{
	"name":"act03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"ACLA_024800 origin recognition complex subunit Orc1, putative\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"ACLA_012410 origin recognition complex subunit 2, putative\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"ACLA_057590 hypothetical protein\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"ACLA_070130 origin recognition complex subunit Orc4, putative\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"ACLA_031900 hypothetical protein\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"ACLA_084200 hypothetical protein\tK02608 ORC6; origin recognition complex subunit 6"
				},
				{
					"name":"ACLA_006010 cell division control protein Cdc6, putative\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"ACLA_041360 DNA replication licensing factor Mcm2, putative\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"ACLA_030670 DNA replication licensing factor MCM3\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"ACLA_080870 DNA replication licensing factor MCM4\tK02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]"
				},
				{
					"name":"ACLA_002640 DNA replication licensing factor Mcm5, putative\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"ACLA_013890 DNA replication licensing factor Mcm6, putative\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"ACLA_069170 DNA replication licensing factor Mcm7, putative\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"ACLA_033550 cell cycle protein kinase, putative\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				},
				{
					"name":"ACLA_083210 DBF zinc finger domain protein\tK02309 DBF4; regulatory subunit for Cdc7p protein kinase"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"ACLA_051420 PSF1 domain protein\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"ACLA_070050 DNA replication complex GINS protein (Psf2), putative\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"ACLA_050690 GINS complex subunit Psf3, putative\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"ACLA_082460 GINS DNA replication complex subunit Sld5, putative\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"ACLA_016370 subunit of DNA polymerase II\tK03507 DPB11; DNA replication regulator DPB11"
				},
				{
					"name":"ACLA_020010 cell division control protein 45, putative\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"ACLA_038150 DNA replication protein, putative\tK10736 MCM10; minichromosome maintenance protein 10"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"ACLA_069720 DNA polymerase alpha catalytic subunit, putative\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"ACLA_016000 DNA polymerase alpha\/primase associated subunit\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"ACLA_036970 DNA primase subunit Pri1, putative\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"ACLA_031200 DNA primase large subunit\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"ACLA_037330 DNA polymerase epsilon, catalytic subunit A\/POL2, putative\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"ACLA_068130 DNA polymerase epsilon subunit B, putative\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"ACLA_075510 DNA polymerase delta large chain\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"ACLA_047340 DNA polymerase delta subunit 2, putative\tK02328 POLD2; DNA polymerase delta subunit 2"
				},
				{
					"name":"ACLA_075620 hypothetical protein\tK03504 POLD3; DNA polymerase delta subunit 3"
				},
				{
					"name":"ACLA_084290 DNA polymerase delta subunit 4, putative\tK03505 POLD4; DNA polymerase delta subunit 4"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"ACLA_015680 DNA polymerase gamma\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"ACLA_068000 replication factor A 1, rfa1\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"ACLA_084790 possible replication factor-a protein\tK10739 RFA2; replication factor A2"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"ACLA_071100 chromosome transmission fidelity factor\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"ACLA_036280 DNA replication factor C subunit Rfc2, putative\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"ACLA_095520 DNA replication factor C subunit Rfc4, putative\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"ACLA_003460 DNA replication factor C subunit Rfc3, putative\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"ACLA_071120 DNA replication factor C subunit Rfc5, putative\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"ACLA_025490 reverse transcriptase, RNaseH, putative\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"ACLA_027410 RNase H domain protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"ACLA_027000 ribonuclease HI large subunit\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				},
				{
					"name":"ACLA_089130 hypothetical protein\tK10745 RNASEH2C; ribonuclease H2 subunit C"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"ACLA_029740 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"ACLA_051220 DNA replication helicase Dna2, putative\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"ACLA_094400 DNA helicase, putative\tK19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]"
				},
				{
					"name":"ACLA_034020 Flap endonuclease, putative\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"ACLA_037000 exonuclease, putative\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"ACLA_080840 DNA ligase Cdc9, putative\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				},
				{
					"name":"ACLA_076130 hypothetical protein\tK26118 ATAD5; ATPase family AAA domain-containing protein 5"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"ACLA_096870 C-5 cytosine methyltransferase DmtA\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex",
					"children":[
					{
						"name":"ACLA_075070 telomere-binding protein alpha subunit, central domain, putative\tK11109 POT1; protection of telomeres protein 1"
					},
					{
						"name":"ACLA_081720 hypothetical protein\tK11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1"
					}
					]
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins",
					"children":[
					{
						"name":"ACLA_024990 SIR2 family histone deacetylase (Hst4), putative\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					},
					{
						"name":"ACLA_051130 chromatin regulatory protein sir2\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					},
					{
						"name":"ACLA_063800 SIR2 family histone deacetylase, putative\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					},
					{
						"name":"ACLA_068430 SIR2 family histone deacetylase, putative\tK11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"ACLA_006280 telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"ACLA_052640 snoRNP protein (gar1), putative\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"ACLA_021850 ribosome biogenesis protein Nhp2\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"ACLA_001170 Nop10 family nucleolar RNA-binding protein\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"ACLA_008990 centromere\/microtubule binding protein cbf5\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"ACLA_006280 telomerase reverse transcriptase\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"ACLA_047110 small nuclear ribonucleoprotein SmB, putative\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"ACLA_089530 small nuclear ribonucleoprotein SmD1, putative\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"ACLA_015740 small nuclear ribonucleoprotein SmD2, putative\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"ACLA_049460 small nuclear ribonucleoprotein SmD3, putative\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"ACLA_007670 small nuclear ribonucleoprotein SmE, putative\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"ACLA_074440 LSM domain protein\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"ACLA_058360 small nuclear ribonucleoprotein SmG, putative\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"ACLA_036280 DNA replication factor C subunit Rfc2, putative\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"ACLA_095520 DNA replication factor C subunit Rfc4, putative\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"ACLA_003460 DNA replication factor C subunit Rfc3, putative\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"ACLA_071120 DNA replication factor C subunit Rfc5, putative\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"ACLA_085070 meiotic recombination protein Mre11\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"ACLA_051660 DNA repair protein Rad50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"ACLA_015700 ataxia telangiectasia mutated (atm)\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"ACLA_089690 RecQ family helicase MusN\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
				},
				{
					"name":"ACLA_097940 DNA repair protein RAD1, putative\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"ACLA_010570 poly(ADP)-ribose polymerase PARP, putative\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
				},
				{
					"name":"ACLA_005360 G-patch domain protein\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"ACLA_073900 hypothetical protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"ACLA_016360 mitochondrial DNA helicase (Pif1), putative\tK15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]"
				},
				{
					"name":"ACLA_084470 hypothetical protein\tK23314 WRAP53; telomerase Cajal body protein 1"
				},
				{
					"name":"ACLA_085900 hypothetical protein\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"ACLA_005800 DUF602 domain protein\tK25186 RTF2; replication termination factor 2"
				},
				{
					"name":"ACLA_014560 MYB DNA binding protein (Tbf1), putative\tK22485 TBF1; protein TBF1"
				},
				{
					"name":"ACLA_085550 RNP domain protein\tK28506 GBP2; serine\/arginine (SR)-type shuttling mRNA binding protein"
				},
				{
					"name":"ACLA_010380 RNP domain protein\tK28514 TCG1; single-stranded TG1-3 DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"ACLA_031120 topoisomerase I\tK03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"ACLA_087000 DNA topoisomerase II\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"ACLA_092130 DNA topoisomerase III, putative\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)"
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"ACLA_025490 reverse transcriptase, RNaseH, putative\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"ACLA_027410 RNase H domain protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"ACLA_025490 reverse transcriptase, RNaseH, putative\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"ACLA_027410 RNase H domain protein\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"ACLA_051220 DNA replication helicase Dna2, putative\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"ACLA_034020 Flap endonuclease, putative\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"ACLA_080840 DNA ligase Cdc9, putative\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	}
	]
}