{
	"name":"and03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors"
				},
				{
					"name":"Cap binding complex"
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)"
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)"
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex"
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex"
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors"
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex"
				},
				{
					"name":"N6-methyltransferase complex"
				},
				{
					"name":"Poly(A) addition factors"
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors"
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex"
				},
				{
					"name":"TREX complex"
				},
				{
					"name":"TREX-2 complex"
				},
				{
					"name":"Nuclear pore complex"
				},
				{
					"name":"Ran-mediated transport factors"
				},
				{
					"name":"eIF4F and regulatory proteins"
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors"
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex"
				},
				{
					"name":"Protein phosphatase 2A"
				},
				{
					"name":"Other surveillance factors"
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex"
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins"
				},
				{
					"name":"Other mRNA localization factors"
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule"
				},
				{
					"name":"P-body specific factors"
				},
				{
					"name":"Stress granule specific factors"
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex"
				},
				{
					"name":"Lsm complex"
				},
				{
					"name":"5' exonucleases"
				},
				{
					"name":"Other 5'-3' decay factors"
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors"
				},
				{
					"name":"Exosome cofactors"
				},
				{
					"name":"TRAMP complex"
				},
				{
					"name":"Ski complex"
				},
				{
					"name":"Ccr4-NOT complex"
				},
				{
					"name":"Pan complex"
				},
				{
					"name":"Other 3'-5' decay factors"
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"GRQ40_06530 ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"GRQ40_06970 RNase J family beta-CASP ribonuclease\tK12574 rnj; ribonuclease J [EC:3.1.-.-]"
					},
					{
						"name":"GRQ40_07065 rny; ribonuclease Y\tK18682 rny; ribonucrease Y [EC:3.1.-.-]"
					},
					{
						"name":"GRQ40_16140 rnr; ribonuclease R\tK12573 rnr; ribonuclease R [EC:3.1.13.1]"
					},
					{
						"name":"GRQ40_03685 yhaM; 3'-5' exoribonuclease YhaM\tK03698 cbf; 3'-5' exoribonuclease [EC:3.1.-.-]"
					},
					{
						"name":"GRQ40_08685 oligoribonuclease\tK28891 nrnB; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"GRQ40_01625 DEAD\/DEAH box helicase\tK05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]"
					},
					{
						"name":"GRQ40_13150 DEAD\/DEAH box helicase\tK18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7]"
					},
					{
						"name":"GRQ40_12020 RecQ family ATP-dependent DNA helicase\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"GRQ40_16155 phosphopyruvate hydratase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"GRQ40_06925 pnp; polyribonucleotide nucleotidyltransferase\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"GRQ40_17715 rho; transcription termination factor Rho\tK03628 rho; transcription termination factor Rho"
					},
					{
						"name":"GRQ40_14535 pfkA; 6-phosphofructokinase\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"GRQ40_13300 dnaK; molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"GRQ40_01820 groL; chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					},
					{
						"name":"GRQ40_07250 hfq; RNA chaperone Hfq\tK03666 hfq; host factor-I protein"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"GRQ40_05795 RNA degradosome polyphosphate kinase\tK00937 ppk1; polyphosphate kinase [EC:2.7.4.1]"
					},
					{
						"name":"GRQ40_16675 csrA; carbon storage regulator CsrA\tK03563 csrA; carbon storage regulator"
					},
					{
						"name":"GRQ40_08215 rraA; ribonuclease E activity regulator RraA\tK02553 rraA; regulator of ribonuclease activity A"
					},
					{
						"name":"GRQ40_16225 rapZ; RNase adapter RapZ\tK06958 rapZ; RNase adapter protein RapZ"
					}
					]
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome"
				},
				{
					"name":"Cofactors"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}