{ "name":"amj03019", "children":[ { "name":"Eukaryotic type", "children":[ { "name":"mRNA processing factors", "children":[ { "name":"5' end processing", "children":[ { "name":"Capping factors", "children":[ { "name":"102566708 RNMT; RNA guanine-7 methyltransferase\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]" }, { "name":"102570226 RNGTT; RNA guanylyltransferase and 5'-phosphatase\tK13917 RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74]" }, { "name":"102572082 CDK7; cyclin dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]" }, { "name":"102558730 CMTR1; cap methyltransferase 1\tK14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57]" }, { "name":"102567886 CMTR2; cap methyltransferase 2\tK14590 CMTR2; cap2 methyltransferase [EC:2.1.1.296]" }, { "name":"102569605 FAM103A1; family with sequence similarity 103 member A1\tK18708 FAM103A1; RNMT-activating mini protein" } ] }, { "name":"Cap binding complex", "children":[ { "name":"102558634 NCBP1; nuclear cap binding protein subunit 1\tK12882 NCBP1; nuclear cap-binding protein subunit 1" }, { "name":"102574330 NCBP2; nuclear cap binding protein subunit 2\tK12883 NCBP2; nuclear cap-binding protein subunit 2" } ] } ] }, { "name":"3' end processing", "children":[ { "name":"Pre-mRNA cleavage factor Im (CFIm)", "children":[ { "name":"102561517 NUDT21; nudix hydrolase 21\tK14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5" }, { "name":"102562174 CPSF6; cleavage and polyadenylation specific factor 6\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7" }, { "name":"102566408 CPSF7; cleavage and polyadenylation specific factor 7\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7" } ] }, { "name":"Pre-mRNA cleavage factor IIm (CFIIm)", "children":[ { "name":"102571624 CLP1; cleavage and polyadenylation factor I subunit 1\tK14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]" }, { "name":"102562671 PCF11; PCF11 cleavage and polyadenylation factor subunit\tK14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11" } ] }, { "name":"Cleavage and polyadenylation specificity factor (CPSF) complex", "children":[ { "name":"102573392 CPSF1; cleavage and polyadenylation specific factor 1\tK14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1" }, { "name":"102562255 CPSF2; cleavage and polyadenylation specific factor 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2" }, { "name":"102558228 CPSF3; cleavage and polyadenylation specific factor 3\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]" }, { "name":"102564540 CPSF4L; cleavage and polyadenylation specific factor 4 like\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4" }, { "name":"102570582 CPSF4; cleavage and polyadenylation specific factor 4\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4" }, { "name":"102558977 FIP1L1; factor interacting with PAPOLA and CPSF1\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1" }, { "name":"102559698 pre-mRNA 3'-end-processing factor FIP1\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1" }, { "name":"102567056 WDR33; WD repeat domain 33\tK15542 PFS2; polyadenylation factor subunit 2" }, { "name":"102576545 WDR82; WD repeat domain 82\tK14962 WDR82; COMPASS component SWD2" }, { "name":"102560817 PPP1CB; protein phosphatase 1 catalytic subunit beta\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"102564750 PPP1CC; protein phosphatase 1 catalytic subunit gamma\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"102565419 PPP1CA; protein phosphatase 1 catalytic subunit alpha\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]" }, { "name":"102559944 SSU72; SSU72 homolog, RNA polymerase II CTD phosphatase\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]" } ] }, { "name":"Cleavage stimulation factor (CSTF) complex", "children":[ { "name":"102562147 CSTF1; cleavage stimulation factor subunit 1\tK14406 CSTF1; cleavage stimulation factor subunit 1" }, { "name":"102560836 CSTF2; cleavage stimulation factor subunit 2\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"102559146 CSTF3; cleavage stimulation factor subunit 3\tK14408 CSTF3; cleavage stimulation factor subunit 3" }, { "name":"102568318 SYMPK; symplekin\tK06100 SYMPK; symplekin" }, { "name":"106739740 symplekin-like\tK06100 SYMPK; symplekin" } ] }, { "name":"U7-dependent histone pre-mRNA processing factors", "children":[ { "name":"102563761 SNRPB; small nuclear ribonucleoprotein polypeptides B and B1\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'" }, { "name":"102571276 SNRPD3; small nuclear ribonucleoprotein D3 polypeptide\tK11088 SNRPD3; small nuclear ribonucleoprotein D3" }, { "name":"102567670 SNRPE; small nuclear ribonucleoprotein polypeptide E\tK11097 SNRPE; small nuclear ribonucleoprotein E" }, { "name":"102576464 SNRPF; small nuclear ribonucleoprotein polypeptide F\tK11098 SNRPF; small nuclear ribonucleoprotein F" }, { "name":"106737822 SNRPG; small nuclear ribonucleoprotein polypeptide G\tK11099 SNRPG; small nuclear ribonucleoprotein G" }, { "name":"102561313 LSM10; LSM10, U7 small nuclear RNA associated\tK25591 LSM10; U7 snRNA-associated Sm-like protein LSm10" }, { "name":"102568776 LSM11; LSM11, U7 small nuclear RNA associated\tK25592 LSM11; U7 snRNA-associated Sm-like protein LSm11" }, { "name":"102562255 CPSF2; cleavage and polyadenylation specific factor 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2" }, { "name":"102558228 CPSF3; cleavage and polyadenylation specific factor 3\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]" }, { "name":"102560836 CSTF2; cleavage stimulation factor subunit 2\tK14407 CSTF2; cleavage stimulation factor subunit 2" }, { "name":"102568318 SYMPK; symplekin\tK06100 SYMPK; symplekin" }, { "name":"106739740 symplekin-like\tK06100 SYMPK; symplekin" }, { "name":"102565949 histone RNA hairpin-binding protein\tK18710 SLBP; histone RNA hairpin-binding protein" }, { "name":"102566583 SLBP; histone RNA hairpin-binding protein\tK18710 SLBP; histone RNA hairpin-binding protein" }, { "name":"109286360 oocyte-specific histone RNA stem-loop-binding protein 2-like\tK18710 SLBP; histone RNA hairpin-binding protein" }, { "name":"102563755 CASP8AP2; caspase 8 associated protein 2\tK25593 CASP8AP2; CASP8-associated protein 2" } ] }, { "name":"DRB sensitivity inducing factor (DSIF) complex", "children":[ { "name":"102575684 SUPT4H1; SPT4 homolog, DSIF elongation factor subunit\tK15171 SUPT4H1; transcription elongation factor SPT4" }, { "name":"102576735 SUPT5H; SPT5 homolog, DSIF elongation factor subunit\tK15172 SUPT5H; transcription elongation factor SPT5" } ] }, { "name":"N6-methyltransferase complex", "children":[ { "name":"102564955 METTL3; methyltransferase like 3\tK05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]" }, { "name":"102561217 METTL14; methyltransferase like 14\tK23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit" }, { "name":"102569473 METTL4; methyltransferase like 4\tK24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]" }, { "name":"102560118 METTL16; methyltransferase like 16\tK11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]" }, { "name":"102565275 WTAP; Wilms tumor 1 associated protein\tK22824 WTAP; pre-mRNA-splicing regulator WTAP" }, { "name":"102569262 KIAA1429 ortholog\tK22910 VIRMA; protein virilizer" }, { "name":"102570749 RBM15B; RNA binding motif protein 15B\tK13190 RBM15; RNA-binding protein 15" }, { "name":"102575847 RBM15; RNA binding motif protein 15\tK13190 RBM15; RNA-binding protein 15" }, { "name":"102561967 ZC3H13; zinc finger CCCH-type containing 13\tK22909 ZC3H13; zinc finger CCCH domain-containing protein 13" }, { "name":"102575587 CBLL1; Cbl proto-oncogene like 1\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]" } ] }, { "name":"Poly(A) addition factors", "children":[ { "name":"102558962 PAPOLG; poly(A) polymerase gamma\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"102561274 PAPOLA; poly(A) polymerase alpha\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]" }, { "name":"102572706 PAPD4; poly(A) RNA polymerase D4, non-canonical\tK14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]" }, { "name":"102568708 TUT1; terminal uridylyl transferase 1, U6 snRNA-specific\tK18709 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase [EC:2.7.7.19 2.7.7.52]" } ] }, { "name":"Negative regulators of mRNA 3' end processing", "children":[ { "name":"102570525 BARD1; BRCA1 associated RING domain 1\tK10683 BARD1; BRCA1-associated RING domain protein 1" }, { "name":"102574585 RBM26; RNA binding motif protein 26\tK13192 RBM26; RNA-binding protein 26" }, { "name":"102565118 FTO; FTO, alpha-ketoglutarate dependent dioxygenase\tK19469 FTO; mRNA N6-methyladenine demethylase [EC:1.14.11.53]" }, { "name":"102562503 ALKBH5; alkB homolog 5, RNA demethylase\tK10767 ALKBH5; mRNA N6-methyladenine demethylase [EC:1.14.11.53]" }, { "name":"102575271 TARDBP; TAR DNA binding protein\tK23600 TARDBP; TAR DNA-binding protein 43" } ] } ] }, { "name":"Other processing factors", "children":[ { "name":"102569861 DHX40; DEAH-box helicase 40\tK18711 DHX40; ATP-dependent RNA helicase DHX40 [EC:5.6.2.6]" }, { "name":"102559277 KIN; Kin17 DNA and RNA binding protein\tK13102 KIN; DNA\/RNA-binding protein KIN17" }, { "name":"102576459 METTL8; methyltransferase like 8\tK24975 METTL8; mRNA N(3)-methylcytidine methyltransferase METTL8 [EC:2.1.1.-]" }, { "name":"102565941 METTL22; methyltransferase like 22\tK23040 METTL22; methyltransferase-like protein 22 [EC:2.1.1.-]" }, { "name":"102562016 FAM46B; family with sequence similarity 46 member B\tK23033 TENT5A_B; terminal nucleotidyltransferase 5A\/B [EC:2.7.7.-]" }, { "name":"102567058 FAM46A; family with sequence similarity 46 member A\tK23033 TENT5A_B; terminal nucleotidyltransferase 5A\/B [EC:2.7.7.-]" }, { "name":"102575082 FAM46C; family with sequence similarity 46 member C\tK23034 TENT5C; terminal nucleotidyltransferase 5C [EC:2.7.7.19]" }, { "name":"102569410 FAM46D; family with sequence similarity 46 member D\tK23035 TENT5D; terminal nucleotidyltransferase 5D [EC:2.7.7.19]" }, { "name":"102558499 ZC3H14; zinc finger CCCH-type containing 14\tK23038 ZC3H14; zinc finger CCCH domain-containing protein 14" }, { "name":"102558996 SRRT; serrate, RNA effector molecule\tK27103 SRRT; serrate RNA effector molecule" } ] } ] }, { "name":"mRNA surveillance and transport factors", "children":[ { "name":"Transport factors", "children":[ { "name":"EJC complex", "children":[ { "name":"102571869 RBM8A; RNA binding motif protein 8A\tK12876 RBM8A; RNA-binding protein 8A" }, { "name":"102568518 MAGOH; mago homolog, exon junction complex core component\tK12877 MAGOH; protein mago nashi" }, { "name":"102562580 ALYREF; Aly\/REF export factor\tK12881 THOC4; THO complex subunit 4" }, { "name":"102570178 DDX39A; spliceosome RNA helicase DDX39B\tK12812 DDX39B; ATP-dependent RNA helicase UAP56\/SUB2 [EC:5.6.2.7]" }, { "name":"102564262 EIF4A3; eukaryotic translation initiation factor 4A3\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"102565297 CCDC174; coiled-coil domain containing 174\tK25178 CCDC174; coiled-coil domain-containing protein 174" }, { "name":"102561950 CASC3; cancer susceptibility candidate 3\tK14323 CASC3; protein CASC3" }, { "name":"102567573 SAP18; Sin3A associated protein 18\tK14324 SAP18; histone deacetylase complex subunit SAP18" }, { "name":"102577072 PNN; pinin, desmosome associated protein\tK13114 PNN; pinin" }, { "name":"102574582 ACIN1; apoptotic chromatin condensation inducer 1\tK12875 ACIN1; apoptotic chromatin condensation inducer in the nucleus" }, { "name":"102572934 RNPS1; RNA binding protein with serine rich domain 1\tK14325 RNPS1; RNA-binding protein with serine-rich domain 1" }, { "name":"102566147 SRRM1; serine and arginine repetitive matrix 1\tK13171 SRRM1; serine\/arginine repetitive matrix protein 1" } ] }, { "name":"TREX complex", "children":[ { "name":"102559048 THOC1; THO complex 1\tK12878 THOC1; THO complex subunit 1" }, { "name":"102570502 THOC2; THO complex 2\tK12879 THOC2; THO complex subunit 2" }, { "name":"102561118 THOC3; THO complex 3\tK12880 THOC3; THO complex subunit 3" }, { "name":"102562580 ALYREF; Aly\/REF export factor\tK12881 THOC4; THO complex subunit 4" }, { "name":"102557709 THOC5; THO complex 5\tK13174 THOC5; THO complex subunit 5" }, { "name":"102573868 THOC6; THO complex 6\tK13175 THOC6; THO complex subunit 6" }, { "name":"102565342 THOC7; THO complex 7\tK13176 THOC7; THO complex subunit 7" }, { "name":"102562001 CHTOP; chromatin target of PRMT1\tK28424 CHTOP; chromatin target of PRMT1 protein" } ] }, { "name":"TREX-2 complex", "children":[ { "name":"102559027 PCID2; PCI domain containing 2\tK23801 PCID2; nuclear mRNA export protein PCID2\/THP1" }, { "name":"102572577 SEM1; SEM1, 26S proteasome complex subunit\tK10881 SHFM1; 26 proteasome complex subunit DSS1" }, { "name":"102565946 ENY2; ENY2, transcription and export complex 2 subunit\tK11368 ENY2; enhancer of yellow 2 transcription factor" }, { "name":"102562375 CETN2; centrin-2\tK10840 CETN2; centrin-2" }, { "name":"102561845 CETN3; centrin 3\tK16466 CETN3; centrin-3" }, { "name":"102570357 MCM3AP; minichromosome maintenance complex component 3 associated protein\tK24317 MCM3AP; germinal-center associated nuclear protein [EC:2.3.1.48]" } ] }, { "name":"Nuclear pore complex", "children":[ { "name":"102568859 TPR; translocated promoter region, nuclear basket protein\tK09291 TPR; nucleoprotein TPR" }, { "name":"102571329 RAE1; ribonucleic acid export 1\tK14298 RAE1; mRNA export factor" }, { "name":"102560870 SEC13; SEC13 homolog, nuclear pore and COPII coat complex component\tK14004 SEC13; protein transport protein SEC13" }, { "name":"102558527 NUP37; nucleoporin 37\tK14302 NUP37; nuclear pore complex protein Nup37" }, { "name":"102565841 NUP85; nucleoporin 85\tK14304 NUP85; nuclear pore complex protein Nup85" }, { "name":"102568679 NUP43; nucleoporin 43\tK14305 NUP43; nuclear pore complex protein Nup43" }, { "name":"102573733 NUP50; nucleoporin 50\tK14295 NUP50; nuclear pore complex protein Nup50" }, { "name":"102570109 NUP54; nucleoporin 54\tK14308 NUP54; nuclear pore complex protein Nup54" }, { "name":"102573915 NUP62CL; nucleoporin 62 C-terminal like\tK14306 NUP62; nuclear pore complex protein Nup62" }, { "name":"102563177 NUP88; nucleoporin 88\tK14318 NUP88; nuclear pore complex protein Nup88" }, { "name":"102572578 NUP93; nucleoporin 93\tK14309 NUP93; nuclear pore complex protein Nup93" }, { "name":"102568743 NUP98; nucleoporin 98\tK14297 NUP98; nuclear pore complex protein Nup98-Nup96" }, { "name":"102562648 NUP107; nucleoporin 107\tK14301 NUP107; nuclear pore complex protein Nup107" }, { "name":"102571882 NUP133; nucleoporin 133\tK14300 NUP133; nuclear pore complex protein Nup133" }, { "name":"102575165 NUP188; nucleoporin 188\tK14311 NUP188; nuclear pore complex protein Nup188" }, { "name":"102572234 NUP153; nucleoporin 153\tK14296 NUP153; nuclear pore complex protein Nup153" }, { "name":"102559967 NUP155; nucleoporin 155\tK14312 NUP155; nuclear pore complex protein Nup155" }, { "name":"102571508 NUP160; nucleoporin 160\tK14303 NUP160; nuclear pore complex protein Nup160" }, { "name":"102558827 NUP35; nucleoporin 35\tK14313 NUP35; nuclear pore complex protein Nup53" }, { "name":"102570073 NUP205; nucleoporin 205\tK14310 NUP205; nuclear pore complex protein Nup205" }, { "name":"102560235 NUP210; nucleoporin 210\tK14314 NUP210; nuclear pore complex protein Nup210" }, { "name":"106736737 NUP210L; nucleoporin 210 like\tK14314 NUP210; nuclear pore complex protein Nup210" }, { "name":"102568058 NUP214; nucleoporin 214\tK14317 NUP214; nuclear pore complex protein Nup214" }, { "name":"102563989 POM121C; POM121 transmembrane nucleoporin C\tK14316 POM121; nuclear pore complex protein Nup121" }, { "name":"102564002 NUP58; nucleoporin 58\tK14307 NUPL1; nucleoporin p58\/p45" }, { "name":"102567417 NUPL2; nucleoporin like 2\tK14321 NUPL2; nucleoporin-like protein 2" }, { "name":"102567350 NDC1; NDC1 transmembrane nucleoporin\tK14315 NDC1; nucleoporin NDC1" }, { "name":"102567557 SEH1L; SEH1 like nucleoporin\tK14299 SEH1; nucleoporin SEH1" }, { "name":"102558542 E3 SUMO-protein ligase RanBP2\tK12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]" }, { "name":"102566527 SENP2; SUMO1\/sentrin\/SMT3 specific peptidase 2\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"109285707 sentrin-specific protease 2-like\tK03345 SENP2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]" }, { "name":"102557668 AAAS; aladin WD repeat nucleoporin\tK14320 AAAS; aladin" }, { "name":"102561845 CETN3; centrin 3\tK16466 CETN3; centrin-3" }, { "name":"102567154 GLE1; GLE1, RNA export mediator\tK18723 GLE1; nucleoporin GLE1" }, { "name":"102564521 NXF1; nuclear RNA export factor 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"106737160 nuclear RNA export factor 1-like\tK14284 NXF; nuclear RNA export factor" }, { "name":"102577210 NXT2; nuclear transport factor 2 like export factor 2\tK14285 NXT1_2; NTF2-related export protein 1\/2" } ] }, { "name":"Ran-mediated transport factors", "children":[ { "name":"102562653 RAN; RAN, member RAS oncogene family\tK07936 RAN; GTP-binding nuclear protein Ran" }, { "name":"102558528 ANP32A; acidic nuclear phosphoprotein 32 family member A\tK18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A\/C\/D" }, { "name":"102562326 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B\tK18647 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B" }, { "name":"102571923 TNFSF12; tumor necrosis factor ligand superfamily member 13\tK05475 TNFSF13; tumor necrosis factor ligand superfamily member 13" }, { "name":"102563037 ELAVL1; ELAV like RNA binding protein 1\tK13088 ELAVL1; ELAV-like protein 1" }, { "name":"102559157 ELAVL3; ELAV like RNA binding protein 3\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"102564681 ELAVL4; ELAV like RNA binding protein 4\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"102570328 ELAVL2; ELAV like RNA binding protein 2\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4" }, { "name":"102561799 FAF2; Fas associated factor family member 2\tK18726 FAF2; FAS-associated factor 2" }, { "name":"102564467 VCP; valosin containing protein\tK13525 VCP; transitional endoplasmic reticulum ATPase" }, { "name":"102572181 VCPKMT; valosin containing protein lysine methyltransferase\tK21806 VCPKMT; protein N-lysine methyltransferase METTL21D [EC:2.1.1.-]" }, { "name":"102573420 TNPO2; transportin 2\tK18727 TNPO2; transportin-2" }, { "name":"102560721 XPO1; exportin 1\tK14290 XPO1; exportin-1" }, { "name":"102565432 XPO7; exportin 7\tK18460 XPO7; exportin-7" }, { "name":"102564966 RANBP17; RAN binding protein 17\tK24115 RANBP17; Ran-binding protein 17" }, { "name":"102572295 RANGAP1; Ran GTPase activating protein 1\tK14319 RANGAP1; Ran GTPase-activating protein 1" }, { "name":"102577376 TAF15; TATA-binding protein-associated factor 2N\tK14651 TAF15; transcription initiation factor TFIID subunit 15" }, { "name":"102566655 NUTF2; nuclear transport factor 2\tK28773 NUTF2; nuclear transport factor 2" }, { "name":"102571883 nuclear transport factor 2\tK28773 NUTF2; nuclear transport factor 2" } ] }, { "name":"eIF4F and regulatory proteins", "children":[ { "name":"102557827 EIF4E; eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"102563175 EIF4E2; eukaryotic translation initiation factor 4E family member 2\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"102564304 EIF4E1B; eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"102559744 EIF4A1; eukaryotic translation initiation factor 4A1\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"106736926 EIF4A2; eukaryotic translation initiation factor 4A2\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"102558024 EIF4G2; eukaryotic translation initiation factor 4 gamma 2\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"102575196 EIF4G3; eukaryotic translation initiation factor 4 gamma 3\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"106736899 EIF4G1; eukaryotic translation initiation factor 4 gamma 1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"102570839 EIF4B; eukaryotic translation initiation factor 4B\tK03258 EIF4B; translation initiation factor 4B" }, { "name":"102569421 EIF4H; eukaryotic translation initiation factor 4H\tK24086 EIF4H; translation initiation factor 4H" }, { "name":"102575532 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1\tK07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1" }, { "name":"102567759 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2\tK18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2" }, { "name":"102565581 EIF4EBP3; eukaryotic translation initiation factor 4E binding protein 3\tK18645 EIF4EBP3; eukaryotic translation initiation factor 4E binding protein 3" }, { "name":"102561854 EIF4ENIF1; eukaryotic translation initiation factor 4E nuclear import factor 1\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter" }, { "name":"102562095 ANGEL2; angel homolog 2\tK18729 ANGEL; protein angel" }, { "name":"102571452 ANGEL1; angel homolog 1\tK18729 ANGEL; protein angel" }, { "name":"102565555 FXR2; fragile X mental retardation syndrome-related protein 2\tK15516 FMR; fragile X mental retardation protein" }, { "name":"102568696 FXR1; FMR1 autosomal homolog 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"106736684 FMR1; fragile X mental retardation 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"109283579 fragile X mental retardation syndrome-related protein 2-like\tK15516 FMR; fragile X mental retardation protein" }, { "name":"102571910 CYFIP2; cytoplasmic FMR1-interacting protein 2\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"102573610 CYFIP1; cytoplasmic FMR1-interacting protein 1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"102567754 GEMIN5; gem nuclear organelle associated protein 5\tK13133 GEMIN5; gem associated protein 5" }, { "name":"102565713 TACC3; transforming acidic coiled-coil containing protein 3\tK14283 TACC3; transforming acidic coiled-coil-containing protein 3" }, { "name":"102557656 CPEB2; cytoplasmic polyadenylation element binding protein 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102563713 CPEB1; cytoplasmic polyadenylation element binding protein 1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102573824 CPEB3; cytoplasmic polyadenylation element binding protein 3\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"106737061 CPEB4; cytoplasmic polyadenylation element binding protein 4\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102564422 DDX3X; DEAD-box helicase 3, X-linked\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"102559918 GIGYF1; GRB10 interacting GYF protein 1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"102570469 GIGYF2; GRB10 interacting GYF protein 2\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"102559521 PABPC4; poly(A) binding protein cytoplasmic 4\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"102561462 PABPC1L; poly(A) binding protein cytoplasmic 1 like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"102570387 PABPC1; poly(A) binding protein cytoplasmic 1\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"102562575 PAIP1; poly(A) binding protein interacting protein 1\tK14322 PAIP1; polyadenylate-binding protein-interacting protein 1" }, { "name":"102567579 PAIP2B; poly(A) binding protein interacting protein 2B\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2" }, { "name":"102574289 PAIP2; poly(A) binding protein interacting protein 2\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2" }, { "name":"102573582 SKIV2L; Ski2 like RNA helicase\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]" }, { "name":"102564882 DEAF1; DEAF1, transcription factor\tK23041 DEAF1; deformed epidermal autoregulatory factor 1" }, { "name":"102569842 MCTS1; MCTS1, re-initiation and release factor\tK07575 MCTS; malignant T-cell-amplified sequence" }, { "name":"102562901 DENR; density regulated re-initiation and release factor\tK24272 DENR; density-regulated protein" } ] }, { "name":"APOBEC1-ACF complex", "children":[ { "name":"102571342 APOBEC1; C->U-editing enzyme APOBEC-1\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"102571574 APOBEC1A; C->U-editing enzyme APOBEC-1\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"109281895 C->U-editing enzyme APOBEC-1-like\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"102560577 A1CF; APOBEC1 complementation factor\tK24978 A1CF; APOBEC1 complementation factor" } ] }, { "name":"Other transport factors", "children":[ { "name":"102558034 PYM1; PYM homolog 1, exon junction complex associated factor\tK14294 WIBG; partner of Y14 and mago" }, { "name":"102561135 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"102574459 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"102569720 MSI1; musashi RNA binding protein 1\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"102570412 DAZAP1; DAZ associated protein 1\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"102577105 MSI2; musashi RNA binding protein 2\tK14411 MSI; RNA-binding protein Musashi" }, { "name":"102565735 HBS1L; HBS1 like translational GTPase\tK14416 HBS1; elongation factor 1 alpha-like protein" }, { "name":"102557765 PELO; pelota homolog (Drosophila)\tK06965 PELO; protein pelota" }, { "name":"102560911 PABPN1L; poly(A) binding protein nuclear 1 like, cytoplasmic\tK14396 PABPN1; polyadenylate-binding protein 2" }, { "name":"106737025 PABPN1; poly(A) binding protein nuclear 1\tK14396 PABPN1; polyadenylate-binding protein 2" }, { "name":"102562539 DDX19B; ATP-dependent RNA helicase DDX19B\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]" }, { "name":"106736670 DDX25; DEAD-box helicase 25\tK18656 DDX25; ATP-dependent RNA helicase DDX25 [EC:5.6.2.7]" }, { "name":"102571642 XAB2; XPA binding protein 2\tK12867 SYF1; pre-mRNA-splicing factor SYF1" }, { "name":"102558497 SARNP; SAP domain containing ribonucleoprotein\tK18732 SARNP; SAP domain-containing ribonucleoprotein" }, { "name":"102573033 RCC1; regulator of chromosome condensation 1\tK11493 RCC1; regulator of chromosome condensation" }, { "name":"102562088 la-related protein 6\tK18733 LARP6; la-related protein 6" }, { "name":"102572179 LARP6; La ribonucleoprotein domain family member 6\tK18733 LARP6; la-related protein 6" }, { "name":"102574114 PURA; purine rich element binding protein A\tK21772 PURA; transcriptional activator protein Pur-alpha" }, { "name":"102557746 PURB; purine rich element binding protein B\tK21799 PURB; transcriptional activator protein Pur-beta" }, { "name":"102576712 POLDIP3; DNA polymerase delta interacting protein 3\tK22414 POLDIP3; polymerase delta-interacting protein 3" }, { "name":"106737263 ZC3H11A; zinc finger CCCH-type containing 11A\tK22415 ZC3H11; zinc finger CCCH domain-containing protein 11" }, { "name":"102576910 LENG8; leukocyte receptor cluster member 8\tK23802 LENG8; SAC3 family protein LENG8\/THP3" }, { "name":"102567442 PATL2; PAT1 homolog 2\tK24823 PATL2; protein PAT1 homolog 2" }, { "name":"102560005 FYTTD1; forty-two-three domain containing 1\tK28772 FYTTD1; UAP56-interacting factor" }, { "name":"102571232 UAP56-interacting factor\tK28772 FYTTD1; UAP56-interacting factor" } ] } ] }, { "name":"Surveillance factors", "children":[ { "name":"Surveillance complex", "children":[ { "name":"102572464 ETF1; eukaryotic translation termination factor 1\tK03265 ETF1; peptide chain release factor subunit 1" }, { "name":"102570671 GSPT1; G1 to S phase transition 1\tK03267 ERF3; peptide chain release factor subunit 3" }, { "name":"102576388 UPF1; UPF1, RNA helicase and ATPase\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"102558003 UPF2; UPF2 regulator of nonsense transcripts homolog (yeast)\tK14327 UPF2; regulator of nonsense transcripts 2" }, { "name":"102564547 UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast)\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"102569632 UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast)\tK14328 UPF3; regulator of nonsense transcripts 3" } ] }, { "name":"Protein phosphatase 2A", "children":[ { "name":"102576713 PPP2CB; protein phosphatase 2 catalytic subunit beta\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]" }, { "name":"102576911 PPP2CA; protein phosphatase 2 catalytic subunit alpha\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]" }, { "name":"102571411 PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A" }, { "name":"102559987 PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"102572311 PPP2R2A; protein phosphatase 2 regulatory subunit Balpha\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"102574203 PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"102574435 PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B" }, { "name":"102559220 PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"102562834 PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"106737028 PPP2R3B; protein phosphatase 2 regulatory subunit B''beta\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''" }, { "name":"102559929 PPP2R5B; protein phosphatase 2 regulatory subunit B'beta\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"102562888 PPP2R5D; protein phosphatase 2 regulatory subunit B'delta\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"102564365 PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"102567782 PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" }, { "name":"106737003 PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'" } ] }, { "name":"Other surveillance factors", "children":[ { "name":"102561568 SMG1; SMG1, nonsense mediated mRNA decay associated PI3K related kinase\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"102561317 SMG5; SMG5, nonsense mediated mRNA decay factor\tK11125 SMG5; protein SMG5" }, { "name":"106737087 SMG6; SMG6, nonsense mediated mRNA decay factor\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]" }, { "name":"102558375 SMG7; SMG7, nonsense mediated mRNA decay factor\tK14409 SMG7; protein SMG7" }, { "name":"102572627 SMG8; SMG8, nonsense mediated mRNA decay factor\tK18734 SMG8; protein SMG8" }, { "name":"102575848 SMG9; SMG9, nonsense mediated mRNA decay factor\tK18735 SMG9; protein SMG9" }, { "name":"102559918 GIGYF1; GRB10 interacting GYF protein 1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"102570469 GIGYF2; GRB10 interacting GYF protein 2\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein" }, { "name":"102566086 SECISBP2; SECIS binding protein 2\tK19539 SECISBP2; selenocysteine insertion sequence-binding protein 2" }, { "name":"102567654 SECISBP2L; SECIS binding protein 2 like\tK19539 SECISBP2; selenocysteine insertion sequence-binding protein 2" }, { "name":"102563784 DHX34; DExH-box helicase 34\tK20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6]" }, { "name":"102563302 GTPBP1; GTP binding protein 1\tK24887 GTPBP1; GTP-binding protein 1" } ] } ] }, { "name":"Factors involved in mRNA localization", "children":[ { "name":"Cargo complex", "children":[ { "name":"102561767 PUM3; pumilio RNA binding family member 3\tK14844 PUF6; pumilio homology domain family member 6" }, { "name":"102563609 MYO5C; myosin VC\tK10357 MYO5; myosin V" }, { "name":"102563838 MYO5B; myosin VB\tK10357 MYO5; myosin V" }, { "name":"102564065 MYO5A; myosin VA\tK10357 MYO5; myosin V" }, { "name":"102577330 unconventional myosin-Vb\tK10357 MYO5; myosin V" }, { "name":"102569104 BICD1; BICD cargo adaptor 1\tK18739 BICD; protein bicaudal D" }, { "name":"102577234 BICD2; BICD cargo adaptor 2\tK18739 BICD; protein bicaudal D" }, { "name":"102563088 EXD1; exonuclease 3'-5' domain containing 1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1" } ] }, { "name":"Factors that have mRNA localization signals", "children":[ { "name":"102561800 actin, cytoplasmic type 5\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"102565683 ACTB; actin, cytoplasmic 2\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"102568338 actin, cytoplasmic type 5\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"102568693 ACTB; actin beta\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"102571385 ACTBL2; actin, beta like 2\tK05692 ACTB_G1; actin beta\/gamma 1" }, { "name":"102569556 MBP; myelin basic protein\tK17269 MBP; myelin basic protein" }, { "name":"106736710 VIM; vimentin\tK07606 VIM; vimentin" }, { "name":"102561083 MYC; v-myc avian myelocytomatosis viral oncogene homolog\tK04377 MYC; Myc proto-oncogene protein" }, { "name":"102576145 GDF1; growth differentiation factor 1\tK05495 GDF1; growth differentiation factor 1" }, { "name":"102557665 TBX6; T-box-containing protein TBX6L\tK10180 TBX6; T-box protein 6" }, { "name":"102577240 TBX6; T-box transcription factor TBX6\tK10180 TBX6; T-box protein 6" }, { "name":"109282791 NANOS1; nanos C2HC-type zinc finger 1\tK18741 NANOS1; protein nanos 1" } ] }, { "name":"Trans-acting binding proteins", "children":[ { "name":"106737676 ZBP1; Z-DNA binding protein 1\tK12965 ZBP1; Z-DNA binding protein 1" }, { "name":"102565032 FUBP3; far upstream element binding protein 3\tK13210 FUBP; far upstream element-binding protein" }, { "name":"102565587 KHSRP; KH-type splicing regulatory protein\tK13210 FUBP; far upstream element-binding protein" }, { "name":"106737079 FUBP1; far upstream element binding protein 1\tK13210 FUBP; far upstream element-binding protein" }, { "name":"102558264 EEF1A2; eukaryotic translation elongation factor 1 alpha 2\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"102560544 elongation factor 1-alpha\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"102566461 elongation factor 1-alpha, oocyte form-like\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"102567085 EEF1A1; eukaryotic translation elongation factor 1 alpha 1\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"102562191 EEF1G; eukaryotic translation elongation factor 1 gamma\tK03233 EEF1G; elongation factor 1-gamma" }, { "name":"102575612 HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2\/B1\tK13158 HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2\/B1" }, { "name":"102570010 HAX1; HCLS1 associated protein X-1\tK16220 HAX1; HCLS1-associated protein X-1" }, { "name":"102576185 AGFG1; ArfGAP with FG repeats 1\tK15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1" }, { "name":"102558439 STAU1; staufen double-stranded RNA binding protein 1\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"102575164 STAU2; staufen double-stranded RNA binding protein 2\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"102566100 IGF2BP3; insulin like growth factor 2 mRNA binding protein 3\tK13197 IGF2BP3; insulin-like growth factor 2 mRNA-binding protein 3" }, { "name":"102559984 PTBP1; polypyrimidine tract binding protein 1\tK13218 PTBP1; polypyrimidine tract-binding protein 1" }, { "name":"102557656 CPEB2; cytoplasmic polyadenylation element binding protein 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102563713 CPEB1; cytoplasmic polyadenylation element binding protein 1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102573824 CPEB3; cytoplasmic polyadenylation element binding protein 3\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"106737061 CPEB4; cytoplasmic polyadenylation element binding protein 4\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" } ] }, { "name":"Other mRNA localization factors", "children":[ { "name":"102565555 FXR2; fragile X mental retardation syndrome-related protein 2\tK15516 FMR; fragile X mental retardation protein" }, { "name":"102568696 FXR1; FMR1 autosomal homolog 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"106736684 FMR1; fragile X mental retardation 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"109283579 fragile X mental retardation syndrome-related protein 2-like\tK15516 FMR; fragile X mental retardation protein" }, { "name":"102571910 CYFIP2; cytoplasmic FMR1-interacting protein 2\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"102573610 CYFIP1; cytoplasmic FMR1-interacting protein 1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein" }, { "name":"106737100 PCBP2; poly(rC) binding protein 2\tK13162 PCBP2; poly(rC)-binding protein 2" }, { "name":"102558349 poly(rC)-binding protein 3\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4" }, { "name":"102561411 PCBP3; poly(rC) binding protein 3\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4" }, { "name":"102567643 PCBP4; poly(rC) binding protein 4\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4" }, { "name":"102558754 CAPRIN1; cell cycle associated protein 1\tK18743 CAPRIN1; caprin-1" }, { "name":"102559657 CAPRIN2; caprin family member 2\tK18744 CAPRIN2; caprin-2" }, { "name":"102562836 YBX1; Y-box binding protein 1\tK09276 YBX1; Y-box-binding protein 1" }, { "name":"106737394 nuclease-sensitive element-binding protein 1\tK09276 YBX1; Y-box-binding protein 1" } ] } ] }, { "name":"mRNA cycle factors", "children":[ { "name":"Common to processing body (P body) and stress granule", "children":[ { "name":"102558616 XRN1; 5'-3' exoribonuclease 1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]" }, { "name":"102569604 AGO2; argonaute 2, RISC catalytic component\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"102577170 AGO4; argonaute 4, RISC catalytic component\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"102577396 AGO3; protein argonaute-3\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"106736731 AGO1; protein argonaute-1\tK11593 ELF2C; eukaryotic translation initiation factor 2C" }, { "name":"102557827 EIF4E; eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"102563175 EIF4E2; eukaryotic translation initiation factor 4E family member 2\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"102564304 EIF4E1B; eukaryotic translation initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E" }, { "name":"102576388 UPF1; UPF1, RNA helicase and ATPase\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"102564422 DDX3X; DEAD-box helicase 3, X-linked\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]" }, { "name":"102566221 DDX6; DEAD-box helicase 6\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]" }, { "name":"102558572 MEX3C; mex-3 RNA binding family member C\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"102561145 MEX3B; mex-3 RNA binding family member B\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"102562248 MEX3A; mex-3 RNA binding family member A\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"102576874 MEX3D; mex-3 RNA binding family member D\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]" }, { "name":"102570632 FASTK; Fas activated serine\/threonine kinase\tK08290 FASTK; Fas-activated serine\/threonine kinase [EC:2.7.11.8]" }, { "name":"102565858 LSM14B; LSM family member 14B\tK18749 LSM14; protein LSM14" }, { "name":"102576328 LSM14A; LSM14A, mRNA processing body assembly factor\tK18749 LSM14; protein LSM14" }, { "name":"106737100 PCBP2; poly(rC) binding protein 2\tK13162 PCBP2; poly(rC)-binding protein 2" }, { "name":"102562836 YBX1; Y-box binding protein 1\tK09276 YBX1; Y-box-binding protein 1" }, { "name":"106737394 nuclease-sensitive element-binding protein 1\tK09276 YBX1; Y-box-binding protein 1" }, { "name":"102563296 WTIP; Wilms tumor 1 interacting protein\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"102565583 LIMD1; LIM domains containing 1\tK16682 AJUBA; LIM domain-containing protein" }, { "name":"102571342 APOBEC1; C->U-editing enzyme APOBEC-1\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"102571574 APOBEC1A; C->U-editing enzyme APOBEC-1\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"109281895 C->U-editing enzyme APOBEC-1-like\tK16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]" }, { "name":"102574914 MOV10; Mov10 RISC complex RNA helicase\tK18422 MOV10; helicase MOV-10 [EC:5.6.2.5]" }, { "name":"102567536 PNRC2; proline rich nuclear receptor coactivator 2\tK18751 PNRC2; proline-rich nuclear receptor coactivator 2" }, { "name":"106736828 TNPO1; transportin 1\tK18752 TNPO1; transportin-1" }, { "name":"102561568 SMG1; SMG1, nonsense mediated mRNA decay associated PI3K related kinase\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]" }, { "name":"102561317 SMG5; SMG5, nonsense mediated mRNA decay factor\tK11125 SMG5; protein SMG5" }, { "name":"106737087 SMG6; SMG6, nonsense mediated mRNA decay factor\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]" }, { "name":"102558375 SMG7; SMG7, nonsense mediated mRNA decay factor\tK14409 SMG7; protein SMG7" }, { "name":"102559857 ZFP36L2; ZFP36 ring finger protein like 2\tK18753 ZFP36L; butyrate response factor" }, { "name":"102568619 ZFP36L1; ZFP36 ring finger protein like 1\tK18753 ZFP36L; butyrate response factor" }, { "name":"102558103 LIN28A; lin-28 homolog A\tK18754 LIN28; protein lin-28" }, { "name":"102561153 LIN28B; lin-28 homolog B\tK18754 LIN28; protein lin-28" }, { "name":"102572238 HTT; huntingtin\tK04533 HD; huntingtin" }, { "name":"106736835 IPO8; importin 8\tK18755 IPO8; importin-8" }, { "name":"102572948 BICC1; BicC family RNA binding protein 1\tK18756 BICC1; protein bicaudal C" }, { "name":"102561135 HNRNPA1; heterogeneous nuclear ribonucleoprotein A1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"102574459 HNRNPA3; heterogeneous nuclear ribonucleoprotein A3\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3" }, { "name":"102572143 PRKACB; protein kinase cAMP-activated catalytic subunit beta\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"106737076 cAMP-dependent protein kinase catalytic subunit alpha\tK04345 PKA; protein kinase A [EC:2.7.11.11]" }, { "name":"102561658 LARP1B; La ribonucleoprotein domain family member 1B\tK18757 LARP1; la-related protein 1" }, { "name":"102567992 LARP1; La ribonucleoprotein domain family member 1\tK18757 LARP1; la-related protein 1" }, { "name":"102572215 ATXN2; ataxin 2\tK23625 ATXN2; ataxin-2" } ] }, { "name":"P-body specific factors", "children":[ { "name":"102567941 DCP2; decapping mRNA 2\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]" }, { "name":"102563256 DCP1A; decapping mRNA 1A\tK12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]" }, { "name":"102568669 DCP1B; decapping mRNA 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]" }, { "name":"102573407 LSM1; LSM1 homolog, mRNA degradation associated\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1" }, { "name":"102567974 LSM2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2" }, { "name":"102574303 LSM3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"102558189 LSM4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4" }, { "name":"102565642 LSM5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5" }, { "name":"102563750 LSM6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6" }, { "name":"102576963 LSM7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7" }, { "name":"102569069 LSM8; LSM8 homolog, U6 small nuclear RNA associated\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8" }, { "name":"102559216 KLC4; kinesin light chain 4\tK10407 KLC; kinesin light chain" }, { "name":"102566917 KLC3; kinesin light chain 3\tK10407 KLC; kinesin light chain" }, { "name":"106737186 KLC1; kinesin light chain 1\tK10407 KLC; kinesin light chain" }, { "name":"102563609 MYO5C; myosin VC\tK10357 MYO5; myosin V" }, { "name":"102563838 MYO5B; myosin VB\tK10357 MYO5; myosin V" }, { "name":"102564065 MYO5A; myosin VA\tK10357 MYO5; myosin V" }, { "name":"102577330 unconventional myosin-Vb\tK10357 MYO5; myosin V" }, { "name":"102565074 TUBA4A; tubulin alpha chain\tK07374 TUBA; tubulin alpha" }, { "name":"102565488 tubulin alpha-3 chain\tK07374 TUBA; tubulin alpha" }, { "name":"102573476 tubulin alpha-8 chain\tK07374 TUBA; tubulin alpha" }, { "name":"102576504 TUBAL3; tubulin alpha-8 chain\tK07374 TUBA; tubulin alpha" }, { "name":"106738009 tubulin alpha-1C chain\tK07374 TUBA; tubulin alpha" }, { "name":"102557656 CPEB2; cytoplasmic polyadenylation element binding protein 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102563713 CPEB1; cytoplasmic polyadenylation element binding protein 1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102573824 CPEB3; cytoplasmic polyadenylation element binding protein 3\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"106737061 CPEB4; cytoplasmic polyadenylation element binding protein 4\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein" }, { "name":"102567754 GEMIN5; gem nuclear organelle associated protein 5\tK13133 GEMIN5; gem associated protein 5" }, { "name":"102565713 TACC3; transforming acidic coiled-coil containing protein 3\tK14283 TACC3; transforming acidic coiled-coil-containing protein 3" }, { "name":"102570380 TNRC6B; trinucleotide repeat containing 6B\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"102573580 TNRC6A; trinucleotide repeat containing 6A\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"102573974 TNRC6C; trinucleotide repeat containing 6C\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein" }, { "name":"102566632 CNOT1; CCR4-NOT transcription complex subunit 1\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1" }, { "name":"102566992 CNOT2; CCR4-NOT transcription complex subunit 2\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2" }, { "name":"102567965 CNOT3; CCR4-NOT transcription complex subunit 3\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3" }, { "name":"102569372 CNOT4; CCR4-NOT transcription complex subunit 4\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]" }, { "name":"102558230 CNOT6; CCR4-NOT transcription complex subunit 6\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"106737139 CNOT6L; CCR4-NOT transcription complex subunit 6 like\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"102563009 CNOT7; CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"102566369 CNOT8; CCR4-NOT transcription complex subunit 8\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"102577409 KIAA0355 ortholog\tK26671 GARRE1; granule associated Rac and RHOG effector protein 1" }, { "name":"102563809 DIS3L2; DIS3 like 3'-5' exoribonuclease 2\tK18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]" }, { "name":"102568939 PAN2; PAN2 poly(A) specific ribonuclease subunit\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]" }, { "name":"102565456 PAN3; PAN3 poly(A) specific ribonuclease subunit\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3" }, { "name":"102558693 protein BTG1\tK14443 TOB; protein Tob\/BTG" }, { "name":"102560710 BTG4; BTG anti-proliferation factor 4\tK14443 TOB; protein Tob\/BTG" }, { "name":"102565886 BTG2; BTG anti-proliferation factor 2\tK14443 TOB; protein Tob\/BTG" }, { "name":"102568514 BTG1; BTG anti-proliferation factor 1\tK14443 TOB; protein Tob\/BTG" }, { "name":"102572296 TOB1; transducer of ERBB2, 1\tK14443 TOB; protein Tob\/BTG" }, { "name":"102576158 TOB2; transducer of ERBB2, 2\tK14443 TOB; protein Tob\/BTG" }, { "name":"106738241 maternal B9.15 protein\tK14443 TOB; protein Tob\/BTG" }, { "name":"102561854 EIF4ENIF1; eukaryotic translation initiation factor 4E nuclear import factor 1\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter" }, { "name":"102567667 PATL1; PAT1 homolog 1, processing body mRNA decay factor\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1" }, { "name":"102567332 EDC3; enhancer of mRNA decapping 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3" }, { "name":"102568287 EDC4; enhancer of mRNA decapping 4\tK12616 EDC4; enhancer of mRNA-decapping protein 4" }, { "name":"109286172 NANOS2; nanos C2HC-type zinc finger 2\tK18760 NANOS2; protein nanos 2" }, { "name":"102558003 UPF2; UPF2 regulator of nonsense transcripts homolog (yeast)\tK14327 UPF2; regulator of nonsense transcripts 2" }, { "name":"102564547 UPF3B; UPF3 regulator of nonsense transcripts homolog B (yeast)\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"102569632 UPF3A; UPF3 regulator of nonsense transcripts homolog A (yeast)\tK14328 UPF3; regulator of nonsense transcripts 3" }, { "name":"102573126 TRIM71; tripartite motif containing 71\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]" }, { "name":"102565459 POLR2G; RNA polymerase II subunit G\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7" }, { "name":"102558195 EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2\tK16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]" }, { "name":"102559920 ZAR1L; zygote arrest 1-like\tK18762 ZAR1; zygote arrest protein 1" }, { "name":"102560606 ZAR1; zygote arrest 1\tK18762 ZAR1; zygote arrest protein 1" }, { "name":"102558236 YTHDF3; YTH N6-methyladenosine RNA binding protein 3\tK20102 YTHDF; YTH domain-containing family protein" }, { "name":"102570222 YTHDF1; YTH N6-methyladenosine RNA binding protein 1\tK20102 YTHDF; YTH domain-containing family protein" }, { "name":"102573556 YTHDF2; YTH N6-methyladenosine RNA binding protein 2\tK20102 YTHDF; YTH domain-containing family protein" } ] }, { "name":"Stress granule specific factors", "children":[ { "name":"102562025 TIAL1; TIA1 cytotoxic granule associated RNA binding protein like 1\tK13201 TIA1; nucleolysin TIA-1\/TIAR" }, { "name":"106736918 TIA1; TIA1 cytotoxic granule associated RNA binding protein\tK13201 TIA1; nucleolysin TIA-1\/TIAR" }, { "name":"102559521 PABPC4; poly(A) binding protein cytoplasmic 4\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"102561462 PABPC1L; poly(A) binding protein cytoplasmic 1 like\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"102570387 PABPC1; poly(A) binding protein cytoplasmic 1\tK13126 PABPC; polyadenylate-binding protein" }, { "name":"102558439 STAU1; staufen double-stranded RNA binding protein 1\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"102575164 STAU2; staufen double-stranded RNA binding protein 2\tK17597 STAU; double-stranded RNA-binding protein Staufen" }, { "name":"102565555 FXR2; fragile X mental retardation syndrome-related protein 2\tK15516 FMR; fragile X mental retardation protein" }, { "name":"102568696 FXR1; FMR1 autosomal homolog 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"106736684 FMR1; fragile X mental retardation 1\tK15516 FMR; fragile X mental retardation protein" }, { "name":"109283579 fragile X mental retardation syndrome-related protein 2-like\tK15516 FMR; fragile X mental retardation protein" }, { "name":"106737676 ZBP1; Z-DNA binding protein 1\tK12965 ZBP1; Z-DNA binding protein 1" }, { "name":"102563037 ELAVL1; ELAV like RNA binding protein 1\tK13088 ELAVL1; ELAV-like protein 1" }, { "name":"102562340 G3BP1; G3BP stress granule assembly factor 1\tK17265 G3BP1; Ras GTPase-activating protein-binding protein 1 [EC:5.6.2.5 5.6.2.3]" }, { "name":"102570278 G3BP2; G3BP stress granule assembly factor 2\tK24983 G3BP2; Ras GTPase-activating protein-binding protein 2" }, { "name":"102562616 EIF2A; eukaryotic translation initiation factor 2A\tK15026 EIF2A; translation initiation factor 2A" }, { "name":"102558660 EIF3B; eukaryotic translation initiation factor 3 subunit B\tK03253 EIF3B; translation initiation factor 3 subunit B" }, { "name":"102559744 EIF4A1; eukaryotic translation initiation factor 4A1\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"106736926 EIF4A2; eukaryotic translation initiation factor 4A2\tK03257 EIF4A; translation initiation factor 4A" }, { "name":"102564262 EIF4A3; eukaryotic translation initiation factor 4A3\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]" }, { "name":"102570839 EIF4B; eukaryotic translation initiation factor 4B\tK03258 EIF4B; translation initiation factor 4B" }, { "name":"102558024 EIF4G2; eukaryotic translation initiation factor 4 gamma 2\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"102575196 EIF4G3; eukaryotic translation initiation factor 4 gamma 3\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"106736899 EIF4G1; eukaryotic translation initiation factor 4 gamma 1\tK03260 EIF4G; translation initiation factor 4G" }, { "name":"102561736 RPS6KA6; ribosomal protein S6 kinase A6\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102563194 RPS6KA1; ribosomal protein S6 kinase A1\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102571036 RPS6KA2; ribosomal protein S6 kinase A2\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102574678 RPS6KA3; ribosomal protein S6 kinase A3\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]" }, { "name":"102574051 RACK1; receptor for activated C kinase 1\tK14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein" }, { "name":"102564363 TRAF2; TNF receptor associated factor 2\tK03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]" }, { "name":"102564521 NXF1; nuclear RNA export factor 1\tK14284 NXF; nuclear RNA export factor" }, { "name":"106737160 nuclear RNA export factor 1-like\tK14284 NXF; nuclear RNA export factor" }, { "name":"102560058 TDRD3; tudor domain containing 3\tK18404 TDRD3; tudor domain-containing protein 3" }, { "name":"102560524 LARP4B; La ribonucleoprotein domain family member 4B\tK18763 LARP4; la-related protein 4" }, { "name":"102570552 LARP4; La ribonucleoprotein domain family member 4\tK18763 LARP4; la-related protein 4" } ] } ] } ] }, { "name":"mRNA degradation factors", "children":[ { "name":"5'-3' decay", "children":[ { "name":"Decapping complex", "children":[ { "name":"102563256 DCP1A; decapping mRNA 1A\tK12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]" }, { "name":"102568669 DCP1B; decapping mRNA 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]" }, { "name":"102567941 DCP2; decapping mRNA 2\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]" }, { "name":"102566221 DDX6; DEAD-box helicase 6\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]" }, { "name":"102567332 EDC3; enhancer of mRNA decapping 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3" }, { "name":"102568287 EDC4; enhancer of mRNA decapping 4\tK12616 EDC4; enhancer of mRNA-decapping protein 4" }, { "name":"102567667 PATL1; PAT1 homolog 1, processing body mRNA decay factor\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1" } ] }, { "name":"Lsm complex", "children":[ { "name":"102573407 LSM1; LSM1 homolog, mRNA degradation associated\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1" }, { "name":"102567974 LSM2; LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2" }, { "name":"102574303 LSM3; LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3" }, { "name":"102558189 LSM4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4" }, { "name":"102565642 LSM5; LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5" }, { "name":"102563750 LSM6; LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6" }, { "name":"102576963 LSM7; LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7" }, { "name":"102569069 LSM8; LSM8 homolog, U6 small nuclear RNA associated\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8" } ] }, { "name":"5' exonucleases", "children":[ { "name":"102558616 XRN1; 5'-3' exoribonuclease 1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]" }, { "name":"102558593 XRN2; 5'-3' exoribonuclease 2\tK12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]" }, { "name":"109283987 U8 snoRNA-decapping enzyme-like\tK16855 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]" } ] }, { "name":"Other 5'-3' decay factors", "children":[ { "name":"102564856 DCPS; decapping enzyme, scavenger\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]" }, { "name":"102566270 HELZ; helicase with zinc finger\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]" } ] } ] }, { "name":"3'-5' decay", "children":[ { "name":"Core exosome factors", "children":[ { "name":"102564265 EXOSC1; exosome component 1\tK07573 CSL4; exosome complex component CSL4" }, { "name":"102564570 EXOSC2; exosome component 2\tK03679 RRP4; exosome complex component RRP4" }, { "name":"109280183 EXOSC3; exosome component 3\tK03681 RRP40; exosome complex component RRP40" }, { "name":"102558508 EXOSC4; exosome component 4\tK11600 RRP41; exosome complex component RRP41" }, { "name":"102566841 EXOSC5; exosome component 5\tK12590 RRP46; exosome complex component RRP46" }, { "name":"102559513 EXOSC7; exosome component 7\tK12589 RRP42; exosome complex component RRP42" }, { "name":"102570790 EXOSC8; exosome component 8\tK12586 RRP43; exosome complex component RRP43" }, { "name":"102566442 EXOSC9; exosome component 9\tK03678 RRP45; exosome complex component RRP45" } ] }, { "name":"Exosome cofactors", "children":[ { "name":"102573458 DIS3; DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease\tK12585 DIS3; exosome complex exonuclease DIS3\/RRP44 [EC:3.1.13.-]" }, { "name":"102559473 DIS3L; DIS3 like exosome 3'-5' exoribonuclease\tK18681 DIS3L; DIS3-like exonuclease 1 [EC:3.1.13.-]" }, { "name":"102559222 EXOSC10; exosome component 10\tK12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]" }, { "name":"102573780 C1D; C1D nuclear receptor corepressor\tK12592 C1D; exosome complex protein LRP1" }, { "name":"102573131 MPHOSPH6; M-phase phosphoprotein 6\tK12593 MPHOSPH6; M-phase phosphoprotein 6, animal type" }, { "name":"102560877 DDX60; DExD\/H-box helicase 60\tK20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]" } ] }, { "name":"TRAMP complex", "children":[ { "name":"102563533 PAPD5; poly(A) RNA polymerase D5, non-canonical\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]" }, { "name":"102564760 PAPD7; poly(A) RNA polymerase D7, non-canonical\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]" }, { "name":"102561649 ZCCHC7; zinc finger CCHC-type containing 7\tK12597 AIR1_2; protein AIR1\/2" }, { "name":"102557938 SKIV2L2; Ski2 like RNA helicase 2\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]" } ] }, { "name":"Ski complex", "children":[ { "name":"102573582 SKIV2L; Ski2 like RNA helicase\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]" }, { "name":"102568677 TTC37; tetratricopeptide repeat domain 37\tK12600 SKI3; superkiller protein 3" }, { "name":"102576673 WDR61; WD repeat domain 61\tK12602 WDR61; WD repeat-containing protein 61" } ] }, { "name":"Ccr4-NOT complex", "children":[ { "name":"102558230 CNOT6; CCR4-NOT transcription complex subunit 6\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"106737139 CNOT6L; CCR4-NOT transcription complex subunit 6 like\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]" }, { "name":"102566632 CNOT1; CCR4-NOT transcription complex subunit 1\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1" }, { "name":"102566992 CNOT2; CCR4-NOT transcription complex subunit 2\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2" }, { "name":"102567965 CNOT3; CCR4-NOT transcription complex subunit 3\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3" }, { "name":"102569372 CNOT4; CCR4-NOT transcription complex subunit 4\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]" }, { "name":"102563009 CNOT7; CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"102566369 CNOT8; CCR4-NOT transcription complex subunit 8\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8" }, { "name":"102573188 CNOT9; CCR4-NOT transcription complex subunit 9\tK12606 RCD1; CCR4-NOT transcription complex subunit 9" }, { "name":"102572885 CNOT10; CCR4-NOT transcription complex subunit 10\tK12607 CNOT10; CCR4-NOT transcription complex subunit 10" } ] }, { "name":"Pan complex", "children":[ { "name":"102568939 PAN2; PAN2 poly(A) specific ribonuclease subunit\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]" }, { "name":"102565456 PAN3; PAN3 poly(A) specific ribonuclease subunit\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3" } ] }, { "name":"Other 3'-5' decay factors", "children":[ { "name":"102562455 PARN; poly(A)-specific ribonuclease\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]" }, { "name":"102564350 PNLDC1; PARN like, ribonuclease domain containing 1\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]" }, { "name":"102573095 DHX36; DEAH-box helicase 36\tK14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]" }, { "name":"102558693 protein BTG1\tK14443 TOB; protein Tob\/BTG" }, { "name":"102560710 BTG4; BTG anti-proliferation factor 4\tK14443 TOB; protein Tob\/BTG" }, { "name":"102565886 BTG2; BTG anti-proliferation factor 2\tK14443 TOB; protein Tob\/BTG" }, { "name":"102568514 BTG1; BTG anti-proliferation factor 1\tK14443 TOB; protein Tob\/BTG" }, { "name":"102572296 TOB1; transducer of ERBB2, 1\tK14443 TOB; protein Tob\/BTG" }, { "name":"102576158 TOB2; transducer of ERBB2, 2\tK14443 TOB; protein Tob\/BTG" }, { "name":"106738241 maternal B9.15 protein\tK14443 TOB; protein Tob\/BTG" }, { "name":"102567362 NOCT; nocturnin\tK18764 NOCT; nocturnin [EC:3.1.3.108]" }, { "name":"102573989 ERI1; exoribonuclease 1\tK18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-]" }, { "name":"102567635 ERI2; ERI1 exoribonuclease family member 2\tK18417 ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-]" }, { "name":"102564856 DCPS; decapping enzyme, scavenger\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]" }, { "name":"102574717 PDE12; phosphodiesterase 12\tK19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]" }, { "name":"102577130 IREB2; iron responsive element binding protein 2\tK22416 IREB2; iron-responsive element-binding protein 2" }, { "name":"102566270 HELZ; helicase with zinc finger\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]" }, { "name":"102563259 HELZ2; helicase with zinc finger 2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]" }, { "name":"102560562 NRDE2; NRDE-2, necessary for RNA interference, domain containing\tK26109 NRDE2; nuclear exosome regulator NRDE2" }, { "name":"102568081 SAMD4B; sterile alpha motif domain containing 4B\tK27396 SMG; protein Smaug" }, { "name":"102570182 SAMD4A; sterile alpha motif domain containing 4A\tK27396 SMG; protein Smaug" }, { "name":"102562562 FOCAD; focadhesin\tK27498 FOCAD; focadhesin" } ] } ] }, { "name":"Other degradation factors", "children":[ { "name":"RNases", "children":[ { "name":"102568630 RNASE1; ribonuclease\tK01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]" }, { "name":"102573106 ribonuclease\tK01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]" }, { "name":"106739133 ribonuclease pancreatic-like\tK01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]" }, { "name":"102560386 ZC3H12A; zinc finger CCCH-type containing 12A\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"102567095 ZC3H12C; zinc finger CCCH-type containing 12C\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"102569537 ZC3H12D; zinc finger CCCH-type containing 12D\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" }, { "name":"102575083 ZC3H12B; zinc finger CCCH-type containing 12B\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]" } ] } ] } ] } ] }, { "name":"Prokaryotic type", "children":[ { "name":"Bacterial mRNA degradation factors", "children":[ { "name":"RNA degradosome components", "children":[ { "name":"Ribonucreases", "children":[ { "name":"102563935 DROSHA; drosha ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]" }, { "name":"102573843 REXO2; RNA exonuclease 2\tK13288 orn; oligoribonuclease [EC:3.1.-.-]" } ] }, { "name":"Helicases" }, { "name":"Other RNA degradosome components", "children":[ { "name":"102569721 ENO2; enolase 2\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"102573637 ENO1; enolase 1\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"102575979 ENO3; beta-enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]" }, { "name":"102562026 PNPT1; polyribonucleotide nucleotidyltransferase 1\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]" }, { "name":"102566462 PFKP; phosphofructokinase, platelet\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" }, { "name":"102571356 PFKL; phosphofructokinase, liver type\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" }, { "name":"102576399 PFKM; phosphofructokinase, muscle\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]" } ] } ] }, { "name":"Other RNA degradation factors", "children":[ { "name":"Chaperones", "children":[ { "name":"102567093 HSPA9; heat shock protein family A (Hsp70) member 9\tK04043 dnaK; molecular chaperone DnaK" }, { "name":"102570408 HSPD1; heat shock protein family D (Hsp60) member 1\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]" } ] }, { "name":"Others" }, { "name":"Bacterial Small RNA Regulators" } ] } ] }, { "name":"Archeal mRNA degradation factors", "children":[ { "name":"Exosome components", "children":[ { "name":"Core exosome", "children":[ { "name":"102564570 EXOSC2; exosome component 2\tK03679 RRP4; exosome complex component RRP4" }, { "name":"102564265 EXOSC1; exosome component 1\tK07573 CSL4; exosome complex component CSL4" } ] }, { "name":"Cofactors", "children":[ { "name":"102558508 EXOSC4; exosome component 4\tK11600 RRP41; exosome complex component RRP41" }, { "name":"102559513 EXOSC7; exosome component 7\tK12589 RRP42; exosome complex component RRP42" } ] }, { "name":"Others" } ] } ] } ] } ] }