{
	"name":"amer04031",
	"children":[
	{
		"name":"Heterotrimeric G-proteins",
		"children":[
		{
			"name":"Alpha Subunits",
			"children":[
			{
				"name":"Alpha type 1 (Gi\/o) [OT]",
				"children":[
				{
					"name":"121593232 G protein alpha i subunit isoform X1\tK04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha"
				},
				{
					"name":"121594530 G protein alpha o subunit isoform X1\tK04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 2 (Gs)",
				"children":[
				{
					"name":"121599002 guanine nucleotide-binding protein G(s) subunit alpha\tK04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 3 (Gq\/11) [OT]",
				"children":[
				{
					"name":"121593908 G protein alpha q subunit isoform X1\tK04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 4 (G12\/13)",
				"children":[
				{
					"name":"121596778 guanine nucleotide-binding protein subunit alpha homolog\tK04346 GNA12; guanine nucleotide-binding protein subunit alpha-12"
				},
				{
					"name":"121602548 guanine nucleotide-binding protein subunit alpha homolog\tK04346 GNA12; guanine nucleotide-binding protein subunit alpha-12"
				}
				]
			},
			{
				"name":"Alpha others - lower eukaryotes",
				"children":[
				{
					"name":"121594821 guanine nucleotide-binding protein G(f) subunit alpha\tK04640 GNA; guanine nucleotide-binding protein subunit alpha, other"
				},
				{
					"name":"121603367 LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(f) subunit alpha-like\tK04640 GNA; guanine nucleotide-binding protein subunit alpha, other"
				}
				]
			}
			]
		},
		{
			"name":"Beta Subunits",
			"children":[
			{
				"name":"Beta [OT]",
				"children":[
				{
					"name":"121593233 guanine nucleotide-binding protein subunit beta-1\tK04536 GNB1; guanine nucleotide-binding protein G(I)\/G(S)\/G(T) subunit beta-1"
				},
				{
					"name":"121600853 guanine nucleotide-binding protein subunit beta-5 isoform X1\tK04539 GNB5; guanine nucleotide-binding protein subunit beta-5"
				},
				{
					"name":"121590953 guanine nucleotide-binding protein subunit beta-2\tK07972 GNB; guanine nucleotide-binding protein subunit beta, other"
				}
				]
			}
			]
		},
		{
			"name":"Gamma Subunits",
			"children":[
			{
				"name":"Gamma [OT]",
				"children":[
				{
					"name":"121596140 guanine nucleotide-binding protein subunit gamma-e isoform X1\tK04547 GNG13; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-13"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Small (monomeric) G-proteins",
		"children":[
		{
			"name":"Ras Family",
			"children":[
			{
				"name":"Ras [OT]",
				"children":[
				{
					"name":"121590048 GTPase HRas\tK07827 KRAS; GTPase KRas"
				},
				{
					"name":"121588712 ras-like protein 2\tK07830 RRAS2; Ras-related protein R-Ras2"
				}
				]
			},
			{
				"name":"Rit"
			},
			{
				"name":"Ral",
				"children":[
				{
					"name":"121600271 ras-related protein Ral-a isoform X1\tK07834 RALA; Ras-related protein Ral-A"
				}
				]
			},
			{
				"name":"Rap [OT]",
				"children":[
				{
					"name":"121588550 ras-related protein Rap1\tK04353 RAP1A; Ras-related protein Rap-1A"
				},
				{
					"name":"121591436 ras-related protein Rap-2a\tK07838 RAP2B; Ras-related protein Rap-2B"
				}
				]
			},
			{
				"name":"Di-Ras [OT]",
				"children":[
				{
					"name":"121593571 GTP-binding protein Di-Ras2\tK07841 DIRAS2; DIRAS family, GTP-binding Ras-like 2"
				}
				]
			},
			{
				"name":"RasD"
			},
			{
				"name":"Rad\/Gem\/Kir [OT]",
				"children":[
				{
					"name":"121593349 GTP-binding protein Rit2\tK07847 REM1; Rad and Gem related GTP binding protein 1"
				},
				{
					"name":"121594755 uncharacterized protein LOC121594755 isoform X1\tK07847 REM1; Rad and Gem related GTP binding protein 1"
				},
				{
					"name":"121602146 GTP-binding protein Rit2-like\tK07847 REM1; Rad and Gem related GTP binding protein 1"
				}
				]
			},
			{
				"name":"Rheb",
				"children":[
				{
					"name":"121588797 GTP-binding protein Rheb homolog\tK07208 RHEB; Ras homolog enriched in brain"
				}
				]
			},
			{
				"name":"Nki-Ras",
				"children":[
				{
					"name":"121600582 NF-kappa-B inhibitor-interacting Ras-like protein\tK17197 NKIRAS; NF-kappa-B inhibitor-interacting Ras-like protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"121588359 ras-like protein family member 10B\tK07851 RASL10B; Ras-like protein family member 10B"
				},
				{
					"name":"121590304 ras-related and estrogen-regulated growth inhibitor-like\tK17198 RERGL; Ras-related and estrogen-regulated growth inhibitor-like protein"
				},
				{
					"name":"121597198 LOW QUALITY PROTEIN: ras-related and estrogen-regulated growth inhibitor-like protein\tK17198 RERGL; Ras-related and estrogen-regulated growth inhibitor-like protein"
				},
				{
					"name":"121602338 ras-related and estrogen-regulated growth inhibitor-like protein\tK17198 RERGL; Ras-related and estrogen-regulated growth inhibitor-like protein"
				}
				]
			}
			]
		},
		{
			"name":"Rho Family",
			"children":[
			{
				"name":"RhoA\/B\/C [OT]",
				"children":[
				{
					"name":"121594850 ras-like GTP-binding protein Rho1 isoform X1\tK04513 RHOA; Ras homolog gene family, member A"
				},
				{
					"name":"121602141 ras-like GTP-binding protein Rho1 isoform X1\tK04513 RHOA; Ras homolog gene family, member A"
				},
				{
					"name":"121602887 ras-like GTP-binding protein Rho1 isoform X1\tK04513 RHOA; Ras homolog gene family, member A"
				}
				]
			},
			{
				"name":"Rnd [OT]"
			},
			{
				"name":"Rac\/Cdc42 [OT]",
				"children":[
				{
					"name":"121587976 ras-related C3 botulinum toxin substrate 1\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"121588842 ras-like GTP-binding protein RhoL\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"121592558 ras-related protein Rac1\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"121594785 ras-like GTP-binding protein RhoL\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"121590084 cdc42 homolog\tK04393 CDC42; cell division control protein 42"
				}
				]
			},
			{
				"name":"RhoBTB",
				"children":[
				{
					"name":"121594876 rho-related BTB domain-containing protein 1 isoform X1\tK07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1\/2"
				}
				]
			},
			{
				"name":"Miro",
				"children":[
				{
					"name":"121597834 mitochondrial Rho GTPase isoform X1\tK07870 RHOT1; mitochondrial Rho GTPase 1 [EC:3.6.5.-]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Rab Family",
			"children":[
			{
				"name":"Rab1\/35 [OT]",
				"children":[
				{
					"name":"121591035 ras-related protein Rab-1A\tK07874 RAB1A; Ras-related protein Rab-1A"
				},
				{
					"name":"121587746 ras-related protein Rab-35-like\tK07876 RAB35; Ras-related protein Rab-35"
				}
				]
			},
			{
				"name":"Rab2\/4\/14 [OT]",
				"children":[
				{
					"name":"121593550 ras-related protein Rab-2A\tK07877 RAB2A; Ras-related protein Rab-2A"
				},
				{
					"name":"121589656 ras-related protein Rab-4B\tK07880 RAB4B; Ras-related protein Rab-4B"
				},
				{
					"name":"121597033 ras-related protein Rab-14\tK07881 RAB14; Ras-related protein Rab-14"
				}
				]
			},
			{
				"name":"Rab3\/27 [OT]",
				"children":[
				{
					"name":"121592636 ras-related protein Rab-3 isoform X1\tK07883 RAB3C; Ras-related protein Rab-3C"
				}
				]
			},
			{
				"name":"Rab5\/17\/22\/31 [OT]",
				"children":[
				{
					"name":"121596581 ras-related protein Rab-5B\tK07888 RAB5B; Ras-related protein Rab-5B"
				}
				]
			},
			{
				"name":"Rab6\/41 [OT]",
				"children":[
				{
					"name":"121598994 LOW QUALITY PROTEIN: ras-related protein Rab6-like\tK07893 RAB6A_C_D; Ras-related protein Rab-6A\/C\/D [EC:3.6.5.2]"
				},
				{
					"name":"121601261 ras-related protein Rab6 isoform X1\tK07893 RAB6A_C_D; Ras-related protein Rab-6A\/C\/D [EC:3.6.5.2]"
				}
				]
			},
			{
				"name":"Rab7\/9 [OT]",
				"children":[
				{
					"name":"121590027 ras-related protein Rab-7a\tK07897 RAB7A; Ras-related protein Rab-7A [EC:3.6.5.2]"
				},
				{
					"name":"121595941 ras-related protein Rab-9B isoform X1\tK07899 RAB9A; Ras-related protein Rab-9A"
				}
				]
			},
			{
				"name":"Rab8\/10\/13 [OT]",
				"children":[
				{
					"name":"121588140 ras-related protein Rab-8A\tK07901 RAB8A; Ras-related protein Rab-8A"
				},
				{
					"name":"121588906 ras-related protein Rab-10\tK07903 RAB10; Ras-related protein Rab-10"
				}
				]
			},
			{
				"name":"Rab11\/25 [OT]",
				"children":[
				{
					"name":"121603433 ras-related protein Rab-11A\tK07904 RAB11A; Ras-related protein Rab-11A"
				}
				]
			},
			{
				"name":"Rab12\/18",
				"children":[
				{
					"name":"121600333 ras-related protein Rab-18-B\tK07910 RAB18; Ras-related protein Rab-18"
				}
				]
			},
			{
				"name":"Rab15"
			},
			{
				"name":"Rab19\/30\/43 [OT]",
				"children":[
				{
					"name":"121589939 ras-related protein Rab-30\tK07917 RAB30; Ras-related protein Rab-30"
				},
				{
					"name":"121593265 ras-related protein Rab-43\tK07930 RAB43; Ras-related protein Rab-43"
				}
				]
			},
			{
				"name":"Rab20\/21\/24 [OT]"
			},
			{
				"name":"Rab23",
				"children":[
				{
					"name":"121600578 ras-related protein Rab-23\tK06234 RAB23; Ras-related protein Rab-23"
				}
				]
			},
			{
				"name":"Rab26\/37"
			},
			{
				"name":"Rab28"
			},
			{
				"name":"Rab29\/32\/38 [OT]"
			},
			{
				"name":"Rab33"
			},
			{
				"name":"Rab34\/36",
				"children":[
				{
					"name":"121594285 ras-related protein Rab-36\tK07922 RAB36; Ras-related protein Rab-36"
				}
				]
			},
			{
				"name":"Rab39\/42 [OT]",
				"children":[
				{
					"name":"121591661 ras-related protein Rab-39B\tK07925 RAB39B; Ras-related protein Rab-39B"
				}
				]
			},
			{
				"name":"Rab40",
				"children":[
				{
					"name":"121592450 ras-related protein Rab-40C\tK07928 RAB40; Ras-related protein Rab-40"
				}
				]
			},
			{
				"name":"Rab45"
			},
			{
				"name":"Rab-like"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"121591632 ras-related protein Rab-8A\tK07976 RAB; Rab family, other"
				}
				]
			}
			]
		},
		{
			"name":"Ran Family",
			"children":[
			{
				"name":"Ran",
				"children":[
				{
					"name":"121591409 GTP-binding nuclear protein Ran\tK07936 RAN; GTP-binding nuclear protein Ran"
				}
				]
			}
			]
		},
		{
			"name":"Arf\/Sar Family",
			"children":[
			{
				"name":"Arf [OT]",
				"children":[
				{
					"name":"121599044 ADP-ribosylation factor 1\tK07937 ARF1_2; ADP-ribosylation factor 1\/2"
				},
				{
					"name":"121588664 ADP-ribosylation factor 2\tK07939 ARF4; ADP-ribosylation factor 4"
				},
				{
					"name":"121591948 ADP-ribosylation factor 6\tK07941 ARF6; ADP-ribosylation factor 6"
				}
				]
			},
			{
				"name":"Arl1\/Arl5 [OT]",
				"children":[
				{
					"name":"121599625 ADP-ribosylation factor-like protein 1\tK07942 ARL1; ADP-ribosylation factor-like protein 1"
				},
				{
					"name":"121599267 ADP-ribosylation factor-like protein 5B\tK07950 ARL5B; ADP-ribosylation factor-like protein 5B"
				}
				]
			},
			{
				"name":"Arl2\/Arl3",
				"children":[
				{
					"name":"121592449 ADP-ribosylation factor-like protein 2\tK07943 ARL2; ADP-ribosylation factor-like protein 2"
				},
				{
					"name":"121588910 ADP-ribosylation factor-like protein 3 isoform X1\tK07944 ARL3; ADP-ribosylation factor-like protein 3"
				}
				]
			},
			{
				"name":"Arl4\/Arl7"
			},
			{
				"name":"Arl6",
				"children":[
				{
					"name":"121598637 ADP-ribosylation factor-like protein 6 isoform X1\tK07951 ARL6; ADP-ribosylation factor-like protein 6"
				}
				]
			},
			{
				"name":"Arp",
				"children":[
				{
					"name":"121590192 ADP-ribosylation factor-related protein 1 isoform X1\tK07952 ARFRP1; ADP-ribosylation factor related protein 1"
				}
				]
			},
			{
				"name":"Sar",
				"children":[
				{
					"name":"121599990 GTP-binding protein SAR1b\tK07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]"
				}
				]
			},
			{
				"name":"Arl8",
				"children":[
				{
					"name":"121588275 ADP-ribosylation factor-like protein 8\tK07955 ARL8; ADP-ribosylation factor-like protein 8"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"121601802 ADP-ribosylation factor-like protein 13B\tK07962 ARL13B; ADP-ribosylation factor-like protein 13B"
				},
				{
					"name":"121603447 LOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 13B\tK07962 ARL13B; ADP-ribosylation factor-like protein 13B"
				}
				]
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"121593376 rab-like protein 3 isoform X1\tK07933 RABL3; Rab-like protein 3"
			},
			{
				"name":"121591448 signal recognition particle receptor subunit beta\tK12272 SRPRB; signal recognition particle receptor subunit beta"
			},
			{
				"name":"121591685 GTP-binding protein 2 isoform X1\tK24888 GTPBP2; GTP-binding protein 2"
			}
			]
		}
		]
	}
	]
}