{
	"name":"alw02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"FOB21_00455 cas1f; type I-F CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"FOB21_00460 CRISPR-associated endonuclease Cas3''\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors",
				"children":[
				{
					"name":"FOB21_00475 cas6f; type I-F CRISPR-associated endoribonuclease Cas6\/Csy4\tK19130 csy4; CRISPR-associated endonuclease Csy4 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"FOB21_03500 type I restriction endonuclease subunit R\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"FOB21_13820 HsdR family type I site-specific deoxyribonuclease\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"FOB21_13795 restriction endonuclease subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"FOB21_13790 type I restriction-modification system subunit M\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"FOB21_08510 DNA modification methylase\tK07318 K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"FOB21_08880 restriction endonuclease\tK07448 mrr; restriction system protein"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE"
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"FOB21_00110 type II toxin-antitoxin system mRNA interferase toxin, RelE\/StbE family\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"FOB21_00125 type II toxin-antitoxin system mRNA interferase toxin, RelE\/StbE family\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"FOB21_00105 type II toxin-antitoxin system RelB\/DinJ family antitoxin\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				},
				{
					"name":"FOB21_00130 type II toxin-antitoxin system RelB\/DinJ family antitoxin\tK18918 relB; RHH-type transcriptional regulator, rel operon repressor \/ antitoxin RelB"
				},
				{
					"name":"FOB21_01795 hypothetical protein\tK18923 stbD; antitoxin StbD"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"FOB21_17075 type II toxin-antitoxin system mRNA interferase toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB",
				"children":[
				{
					"name":"FOB21_00385 type II toxin-antitoxin system HipA family toxin\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"FOB21_01375 type II toxin-antitoxin system HipA family toxin\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				},
				{
					"name":"FOB21_09345 type II toxin-antitoxin system HipA family toxin\tK07154 hipA; serine\/threonine-protein kinase HipA [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"FOB21_10925 transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"FOB21_17015 PIN domain-containing protein\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"FOB21_17020 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK18829 mvpT; antitoxin VapB"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"FOB21_10620 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"FOB21_14035 MreB\/Mrl family cell shape determining protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"FOB21_08575 parC; DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"FOB21_10440 parE; DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"FOB21_08150 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB",
				"children":[
				{
					"name":"FOB21_07410 succinate dehydrogenase assembly factor 2\tK09159 cptB; antitoxin CptB"
				}
				]
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"FOB21_16855 IscS subfamily cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}