{
	"name":"afun04121",
	"children":[
	{
		"name":"Ubiquitins and ubiquitin-like proteins",
		"children":[
		{
			"name":"Ubiquitins",
			"children":[
			{
				"name":"125761906 polyubiquitin-C isoform X1\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"125763774 polyubiquitin-C isoform X1\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"125763775 polyubiquitin-C-like\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"125762839 ubiquitin-60S ribosomal protein L40 isoform X1\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"125766280 ubiquitin-40S ribosomal protein S27a\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			}
			]
		},
		{
			"name":"Ubiquitin-like proteins (UBLs)",
			"children":[
			{
				"name":"125765865 NEDD8\tK12158 NEDD8; ubiquitin-like protein Nedd8"
			},
			{
				"name":"125765185 FAU ubiquitin-like and ribosomal protein S30\tK02983 RP-S30e; small subunit ribosomal protein S30e"
			},
			{
				"name":"125771261 FAU ubiquitin-like and ribosomal protein S30\tK02983 RP-S30e; small subunit ribosomal protein S30e"
			},
			{
				"name":"125761023 small ubiquitin-related modifier 2-like\tK12160 SUMO; small ubiquitin-related modifier"
			},
			{
				"name":"125761388 small ubiquitin-related modifier 2-like\tK12160 SUMO; small ubiquitin-related modifier"
			},
			{
				"name":"125760532 gamma-aminobutyric acid receptor-associated protein\tK08341 GABARAP; GABA(A) receptor-associated protein"
			},
			{
				"name":"125771373 autophagy protein 12-like\tK08336 ATG12; ubiquitin-like protein ATG12"
			},
			{
				"name":"125768029 ubiquitin-related modifier 1 homolog\tK12161 URM1; ubiquitin related modifier 1"
			},
			{
				"name":"125763143 ubiquitin-fold modifier 1\tK12162 UFM1; ubiquitin-fold modifier 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-activating enzymes (E1)",
		"children":[
		{
			"name":"Ubiquitin activating enzyme",
			"children":[
			{
				"name":"125770141 ubiquitin-like modifier-activating enzyme 1\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			}
			]
		},
		{
			"name":"UBL-activating enzymes",
			"children":[
			{
				"name":"125763210 SUMO-activating enzyme subunit 1\tK10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]"
			},
			{
				"name":"125762297 SUMO-activating enzyme subunit 2\tK10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]"
			},
			{
				"name":"125768870 nedd8-activating enzyme E1 catalytic subunit\tK10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]"
			},
			{
				"name":"125771559 nedd8-activating enzyme E1 regulatory subunit\tK04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit"
			},
			{
				"name":"125774707 adenylyltransferase and sulfurtransferase MOCS3\tK11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]"
			},
			{
				"name":"125775069 ubiquitin-like modifier-activating enzyme 5\tK12164 UBA5; ubiquitin-like modifier-activating enzyme 5"
			},
			{
				"name":"125762963 ubiquitin-like modifier-activating enzyme atg7 isoform X1\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-conjugating enzymes (E2)",
		"children":[
		{
			"name":"Ubiquitin-conjugating enzymes",
			"children":[
			{
				"name":"125765876 ubiquitin-conjugating enzyme E2-17 kDa\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
			},
			{
				"name":"125767924 ubiquitin-conjugating enzyme E2 C\tK06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]"
			},
			{
				"name":"125761775 ubiquitin-conjugating enzyme E2 2-like\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"125763467 ubiquitin-conjugating enzyme E2-17 kDa\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"125762802 ubiquitin-conjugating enzyme E2-24 kDa\tK20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]"
			},
			{
				"name":"125765835 ubiquitin-conjugating enzyme E2 G1\tK10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]"
			},
			{
				"name":"125765991 ubiquitin-conjugating enzyme E2 G2\tK04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]"
			},
			{
				"name":"125766722 ubiquitin-conjugating enzyme E2 H\tK10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]"
			},
			{
				"name":"125769309 ubiquitin-conjugating enzyme E2 J2\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"125770510 ubiquitin-conjugating enzyme E2-22 kDa isoform X1\tK04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]"
			},
			{
				"name":"125767782 ubiquitin-conjugating enzyme E2-18 kDa isoform X1\tK04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]"
			},
			{
				"name":"125771912 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
			},
			{
				"name":"125764855 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O\tK10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]"
			},
			{
				"name":"125761231 ubiquitin-conjugating enzyme E2 Q2 isoform X1\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"125765596 ubiquitin-conjugating enzyme E2Q-like protein 1\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"125764880 ubiquitin-conjugating enzyme E2 R2\tK02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]"
			},
			{
				"name":"125768925 ubiquitin-conjugating enzyme E2 W isoform X1\tK10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]"
			},
			{
				"name":"125763278 baculoviral IAP repeat-containing protein 6 isoform X1\tK10586 BIRC6; baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]"
			}
			]
		},
		{
			"name":"UBL-conjugating enzymes",
			"children":[
			{
				"name":"125767366 SUMO-conjugating enzyme UBC9-B\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"125767367 SUMO-conjugating enzyme UBC9-B\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"125767368 SUMO-conjugating enzyme UBC9-B-like\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"125768663 NEDD8-conjugating enzyme UBE2F-like\tK10687 UBE2F; ubiquitin-conjugating enzyme E2 F [EC:2.3.2.34]"
			},
			{
				"name":"125770725 NEDD8-conjugating enzyme Ubc12\tK10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]"
			},
			{
				"name":"125769765 ubiquitin-like-conjugating enzyme ATG3\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
			},
			{
				"name":"125773666 ubiquitin-like-conjugating enzyme ATG10\tK17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10"
			},
			{
				"name":"125765679 ubiquitin-fold modifier-conjugating enzyme 1\tK12165 UFC1; ufm1-conjugating enzyme 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin ligases (E3)",
		"children":[
		{
			"name":"HECT type E3",
			"children":[
			{
				"name":"125772312 ubiquitin-protein ligase E3A isoform X1\tK10587 UBE3A; ubiquitin-protein ligase E3 A [EC:2.3.2.26]"
			},
			{
				"name":"125768528 ubiquitin-protein ligase E3B\tK10588 UBE3B; ubiquitin-protein ligase E3 B [EC:2.3.2.26]"
			},
			{
				"name":"125767471 ubiquitin-protein ligase E3C\tK10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]"
			},
			{
				"name":"125769769 E3 ubiquitin-protein ligase SMURF2\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"125762659 E3 ubiquitin-protein ligase Su(dx)-like isoform X1\tK05633 WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]"
			},
			{
				"name":"125763745 E3 ubiquitin-protein ligase TRIP12\tK10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]"
			},
			{
				"name":"125762524 E3 ubiquitin-protein ligase Nedd-4-like isoform X1\tK10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]"
			},
			{
				"name":"125763287 E3 ubiquitin-protein ligase Nedd-4 isoform X1\tK10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]"
			},
			{
				"name":"125763381 apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1\tK22370 AREL1; apoptosis-resistant E3 ubiquitin protein ligase 1 [EC:2.3.2.26]"
			},
			{
				"name":"125764388 E3 ubiquitin-protein ligase hyd isoform X1\tK10593 EDD1; E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]"
			},
			{
				"name":"125770126 probable E3 ubiquitin-protein ligase HERC2\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
			},
			{
				"name":"125770335 probable E3 ubiquitin-protein ligase HERC4 isoform X1\tK10615 HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]"
			},
			{
				"name":"125765181 E3 ubiquitin-protein ligase HECW2\tK12168 HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]"
			},
			{
				"name":"125763340 E3 ubiquitin-protein ligase Ufd4 isoform X1\tK12231 HECTD1; E3 ubiquitin-protein ligase HECTD1 [EC:2.3.2.26]"
			},
			{
				"name":"HECT type E3 associated proteins",
				"children":[
				{
					"name":"125768025 NEDD4 family-interacting protein 1\tK25839 NDFIP; NEDD4 family-interacting protein"
				}
				]
			}
			]
		},
		{
			"name":"U-box type E3",
			"children":[
			{
				"name":"125760995 ubiquitin conjugation factor E4 A\tK10596 UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]"
			},
			{
				"name":"125763368 ubiquitin conjugation factor E4 B\tK10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]"
			},
			{
				"name":"125764534 E3 ubiquitin-protein ligase CHIP\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
			},
			{
				"name":"125768653 RING-type E3 ubiquitin-protein ligase PPIL2\tK10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]"
			},
			{
				"name":"125771857 pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"Single Ring-finger type E3",
			"children":[
			{
				"name":"BRE1 proteins",
				"children":[
				{
					"name":"125771278 E3 ubiquitin-protein ligase Bre1 isoform X1\tK10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"CBL proteins",
				"children":[
				{
					"name":"125769736 E3 ubiquitin-protein ligase CBL-B isoform X1\tK04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"SINA (Seven in absentia) proteins",
				"children":[
				{
					"name":"125770700 E3 ubiquitin-protein ligase sina\tK04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Ligand of Numb proteins"
			},
			{
				"name":"March proteins",
				"children":[
				{
					"name":"125770642 uncharacterized protein LOC125770642\tK10656 MARCH1_8; E3 ubiquitin-protein ligase MARCH1\/8 [EC:2.3.2.27]"
				},
				{
					"name":"125771018 E3 ubiquitin-protein ligase MARCHF2-like\tK10657 MARCH2_3; E3 ubiquitin-protein ligase MARCH2\/3 [EC:2.3.2.27]"
				},
				{
					"name":"125771958 E3 ubiquitin-protein ligase MARCHF5\tK10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]"
				},
				{
					"name":"125770637 E3 ubiquitin-protein ligase MARCHF6\tK10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"MDM2\/MDM4 proteins"
			},
			{
				"name":"NFX1 proteins",
				"children":[
				{
					"name":"125766306 protein shuttle craft\tK12236 NFX1; transcriptional repressor NF-X1"
				},
				{
					"name":"125769208 NF-X1-type zinc finger protein NFXL1\tK15683 NFXL1; NF-X1-type zinc finger protein NFXL1"
				}
				]
			},
			{
				"name":"Pellino proteins",
				"children":[
				{
					"name":"125765322 protein pellino\tK11964 PELI; pellino [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Peripheral membrane proteins",
				"children":[
				{
					"name":"125773342 peroxisome biogenesis factor 10\tK13346 PEX10; peroxin-10 [EC:2.3.2.27]"
				},
				{
					"name":"125769657 peroxisome assembly protein 12\tK13345 PEX12; peroxin-12"
				},
				{
					"name":"125769033 peroxisome biogenesis factor 2\tK06664 PEX2; peroxin-2 [EC:2.3.2.27 2.3.2.36]"
				}
				]
			},
			{
				"name":"RBR proteins",
				"children":[
				{
					"name":"125769385 E3 ubiquitin-protein ligase parkin\tK04556 PARK2; parkin [EC:2.3.2.31]"
				},
				{
					"name":"125767955 E3 ubiquitin-protein ligase ariadne-1 isoform X1\tK11968 ARIH1; ariadne-1 [EC:2.3.2.31]"
				},
				{
					"name":"125767139 potential E3 ubiquitin-protein ligase ariadne-2\tK11969 ARIH2; ariadne-2 [EC:2.3.2.31]"
				},
				{
					"name":"125760670 E3 ubiquitin-protein ligase RNF19A-like isoform X1\tK11972 RNF19A; E3 ubiquitin-protein ligase RNF19A [EC:2.3.2.31]"
				},
				{
					"name":"125761785 E3 ubiquitin-protein ligase lubel isoform X1\tK11974 RNF31; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]"
				},
				{
					"name":"125772122 uncharacterized protein LOC125772122\tK20804 RNF34; E3 ubiquitin-protein ligase RNF34 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"TRAF proteins",
				"children":[
				{
					"name":"125765449 TNF receptor-associated factor 6\tK03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"TRIM\/RBCC proteins",
				"children":[
				{
					"name":"125761638 brain tumor protein\tK11997 TRIM2_3; tripartite motif-containing protein 2\/3"
				},
				{
					"name":"125766320 E3 ubiquitin-protein ligase TRIM9 isoform X1\tK10649 TRIM9_67; tripartite motif-containing protein 9\/67"
				},
				{
					"name":"125760422 E3 ubiquitin-protein ligase TRIM33-like isoform X1\tK08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]"
				},
				{
					"name":"125774977 tripartite motif-containing protein 45\tK12021 TRIM45; tripartite motif-containing protein 45"
				},
				{
					"name":"125768824 protein wech\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"UBR box proteins",
				"children":[
				{
					"name":"125767776 E3 ubiquitin-protein ligase UBR1\tK10626 UBR2; E3 ubiquitin-protein ligase UBR2 [EC:2.3.2.27]"
				},
				{
					"name":"125761460 E3 ubiquitin-protein ligase Ubr3\tK11978 UBR3; E3 ubiquitin-protein ligase UBR3 [EC:2.3.2.27]"
				},
				{
					"name":"125765893 protein purity of essence isoform X1\tK10691 UBR4; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]"
				},
				{
					"name":"125763493 putative E3 ubiquitin-protein ligase UBR7\tK11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"ATL proteins"
			},
			{
				"name":"Other single Ring-finger type E3",
				"children":[
				{
					"name":"125771439 E3 ubiquitin-protein ligase AMFR-like\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				},
				{
					"name":"125770856 LOW QUALITY PROTEIN: death-associated inhibitor of apoptosis 2-like\tK16061 BIRC7_8; baculoviral IAP repeat-containing protein 7\/8"
				},
				{
					"name":"125771305 death-associated inhibitor of apoptosis 1\tK16061 BIRC7_8; baculoviral IAP repeat-containing protein 7\/8"
				},
				{
					"name":"125771323 death-associated inhibitor of apoptosis 1-like\tK16061 BIRC7_8; baculoviral IAP repeat-containing protein 7\/8"
				},
				{
					"name":"125765429 BRCA1-associated protein\tK10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]"
				},
				{
					"name":"125766102 E3 ubiquitin-protein ligase Hakai\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]"
				},
				{
					"name":"125775204 E3 ubiquitin-protein ligase Hakai-like\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]"
				},
				{
					"name":"125763732 homeotic protein female sterile isoform X1\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
				},
				{
					"name":"125772660 protein deltex\tK06058 DTX; deltex [EC:2.3.2.27]"
				},
				{
					"name":"125772223 E3 ubiquitin-protein ligase FANCL\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
				},
				{
					"name":"125764050 E3 ubiquitin-protein ligase KCMF1\tK22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]"
				},
				{
					"name":"125770565 E3 ubiquitin-protein ligase LRSAM1-like\tK10641 LRSAM1; E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27]"
				},
				{
					"name":"125771249 E3 ubiquitin-protein ligase listerin\tK22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]"
				},
				{
					"name":"125766350 PE-PGRS family protein PE_PGRS16-like isoform X1\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]"
				},
				{
					"name":"125761496 E3 ubiquitin-protein ligase MIB2\tK10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]"
				},
				{
					"name":"125770138 E3 ubiquitin-protein ligase mind-bomb\tK10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]"
				},
				{
					"name":"125770269 E3 ubiquitin-protein ligase makorin-2-like\tK15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]"
				},
				{
					"name":"125769294 mitochondrial E3 ubiquitin protein ligase 1\tK15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]"
				},
				{
					"name":"125769531 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase highwire\tK10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]"
				},
				{
					"name":"125774846 E3 ubiquitin-protein ligase MYLIP\tK10637 MYLIP; E3 ubiquitin-protein ligase MYLIP [EC:2.3.2.27]"
				},
				{
					"name":"125766406 protein neuralized isoform X1\tK01931 NEUR; protein neuralized [EC:2.3.2.27]"
				},
				{
					"name":"125764590 RING finger and CHY zinc finger domain-containing protein 1\tK10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"125761475 E3 ubiquitin-protein ligase COP1-like\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
				},
				{
					"name":"125772124 E3 ubiquitin-protein ligase RFWD3\tK15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]"
				},
				{
					"name":"125764164 E3 ubiquitin-protein ligase RING1 isoform X1\tK10695 RNF1_2; E3 ubiquitin-protein ligase RNF1\/2 [EC:2.3.2.27]"
				},
				{
					"name":"125771487 E3 ubiquitin-protein ligase RNF185-like isoform X1\tK10666 RNF5_185; E3 ubiquitin-protein ligase RNF5\/185 [EC:2.3.2.27]"
				},
				{
					"name":"125766230 RING finger protein 10\tK26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]"
				},
				{
					"name":"125766410 uncharacterized protein LOC125766410 isoform X1\tK15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]"
				},
				{
					"name":"125770616 E3 ubiquitin-protein ligase RNF25\tK10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]"
				},
				{
					"name":"125760923 E3 ubiquitin-protein ligase NRDP1\tK11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]"
				},
				{
					"name":"125774702 E3 ubiquitin-protein ligase Iruka isoform X1\tK11982 RNF115_126; E3 ubiquitin-protein ligase RNF115\/126 [EC:2.3.2.27]"
				},
				{
					"name":"125765708 RING finger protein 121\tK15698 RNF121_175; RING finger protein 121\/175"
				},
				{
					"name":"125763363 E3 ubiquitin-protein ligase RNF123 isoform X1\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"125761473 protein TRC8 homolog isoform X1\tK15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]"
				},
				{
					"name":"125764832 E3 ubiquitin-protein ligase rnf146 isoform X1\tK15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]"
				},
				{
					"name":"125772332 E3 ubiquitin ligase RNF157\tK25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]"
				},
				{
					"name":"125766091 E3 ubiquitin-protein ligase RNF220\tK25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]"
				},
				{
					"name":"125774625 E3 ubiquitin-protein ligase RNFT1\tK28516 RNFT2; E3 ubiquitin-protein ligase RNFT2"
				},
				{
					"name":"125765549 U4\/U6.U5 tri-snRNP-associated protein 1\tK11984 SART1; U4\/U6.U5 tri-snRNP-associated protein 1"
				},
				{
					"name":"125768113 E3 ubiquitin-protein ligase SHPRH\tK15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]"
				},
				{
					"name":"125769583 E3 ubiquitin-protein ligase SH3RF1\tK12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"
				},
				{
					"name":"125764074 E3 ubiquitin-protein ligase HRD1-like\tK10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]"
				},
				{
					"name":"125771733 E3 ubiquitin-protein ligase TM129\tK22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]"
				},
				{
					"name":"125767657 E3 ubiquitin-protein ligase TRAIP\tK11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]"
				},
				{
					"name":"125770491 E3 ubiquitin-protein ligase TRAIP-like isoform X1\tK11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]"
				},
				{
					"name":"125762610 RING finger protein unkempt\tK23047 UNKL; E3 ubiquitin-protein ligase UNKL [EC:2.3.2.27]"
				},
				{
					"name":"125767268 E3 ubiquitin-protein ligase ZNF598\tK22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]"
				},
				{
					"name":"125771272 E3 ubiquitin-protein ligase znrf2-like\tK10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1\/2 [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Atypical E3",
			"children":[
			{
				"name":"125771611 non-structural maintenance of chromosomes element 1 homolog\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
			},
			{
				"name":"125763685 interferon regulatory factor 2-binding protein-like A isoform X1\tK22383 IRF2BP; interferon regulatory factor 2-binding protein"
			}
			]
		},
		{
			"name":"UBL E3 ligases",
			"children":[
			{
				"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
			},
			{
				"name":"125765394 E3 SUMO-protein ligase RanBP2\tK12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]"
			},
			{
				"name":"125767844 E3 SUMO-protein ligase PIAS2 isoform X1\tK04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]"
			},
			{
				"name":"125762966 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125762967 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125764254 E3 SUMO-protein ligase ZBED1-like isoform X1\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125765563 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125765582 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125767225 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125767765 zinc finger BED domain-containing protein 4-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125768837 zinc finger BED domain-containing protein 4-like isoform X1\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125768915 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125768920 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125769457 zinc finger BED domain-containing protein 4-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125771456 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125771469 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125774258 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125774554 E3 SUMO-protein ligase ZBED1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"125761550 E3 UFM1-protein ligase 1 homolog\tK22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]"
			},
			{
				"name":"125763181 DCN1-like protein 1\tK17822 DCUN1D1_2; DCN1-like protein 1\/2"
			},
			{
				"name":"125768241 DCN1-like protein 3\tK17823 DCUN1D3; DCN1-like protein 3"
			},
			{
				"name":"125765139 DCN1-like protein 4 isoform X1\tK17824 DCUN1D4_5; DCN1-like protein 4\/5"
			}
			]
		},
		{
			"name":"Multi subunit type E3",
			"children":[
			{
				"name":"SCF complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"125766201 cullin-1\tK03347 CUL1; cullin 1"
					}
					]
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"125766371 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"125774732 uncharacterized protein LOC125774732\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (F-box)",
					"children":[
					{
						"name":"125764209 beta-TrCP\tK03362 FBXW1_11; F-box and WD-40 domain protein 1\/11"
					},
					{
						"name":"125770471 F-box\/WD repeat-containing protein 4\tK10262 FBXW4; F-box and WD-40 domain protein 4"
					},
					{
						"name":"125763726 F-box\/WD repeat-containing protein 5 isoform X1\tK10263 FBXW5; F-box and WD-40 domain protein 5"
					},
					{
						"name":"125769882 S-phase kinase-associated protein 2\tK03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)"
					},
					{
						"name":"125763301 F-box\/LRR-repeat protein 20 isoform X1\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"125771933 F-box\/LRR-repeat protein 4\tK10270 FBXL4; F-box and leucine-rich repeat protein 4"
					},
					{
						"name":"125771950 F-box\/LRR-repeat protein 6\tK10272 FBXL6; F-box and leucine-rich repeat protein 6"
					},
					{
						"name":"125762221 F-box\/LRR-repeat protein 7\tK10273 FBXL7; F-box and leucine-rich repeat protein 7"
					},
					{
						"name":"125767325 uncharacterized protein LOC125767325\tK10275 FBXL9; F-box and leucine-rich repeat protein 9"
					},
					{
						"name":"125770170 F-box\/LRR-repeat protein 7-like\tK10275 FBXL9; F-box and leucine-rich repeat protein 9"
					},
					{
						"name":"125771959 F-box\/LRR-repeat protein 2-like\tK10275 FBXL9; F-box and leucine-rich repeat protein 9"
					},
					{
						"name":"125760879 jmjC domain-containing histone demethylation protein 1\tK10276 FBXL10_11; F-box and leucine-rich repeat protein 10\/11 [EC:1.14.11.27]"
					},
					{
						"name":"125766182 F-box\/LRR-repeat protein 14\tK10280 FBXL14; F-box and leucine-rich repeat protein 14"
					},
					{
						"name":"125763549 F-box\/LRR-repeat protein 15\tK10281 FBXL15; F-box and leucine-rich repeat protein 15"
					},
					{
						"name":"125770179 F-box\/LRR-repeat protein 16\tK10282 FBXL16; F-box and leucine-rich repeat protein 16"
					},
					{
						"name":"125771160 F-box only protein 9\tK10295 FBXO9; F-box protein 9"
					},
					{
						"name":"125774674 F-box only protein 11\tK10297 FBXO11; F-box protein 11"
					},
					{
						"name":"125770228 F-box only protein 25\tK10305 FBXO25_32; F-box protein 25\/32"
					},
					{
						"name":"125767899 uncharacterized protein LOC125767899\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"125768274 putative uncharacterized protein DDB_G0282129 isoform X1\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"125770862 F-box only protein 33\tK10310 FBXO33; F-box protein 33"
					},
					{
						"name":"125770190 uncharacterized protein LOC125770190\tK10314 FBXO39; F-box protein 39"
					},
					{
						"name":"125771786 F-box only protein 42\tK10317 FBXO42; F-box protein 42"
					},
					{
						"name":"125768109 F-box\/SPRY domain-containing protein 1\tK10319 FBXO45; F-box protein 45"
					}
					]
				}
				]
			},
			{
				"name":"Cul2 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"125763248 cullin-2\tK03870 CUL2; cullin 2"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"125763740 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"125767107 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"125762094 elongin-B\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"125765176 protein Vhl\tK03871 VHL; von Hippel-Lindau disease tumor supressor"
					},
					{
						"name":"125761717 leucine-rich repeat protein 1\tK10348 LRR1; LRR-repeat protein 1"
					},
					{
						"name":"125761087 protein fem-1 homolog C\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"125762573 protein fem-1 homolog CG6966 isoform X1\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"125771289 protein fem-1 homolog B\tK10349 FEM1B; protein fem-1 homolog B"
					},
					{
						"name":"125768772 amyloid protein-binding protein 2\tK25806 APPBP2; amyloid protein-binding protein 2"
					},
					{
						"name":"125763507 kelch domain-containing protein 3\tK25808 KLHDC3; kelch domain-containing protein 3"
					},
					{
						"name":"125770001 kelch domain-containing protein 10 homolog\tK25809 KLHDC10; kelch domain-containing protein 10"
					},
					{
						"name":"125771552 protein zer-1 homolog\tK10350 ZYG11; Zyg-11 protein"
					},
					{
						"name":"125761686 zinc finger SWIM domain-containing protein 8 homolog\tK25207 ZSWIM8; zinc finger SWIM domain-containing protein 8"
					}
					]
				}
				]
			},
			{
				"name":"Cul3 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"125764093 cullin-3 isoform X1\tK03869 CUL3; cullin 3"
					}
					]
				},
				{
					"name":"Adoptor and target recognizing subunit (BTB)",
					"children":[
					{
						"name":"125764583 kelch-like protein 5 isoform X1\tK10442 KLHL1_4_5; kelch-like protein 1\/4\/5"
					},
					{
						"name":"125763325 ring canal kelch homolog isoform X1\tK10443 KLHL2_3; kelch-like protein 2\/3"
					},
					{
						"name":"125760942 kelch-like protein 10\tK10448 KLHL10; kelch-like protein 10"
					},
					{
						"name":"125764039 kelch-like protein 17\tK10454 KLHL17; kelch-like protein 17 (actinfilin)"
					},
					{
						"name":"125768503 kelch-like protein 18\tK10455 KLHL18; kelch-like protein 18"
					},
					{
						"name":"125764940 kelch-like ECH-associated protein 1B isoform X1\tK10456 KLHL19; kelch-like protein 19"
					},
					{
						"name":"125771629 kelch-like protein diablo isoform X1\tK10457 KLHL20; kelch-like protein 20"
					},
					{
						"name":"125763836 actin-binding protein IPP\tK13956 IPP; actin-binding protein IPP"
					},
					{
						"name":"125765298 BTB\/POZ domain-containing protein 6-B isoform X1\tK10478 BTBD3_6; BTB\/POZ domain-containing protein 3\/6"
					},
					{
						"name":"125764674 BTB\/POZ domain-containing protein 7\tK10479 BTBD7; BTB\/POZ domain-containing protein 7"
					},
					{
						"name":"125772129 BTB\/POZ domain-containing protein 9\tK10481 BTBD9; BTB\/POZ domain-containing protein 9"
					},
					{
						"name":"125770886 protein germ cell-less\tK10485 BTBD13; BTB\/POZ domain-containing protein 13 (germ cell-less protein-like 1)"
					},
					{
						"name":"125768155 uncharacterized protein LOC125768155 isoform X1\tK10521 ABTB2; ankyrin repeat and BTB\/POZ domain-containing protein 2"
					},
					{
						"name":"125771682 rho-related BTB domain-containing protein 1 isoform X1\tK07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1\/2"
					},
					{
						"name":"125769077 BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3\tK15074 BACURD; BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein"
					},
					{
						"name":"125768604 BTB\/POZ domain-containing protein Tiwaz\tK21754 KCTD1_15; BTB\/POZ domain-containing protein KCTD1\/15"
					},
					{
						"name":"125765012 BTB\/POZ domain-containing protein KCTD5\tK21914 KCTD2_5_17; BTB\/POZ domain-containing protein KCTD2\/5\/17"
					},
					{
						"name":"125763312 SH3KBP1-binding protein 1 isoform X1\tK21915 KCTD3; BTB\/POZ domain-containing protein KCTD3"
					},
					{
						"name":"125765385 BTB\/POZ domain-containing protein KCTD12\tK21918 KCTD8_12_16; BTB\/POZ domain-containing protein KCTD8\/12\/16"
					},
					{
						"name":"125773316 BTB\/POZ domain-containing protein KCTD9\tK21919 KCTD9; BTB\/POZ domain-containing protein KCTD9"
					},
					{
						"name":"125760651 protein roadkill isoform X1\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"125774786 leucine-zipper-like transcriptional regulator 1 homolog\tK23330 LZTR1; leucine-zipper-like transcriptional regulator 1"
					}
					]
				}
				]
			},
			{
				"name":"Cul4 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"125768203 cullin-4B\tK10609 CUL4; cullin 4"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"125766055 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (DCAF)",
					"children":[
					{
						"name":"125760901 DET1 homolog\tK10571 DET1; de-etiolated-1"
					},
					{
						"name":"125761475 E3 ubiquitin-protein ligase COP1-like\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
					},
					{
						"name":"125765683 DET1- and DDB1-associated protein 1\tK11792 DDA1; DET1- and DDB1-associated protein 1"
					},
					{
						"name":"125769876 protein cereblon\tK11793 CRBN; cereblon"
					},
					{
						"name":"125770132 protein mahjong\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]"
					},
					{
						"name":"125770646 protein lethal(2)denticleless\tK11790 DTL; denticleless"
					},
					{
						"name":"125762903 DDB1- and CUL4-associated factor 7\tK11805 DCAF7; DDB1- and CUL4-associated factor 7"
					},
					{
						"name":"125772043 DDB1- and CUL4-associated factor 8-like\tK11804 DCAF8; DDB1- and CUL4-associated factor 8"
					},
					{
						"name":"125762576 WD and tetratricopeptide repeats protein 1\tK11807 WDTC1; WD and tetratricopeptide repeats protein 1"
					},
					{
						"name":"125766641 DDB1- and CUL4-associated factor 10\tK11802 DCAF10; DDB1- and CUL4-associated factor 10"
					},
					{
						"name":"125767259 DDB1- and CUL4-associated factor 10 homolog\tK11802 DCAF10; DDB1- and CUL4-associated factor 10"
					},
					{
						"name":"125763300 DDB1- and CUL4-associated factor 11\tK11801 DCAF11; DDB1- and CUL4-associated factor 11"
					},
					{
						"name":"125765800 DDB1- and CUL4-associated factor 12 homolog\tK11803 DCAF12; DDB1- and CUL4-associated factor 12"
					},
					{
						"name":"125762968 DDB1- and CUL4-associated factor 13\tK11806 DCAF13; DDB1- and CUL4-associated factor 13"
					},
					{
						"name":"125766386 bromodomain and WD repeat-containing protein 3 isoform X1\tK11798 BRWD1_3; bromodomain and WD repeat domain containing protein 1\/3"
					},
					{
						"name":"125772363 WD repeat-containing protein 26 homolog\tK22382 WDR26; WD repeat-containing protein 26"
					},
					{
						"name":"125762886 gastrulation defective protein 1 homolog\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			},
			{
				"name":"Cul5 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125769172 RING-box protein 2\tK10611 RBX2; RING-box protein 2"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"125764959 cullin-5\tK10612 CUL5; cullin 5"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"125763740 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"125767107 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"125762094 elongin-B\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"125768745 uncharacterized protein LOC125768745\tK04699 SOCS6_7; suppressor of cytokine signaling 6\/7"
					},
					{
						"name":"125772261 uncharacterized protein LOC125772261\tK04699 SOCS6_7; suppressor of cytokine signaling 6\/7"
					},
					{
						"name":"125766821 uncharacterized protein LOC125766821\tK10339 ASB17; ankyrin repeat and SOCS box protein 17"
					},
					{
						"name":"125763954 SPRY domain-containing SOCS box protein 3\tK10345 SPSB3; SPRY domain-containing SOCS box protein 3"
					},
					{
						"name":"125769971 SPRY domain-containing SOCS box protein 3 isoform X1\tK10345 SPSB3; SPRY domain-containing SOCS box protein 3"
					},
					{
						"name":"125764339 ras-related protein Rab-40B\tK07928 RAB40; Ras-related protein Rab-40"
					},
					{
						"name":"125762167 RING finger and SPRY domain-containing protein 1-like\tK23332 RSPRY1; RING finger and SPRY domain-containing protein 1"
					}
					]
				}
				]
			},
			{
				"name":"Cul7 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"125766371 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"125774732 uncharacterized protein LOC125774732\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul8 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein"
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul9 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125771914 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				}
				]
			},
			{
				"name":"APC\/C",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"125762205 anaphase-promoting complex subunit 11\tK03358 APC11; anaphase-promoting complex subunit 11"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"125770564 anaphase-promoting complex subunit 2\tK03349 APC2; anaphase-promoting complex subunit 2"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"125763450 cell division cycle protein 20 homolog\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"125761341 fizzy-related protein homolog\tK03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex"
					}
					]
				},
				{
					"name":"Other subunits",
					"children":[
					{
						"name":"125761493 anaphase-promoting complex subunit 1\tK03348 APC1; anaphase-promoting complex subunit 1"
					},
					{
						"name":"125767267 cell division cycle protein 27 homolog\tK03350 APC3; anaphase-promoting complex subunit 3"
					},
					{
						"name":"125765299 anaphase-promoting complex subunit 4\tK03351 APC4; anaphase-promoting complex subunit 4"
					},
					{
						"name":"125771523 anaphase-promoting complex subunit 5\tK03352 APC5; anaphase-promoting complex subunit 5"
					},
					{
						"name":"125774623 cell division cycle protein 16 homolog\tK03353 APC6; anaphase-promoting complex subunit 6"
					},
					{
						"name":"125766197 cell division cycle protein 23 homolog\tK03355 APC8; anaphase-promoting complex subunit 8"
					},
					{
						"name":"125767993 anaphase-promoting complex subunit 10 isoform X1\tK03357 APC10; anaphase-promoting complex subunit 10"
					},
					{
						"name":"125770748 anaphase-promoting complex subunit 13\tK12456 APC13; anaphase-promoting complex subunit 13"
					},
					{
						"name":"125771375 anaphase-promoting complex subunit 15\tK25228 APC15; anaphase-promoting complex subunit 15"
					}
					]
				}
				]
			},
			{
				"name":"BRCC complex",
				"children":[
				{
					"name":"125764740 DNA repair protein RAD51 homolog A\tK04482 RAD51; DNA repair protein RAD51"
				}
				]
			},
			{
				"name":"KPC complex",
				"children":[
				{
					"name":"125763363 E3 ubiquitin-protein ligase RNF123 isoform X1\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"125765024 ubiquitin-associated domain-containing protein 1 isoform X1\tK12174 KPC2; Kip1 ubiquitination-promoting complex protein 2"
				}
				]
			},
			{
				"name":"LUBAC complex",
				"children":[
				{
					"name":"125761785 E3 ubiquitin-protein ligase lubel isoform X1\tK11974 RNF31; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"CTLH complex",
				"children":[
				{
					"name":"125770210 E3 ubiquitin-protein ligase RMND5A isoform X1\tK23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]"
				},
				{
					"name":"125768850 ran-binding protein 9\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				},
				{
					"name":"125767636 armadillo repeat-containing protein 8-like\tK23336 ARMC8; armadillo repeat-containing protein 8"
				},
				{
					"name":"125770430 muskelin isoform X1\tK23337 MKLN1; muskelin"
				},
				{
					"name":"125760809 E3 ubiquitin-protein transferase MAEA\tK18624 MAEA; macrophage erythroblast attacher"
				},
				{
					"name":"125760641 glucose-induced degradation protein 4 homolog\tK23335 GID4; glucose-induced degradation protein 4"
				},
				{
					"name":"125763041 glucose-induced degradation protein 8 homolog\tK23338 GID8; glucose-induced degradation protein 8"
				},
				{
					"name":"125766363 glucose-induced degradation protein 8-B homolog\tK23338 GID8; glucose-induced degradation protein 8"
				},
				{
					"name":"125763171 protein yippee\tK23339 YPEL5; protein yippee-like 5"
				},
				{
					"name":"125772023 protein yippee-like\tK23339 YPEL5; protein yippee-like 5"
				},
				{
					"name":"125772363 WD repeat-containing protein 26 homolog\tK22382 WDR26; WD repeat-containing protein 26"
				}
				]
			},
			{
				"name":"ERAD complex",
				"children":[
				{
					"name":"125771439 E3 ubiquitin-protein ligase AMFR-like\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				},
				{
					"name":"125763317 transmembrane and ubiquitin-like domain-containing protein 2\tK23340 TMUB; transmembrane and ubiquitin-like domain-containing protein"
				}
				]
			},
			{
				"name":"LMBR1L-GP78-UBAC2 complex",
				"children":[
				{
					"name":"125768852 protein Lilipod\tK25215 LMBR1L; protein LMBR1L"
				},
				{
					"name":"125771439 E3 ubiquitin-protein ligase AMFR-like\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				}
				]
			},
			{
				"name":"STUB1-CHIC2  complex",
				"children":[
				{
					"name":"125764534 E3 ubiquitin-protein ligase CHIP\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"125762037 cysteine-rich hydrophobic domain-containing protein 2\tK28185 CHIC2; cysteine-rich hydrophobic domain-containing protein 2"
				}
				]
			},
			{
				"name":"SLX5-SLX8 complex"
			},
			{
				"name":"Multi subunit type E3 associated proteins",
				"children":[
				{
					"name":"125766108 cullin-associated NEDD8-dissociated protein 1\tK17263 CAND1; cullin-associated NEDD8-dissociated protein 1"
				},
				{
					"name":"125765146 COMM domain-containing protein 2\tK22558 COMMD2; COMM domain containing 2"
				},
				{
					"name":"125760720 COMM domain-containing protein 4 isoform X1\tK22560 COMMD4; COMM domain containing 4"
				},
				{
					"name":"125762546 uncharacterized protein LOC125762546\tK22564 COMMD8; COMM domain containing 8"
				},
				{
					"name":"125767968 coiled-coil domain-containing protein 22 homolog\tK23343 CCDC22; coiled-coil domain-containing protein 22"
				},
				{
					"name":"125761732 DDRGK domain-containing protein 1\tK23344 DDRGK1; DDRGK domain-containing protein 1"
				},
				{
					"name":"125768740 uncharacterized protein LOC125768740\tK23345 GLMN; glomulin"
				},
				{
					"name":"125763051 influenza virus NS1A-binding protein-like isoform X1\tK15046 IVNS1ABP; influenza virus NS1A-binding protein"
				},
				{
					"name":"125765578 uncharacterized protein LOC125765578\tK24350 UBXN7; UBX domain-containing protein 7"
				},
				{
					"name":"125760478 parkin coregulated gene protein homolog\tK26163 PACRG; parkin coregulated gene protein"
				},
				{
					"name":"125769862 parkin coregulated gene protein homolog\tK26163 PACRG; parkin coregulated gene protein"
				},
				{
					"name":"125770413 protein lingerer-like\tK26545 UBAP2; ubiquitin-associated protein 2"
				},
				{
					"name":"125769948 SH3 domain-containing protein Dlish\tK26546 Dlish; SH3 domain-containing protein Dlish"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Deubiquitinating enzyme (DUB)",
		"children":[
		{
			"name":"Ubiquitin-specific proteases (UBPs)",
			"children":[
			{
				"name":"UCH",
				"children":[
				{
					"name":"125770196 ubiquitin carboxyl-terminal hydrolase calypso\tK08588 BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]"
				},
				{
					"name":"125770270 ubiquitin carboxyl-terminal hydrolase\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
				},
				{
					"name":"125772282 ubiquitin carboxyl-terminal hydrolase isozyme L5\tK05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"UBP\/USP",
				"children":[
				{
					"name":"125763902 ubiquitin carboxyl-terminal hydrolase CYLD\tK08601 CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]"
				},
				{
					"name":"125772447 ubiquitin carboxyl-terminal hydrolase 1\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
				},
				{
					"name":"125772531 ubiquitin carboxyl-terminal hydrolase 2 isoform X1\tK11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]"
				},
				{
					"name":"125760598 ubiquitin carboxyl-terminal hydrolase 3-like\tK11986 USP3; ubiquitin carboxyl-terminal hydrolase 3 [EC:3.4.19.12]"
				},
				{
					"name":"125770549 ubiquitin carboxyl-terminal hydrolase 5\tK11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5\/13 [EC:3.4.19.12]"
				},
				{
					"name":"125760702 ubiquitin carboxyl-terminal hydrolase 32 isoform X1\tK11837 USP6_32; ubiquitin carboxyl-terminal hydrolase 6\/32 [EC:3.4.19.12]"
				},
				{
					"name":"125764115 ubiquitin carboxyl-terminal hydrolase 7\tK11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]"
				},
				{
					"name":"125764144 ubiquitin carboxyl-terminal hydrolase 8 isoform X1\tK11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]"
				},
				{
					"name":"125761374 probable ubiquitin carboxyl-terminal hydrolase FAF\tK11840 USP9_24; ubiquitin carboxyl-terminal hydrolase 9\/24 [EC:3.4.19.12]"
				},
				{
					"name":"125767053 ubiquitin carboxyl-terminal hydrolase 46\tK11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12\/46 [EC:3.4.19.12]"
				},
				{
					"name":"125763463 ubiquitin carboxyl-terminal hydrolase 14\tK11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]"
				},
				{
					"name":"125772416 ubiquitin carboxyl-terminal hydrolase 45\tK11844 USP16_45; ubiquitin carboxyl-terminal hydrolase 16\/45 [EC:3.4.19.12]"
				},
				{
					"name":"125763034 ubiquitin carboxyl-terminal hydrolase 20 isoform X1\tK11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20\/33 [EC:3.4.19.12]"
				},
				{
					"name":"125770163 ubiquitin carboxyl-terminal hydrolase nonstop\tK11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22\/27\/51 [EC:3.4.19.12]"
				},
				{
					"name":"125774147 ubiquitin carboxyl-terminal hydrolase 30 homolog\tK11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]"
				},
				{
					"name":"125769241 ubiquitin carboxyl-terminal hydrolase 31\tK11852 USP31; ubiquitin carboxyl-terminal hydrolase 31 [EC:3.4.19.12]"
				},
				{
					"name":"125764890 ubiquitin carboxyl-terminal hydrolase puf isoform X1\tK11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]"
				},
				{
					"name":"125761378 ubiquitin carboxyl-terminal hydrolase 35\tK11854 USP35_38; ubiquitin carboxyl-terminal hydrolase 35\/38 [EC:3.4.19.12]"
				},
				{
					"name":"125768561 ubiquitin carboxyl-terminal hydrolase 47\tK11857 USP47; ubiquitin carboxyl-terminal hydrolase 47 [EC:3.4.19.12]"
				},
				{
					"name":"125762428 uncharacterized protein LOC125762428 isoform X1\tK27920 USP54; ubiquitin carboxyl-terminal hydrolase 54 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"OTU",
				"children":[
				{
					"name":"125763557 ubiquitin thioesterase otubain-like\tK09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]"
				},
				{
					"name":"125764811 OTU domain-containing protein 5-B isoform X1\tK12655 OTUD5; OTU domain-containing protein 5 [EC:3.4.19.12]"
				},
				{
					"name":"125769076 deubiquitinase OTUD6B\tK18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]"
				},
				{
					"name":"125769136 uncharacterized protein LOC125769136 isoform X1\tK11860 OTUD7A_B; OTU domain-containing protein 7 [EC:3.4.19.12]"
				},
				{
					"name":"125766544 ubiquitin thioesterase trabid\tK11862 ZRANB1; ubiquitin thioesterase ZRANB1 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MJD",
				"children":[
				{
					"name":"125770726 josephin-like protein\tK15235 JOSD; josephin [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MINDY",
				"children":[
				{
					"name":"125765088 inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				},
				{
					"name":"125774193 ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"JAMM",
				"children":[
				{
					"name":"125761494 MPN domain-containing protein CG4751\tK24173 MPND; MPN domain-containing protein"
				},
				{
					"name":"125763233 26S proteasome non-ATPase regulatory subunit 14\tK03030 PSMD14; 26S proteasome regulatory subunit N11"
				},
				{
					"name":"125760790 STAM-binding protein-like A\tK11866 STAMBP; STAM-binding protein [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"PPPDE",
				"children":[
				{
					"name":"125768419 deubiquitinase DESI2\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"ZUFSP",
				"children":[
				{
					"name":"125762429 zinc finger-containing ubiquitin peptidase 1-like isoform X1\tK24134 ZUP1; zinc finger-containing ubiquitin peptidase 1 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"BRISC complex"
			}
			]
		},
		{
			"name":"UBL-specific proteases (ULPs)",
			"children":[
			{
				"name":"125769864 sentrin-specific protease 8\tK08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]"
			},
			{
				"name":"125770270 ubiquitin carboxyl-terminal hydrolase\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
			},
			{
				"name":"125773441 uncharacterized protein LOC125773441\tK22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]"
			},
			{
				"name":"COP9 signalosome (CSN) complex",
				"children":[
				{
					"name":"125770958 COP9 signalosome complex subunit 1b\tK12175 GPS1; COP9 signalosome complex subunit 1"
				},
				{
					"name":"125765583 COP9 signalosome complex subunit 2\tK12176 COPS2; COP9 signalosome complex subunit 2"
				},
				{
					"name":"125771985 COP9 signalosome complex subunit 3\tK12177 COPS3; COP9 signalosome complex subunit 3"
				},
				{
					"name":"125760741 COP9 signalosome complex subunit 4\tK12178 COPS4; COP9 signalosome complex subunit 4"
				},
				{
					"name":"125764739 COP9 signalosome complex subunit 5\tK09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]"
				},
				{
					"name":"125762187 COP9 signalosome complex subunit 6\tK12179 COPS6; COP9 signalosome complex subunit 6"
				},
				{
					"name":"125771821 COP9 signalosome complex subunit 7 isoform X1\tK12180 COPS7; COP9 signalosome complex subunit 7"
				},
				{
					"name":"125761513 COP9 signalosome complex subunit 8\tK12181 COPS8; COP9 signalosome complex subunit 8"
				},
				{
					"name":"125768112 COP9 signalosome complex subunit 9\tK28062 COPS9; COP9 signalosome complex subunit 9"
				}
				]
			}
			]
		}
		]
	}
	]
}