{
	"name":"ape03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)"
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex"
			},
			{
				"name":"Other initiation factors"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex"
			},
			{
				"name":"DNA polymerase epsilon complex"
			},
			{
				"name":"DNA polymerase delta complex"
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)"
			},
			{
				"name":"RFC (replication factor C)"
			},
			{
				"name":"RNase H"
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"APE_0162 DNA polymerase sliding clamp A\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"APE_0441.1 DNA polymerase sliding clamp B2\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"APE_2182 DNA polymerase sliding clamp B1\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"APE_0115.1 fen; flap structure-specific endonuclease\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"APE_1094.1 ADP-dependent DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"APE_0872.1 DNA (cytosine-5-)-methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"APE_2002 cytosine-specific DNA methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"APE_0433a small nucleolar RNP protein Nop10p\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex"
				}
				]
			},
			{
				"name":"ELG1-RFC complex"
			},
			{
				"name":"MRN complex"
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"APE_1436.1 repair endonuclease XPF\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"APE_2096.1 exosome complex RNA helicase DnaG homologue\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)",
				"children":[
				{
					"name":"APE_0152.1 origin recognition complex subunit 2 Orc2\tK10725 cdc6A; archaeal cell division control protein 6"
				},
				{
					"name":"APE_0475.1 origin recognition complex subunit 1 Orc1\tK10725 cdc6A; archaeal cell division control protein 6"
				},
				{
					"name":"APE_0188.1 minichromosome maintenance protein\tK10726 mcm; replicative DNA helicase Mcm [EC:5.6.2.3]"
				},
				{
					"name":"APE_0438.1 priA; DNA primase small subunit\tK02683 priS; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"APE_0667 priB; putative DNA primase large subunit\tK18882 priL; DNA primase large subunit"
				},
				{
					"name":"APE_0187 hypothetical protein\tK09723 ginS; DNA replication factor GINS"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"APE_0496.1 rnhB; ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases",
					"children":[
					{
						"name":"APE_0099 family B DNA polymerase I\tK02319 pol; DNA polymerase, archaea type [EC:2.7.7.7]"
					},
					{
						"name":"APE_2098.1 family B DNA polymerase II\tK02319 pol; DNA polymerase, archaea type [EC:2.7.7.7]"
					},
					{
						"name":"APE_2229.1 DNA polymerase II\tK02319 pol; DNA polymerase, archaea type [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"APE_0496.1 rnhB; ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"APE_1524.1 rfcL; replication factor C large subunit\tK04800 rfcL; replication factor C large subunit"
					},
					{
						"name":"APE_1522.1 rfcS; replication factor C small subunit\tK04801 rfcS; replication factor C small subunit"
					}
					]
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"APE_0115.1 fen; flap structure-specific endonuclease\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"APE_1094.1 ADP-dependent DNA ligase\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"APE_0703.1 top6A; type II DNA topoisomerase VI subunit A\tK03166 top6A; DNA topoisomerase VI subunit A [EC:5.6.2.2]"
			},
			{
				"name":"APE_0706.1 top6B; type II DNA topoisomerase VI subunit B\tK03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]"
			},
			{
				"name":"APE_1794 topA; DNA topoisomerase I\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
			},
			{
				"name":"APE_1340.1 rgy; reverse gyrase\tK03170 topG; reverse gyrase [EC:5.6.2.2 5.6.2.-]"
			},
			{
				"name":"APE_1376.1 rgy; reverse gyrase\tK03170 topG; reverse gyrase [EC:5.6.2.2 5.6.2.-]"
			}
			]
		}
		]
	}
	]
}