypT; LysR family transcriptional regulator, hypochlorite-specific transcription factor HypT"
				},
				{
					"name":"KIP84_08995 LysR family transcriptional regulator\tK21645 hypT; LysR family transcriptional regulator, hypochlorite-specific transcription factor HypT"
				},
				{
					"name":"KIP84_08435 LysR family transcriptional regulator\tK21699 bauR; LysR family transcriptional regulator, transcriptional activator for bauABCD operon"
				},
				{
					"name":"KIP84_08170 LysR family transcriptional regulator\tK21756 catM; LysR family transcriptional regulator, cis,cis-muconate-responsive activator of cat and ben genes"
				},
				{
					"name":"KIP84_12155 LysR family transcriptional regulator\tK21757 benM; LysR family transcriptional regulator, benzoate and cis,cis-muconate-responsive activator of ben and cat genes"
				}
				]
			},
			{
				"name":"DeoR family"
			},
			{
				"name":"LacI family"
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"KIP84_00375 hutC; histidine utilization repressor\tK05836 hutC; GntR family transcriptional regulator, histidine utilization repressor"
				},
				{
					"name":"KIP84_18205 lldR; transcriptional regulator LldR\tK14348 lldR; GntR family transcriptional regulator, L-lactate dehydrogenase operon regulator"
				},
				{
					"name":"KIP84_01025 PLP-dependent aminotransferase family protein\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				},
				{
					"name":"KIP84_10395 PLP-dependent aminotransferase family protein\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				},
				{
					"name":"KIP84_10980 PLP-dependent aminotransferase family protein\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				},
				{
					"name":"KIP84_17505 PLP-dependent aminotransferase family protein\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				},
				{
					"name":"KIP84_12880 GntR family transcriptional regulator\tK11475 vanR; GntR family transcriptional regulator, vanillate catabolism transcriptional regulator"
				}
				]
			},
			{
				"name":"TetR\/AcrR family",
				"children":[
				{
					"name":"KIP84_13875 betI; transcriptional regulator BetI\tK02167 betI; TetR\/AcrR family transcriptional regulator, transcriptional repressor of bet genes"
				},
				{
					"name":"KIP84_18440 TetR\/AcrR family transcriptional regulator\tK09017 rutR; TetR\/AcrR family transcriptional regulator"
				},
				{
					"name":"KIP84_00955 TetR\/AcrR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"KIP84_04380 TetR\/AcrR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"KIP84_13105 TetR\/AcrR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"KIP84_15745 TetR\/AcrR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"KIP84_00160 TetR\/AcrR family transcriptional regulator\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"KIP84_07460 TetR\/AcrR family transcriptional regulator\tK18137 adeN; TetR\/AcrR family transcriptional regulator, repressor of the adeIJK operon"
				},
				{
					"name":"KIP84_05105 fabR; HTH-type transcriptional repressor FabR\tK22105 fabR; TetR\/AcrR family transcriptional regulator, fatty acid biosynthesis regulator"
				},
				{
					"name":"KIP84_02570 TetR family transcriptional regulator\tK22108 kstR2; TetR\/AcrR family transcriptional regulator, cholesterol catabolism regulator"
				}
				]
			},
			{
				"name":"Lrp\/AsnC family",
				"children":[
				{
					"name":"KIP84_00890 winged helix-turn-helix transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"KIP84_07040 Lrp\/AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"KIP84_09805 Lrp\/AsnC ligand binding domain-containing protein\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"KIP84_10000 Lrp\/AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"KIP84_11510 Lrp\/AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"KIP84_11995 Lrp\/AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"KIP84_18050 Lrp\/AsnC ligand binding domain-containing protein\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				}
				]
			},
			{
				"name":"LuxR family"
			},
			{
				"name":"MarR family",
				"children":[
				{
					"name":"KIP84_15305 MarR family transcriptional regulator\tK23775 ohrR; MarR family transcriptional regulator, organic hydroperoxide resistance regulator"
				}
				]
			},
			{
				"name":"MerR family",
				"children":[
				{
					"name":"KIP84_12095 cueR; Cu(I)-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				},
				{
					"name":"KIP84_10965 soxR; redox-sensitive transcriptional activator SoxR\tK13639 soxR; MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR"
				}
				]
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"KIP84_08815 transcriptional repressor\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"KIP84_14085 fur; ferric iron uptake transcriptional regulator\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"KIP84_17805 transcriptional repressor\tK09823 zur; Fur family transcriptional regulator, zinc uptake regulator"
				}
				]
			},
			{
				"name":"IclR family",
				"children":[
				{
					"name":"KIP84_08025 pcaU; IclR family transcriptional regulator PcaU\tK02624 pcaR; IclR family transcriptional regulator, pca regulon regulatory protein"
				},
				{
					"name":"KIP84_10815 pobR; IclR family transcriptional regulator PobR\tK02624 pcaR; IclR family transcriptional regulator, pca regulon regulatory protein"
				}
				]
			},
			{
				"name":"CRP\/FNR family",
				"children":[
				{
					"name":"KIP84_10080 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"KIP84_12335 crp; cAMP-activated global transcriptional regulator CRP\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				}
				]
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"KIP84_09380 Rrf2 family transcriptional regulator\tK13643 iscR; Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor"
				},
				{
					"name":"KIP84_02165 Rrf2 family transcriptional regulator\tK13771 nsrR; Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"KIP84_10220 metalloregulator ArsR\/SmtB family transcription factor\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				},
				{
					"name":"KIP84_09755 helix-turn-helix transcriptional regulator\tK22042 hlyU; ArsR family transcriptional regulator, virulence genes transcriptional regulator"
				}
				]
			},
			{
				"name":"XRE family"
			},
			{
				"name":"PadR family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"KIP84_14570 biotin--[acetyl-CoA-carboxylase] ligase\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"KIP84_06380 fis; DNA-binding transcriptional regulator Fis\tK03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein"
				},
				{
					"name":"KIP84_11855 protein ninH\tK03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein"
				},
				{
					"name":"KIP84_08845 LysR family transcriptional regulator\tK02019 modE; molybdate transport system regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family",
				"children":[
				{
					"name":"KIP84_11165 transcriptional regulator\tK07722 nikR; CopG family transcriptional regulator, nickel-responsive regulator"
				}
				]
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"KIP84_09810 putA; trifunctional transcriptional regulator\/proline dehydrogenase\/L-glutamate gamma-semialdehyde dehydrogenase\tK13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor \/ proline dehydrogenase \/ delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]"
				}
				]
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"KIP84_18650 metal\/formaldehyde-sensitive transcriptional repressor\tK23240 rcnR; FrmR\/RcnR family transcriptional regulator, repressor of rcnA expression"
				},
				{
					"name":"KIP84_17915 BolA family transcriptional regulator\tK05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator"
				},
				{
					"name":"KIP84_09685 ParB\/RepB\/Spo0J family partition protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"KIP84_00985 tenA; thiaminase II\tK03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]"
				},
				{
					"name":"KIP84_03655 PaaX family transcriptional regulator\tK02616 paaX; phenylacetic acid degradation operon negative regulatory protein"
				},
				{
					"name":"KIP84_10890 paaX; phenylacetic acid degradation operon negative regulatory protein PaaX\tK02616 paaX; phenylacetic acid degradation operon negative regulatory protein"
				},
				{
					"name":"KIP84_10390 FMN-binding negative transcriptional regulator\tK07734 paiB; transcriptional regulator"
				},
				{
					"name":"KIP84_16980 YqgE\/AlgH family protein\tK07735 algH; putative transcriptional regulator"
				},
				{
					"name":"KIP84_17350 dksA; RNA polymerase-binding protein DksA\tK06204 dksA; RNA polymerase-binding transcription factor"
				},
				{
					"name":"KIP84_17480 nrdR; transcriptional regulator NrdR\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"KIP84_05935 rtcR; RNA repair transcriptional activator RtcR\tK14414 rtcR; transcriptional regulatory protein RtcR"
				}
				]
			}
			]
		}
		]
	}
	]
}