{
	"name":"amm01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS",
					"children":[
					{
						"name":"AMES_0615 rifA; rifamycin polyketide synthase\tK15670 rifA; rifamycin polyketide synthase modules 1, 2 and 3 [EC:6.2.1.74]"
					},
					{
						"name":"AMES_0616 rifB; rifamycin polyketide synthase\tK15671 rifB; rifamycin polyketide synthase modules 4, 5 and 6"
					},
					{
						"name":"AMES_0617 rifC; rifamycin polyketide synthase\tK15672 rifC_D; rifamycin polyketide synthase modules 7 and 8"
					},
					{
						"name":"AMES_0618 rifD; rifamycin polyketide synthase\tK15672 rifC_D; rifamycin polyketide synthase modules 7 and 8"
					},
					{
						"name":"AMES_0619 rifE; rifamycin polyketide synthase\tK15673 rifE; rifamycin polyketide synthase modules 9 and 10"
					}
					]
				},
				{
					"name":"Polyene macrolide PKS"
				},
				{
					"name":"Pimaricinolide synthase"
				},
				{
					"name":"Candicidin PKS"
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS",
					"children":[
					{
						"name":"AMES_3329 phenolpthiocerol synthesis type-I polyketide synthase PpsD\tK12443 ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]"
					}
					]
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS"
				},
				{
					"name":"Macrolactin PKS"
				},
				{
					"name":"Difficidin PKS"
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"AMES_6759 type I polyketide synthase\tK15314 sgcE; enediyne polyketide synthase"
				}
				]
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS",
					"children":[
					{
						"name":"AMES_5367 actV; polyketide cyclase\/dehydratase\tK14670 whiEVI; aromatase"
					},
					{
						"name":"AMES_5372 polyketide synthesis cyclase\tK14671 whiEVII; cyclase"
					}
					]
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS",
					"children":[
					{
						"name":"AMES_5370 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"AMES_5369 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"AMES_5368 actI; 3-oxoacyl-ACP synthase acylcarrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"AMES_0395 beta-lactamase class B\tK05555 actIV; cyclase [EC:4.-.-.-]"
					}
					]
				},
				{
					"name":"Nonaketide PKS",
					"children":[
					{
						"name":"AMES_5370 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"AMES_5369 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"AMES_5368 actI; 3-oxoacyl-ACP synthase acylcarrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					}
					]
				},
				{
					"name":"Decaketide PKS",
					"children":[
					{
						"name":"AMES_5370 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II\tK05551 actI1; minimal PKS ketosynthase (KS\/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"AMES_5369 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II\tK05552 actI2; minimal PKS chain-length factor (CLF\/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]"
					},
					{
						"name":"AMES_5368 actI; 3-oxoacyl-ACP synthase acylcarrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type"
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase"
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase"
			},
			{
				"name":"Iturin family lipopeptide synthetase"
			},
			{
				"name":"Fengycin family lipopeptide synthetase"
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase"
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"AMES_3069 mbtH; MbtH protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"AMES_3988 mbtH; MbtH protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"AMES_4709 mbtH; MbtH protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"AMES_4734 mbtH; MbtH protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"AMES_4971 mbtH; MbtH protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"AMES_6146 mbtH; MbtH protein\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase"
			},
			{
				"name":"Bacillibactin synthetase"
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase"
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase"
			},
			{
				"name":"Myxochelin synthetase"
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase"
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase",
			"children":[
			{
				"name":"AMES_6758 hypothetical protein\tK15315 sgcE10; enediyne core biosynthesis thioesterase"
			}
			]
		},
		{
			"name":"Ketoreductase",
			"children":[
			{
				"name":"AMES_6278 hydroxylacyl-CoA dehydrogenase\tK05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]"
			}
			]
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"AMES_0644 mhpA; 3-(3-hydroxy-phenyl)propionate hydroxylase\tK16022 rif19; flavoprotein hydroxylase"
			},
			{
				"name":"AMES_7228 cytochrome P450\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"AMES_3144 microsomal epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"AMES_3889 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"AMES_4260 epocide hydrolase domain-containing protein\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"AMES_4283 microsomal epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"AMES_5479 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"AMES_6122 microsomal epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"AMES_6747 microsomal epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"AMES_5371 cupin 2 domain-containing protein\tK14673 whiEII; putative monooxygenase"
			},
			{
				"name":"AMES_5376 FAD-dependent oxidoreductase\tK14672 whiEVIII; putative polyketide hydroxylase"
			},
			{
				"name":"AMES_5377 FAD-dependent oxidoreductase\tK14672 whiEVIII; putative polyketide hydroxylase"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"AMES_0648 methyltransferase type 11\tK15467 rif14; 27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315]"
			},
			{
				"name":"AMES_3195 O-methyltransferase-related protein\tK20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]"
			}
			]
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Halogenase"
		},
		{
			"name":"beta-Branched incorporating proteins"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"AMES_4698 acyl-CoA dehydrogenase\tK16026 asm15; 2-hydroxy-3-oxopropanoyl-[acyl-carrier-protein] 3-hydroxylase [EC:1.2.99.11]"
			},
			{
				"name":"AMES_4697 FkbH-like protein\tK16027 asm16; methoxymalonate biosynthesis protein"
			},
			{
				"name":"AMES_0620 rifF; N-acetyltransferase\/amide synthase\tK15466 rifF; amide synthase"
			},
			{
				"name":"AMES_0645 acyltransferase\tK16023 rif20; acetyltransferase"
			},
			{
				"name":"AMES_6565 cyclase-dehydratase\tK14627 actVI3; dehydratase [EC:4.2.1.-]"
			},
			{
				"name":"AMES_6768 hypothetical protein\tK21160 sgcE2; enediyne biosynthesis protein E2"
			},
			{
				"name":"AMES_6767 enediyne biosynthesis protein\tK21161 sgcE3; enediyne biosynthesis protein E3"
			},
			{
				"name":"AMES_6766 ASPIC\/UnbV domain-containing protein\tK21162 sgcE4; enediyne biosynthesis protein E4"
			},
			{
				"name":"AMES_6765 hypothetical protein\tK21163 sgcE5; enediyne biosynthesis protein E5"
			},
			{
				"name":"AMES_6764 cytochrome P450\tK21164 sgcE7; enediyne biosynthesis protein E7"
			},
			{
				"name":"AMES_6763 hypothetical protein\tK21165 sgcE8; enediyne biosynthesis protein E8"
			},
			{
				"name":"AMES_6762 oxidoreductase\tK21166 sgcE9; enediyne biosynthesis protein E9"
			},
			{
				"name":"AMES_6760 wyosine base formation\tK21167 sgcE11; enediyne biosynthesis protein E11"
			},
			{
				"name":"AMES_6757 oxidoreductase\tK21185 sgcE6; flavin reductase"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase"
		},
		{
			"name":"Thioesterase"
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"AMES_3910 glycosyl transferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			},
			{
				"name":"AMES_5434 glycosyl transferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			}
			]
		},
		{
			"name":"Aminotransferase"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"AMES_0890 (S)-2-hydroxy-acid oxidase\tK16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]"
			},
			{
				"name":"AMES_4740 aspartate racemase\tK01779 racD; aspartate racemase [EC:5.1.1.13]"
			}
			]
		}
		]
	}
	]
}