{
	"name":"amf03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair"
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"AMF_274 nth; endonuclease III (nth)\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex"
					},
					{
						"name":"DNA polymerase epsilon complex"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex"
					},
					{
						"name":"Cul4-DDB2 complex"
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex"
					},
					{
						"name":"Cul4-CSA complex"
					},
					{
						"name":"Other TCR factor"
					}
					]
				},
				{
					"name":"TFIIH complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Other NER factors"
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"MutL homologs"
				},
				{
					"name":"DNA polymerase delta complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other MMR factors"
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex"
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex"
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins"
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins"
				},
				{
					"name":"RecQ family DNA helicases"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Protein phosphatase 4"
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex"
				},
				{
					"name":"Other HR factors"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex"
				},
				{
					"name":"DNA Ligase 4 complex"
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors"
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors"
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group"
			},
			{
				"name":"Other TLS factors"
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex"
			},
			{
				"name":"HRAD17(Rad24)-RFC complex"
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex"
			},
			{
				"name":"FPC (fork protection complex)"
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex"
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"AMF_598 dut; deoxyuridine 5'triphosphate nucleotidohydrolase (dut)\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair"
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"AMF_934 Conserved hypothetical protein\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"AMF_570 fpg; formamidopyrimidine-DNA glycosylase (fpg)\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"AMF_274 nth; endonuclease III (nth)\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"AMF_441 xthA2; exodeoxyribonuclease III (xthA2)\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"RecJ",
					"children":[
					{
						"name":"AMF_856 recJ; single-stranded-DNA-specific exonuclease (recJ)\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"AMF_112 ligA; DNA ligase (ligA)\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"AMF_335 uvrA; excinuclease ABC subunit A (uvrA)\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"AMF_941 uvrB; excinuclease ABC subunit B (uvrB)\tK03702 uvrB; excinuclease ABC subunit B"
					},
					{
						"name":"AMF_280 uvrC; excinuclease ABC subunit C (uvrC)\tK03703 uvrC; excinuclease ABC subunit C"
					},
					{
						"name":"AMF_271 uvrD; DNA helicase II (uvrD)\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"AMF_112 ligA; DNA ligase (ligA)\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)",
						"children":[
						{
							"name":"AMF_194 rpoB; RNA polymerase beta subunit (rpoB)\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]"
						},
						{
							"name":"AMF_195 rpoC; DNA-directed RNA polymerase beta' chain (rpoC)\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]"
						},
						{
							"name":"AMF_672 rpoA; DNA-directed RNA polymerase alpha chain (rpoA)\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]"
						},
						{
							"name":"AMF_324 rpoZ; DNA-directed RNA polymerase omega subunit (rpoZ)\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]"
						}
						]
					},
					{
						"name":"TRCF (transcription-repair coupling factor)",
						"children":[
						{
							"name":"AMF_091 mfd; transcription repair coupling factor (mfd)\tK03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]"
						}
						]
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"AMF_301 mutS; DNA mismatch repair protein (mutS)\tK03555 mutS; DNA mismatch repair protein MutS"
					}
					]
				},
				{
					"name":"Molecular matchmaker",
					"children":[
					{
						"name":"AMF_248 mutL; DNA mismatch repair protein (mutL)\tK03572 mutL; DNA mismatch repair protein MutL"
					}
					]
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases",
					"children":[
					{
						"name":"AMF_1006 xseA; exodeoxyribonuclease large subunit (xseA)\tK03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]"
					},
					{
						"name":"AMF_068 xseB; exodeoxyribonuclease VII, small subunit\tK03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]"
					}
					]
				},
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"AMF_213 dnaE; DNA polymerase III, alpha subunit (dnaE)\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"AMF_773 dnaN; DNA polymerase III beta chain (dnaN)\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"AMF_894 holA; Putative DNA polymerase III delta subunit (holA)\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"AMF_319 dnaX; DNA polymerase III subunit gamma\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"AMF_467 dnaQ; DNA polymerase III, epsilon chain (dnaQ)\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"AMF_967 dnaZ; DNA polymerase III gamma subunit (dnaZ)\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"AMF_112 ligA; DNA ligase (ligA)\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"AMF_271 uvrD; DNA helicase II (uvrD)\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"AMF_310 ssb; single-strand binding protein (ssb)\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins",
					"children":[
					{
						"name":"AMF_061 recA; recA protein (recA)\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"AMF_130 ruvA; Holliday junction DNA helicase (ruvA)\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"AMF_129 ruvB; Holliday junction DNA helicase (ruvB)\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"AMF_981 ruvC; holliday (crossover) junction endodeoxyribonuclease (ruvC)\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					},
					{
						"name":"AMF_618 priA; primosomal protein N' (priA)\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]"
					},
					{
						"name":"AMF_802 msp3; major surface protein 3 (MSP3)\tK03546 sbcC; DNA repair protein SbcC\/Rad50"
					}
					]
				},
				{
					"name":"RecFOR pathway proteins",
					"children":[
					{
						"name":"AMF_061 recA; recA protein (recA)\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"AMF_116 radA; DNA repair protein (radA)\tK04485 radA; DNA repair protein RadA\/Sms"
					},
					{
						"name":"AMF_917 recF; RECF protein (recF)\tK03629 recF; DNA replication and repair protein RecF"
					},
					{
						"name":"AMF_1012 recG; ATP-dependent DNA helicase (recG)\tK03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]"
					},
					{
						"name":"AMF_856 recJ; single-stranded-DNA-specific exonuclease (recJ)\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
					},
					{
						"name":"AMF_511 recO; DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
					},
					{
						"name":"AMF_286 recR; recombination protein (recR)\tK06187 recR; recombination protein RecR"
					},
					{
						"name":"AMF_130 ruvA; Holliday junction DNA helicase (ruvA)\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"AMF_129 ruvB; Holliday junction DNA helicase (ruvB)\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"AMF_981 ruvC; holliday (crossover) junction endodeoxyribonuclease (ruvC)\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					}
					]
				},
				{
					"name":"AddAB pathway proteins",
					"children":[
					{
						"name":"AMF_711 recB; Putative exodeoxyribonuclease V beta chain\tK16898 addA; ATP-dependent helicase\/nuclease subunit A [EC:5.6.2.4 3.1.-.-]"
					},
					{
						"name":"AMF_308 Conserved hypothetical protein\tK16899 addB; ATP-dependent helicase\/nuclease subunit B [EC:5.6.2.4 3.1.-.-]"
					}
					]
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins",
					"children":[
					{
						"name":"AMF_802 msp3; major surface protein 3 (MSP3)\tK03546 sbcC; DNA repair protein SbcC\/Rad50"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"AMF_273 gyrA; DNA gyrase subunit A (gyrA)\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
						},
						{
							"name":"AMF_480 gyrB2; DNA gyrase subunit B (gyrB2)\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
						},
						{
							"name":"AMF_373 topA; DNA topoisomerase I (topA)\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						}
						]
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"AMF_1041 hupB; Histone-like bacterial DNA-binding protein\tK03530 hupB; DNA-binding protein HU-beta"
						}
						]
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway",
						"children":[
						{
							"name":"AMF_856 recJ; single-stranded-DNA-specific exonuclease (recJ)\tK07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]"
						},
						{
							"name":"AMF_511 recO; DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
						},
						{
							"name":"AMF_286 recR; recombination protein (recR)\tK06187 recR; recombination protein RecR"
						},
						{
							"name":"AMF_112 ligA; DNA ligase (ligA)\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
						}
						]
					},
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"AMF_006 ihfA; presumptive integration host factor alpha-subunit (ihfA)\tK04764 ihfA; integration host factor subunit alpha"
						}
						]
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"AMF_335 uvrA; excinuclease ABC subunit A (uvrA)\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"AMF_941 uvrB; excinuclease ABC subunit B (uvrB)\tK03702 uvrB; excinuclease ABC subunit B"
						}
						]
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"AMF_061 recA; recA protein (recA)\tK03553 recA; recombination protein RecA"
				},
				{
					"name":"AMF_310 ssb; single-strand binding protein (ssb)\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"AMF_598 dut; deoxyuridine 5'triphosphate nucleotidohydrolase (dut)\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"AMF_644 nrdA; ribonuclease-diphosphate reductase alpha chain (nrdA)\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]"
				},
				{
					"name":"AMF_355 nrdB; ribonuceoside-diphosphate reductase beta chain (nrdB)\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}