{
	"name":"acoc04121",
	"children":[
	{
		"name":"Ubiquitins and ubiquitin-like proteins",
		"children":[
		{
			"name":"Ubiquitins",
			"children":[
			{
				"name":"108684601 polyubiquitin-A\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"108694406 polyubiquitin-C\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"108693834 ubiquitin-60S ribosomal protein L40\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"108690564 ubiquitin-40S ribosomal protein S27a\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			}
			]
		},
		{
			"name":"Ubiquitin-like proteins (UBLs)",
			"children":[
			{
				"name":"108689645 NEDD8\tK12158 NEDD8; ubiquitin-like protein Nedd8"
			},
			{
				"name":"108693661 uncharacterized protein LOC108693661\tK02983 RP-S30e; small subunit ribosomal protein S30e"
			},
			{
				"name":"108692690 small ubiquitin-related modifier 3-like\tK12160 SUMO; small ubiquitin-related modifier"
			},
			{
				"name":"108693099 small ubiquitin-related modifier\tK12160 SUMO; small ubiquitin-related modifier"
			},
			{
				"name":"108684352 gamma-aminobutyric acid receptor-associated protein\tK08341 GABARAP; GABA(A) receptor-associated protein"
			},
			{
				"name":"108684377 autophagy protein 12-like\tK08336 ATG12; ubiquitin-like protein ATG12"
			},
			{
				"name":"108692435 ubiquitin-fold modifier 1\tK12162 UFM1; ubiquitin-fold modifier 1"
			},
			{
				"name":"108689177 ubiquitin-like protein 3\tK28515 UBL3; membrane-anchored ubiquitin-fold protein"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-activating enzymes (E1)",
		"children":[
		{
			"name":"Ubiquitin activating enzyme",
			"children":[
			{
				"name":"108691289 ubiquitin-like modifier-activating enzyme 1\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			}
			]
		},
		{
			"name":"UBL-activating enzymes",
			"children":[
			{
				"name":"108688632 SUMO-activating enzyme subunit 1\tK10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]"
			},
			{
				"name":"108684085 SUMO-activating enzyme subunit 2 isoform X1\tK10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]"
			},
			{
				"name":"108692013 NEDD8-activating enzyme E1 catalytic subunit\tK10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]"
			},
			{
				"name":"108688208 NEDD8-activating enzyme E1 regulatory subunit\tK04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit"
			},
			{
				"name":"108685508 adenylyltransferase and sulfurtransferase MOCS3 isoform X1\tK11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]"
			},
			{
				"name":"108694195 ubiquitin-like modifier-activating enzyme 5\tK12164 UBA5; ubiquitin-like modifier-activating enzyme 5"
			},
			{
				"name":"108687131 ubiquitin-like modifier-activating enzyme atg7 isoform X1\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-conjugating enzymes (E2)",
		"children":[
		{
			"name":"Ubiquitin-conjugating enzymes",
			"children":[
			{
				"name":"108692510 ubiquitin-conjugating enzyme E2-17 kDa isoform X1\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
			},
			{
				"name":"108691192 ubiquitin-conjugating enzyme E2 C\tK06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]"
			},
			{
				"name":"108691034 ubiquitin-conjugating enzyme E2-17 kDa\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"108689804 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2-24 kDa-like\tK20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]"
			},
			{
				"name":"108685592 ubiquitin-conjugating enzyme E2 G1\tK10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]"
			},
			{
				"name":"108686301 ubiquitin-conjugating enzyme E2 G2 isoform X1\tK04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]"
			},
			{
				"name":"108687057 ubiquitin-conjugating enzyme E2 H\tK10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]"
			},
			{
				"name":"108692007 ubiquitin-conjugating enzyme E2 J1-like\tK10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]"
			},
			{
				"name":"108688013 ubiquitin-conjugating enzyme E2 J2\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"108690665 ubiquitin-conjugating enzyme E2-22 kDa isoform X1\tK04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]"
			},
			{
				"name":"108684103 ubiquitin-conjugating enzyme E2 L3\tK04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]"
			},
			{
				"name":"108692810 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
			},
			{
				"name":"108687633 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O\tK10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]"
			},
			{
				"name":"108686118 transmembrane protein 231-like\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"108692280 ubiquitin-conjugating enzyme E2 Q2\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"108684217 ubiquitin-conjugating enzyme E2 R2\tK02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]"
			},
			{
				"name":"108688677 ubiquitin-conjugating enzyme E2 S\tK10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]"
			},
			{
				"name":"108687714 ubiquitin-conjugating enzyme E2 W\tK10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]"
			},
			{
				"name":"108684836 baculoviral IAP repeat-containing protein 6\tK10586 BIRC6; baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]"
			}
			]
		},
		{
			"name":"UBL-conjugating enzymes",
			"children":[
			{
				"name":"108690791 NEDD8-conjugating enzyme UBE2F-like\tK10687 UBE2F; ubiquitin-conjugating enzyme E2 F [EC:2.3.2.34]"
			},
			{
				"name":"108694325 NEDD8-conjugating enzyme Ubc12\tK10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]"
			},
			{
				"name":"108684311 ubiquitin-like-conjugating enzyme ATG3\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
			},
			{
				"name":"108688528 ubiquitin-fold modifier-conjugating enzyme 1\tK12165 UFC1; ufm1-conjugating enzyme 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin ligases (E3)",
		"children":[
		{
			"name":"HECT type E3",
			"children":[
			{
				"name":"108684094 ubiquitin-protein ligase E3A isoform X1\tK10587 UBE3A; ubiquitin-protein ligase E3 A [EC:2.3.2.26]"
			},
			{
				"name":"108693076 ubiquitin-protein ligase E3B\tK10588 UBE3B; ubiquitin-protein ligase E3 B [EC:2.3.2.26]"
			},
			{
				"name":"108684074 ubiquitin-protein ligase E3C\tK10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]"
			},
			{
				"name":"108686970 uncharacterized protein LOC108686970\tK20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]"
			},
			{
				"name":"108691895 E3 ubiquitin-protein ligase SMURF2\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"108689148 E3 ubiquitin-protein ligase Su(dx)\tK05633 WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]"
			},
			{
				"name":"108686051 E3 ubiquitin-protein ligase TRIP12 isoform X1\tK10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]"
			},
			{
				"name":"108695007 E3 ubiquitin-protein ligase Nedd-4 isoform X1\tK10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]"
			},
			{
				"name":"108690196 E3 ubiquitin-protein ligase HUWE1 isoform X1\tK10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]"
			},
			{
				"name":"108693058 apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1\tK22370 AREL1; apoptosis-resistant E3 ubiquitin protein ligase 1 [EC:2.3.2.26]"
			},
			{
				"name":"108687863 E3 ubiquitin-protein ligase UBR5 isoform X1\tK10593 EDD1; E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]"
			},
			{
				"name":"108684665 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
			},
			{
				"name":"108687101 probable E3 ubiquitin-protein ligase HERC4\tK10615 HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]"
			},
			{
				"name":"108689174 E3 ubiquitin-protein ligase HECW2\tK12168 HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]"
			},
			{
				"name":"108686813 E3 ubiquitin-protein ligase HECTD1 isoform X1\tK12231 HECTD1; E3 ubiquitin-protein ligase HECTD1 [EC:2.3.2.26]"
			},
			{
				"name":"HECT type E3 associated proteins",
				"children":[
				{
					"name":"108694570 NEDD4 family-interacting protein 1-like\tK25839 NDFIP; NEDD4 family-interacting protein"
				},
				{
					"name":"108692186 UPF0472 protein C16orf72 homolog\tK27699 HAPSTR1; HUWE1-associated protein modifying stress responses 1"
				}
				]
			}
			]
		},
		{
			"name":"U-box type E3",
			"children":[
			{
				"name":"108686271 ubiquitin conjugation factor E4 A\tK10596 UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]"
			},
			{
				"name":"108692783 ubiquitin conjugation factor E4 B\tK10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]"
			},
			{
				"name":"108693032 E3 ubiquitin-protein ligase CHIP isoform X1\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
			},
			{
				"name":"108692675 peptidyl-prolyl cis-trans isomerase-like 2\tK10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]"
			},
			{
				"name":"108689268 pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
			},
			{
				"name":"108691633 E3 ubiquitin-protein ligase RBBP6\tK10624 RBBP6; E3 ubiquitin-protein ligase RBBP6 [EC:2.3.2.27]"
			},
			{
				"name":"108687347 RING finger protein 37\tK10600 UBOX5; U-box domain-containing protein 5 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"Single Ring-finger type E3",
			"children":[
			{
				"name":"BRE1 proteins",
				"children":[
				{
					"name":"108695088 E3 ubiquitin-protein ligase Bre1 isoform X1\tK10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"CBL proteins",
				"children":[
				{
					"name":"108687610 E3 ubiquitin-protein ligase CBL-B-A isoform X1\tK04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"SINA (Seven in absentia) proteins"
			},
			{
				"name":"Ligand of Numb proteins",
				"children":[
				{
					"name":"108690813 PDZ domain-containing protein 4\tK15682 PDZRN3_4; ligand of Numb protein X 3\/4 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"March proteins",
				"children":[
				{
					"name":"108690983 E3 ubiquitin-protein ligase MARCH8-like\tK10656 MARCH1_8; E3 ubiquitin-protein ligase MARCH1\/8 [EC:2.3.2.27]"
				},
				{
					"name":"108690279 E3 ubiquitin-protein ligase MARCH5-like isoform X1\tK10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]"
				},
				{
					"name":"108693164 E3 ubiquitin-protein ligase MARCH6\tK10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"MDM2\/MDM4 proteins"
			},
			{
				"name":"NFX1 proteins",
				"children":[
				{
					"name":"108687752 protein shuttle craft-like\tK12236 NFX1; transcriptional repressor NF-X1"
				},
				{
					"name":"108695085 NF-X1-type zinc finger protein NFXL1 isoform X1\tK15683 NFXL1; NF-X1-type zinc finger protein NFXL1"
				}
				]
			},
			{
				"name":"Pellino proteins",
				"children":[
				{
					"name":"108693746 protein pellino isoform X1\tK11964 PELI; pellino [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Peripheral membrane proteins",
				"children":[
				{
					"name":"108684952 peroxisome biogenesis factor 10\tK13346 PEX10; peroxin-10 [EC:2.3.2.27]"
				},
				{
					"name":"108694151 peroxisome assembly protein 12\tK13345 PEX12; peroxin-12"
				}
				]
			},
			{
				"name":"RBR proteins",
				"children":[
				{
					"name":"108689998 E3 ubiquitin-protein ligase parkin\tK04556 PARK2; parkin [EC:2.3.2.31]"
				},
				{
					"name":"108692281 protein ariadne-1 isoform X1\tK11968 ARIH1; ariadne-1 [EC:2.3.2.31]"
				},
				{
					"name":"108692790 protein ariadne-2 isoform X1\tK11969 ARIH2; ariadne-2 [EC:2.3.2.31]"
				},
				{
					"name":"108689088 uncharacterized protein LOC108689088\tK10630 RBCK1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]"
				},
				{
					"name":"108684065 E3 ubiquitin-protein ligase RNF14-like\tK11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]"
				},
				{
					"name":"108688611 E3 ubiquitin-protein ligase RNF14-like\tK11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]"
				},
				{
					"name":"108694879 E3 ubiquitin-protein ligase RNF19A-like\tK11972 RNF19A; E3 ubiquitin-protein ligase RNF19A [EC:2.3.2.31]"
				},
				{
					"name":"108692610 E3 ubiquitin-protein ligase RNF34 isoform X1\tK20804 RNF34; E3 ubiquitin-protein ligase RNF34 [EC:2.3.2.31]"
				},
				{
					"name":"108690509 probable E3 ubiquitin-protein ligase RNF144A\tK11975 RNF144; E3 ubiquitin-protein ligase RNF144 [EC:2.3.2.31]"
				},
				{
					"name":"108694431 uncharacterized protein LOC108694431\tK20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"TRAF proteins",
				"children":[
				{
					"name":"108693910 TNF receptor-associated factor 6-A-like\tK03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"TRIM\/RBCC proteins",
				"children":[
				{
					"name":"108686719 brain tumor protein-like\tK11997 TRIM2_3; tripartite motif-containing protein 2\/3"
				},
				{
					"name":"108694596 tripartite motif-containing protein 2-like\tK11997 TRIM2_3; tripartite motif-containing protein 2\/3"
				},
				{
					"name":"108693853 E3 ubiquitin-protein ligase TRIM9\tK10649 TRIM9_67; tripartite motif-containing protein 9\/67"
				},
				{
					"name":"108684839 E3 ubiquitin-protein ligase TRIM23-like\tK07963 TRIM23; tripartite motif-containing protein 23 [EC:2.3.2.27]"
				},
				{
					"name":"108689168 E3 ubiquitin-protein ligase TRIM33-like isoform X1\tK08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]"
				},
				{
					"name":"108694803 uncharacterized protein LOC108694803\tK10608 TRIM37; tripartite motif-containing protein 37 [EC:2.3.2.27]"
				},
				{
					"name":"108691950 E3 ubiquitin-protein ligase TRIM71-like\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"UBR box proteins",
				"children":[
				{
					"name":"108689768 E3 ubiquitin-protein ligase UBR2 isoform X1\tK10626 UBR2; E3 ubiquitin-protein ligase UBR2 [EC:2.3.2.27]"
				},
				{
					"name":"108693137 E3 ubiquitin-protein ligase UBR3 isoform X1\tK11978 UBR3; E3 ubiquitin-protein ligase UBR3 [EC:2.3.2.27]"
				},
				{
					"name":"108685479 E3 ubiquitin-protein ligase UBR4\tK10691 UBR4; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]"
				},
				{
					"name":"108685203 putative E3 ubiquitin-protein ligase UBR7\tK11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"ATL proteins"
			},
			{
				"name":"Other single Ring-finger type E3",
				"children":[
				{
					"name":"108694185 E3 ubiquitin-protein ligase AMFR-like\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				},
				{
					"name":"108695029 baculoviral IAP repeat-containing protein 7-like isoform X1\tK16060 BIRC2_3; baculoviral IAP repeat-containing protein 2\/3"
				},
				{
					"name":"108695024 baculoviral IAP repeat-containing protein 7-B-like\tK16061 BIRC7_8; baculoviral IAP repeat-containing protein 7\/8"
				},
				{
					"name":"108695065 LOW QUALITY PROTEIN: putative inhibitor of apoptosis\tK16061 BIRC7_8; baculoviral IAP repeat-containing protein 7\/8"
				},
				{
					"name":"108691754 BRCA1-associated protein isoform X1\tK10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]"
				},
				{
					"name":"108690431 E3 ubiquitin-protein ligase Hakai-like isoform X1\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]"
				},
				{
					"name":"108688151 alpha-protein kinase 1 isoform X1\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
				},
				{
					"name":"108692972 DC-STAMP domain-containing protein 1-like\tK22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]"
				},
				{
					"name":"108693106 protein deltex\tK06058 DTX; deltex [EC:2.3.2.27]"
				},
				{
					"name":"108693562 E3 ubiquitin-protein ligase FANCL\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
				},
				{
					"name":"108689034 E3 ubiquitin-protein ligase KCMF1-like\tK22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]"
				},
				{
					"name":"108685234 E3 ubiquitin-protein ligase LRSAM1-like isoform X1\tK10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]"
				},
				{
					"name":"108687906 E3 ubiquitin-protein ligase listerin\tK22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]"
				},
				{
					"name":"108691258 RNA-binding protein MEX3B\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]"
				},
				{
					"name":"108686151 E3 ubiquitin-protein ligase MIB1\tK10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]"
				},
				{
					"name":"108693807 E3 ubiquitin-protein ligase MIB2\tK10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]"
				},
				{
					"name":"108684550 probable E3 ubiquitin-protein ligase makorin-1 isoform X1\tK15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]"
				},
				{
					"name":"108689577 mitochondrial ubiquitin ligase activator of NFKB 1-like\tK15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]"
				},
				{
					"name":"108691907 E3 ubiquitin-protein ligase MYLIP\tK10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]"
				},
				{
					"name":"108689745 protein neuralized isoform X1\tK01931 NEUR; protein neuralized [EC:2.3.2.27]"
				},
				{
					"name":"108690999 E3 ubiquitin-protein ligase RAD18-like\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"108687664 RING finger and CHY zinc finger domain-containing protein 1 isoform X1\tK10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"108691892 roquin-2\tK15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein"
				},
				{
					"name":"108694868 E3 ubiquitin-protein ligase RFWD2\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
				},
				{
					"name":"108690657 E3 ubiquitin-protein ligase RFWD3-like\tK15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]"
				},
				{
					"name":"108690985 uncharacterized RING finger protein C548.05c-like\tK22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]"
				},
				{
					"name":"108689160 E3 ubiquitin-protein ligase RNF185-like\tK10666 RNF5_185; E3 ubiquitin-protein ligase RNF5\/185 [EC:2.3.2.27]"
				},
				{
					"name":"108690847 E3 ubiquitin-protein ligase RNF8-like\tK10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]"
				},
				{
					"name":"108693018 RING finger protein 10 isoform X1\tK26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]"
				},
				{
					"name":"108684557 RING finger protein 11 isoform X1\tK11980 RNF11; E3 ubiquitin-protein ligase RNF11"
				},
				{
					"name":"108694529 E3 ubiquitin-protein ligase RNF13-like\tK15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]"
				},
				{
					"name":"108693918 E3 ubiquitin-protein ligase RNF25 isoform X1\tK10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]"
				},
				{
					"name":"108693472 RING finger protein 44 isoform X1\tK19041 RNF38_44; E3 ubiquitin-protein ligase RNF38\/44 [EC:2.3.2.27]"
				},
				{
					"name":"108686275 E3 ubiquitin-protein ligase NRDP1 isoform X1\tK11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]"
				},
				{
					"name":"108693761 LOW QUALITY PROTEIN: uncharacterized protein LOC108693761\tK10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]"
				},
				{
					"name":"108692058 E3 ubiquitin-protein ligase RNF115 isoform X1\tK11982 RNF115_126; E3 ubiquitin-protein ligase RNF115\/126 [EC:2.3.2.27]"
				},
				{
					"name":"108685016 RING finger protein 121 isoform X1\tK15698 RNF121_175; RING finger protein 121\/175"
				},
				{
					"name":"108693740 E3 ubiquitin-protein ligase RNF123\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"108688267 protein TRC8 homolog\tK15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]"
				},
				{
					"name":"108690513 E3 ubiquitin-protein ligase RNF146\tK15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]"
				},
				{
					"name":"108690492 RING finger protein 157 isoform X1\tK25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]"
				},
				{
					"name":"108690540 dual specificity protein phosphatase 12-like\tK15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]"
				},
				{
					"name":"108689111 E3 ubiquitin-protein ligase RNF181-like\tK22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]"
				},
				{
					"name":"108691344 E3 ubiquitin-protein ligase Rnf220-like\tK25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]"
				},
				{
					"name":"108684599 RING finger and transmembrane domain-containing protein 2 isoform X1\tK28516 RNFT2; E3 ubiquitin-protein ligase RNFT2"
				},
				{
					"name":"108685390 U4\/U6.U5 tri-snRNP-associated protein 1\tK11984 SART1; U4\/U6.U5 tri-snRNP-associated protein 1"
				},
				{
					"name":"108688565 SH3 domain-containing RING finger protein 3 isoform X1\tK12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"
				},
				{
					"name":"108689805 E3 ubiquitin-protein ligase synoviolin A\tK10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]"
				},
				{
					"name":"108688095 E3 ubiquitin-protein ligase TM129\tK22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]"
				},
				{
					"name":"108684996 E3 ubiquitin-protein ligase TRAIP-like\tK11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]"
				},
				{
					"name":"108686653 E3 ubiquitin-protein ligase TRAIP-like\tK11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]"
				},
				{
					"name":"108685191 E3 ubiquitin-protein ligase UHRF1-like\tK10638 UHRF1; E3 ubiquitin-protein ligase UHRF1 [EC:2.3.2.27]"
				},
				{
					"name":"108684713 RING finger protein unkempt homolog isoform X1\tK23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]"
				},
				{
					"name":"108685991 zinc finger protein 598\tK22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]"
				},
				{
					"name":"108690504 E3 ubiquitin-protein ligase znrf1\tK10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1\/2 [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Atypical E3",
			"children":[
			{
				"name":"108691428 non-structural maintenance of chromosomes element 1 homolog isoform X1\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
			},
			{
				"name":"108686451 interferon regulatory factor 2-binding protein-like B\tK22383 IRF2BP; interferon regulatory factor 2-binding protein"
			}
			]
		},
		{
			"name":"UBL E3 ligases",
			"children":[
			{
				"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
			},
			{
				"name":"108690012 E3 SUMO-protein ligase RanBP2\tK12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]"
			},
			{
				"name":"108689522 E3 SUMO-protein ligase PIAS1 isoform X1\tK04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]"
			},
			{
				"name":"108689762 E3 SUMO-protein ligase NSE2-like\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
			},
			{
				"name":"108688509 uncharacterized protein LOC108688509\tK25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]"
			},
			{
				"name":"108685863 zinc finger BED domain-containing protein 1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"108691898 E3 UFM1-protein ligase 1 homolog\tK22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]"
			},
			{
				"name":"108687773 DCN1-like protein 1 isoform X1\tK17822 DCUN1D1_2; DCN1-like protein 1\/2"
			},
			{
				"name":"108691634 DCN1-like protein 3\tK17823 DCUN1D3; DCN1-like protein 3"
			},
			{
				"name":"108693213 DCN1-like protein 5 isoform X1\tK17824 DCUN1D4_5; DCN1-like protein 4\/5"
			}
			]
		},
		{
			"name":"Multi subunit type E3",
			"children":[
			{
				"name":"SCF complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"108684366 cullin-1\tK03347 CUL1; cullin 1"
					}
					]
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"108687439 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (F-box)",
					"children":[
					{
						"name":"108687324 beta-TrCP isoform X1\tK03362 FBXW1_11; F-box and WD-40 domain protein 1\/11"
					},
					{
						"name":"108686825 F-box\/WD repeat-containing protein 4\tK10262 FBXW4; F-box and WD-40 domain protein 4"
					},
					{
						"name":"108687548 F-box\/WD repeat-containing protein 5 isoform X1\tK10263 FBXW5; F-box and WD-40 domain protein 5"
					},
					{
						"name":"108690793 F-box\/WD repeat-containing protein 7 isoform X1\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"108688891 F-box\/WD repeat-containing protein 9-like\tK10265 FBXW9; F-box and WD-40 domain protein 9"
					},
					{
						"name":"108693220 S-phase kinase-associated protein 2\tK03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)"
					},
					{
						"name":"108690280 F-box\/LRR-repeat protein 7-like isoform X1\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"108690415 F-box\/LRR-repeat protein 20 isoform X1\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"108687769 F-box\/LRR-repeat protein 3-like\tK10269 FBXL3; F-box and leucine-rich repeat protein 3"
					},
					{
						"name":"108689341 F-box\/LRR-repeat protein 4-like\tK10270 FBXL4; F-box and leucine-rich repeat protein 4"
					},
					{
						"name":"108694893 F-box\/LRR-repeat protein 7\tK10273 FBXL7; F-box and leucine-rich repeat protein 7"
					},
					{
						"name":"108686307 jmjC domain-containing histone demethylation protein 1\tK10276 FBXL10_11; F-box and leucine-rich repeat protein 10\/11 [EC:1.14.11.27]"
					},
					{
						"name":"108693021 F-box\/LRR-repeat protein 14\tK10280 FBXL14; F-box and leucine-rich repeat protein 14"
					},
					{
						"name":"108690081 F-box\/LRR-repeat protein 16\tK10282 FBXL16; F-box and leucine-rich repeat protein 16"
					},
					{
						"name":"108692787 F-box only protein 44-like\tK10100 FBXO6; F-box protein 6"
					},
					{
						"name":"108692750 uncharacterized protein LOC108692750\tK10293 FBXO7; F-box protein 7"
					},
					{
						"name":"108689388 F-box only protein 9 isoform X1\tK10295 FBXO9; F-box protein 9"
					},
					{
						"name":"108686606 F-box only protein 11\tK10297 FBXO11; F-box protein 11"
					},
					{
						"name":"108686761 uncharacterized protein CG43427 isoform X1\tK06084 LMO7; F-box protein 20"
					},
					{
						"name":"108685524 F-box only protein 21-like\tK10301 FBXO21; F-box protein 21"
					},
					{
						"name":"108690939 F-box only protein 22-like\tK10302 FBXO22; F-box protein 22"
					},
					{
						"name":"108690824 F-box only protein 32\tK10305 FBXO25_32; F-box protein 25\/32"
					},
					{
						"name":"108689591 F-box only protein 28\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"108692912 F-box only protein 28\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"108690722 F-box only protein 33\tK10310 FBXO33; F-box protein 33"
					},
					{
						"name":"108687499 F-box only protein 39-like\tK10314 FBXO39; F-box protein 39"
					},
					{
						"name":"108691579 uncharacterized protein LOC108691579\tK10314 FBXO39; F-box protein 39"
					},
					{
						"name":"108687514 F-box only protein 42-like isoform X1\tK10317 FBXO42; F-box protein 42"
					},
					{
						"name":"108684791 F-box\/SPRY domain-containing protein 1\tK10319 FBXO45; F-box protein 45"
					}
					]
				}
				]
			},
			{
				"name":"Cul2 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"108684405 cullin-2 isoform X1\tK03870 CUL2; cullin 2"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"108691935 transcription elongation factor B polypeptide 1 isoform X1\tK03872 ELOC; elongin-C"
					},
					{
						"name":"108689552 transcription elongation factor B polypeptide 2\tK03873 ELOB; elongin-B"
					},
					{
						"name":"108691314 transcription elongation factor B polypeptide 2-like\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"108692083 von Hippel-Lindau disease tumor suppressor isoform X1\tK03871 VHL; von Hippel-Lindau disease tumor supressor"
					},
					{
						"name":"108689241 leucine-rich repeat protein 1 isoform X1\tK10348 LRR1; LRR-repeat protein 1"
					},
					{
						"name":"108691222 protein fem-1 homolog CG6966 isoform X1\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"108693340 protein fem-1 homolog A isoform X1\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"108694615 protein fem-1 homolog B-like\tK10349 FEM1B; protein fem-1 homolog B"
					},
					{
						"name":"108693202 amyloid protein-binding protein 2 isoform X1\tK25806 APPBP2; amyloid protein-binding protein 2"
					},
					{
						"name":"108693180 kelch domain-containing protein 10 homolog\tK25809 KLHDC10; kelch domain-containing protein 10"
					},
					{
						"name":"108687657 protein zyg-11 homolog B-like isoform X1\tK10350 ZYG11; Zyg-11 protein"
					},
					{
						"name":"108691123 protein zer-1 homolog isoform X1\tK10350 ZYG11; Zyg-11 protein"
					},
					{
						"name":"108686262 LOW QUALITY PROTEIN: zinc finger SWIM domain-containing protein 8\tK25207 ZSWIM8; zinc finger SWIM domain-containing protein 8"
					}
					]
				}
				]
			},
			{
				"name":"Cul3 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"108684101 cullin-3 isoform X1\tK03869 CUL3; cullin 3"
					}
					]
				},
				{
					"name":"Adoptor and target recognizing subunit (BTB)",
					"children":[
					{
						"name":"108685406 kelch-like protein 5\tK10442 KLHL1_4_5; kelch-like protein 1\/4\/5"
					},
					{
						"name":"108687082 ring canal kelch homolog isoform X1\tK10443 KLHL2_3; kelch-like protein 2\/3"
					},
					{
						"name":"108685564 kelch-like protein 10\tK10448 KLHL10; kelch-like protein 10"
					},
					{
						"name":"108693937 kelch-like protein 10\tK10448 KLHL10; kelch-like protein 10"
					},
					{
						"name":"108687189 kelch-like ECH-associated protein 1\tK10456 KLHL19; kelch-like protein 19"
					},
					{
						"name":"108692347 LOW QUALITY PROTEIN: kelch-like protein diablo\tK10457 KLHL20; kelch-like protein 20"
					},
					{
						"name":"108693415 actin-binding protein IPP\tK13956 IPP; actin-binding protein IPP"
					},
					{
						"name":"108684956 BTB\/POZ domain-containing protein 6-B\tK10477 BTBD1_2; BTB\/POZ domain-containing protein 1\/2"
					},
					{
						"name":"108691506 BTB\/POZ domain-containing protein 1-like isoform X1\tK10477 BTBD1_2; BTB\/POZ domain-containing protein 1\/2"
					},
					{
						"name":"108686457 BTB\/POZ domain-containing protein 6\tK10478 BTBD3_6; BTB\/POZ domain-containing protein 3\/6"
					},
					{
						"name":"108687927 BTB\/POZ domain-containing protein 7\tK10479 BTBD7; BTB\/POZ domain-containing protein 7"
					},
					{
						"name":"108689127 uncharacterized protein LOC108689127\tK10480 BTBD8; BTB\/POZ domain-containing protein 8"
					},
					{
						"name":"108691499 LOW QUALITY PROTEIN: BTB\/POZ domain-containing protein 9-like\tK10481 BTBD9; BTB\/POZ domain-containing protein 9"
					},
					{
						"name":"108685625 protein germ cell-less\tK10485 BTBD13; BTB\/POZ domain-containing protein 13 (germ cell-less protein-like 1)"
					},
					{
						"name":"108684303 ankyrin repeat and BTB\/POZ domain-containing protein BTBD11 isoform X1\tK10521 ABTB2; ankyrin repeat and BTB\/POZ domain-containing protein 2"
					},
					{
						"name":"108687365 rho-related BTB domain-containing protein 1\tK07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1\/2"
					},
					{
						"name":"108689367 BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3\tK15074 BACURD; BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein"
					},
					{
						"name":"108687667 BTB\/POZ domain-containing protein KCTD1\tK21754 KCTD1_15; BTB\/POZ domain-containing protein KCTD1\/15"
					},
					{
						"name":"108685101 BTB\/POZ domain-containing protein KCTD5 isoform X1\tK21914 KCTD2_5_17; BTB\/POZ domain-containing protein KCTD2\/5\/17"
					},
					{
						"name":"108686608 BTB\/POZ domain-containing protein KCTD3\tK21915 KCTD3; BTB\/POZ domain-containing protein KCTD3"
					},
					{
						"name":"108685456 BTB\/POZ domain-containing protein KCTD16\tK21918 KCTD8_12_16; BTB\/POZ domain-containing protein KCTD8\/12\/16"
					},
					{
						"name":"108691247 BTB\/POZ domain-containing protein KCTD9\tK21919 KCTD9; BTB\/POZ domain-containing protein KCTD9"
					},
					{
						"name":"108688127 speckle-type POZ protein A isoform X1\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"108688000 leucine-zipper-like transcriptional regulator 1 isoform X1\tK23330 LZTR1; leucine-zipper-like transcriptional regulator 1"
					}
					]
				}
				]
			},
			{
				"name":"Cul4 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"108689376 cullin-4A\tK10609 CUL4; cullin 4"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"108685539 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (DCAF)",
					"children":[
					{
						"name":"108690778 DET1 homolog\tK10571 DET1; de-etiolated-1"
					},
					{
						"name":"108694868 E3 ubiquitin-protein ligase RFWD2\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
					},
					{
						"name":"108685141 DET1- and DDB1-associated protein 1\tK11792 DDA1; DET1- and DDB1-associated protein 1"
					},
					{
						"name":"108693353 protein cereblon isoform X1\tK11793 CRBN; cereblon"
					},
					{
						"name":"108686430 protein mahjong\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]"
					},
					{
						"name":"108687156 protein lethal(2)denticleless\tK11790 DTL; denticleless"
					},
					{
						"name":"108692992 DDB1- and CUL4-associated factor 5\tK11800 DCAF5; DDB1- and CUL4-associated factor 5"
					},
					{
						"name":"108691877 DDB1- and CUL4-associated factor 6-like\tK11795 DCAF6; DDB1- and CUL4-associated factor 6"
					},
					{
						"name":"108688916 LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 7\tK11805 DCAF7; DDB1- and CUL4-associated factor 7"
					},
					{
						"name":"108687100 LOW QUALITY PROTEIN: DDB1- and CUL4-associated factor 8-like\tK11804 DCAF8; DDB1- and CUL4-associated factor 8"
					},
					{
						"name":"108687193 DDB1- and CUL4-associated factor 8-like isoform X1\tK11804 DCAF8; DDB1- and CUL4-associated factor 8"
					},
					{
						"name":"108693699 DDB1- and CUL4-associated factor 8\tK11804 DCAF8; DDB1- and CUL4-associated factor 8"
					},
					{
						"name":"108688198 WD and tetratricopeptide repeats protein 1\tK11807 WDTC1; WD and tetratricopeptide repeats protein 1"
					},
					{
						"name":"108693336 DDB1- and CUL4-associated factor 10\tK11802 DCAF10; DDB1- and CUL4-associated factor 10"
					},
					{
						"name":"108692583 DDB1- and CUL4-associated factor 11\tK11801 DCAF11; DDB1- and CUL4-associated factor 11"
					},
					{
						"name":"108689463 DDB1- and CUL4-associated factor 12\tK11803 DCAF12; DDB1- and CUL4-associated factor 12"
					},
					{
						"name":"108691916 DDB1- and CUL4-associated factor 13\tK11806 DCAF13; DDB1- and CUL4-associated factor 13"
					},
					{
						"name":"108693814 uncharacterized protein LOC108693814 isoform X1\tK11791 DCAF15; DDB1- and CUL4-associated factor 15"
					},
					{
						"name":"108688780 PH-interacting protein isoform X1\tK11798 BRWD1_3; bromodomain and WD repeat domain containing protein 1\/3"
					},
					{
						"name":"108689159 LOW QUALITY PROTEIN: WD repeat-containing protein 26\tK22382 WDR26; WD repeat-containing protein 26"
					},
					{
						"name":"108694312 gastrulation defective protein 1 homolog\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			},
			{
				"name":"Cul5 complex",
				"children":[
				{
					"name":"Ring finger protein"
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"108689763 cullin-5\tK10612 CUL5; cullin 5"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"108691935 transcription elongation factor B polypeptide 1 isoform X1\tK03872 ELOC; elongin-C"
					},
					{
						"name":"108689552 transcription elongation factor B polypeptide 2\tK03873 ELOB; elongin-B"
					},
					{
						"name":"108691314 transcription elongation factor B polypeptide 2-like\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"108684160 uncharacterized protein LOC108684160\tK04698 SOCS5; suppressor of cytokine signaling 5"
					},
					{
						"name":"108686302 uncharacterized protein LOC108686302 isoform X1\tK04699 SOCS6_7; suppressor of cytokine signaling 6\/7"
					},
					{
						"name":"108691304 uncharacterized protein LOC108691304\tK04699 SOCS6_7; suppressor of cytokine signaling 6\/7"
					},
					{
						"name":"108686352 uncharacterized protein LOC108686352\tK10339 ASB17; ankyrin repeat and SOCS box protein 17"
					},
					{
						"name":"108694123 SPRY domain-containing SOCS box protein 3-like isoform X1\tK10345 SPSB3; SPRY domain-containing SOCS box protein 3"
					},
					{
						"name":"108685109 ras-related protein Rab-40B\tK07928 RAB40; Ras-related protein Rab-40"
					},
					{
						"name":"108693345 RING finger and SPRY domain-containing protein 1-like\tK23332 RSPRY1; RING finger and SPRY domain-containing protein 1"
					}
					]
				}
				]
			},
			{
				"name":"Cul7 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"108687439 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul8 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein"
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul9 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"108686312 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				}
				]
			},
			{
				"name":"APC\/C",
				"children":[
				{
					"name":"Ring finger protein"
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"108692785 cell division cycle protein 20 homolog\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"108694302 fizzy-related protein homolog\tK03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex"
					}
					]
				},
				{
					"name":"Other subunits",
					"children":[
					{
						"name":"108688045 anaphase-promoting complex subunit 1 isoform X1\tK03348 APC1; anaphase-promoting complex subunit 1"
					},
					{
						"name":"108686764 cell division cycle protein 27 homolog\tK03350 APC3; anaphase-promoting complex subunit 3"
					},
					{
						"name":"108684247 anaphase-promoting complex subunit 4\tK03351 APC4; anaphase-promoting complex subunit 4"
					},
					{
						"name":"108692014 anaphase-promoting complex subunit 5 isoform X1\tK03352 APC5; anaphase-promoting complex subunit 5"
					},
					{
						"name":"108690038 cell division cycle protein 16 homolog\tK03353 APC6; anaphase-promoting complex subunit 6"
					},
					{
						"name":"108690128 anaphase-promoting complex subunit 7\tK03354 APC7; anaphase-promoting complex subunit 7"
					},
					{
						"name":"108695115 cell division cycle protein 23 homolog\tK03355 APC8; anaphase-promoting complex subunit 8"
					},
					{
						"name":"108687010 anaphase-promoting complex subunit 10 isoform X1\tK03357 APC10; anaphase-promoting complex subunit 10"
					},
					{
						"name":"108691784 anaphase-promoting complex subunit CDC26-like\tK03359 APC12; anaphase-promoting complex subunit 12"
					},
					{
						"name":"108694888 anaphase-promoting complex subunit 13\tK12456 APC13; anaphase-promoting complex subunit 13"
					},
					{
						"name":"108687596 anaphase-promoting complex subunit 15-like\tK25228 APC15; anaphase-promoting complex subunit 15"
					}
					]
				}
				]
			},
			{
				"name":"BRCC complex",
				"children":[
				{
					"name":"108694498 breast cancer type 2 susceptibility protein homolog isoform X1\tK08775 BRCA2; breast cancer 2 susceptibility protein"
				},
				{
					"name":"108688764 lys-63-specific deubiquitinase BRCC36 isoform X1\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
				},
				{
					"name":"108692632 BRCA1-associated RING domain protein 1-like\tK10683 BARD1; BRCA1-associated RING domain protein 1"
				},
				{
					"name":"108685242 BRCA1-A complex subunit BRE-like\tK12173 BRE; BRCA1-A complex subunit BRE"
				},
				{
					"name":"108692620 DNA repair protein RAD51 homolog B\tK04482 RAD51; DNA repair protein RAD51"
				}
				]
			},
			{
				"name":"KPC complex",
				"children":[
				{
					"name":"108693740 E3 ubiquitin-protein ligase RNF123\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"108686226 ubiquitin-associated domain-containing protein 1\tK12174 KPC2; Kip1 ubiquitination-promoting complex protein 2"
				}
				]
			},
			{
				"name":"LUBAC complex",
				"children":[
				{
					"name":"108689088 uncharacterized protein LOC108689088\tK10630 RBCK1; RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"CTLH complex",
				"children":[
				{
					"name":"108688902 protein RMD5 homolog A isoform X1\tK23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]"
				},
				{
					"name":"108686456 ran-binding protein 9 isoform X1\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				},
				{
					"name":"108693319 armadillo repeat-containing protein 8-like\tK23336 ARMC8; armadillo repeat-containing protein 8"
				},
				{
					"name":"108684296 muskelin isoform X1\tK23337 MKLN1; muskelin"
				},
				{
					"name":"108684867 macrophage erythroblast attacher\tK18624 MAEA; macrophage erythroblast attacher"
				},
				{
					"name":"108685102 glucose-induced degradation protein 4 homolog\tK23335 GID4; glucose-induced degradation protein 4"
				},
				{
					"name":"108691596 glucose-induced degradation protein 8 homolog\tK23338 GID8; glucose-induced degradation protein 8"
				},
				{
					"name":"108689817 protein yippee-like 5\tK23339 YPEL5; protein yippee-like 5"
				},
				{
					"name":"108689159 LOW QUALITY PROTEIN: WD repeat-containing protein 26\tK22382 WDR26; WD repeat-containing protein 26"
				}
				]
			},
			{
				"name":"ERAD complex",
				"children":[
				{
					"name":"108694185 E3 ubiquitin-protein ligase AMFR-like\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				},
				{
					"name":"108687138 transmembrane and ubiquitin-like domain-containing protein 2\tK23340 TMUB; transmembrane and ubiquitin-like domain-containing protein"
				},
				{
					"name":"108684878 erlin-2-B-like\tK23341 ERLIN; erlin"
				}
				]
			},
			{
				"name":"LMBR1L-GP78-UBAC2 complex",
				"children":[
				{
					"name":"108687266 protein Lilipod\tK25215 LMBR1L; protein LMBR1L"
				},
				{
					"name":"108694185 E3 ubiquitin-protein ligase AMFR-like\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				}
				]
			},
			{
				"name":"STUB1-CHIC2  complex",
				"children":[
				{
					"name":"108693032 E3 ubiquitin-protein ligase CHIP isoform X1\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"108688752 cysteine-rich hydrophobic domain-containing protein 2\tK28185 CHIC2; cysteine-rich hydrophobic domain-containing protein 2"
				}
				]
			},
			{
				"name":"SLX5-SLX8 complex"
			},
			{
				"name":"Multi subunit type E3 associated proteins",
				"children":[
				{
					"name":"108688153 cullin-associated NEDD8-dissociated protein 1\tK17263 CAND1; cullin-associated NEDD8-dissociated protein 1"
				},
				{
					"name":"108688111 COMM domain-containing protein 2\tK22558 COMMD2; COMM domain containing 2"
				},
				{
					"name":"108685663 COMM domain-containing protein 3\tK22559 COMMD3; COMM domain containing 3"
				},
				{
					"name":"108687316 COMM domain-containing protein 4 isoform X1\tK22560 COMMD4; COMM domain containing 4"
				},
				{
					"name":"108694381 COMM domain-containing protein 5\tK22561 COMMD5; COMM domain containing 5"
				},
				{
					"name":"108688863 COMM domain-containing protein 7-like\tK22563 COMMD7; COMM domain containing 7"
				},
				{
					"name":"108693884 COMM domain-containing protein 8-like\tK22564 COMMD8; COMM domain containing 8"
				},
				{
					"name":"108687960 COMM domain-containing protein 10\tK22566 COMMD10; COMM domain containing 10"
				},
				{
					"name":"108694507 coiled-coil domain-containing protein 22 homolog\tK23343 CCDC22; coiled-coil domain-containing protein 22"
				},
				{
					"name":"108688276 DDRGK domain-containing protein 1\tK23344 DDRGK1; DDRGK domain-containing protein 1"
				},
				{
					"name":"108691286 glomulin-like\tK23345 GLMN; glomulin"
				},
				{
					"name":"108686960 UBX domain-containing protein 7\tK24350 UBXN7; UBX domain-containing protein 7"
				},
				{
					"name":"108685873 parkin coregulated gene protein homolog\tK26163 PACRG; parkin coregulated gene protein"
				},
				{
					"name":"108686296 protein lingerer isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
				},
				{
					"name":"108684484 uncharacterized protein LOC108684484\tK26546 Dlish; SH3 domain-containing protein Dlish"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Deubiquitinating enzyme (DUB)",
		"children":[
		{
			"name":"Ubiquitin-specific proteases (UBPs)",
			"children":[
			{
				"name":"UCH",
				"children":[
				{
					"name":"108694717 ubiquitin carboxyl-terminal hydrolase calypso\tK08588 BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]"
				},
				{
					"name":"108686009 ubiquitin carboxyl-terminal hydrolase isozyme L3\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
				},
				{
					"name":"108686892 ubiquitin carboxyl-terminal hydrolase isozyme L5\tK05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"UBP\/USP",
				"children":[
				{
					"name":"108684783 ubiquitin carboxyl-terminal hydrolase CYLD\tK08601 CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]"
				},
				{
					"name":"108687567 ubiquitin carboxyl-terminal hydrolase 1\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
				},
				{
					"name":"108684841 putative uncharacterized protein DDB_G0277255 isoform X1\tK11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]"
				},
				{
					"name":"108691269 ubiquitin carboxyl-terminal hydrolase 3-like\tK11986 USP3; ubiquitin carboxyl-terminal hydrolase 3 [EC:3.4.19.12]"
				},
				{
					"name":"108685756 ubiquitin carboxyl-terminal hydrolase 5\tK11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5\/13 [EC:3.4.19.12]"
				},
				{
					"name":"108684419 ubiquitin carboxyl-terminal hydrolase 7\tK11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]"
				},
				{
					"name":"108685517 probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1\tK11840 USP9_24; ubiquitin carboxyl-terminal hydrolase 9\/24 [EC:3.4.19.12]"
				},
				{
					"name":"108689709 ubiquitin carboxyl-terminal hydrolase 10\tK11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]"
				},
				{
					"name":"108692224 ubiquitin carboxyl-terminal hydrolase 46\tK11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12\/46 [EC:3.4.19.12]"
				},
				{
					"name":"108692437 ubiquitin carboxyl-terminal hydrolase 14\tK11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]"
				},
				{
					"name":"108690610 ubiquitin carboxyl-terminal hydrolase 45 isoform X1\tK11844 USP16_45; ubiquitin carboxyl-terminal hydrolase 16\/45 [EC:3.4.19.12]"
				},
				{
					"name":"108688541 ubiquitin carboxyl-terminal hydrolase 20\tK11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20\/33 [EC:3.4.19.12]"
				},
				{
					"name":"108692523 ubiquitin carboxyl-terminal hydrolase 22\tK11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22\/27\/51 [EC:3.4.19.12]"
				},
				{
					"name":"108693105 ubiquitin carboxyl-terminal hydrolase 30 homolog\tK11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]"
				},
				{
					"name":"108693477 ubiquitin carboxyl-terminal hydrolase 31-like\tK11852 USP31; ubiquitin carboxyl-terminal hydrolase 31 [EC:3.4.19.12]"
				},
				{
					"name":"108685707 ubiquitin carboxyl-terminal hydrolase 34\tK11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]"
				},
				{
					"name":"108690362 ubiquitin carboxyl-terminal hydrolase 35-like\tK11854 USP35_38; ubiquitin carboxyl-terminal hydrolase 35\/38 [EC:3.4.19.12]"
				},
				{
					"name":"108694095 ubiquitin carboxyl-terminal hydrolase 36-like isoform X1\tK11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36\/42 [EC:3.4.19.12]"
				},
				{
					"name":"108690755 ubiquitin carboxyl-terminal hydrolase 47 isoform X1\tK11857 USP47; ubiquitin carboxyl-terminal hydrolase 47 [EC:3.4.19.12]"
				},
				{
					"name":"108692392 ubiquitin carboxyl-terminal hydrolase 48-like\tK11858 USP48; ubiquitin carboxyl-terminal hydrolase 48 [EC:3.4.19.12]"
				},
				{
					"name":"108685383 uncharacterized protein LOC108685383\tK27920 USP54; ubiquitin carboxyl-terminal hydrolase 54 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"OTU",
				"children":[
				{
					"name":"108694648 ubiquitin thioesterase otubain-like\tK09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]"
				},
				{
					"name":"108695008 OTU domain-containing protein 5-B\tK12655 OTUD5; OTU domain-containing protein 5 [EC:3.4.19.12]"
				},
				{
					"name":"108692933 OTU domain-containing protein 6B\tK18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]"
				},
				{
					"name":"108684216 OTU domain-containing protein 7B-like isoform X1\tK11860 OTUD7A_B; OTU domain-containing protein 7 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MJD",
				"children":[
				{
					"name":"108687659 ataxin-3-like isoform X1\tK11863 ATXN3; ataxin-3 [EC:3.4.22.-]"
				}
				]
			},
			{
				"name":"MINDY",
				"children":[
				{
					"name":"108687339 protein FAM188A homolog\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				},
				{
					"name":"108689825 protein FAM188B2\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"JAMM",
				"children":[
				{
					"name":"108688764 lys-63-specific deubiquitinase BRCC36 isoform X1\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
				},
				{
					"name":"108689546 26S proteasome non-ATPase regulatory subunit 14\tK03030 PSMD14; 26S proteasome regulatory subunit N11"
				},
				{
					"name":"108688257 STAM-binding protein-like A isoform X1\tK11866 STAMBP; STAM-binding protein [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"PPPDE",
				"children":[
				{
					"name":"108692521 desumoylating isopeptidase 2\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"ZUFSP",
				"children":[
				{
					"name":"108686198 zinc finger with UFM1-specific peptidase domain protein-like isoform X1\tK24134 ZUP1; zinc finger-containing ubiquitin peptidase 1 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"BRISC complex",
				"children":[
				{
					"name":"108684526 BRISC complex subunit FAM175B-like\tK20799 FAM175B; BRISC complex subunit Abro1"
				},
				{
					"name":"108689422 BRISC and BRCA1-A complex member 1-like\tK20776 BABAM; BRISC and BRCA1-A complex member 1"
				},
				{
					"name":"108688764 lys-63-specific deubiquitinase BRCC36 isoform X1\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
				},
				{
					"name":"108685242 BRCA1-A complex subunit BRE-like\tK12173 BRE; BRCA1-A complex subunit BRE"
				}
				]
			}
			]
		},
		{
			"name":"UBL-specific proteases (ULPs)",
			"children":[
			{
				"name":"108692874 sentrin-specific protease 1-like\tK08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]"
			},
			{
				"name":"108687969 uncharacterized protein LOC108687969 isoform X1\tK08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]"
			},
			{
				"name":"108685527 sentrin-specific protease 8-like\tK08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]"
			},
			{
				"name":"108686009 ubiquitin carboxyl-terminal hydrolase isozyme L3\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
			},
			{
				"name":"108692659 uncharacterized protein LOC108692659 isoform X1\tK22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]"
			},
			{
				"name":"COP9 signalosome (CSN) complex",
				"children":[
				{
					"name":"108690122 COP9 signalosome complex subunit 1\tK12175 GPS1; COP9 signalosome complex subunit 1"
				},
				{
					"name":"108692700 COP9 signalosome complex subunit 2\tK12176 COPS2; COP9 signalosome complex subunit 2"
				},
				{
					"name":"108694143 COP9 signalosome complex subunit 3\tK12177 COPS3; COP9 signalosome complex subunit 3"
				},
				{
					"name":"108684965 COP9 signalosome complex subunit 4\tK12178 COPS4; COP9 signalosome complex subunit 4"
				},
				{
					"name":"108693511 COP9 signalosome complex subunit 5 isoform X1\tK09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]"
				},
				{
					"name":"108694339 COP9 signalosome complex subunit 6\tK12179 COPS6; COP9 signalosome complex subunit 6"
				},
				{
					"name":"108690751 COP9 signalosome complex subunit 7\tK12180 COPS7; COP9 signalosome complex subunit 7"
				},
				{
					"name":"108689050 COP9 signalosome complex subunit 8\tK12181 COPS8; COP9 signalosome complex subunit 8"
				},
				{
					"name":"108690021 myeloma-overexpressed gene 2 protein homolog\tK28062 COPS9; COP9 signalosome complex subunit 9"
				}
				]
			}
			]
		}
		]
	}
	]
}