{
	"name":"apz03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)"
			},
			{
				"name":"CDK (cyclin dependent kinase)"
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)"
			},
			{
				"name":"GINS complex"
			},
			{
				"name":"Other initiation factors"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex"
			},
			{
				"name":"DNA polymerase epsilon complex"
			},
			{
				"name":"DNA polymerase delta complex"
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)"
			},
			{
				"name":"RPA (replication protein A)"
			},
			{
				"name":"RFC (replication factor C)"
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"APA32_19750 ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				}
				]
			},
			{
				"name":"Other elongation factors"
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex"
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"Dyskerin complex"
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"Sm core complex"
				}
				]
			},
			{
				"name":"ELG1-RFC complex"
			},
			{
				"name":"MRN complex"
			},
			{
				"name":"Other termination factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"APA32_16460 hu; histone-like bacterial DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"APA32_26450 hu; histone-like bacterial DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"APA32_40350 hu; histone-like bacterial DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"APA32_41420 hu; histone-like bacterial DNA-binding protein HU\tK03530 hupB; DNA-binding protein HU-beta"
				},
				{
					"name":"APA32_16990 integration host factor DNA-binding alpha subunit\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"APA32_16930 integration host factor DNA-binding beta subunit\tK05788 ihfB; integration host factor subunit beta"
				},
				{
					"name":"APA32_12320 dnaA; chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"APA32_06910 dnaB; DNA helicase DnaB\tK02314 dnaB; replicative DNA helicase [EC:5.6.2.3]"
				},
				{
					"name":"APA32_09900 DNA primase\tK02316 dnaG; DNA primase [EC:2.7.7.101]"
				},
				{
					"name":"APA32_40640 repC; replication protein C\tK18996 repC; replication initiation protein RepC"
				},
				{
					"name":"APA32_25720 ssb; single-strand DNA binding protein Ssb\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"APA32_19490 DNA polymerase III alpha subunit\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"APA32_12310 DNA polymerase III beta subunit\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"APA32_07220 holC; DNA polymerase III chi subunit HolC\tK02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]"
					},
					{
						"name":"APA32_25500 DNA polymerase III delta subunit\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"APA32_11460 dnaC; DNA polymerase III delta prime subunit DnaC\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"APA32_08710 DNA polymerase III exonuclease epsilon subunit\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"APA32_20310 DNA polymerase III exonuclease epsilon subunit like protein\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"APA32_00520 DNA polymerase III gamma\/tau subunit\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"APA32_19750 ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"APA32_09680 ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"APA32_21430 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"APA32_19090 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"APA32_19750 ribonuclease H\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"APA32_09680 ribonuclease HII\tK03470 rnhB; ribonuclease HII [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"APA32_24320 DNA gyrase subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
			},
			{
				"name":"APA32_12290 DNA gyrase subunit B Hsp90-like ATPase\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
			},
			{
				"name":"APA32_19400 DNA topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
			},
			{
				"name":"APA32_07440 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
			},
			{
				"name":"APA32_07530 DNA topoisomerase I\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
			}
			]
		}
		]
	}
	]
}