{
	"name":"amyy01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS"
				},
				{
					"name":"Polyene macrolide PKS"
				},
				{
					"name":"Pimaricinolide synthase"
				},
				{
					"name":"Candicidin PKS"
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS",
					"children":[
					{
						"name":"YIM_33630 ppsA4; Phthiocerol\/phenolphthiocerol synthesis polyketide synthase type I PpsA\tK12443 ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]"
					},
					{
						"name":"YIM_42700 ppsA7; Phthiocerol\/phenolphthiocerol synthesis polyketide synthase type I PpsA\tK12443 ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]"
					}
					]
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS"
				},
				{
					"name":"Macrolactin PKS"
				},
				{
					"name":"Difficidin PKS"
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"YIM_40785 ppsA6; Phthiocerol\/phenolphthiocerol synthesis polyketide synthase type I PpsA\tK15314 sgcE; enediyne polyketide synthase"
				}
				]
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS"
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS",
					"children":[
					{
						"name":"YIM_23710 Actinorhodin polyketide synthase acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					},
					{
						"name":"YIM_19405 Metallo-beta-lactamase superfamily protein\tK05555 actIV; cyclase [EC:4.-.-.-]"
					}
					]
				},
				{
					"name":"Nonaketide PKS",
					"children":[
					{
						"name":"YIM_23710 Actinorhodin polyketide synthase acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					}
					]
				},
				{
					"name":"Decaketide PKS",
					"children":[
					{
						"name":"YIM_23710 Actinorhodin polyketide synthase acyl carrier protein\tK05553 actI3; minimal PKS acyl carrier protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"YIM_22225 Alpha-pyrone synthesis polyketide synthase-like Pks11\tK16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246]"
				}
				]
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase",
				"children":[
				{
					"name":"YIM_39185 srfAA; Surfactin synthase subunit 1\tK12743 PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase [EC:6.3.2.26]"
				}
				]
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase"
			},
			{
				"name":"Iturin family lipopeptide synthetase"
			},
			{
				"name":"Fengycin family lipopeptide synthetase"
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase"
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"YIM_17240 MbtH-like protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"YIM_18515 MbtH-like protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"YIM_18520 MbtH-like protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"YIM_22885 MbtH-like protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"YIM_25315 MbtH-like protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"YIM_25775 MbtH-like protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"YIM_32320 MbtH-like protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"YIM_40210 MbtH-like protein\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"YIM_26035 dhbB2; Isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase",
				"children":[
				{
					"name":"YIM_26035 dhbB2; Isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase"
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase",
				"children":[
				{
					"name":"YIM_26035 dhbB2; Isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Myxochelin synthetase",
				"children":[
				{
					"name":"YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"YIM_26035 dhbB2; Isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				}
				]
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase",
				"children":[
				{
					"name":"YIM_26035 dhbB2; Isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"YIM_26040 dhbE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase",
			"children":[
			{
				"name":"YIM_40780 1,4-dihydroxy-2-naphthoyl-CoA hydrolase\tK15315 sgcE10; enediyne core biosynthesis thioesterase"
			}
			]
		},
		{
			"name":"Ketoreductase",
			"children":[
			{
				"name":"YIM_22710 lcdH1; L-carnitine dehydrogenase\tK05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]"
			}
			]
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"YIM_39550 Cytochrome P450-SU1\tK16389 amphN; cytochrome P450 monooxygenase"
			},
			{
				"name":"YIM_39555 penM; Pentalenolactone synthase\tK16390 amphL; cytochrome P450 monooxygenase"
			},
			{
				"name":"YIM_37285 Cytochrome P450 107B1\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"YIM_40790 Cytochrome P450 107B1\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"YIM_40820 nphA2; 4-nitrophenol 2-monooxygenase, oxygenase component\tK21184 sgcC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]"
			},
			{
				"name":"YIM_04210 dhmA2; Haloalkane dehalogenase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_18405 Fluoroacetate dehalogenase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_24530 haloalkane dehalogenase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_25920 hypothetical protein\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_26600 hypothetical protein\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_29860 Soluble epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_33920 Soluble epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_42885 Fluoroacetate dehalogenase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"YIM_22215 caiD5; Carnitinyl-CoA dehydratase\tK16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"YIM_09465 dnrK1; Carminomycin 4-O-methyltransferase\tK20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]"
			},
			{
				"name":"YIM_15125 dnrK2; Carminomycin 4-O-methyltransferase\tK20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"YIM_39540 rebG5; 4'-demethylrebeccamycin synthase\tK16388 amphDI; polyene glycosyltransferase"
			}
			]
		},
		{
			"name":"Halogenase",
			"children":[
			{
				"name":"YIM_16050 lodB; Putative FAD-dependent oxidoreductase LodB\tK16431 cepH; FAD-dependent halogenase [EC:1.14.19.-]"
			}
			]
		},
		{
			"name":"beta-Branched incorporating proteins"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"YIM_38365 hypothetical protein\tK14627 actVI3; dehydratase [EC:4.2.1.-]"
			},
			{
				"name":"YIM_41025 hypothetical protein\tK21160 sgcE2; enediyne biosynthesis protein E2"
			},
			{
				"name":"YIM_41020 hypothetical protein\tK21161 sgcE3; enediyne biosynthesis protein E3"
			},
			{
				"name":"YIM_41015 ASPIC and UnbV\tK21162 sgcE4; enediyne biosynthesis protein E4"
			},
			{
				"name":"YIM_41010 hypothetical protein\tK21163 sgcE5; enediyne biosynthesis protein E5"
			},
			{
				"name":"YIM_41005 Epi-isozizaene 5-monooxygenase\/(E)-beta-farnesene synthase\tK21164 sgcE7; enediyne biosynthesis protein E7"
			},
			{
				"name":"YIM_41000 hypothetical protein\tK21165 sgcE8; enediyne biosynthesis protein E8"
			},
			{
				"name":"YIM_40995 choA2; Cholesterol oxidase precursor\tK21166 sgcE9; enediyne biosynthesis protein E9"
			},
			{
				"name":"YIM_40975 hypothetical protein\tK21167 sgcE11; enediyne biosynthesis protein E11"
			},
			{
				"name":"YIM_40805 lgrB10; Linear gramicidin synthase subunit B\tK21186 sgcC5; condensation enzyme"
			},
			{
				"name":"YIM_40775 hsaB2; Flavin-dependent monooxygenase, reductase subunit HsaB\tK21185 sgcE6; flavin reductase"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase"
		},
		{
			"name":"Thioesterase"
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"YIM_26400 novM3; L-noviosyl transferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			}
			]
		},
		{
			"name":"Aminotransferase"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"YIM_39180 cefE1; Deacetoxycephalosporin C synthase\tK04126 PCBC; isopenicillin-N synthase [EC:1.21.3.1]"
			},
			{
				"name":"YIM_39195 cefD; Isopenicillin N epimerase\tK04127 cefD; isopenicillin-N epimerase [EC:5.1.1.17]"
			},
			{
				"name":"YIM_39200 cefE2; Deacetoxycephalosporin C synthase\tK12744 cefE; deacetoxycephalosporin-C synthase [EC:1.14.20.1]"
			},
			{
				"name":"YIM_39165 cefF; Deacetoxycephalosporin C hydroxylase\tK12745 cefF; deacetoxycephalosporin-C hydroxylase [EC:1.14.11.26]"
			},
			{
				"name":"YIM_39160 novN2; Decarbamoylnovobiocin carbamoyltransferase\tK04128 cmcH; hydroxymethyl cephem carbamoyltransferase [EC:2.1.3.7]"
			},
			{
				"name":"YIM_39175 Rhamnosyl O-methyltransferase precursor\tK18062 cmcI; cephamycin C biosynthesis protein"
			},
			{
				"name":"YIM_39170 hypothetical protein\tK18063 cmcJ; cephamycin C biosynthesis protein"
			},
			{
				"name":"YIM_21185 Lactate 2-monooxygenase\tK16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]"
			},
			{
				"name":"YIM_22220 enoyl-CoA hydratase\tK16425 dpgB; isomerase DpgB"
			},
			{
				"name":"YIM_22215 caiD5; Carnitinyl-CoA dehydratase\tK16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]"
			},
			{
				"name":"YIM_22195 caiD4; Carnitinyl-CoA dehydratase\tK16426 dpgD; dehydration protein DpgD"
			},
			{
				"name":"YIM_25325 Aspartate racemase\tK01779 racD; aspartate racemase [EC:5.1.1.13]"
			},
			{
				"name":"YIM_40855 Aspartate racemase\tK01779 racD; aspartate racemase [EC:5.1.1.13]"
			}
			]
		}
		]
	}
	]
}