{
	"name":"acip01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"CBP36_10730 class A beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"CBP36_01800 two-component sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"CBP36_07545 two-component sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"CBP36_07900 two-component sensor histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"CBP36_01805 DNA-binding response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"CBP36_07550 DNA-binding response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"CBP36_07895 DNA-binding response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"CBP36_04110 D-Ala-D-Ala dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"CBP36_04980 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"CBP36_06510 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"CBP36_09475 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"CBP36_09670 efflux transporter periplasmic adaptor subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"CBP36_04985 multidrug efflux RND transporter permease subunit\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"CBP36_06505 hydrophobe\/amphiphile efflux-1 family RND transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"CBP36_09470 multidrug transporter AcrB\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"CBP36_09675 nodulation protein NolG\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"CBP36_03315 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_04990 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_06310 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_06500 transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_17630 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"CBP36_07425 efflux transporter periplasmic adaptor subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"CBP36_07430 multidrug transporter AcrB\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"CBP36_03315 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_04990 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_06310 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_06500 transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_17630 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"CBP36_03315 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_04990 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_06310 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_06500 transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"CBP36_17630 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"CBP36_00190 Cu(I)-responsive transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"CBP36_09455 transporter\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"CBP36_09690 channel protein TolC\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"CBP36_09455 transporter\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"CBP36_09690 channel protein TolC\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}