{
	"name":"arab03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"EKO05_0004162 Methylated-DNA--[protein]-cysteine S-methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"EKO05_0002622 Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				},
				{
					"name":"EKO05_0004572 Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"EKO05_0009513 Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"EKO05_0003814 Thymine-DNA glycosylase\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"EKO05_0000870 uncharacterized protein\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"EKO05_0002034 DNA-(apurinic or apyrimidinic site) lyase\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"EKO05_0000847 DNA-(apurinic or apyrimidinic site) lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"EKO05_0007632 DNA-(apurinic or apyrimidinic site) lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"EKO05_0000361 DNA-(apurinic or apyrimidinic site) lyase\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"EKO05_0004458 DNA-(apurinic or apyrimidinic site) lyase\tK10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"EKO05_0007659 DNA-directed DNA polymerase\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"EKO05_0008031 DNA polymerase delta small subunit Cdc1\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"EKO05_0009277 uncharacterized protein\tK03505 POLD4; DNA polymerase delta subunit 4"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"EKO05_0009539 DNA-directed DNA polymerase\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"EKO05_0000523 DNA-directed DNA polymerase\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"EKO05_0001863 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"EKO05_0000132 Elongation of fatty acids protein 2\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"EKO05_0001761 uncharacterized protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"EKO05_0011124 uncharacterized protein\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"EKO05_0005527 uncharacterized protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"EKO05_0007112 NAD(+) ADP-ribosyltransferase\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"EKO05_0005603 uncharacterized protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"EKO05_0010891 uncharacterized protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"EKO05_0008632 UV excision repair protein rad23\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"EKO05_0003090 Cullin-RING-type E3 NEDD8 transferase\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"EKO05_0005276 uncharacterized protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"EKO05_0009133 uncharacterized protein\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"NER4 complex",
						"children":[
						{
							"name":"EKO05_0006454 UV-damaged DNA-binding protein rad7\tK15082 RAD7; DNA repair protein RAD7"
						},
						{
							"name":"EKO05_0002825 DNA repair protein rad16\tK15083 RAD16; DNA repair protein RAD16"
						}
						]
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"EKO05_0003707 DNA-directed RNA polymerase II subunit RPB1\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"EKO05_0003642 DNA-directed RNA polymerase II subunit RPB2\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"EKO05_0006219 RNA polymerase II subunit 3\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"EKO05_0001900 RNA polymerase B\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"EKO05_0000313 DNA-directed RNA polymerases II 24 kDa polypeptide (RNA polymerase II subunit 5)\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"EKO05_0004189 subunit common to RNA polymerases I, II, and III\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"EKO05_0002350 DNA-directed RNA polymerase II subunit\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"EKO05_0009037 DNA-directed RNA polymerases I, II, and III subunit RPABC3\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"EKO05_0011223 uncharacterized protein\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"EKO05_0004873 DNA-directed RNA Polymerase II subunit L, variant 2\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"EKO05_0003090 Cullin-RING-type E3 NEDD8 transferase\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"EKO05_0005276 uncharacterized protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"EKO05_0009133 uncharacterized protein\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"EKO05_0008445 uncharacterized protein\tK10570 ERCC8; DNA excision repair protein ERCC-8"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"EKO05_0004854 DNA repair protein rhp26\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"EKO05_0003123 uncharacterized protein\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"EKO05_0009932 DNA helicase\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0001015 DNA helicase\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"EKO05_0005968 RNA polymerase II transcription factor B subunit 1\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"EKO05_0008762 uncharacterized protein\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"EKO05_0001731 RNA polymerase II transcription factor B subunit 4\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"EKO05_0004817 RNA polymerase II transcription factor B 52 kDa subunit\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"EKO05_0005685 uncharacterized protein\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"EKO05_0008207 [Pyruvate dehydrogenase (acetyl-transferring)] kinase\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"EKO05_0002984 uncharacterized protein\tK06634 CCNH; cyclin H"
					},
					{
						"name":"EKO05_0010845 TFIIH\/NER complex subunit\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"EKO05_0000568 Replication factor A protein 1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"EKO05_0001517 Replication factor A protein 2\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"EKO05_0007608 uncharacterized protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"EKO05_0003055 DNA repair protein rad14\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"EKO05_0001698 ssDNA endonuclease and repair protein rad10\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"EKO05_0006645 DNA repair protein RAD16\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"EKO05_0004123 DNA repair protein rad2\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"EKO05_0001761 uncharacterized protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"EKO05_0001909 uncharacterized protein\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"EKO05_0007311 Cytosolic iron-sulfur protein assembly protein\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"EKO05_0001843 uncharacterized protein\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"EKO05_0000245 uncharacterized protein\tK03869 CUL3; cullin 3"
					},
					{
						"name":"EKO05_0001653 elongin C\tK03872 ELOC; elongin-C"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"EKO05_0001193 MSH2 protein\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"EKO05_0008140 Mismatch repair protein msh3\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"EKO05_0004243 DNA mismatch repair protein msh6\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"EKO05_0009207 DNA mismatch repair protein Mlh1\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"EKO05_0000969 ATP-binding mismatch repair protein\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"EKO05_0007525 DNA mismatch repair protein\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"EKO05_0007659 DNA-directed DNA polymerase\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"EKO05_0008031 DNA polymerase delta small subunit Cdc1\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"EKO05_0009277 uncharacterized protein\tK03505 POLD4; DNA polymerase delta subunit 4"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"EKO05_0000568 Replication factor A protein 1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"EKO05_0001517 Replication factor A protein 2\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"EKO05_0007608 uncharacterized protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"EKO05_0006182 DNA replication factor C complex subunit Rfc1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"EKO05_0001940 Subunit of heteropentameric Replication factor C (RF-C)\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"EKO05_0008604 replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"EKO05_0002854 Subunit of heteropentameric Replication factor C (RF-C)\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"EKO05_0006307 Replication factor C (RF-C) subunit\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"EKO05_0001863 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"EKO05_0009826 Rad2 nuclease\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"EKO05_0001761 uncharacterized protein\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"EKO05_0000621 uncharacterized protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"EKO05_0001401 meiotic recombination\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"EKO05_0003639 DNA repair protein rad50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"EKO05_0001401 meiotic recombination\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"EKO05_0003639 DNA repair protein rad50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"EKO05_0001365 RecA recombinase Rhp51\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"EKO05_0001365 RecA recombinase Rhp51\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"EKO05_0008769 DNA repair protein rhp57\tK10958 RAD57; DNA repair protein RAD57"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"EKO05_0007374 DNA repair protein rad52\tK10873 RAD52; DNA repair and recombination protein RAD52"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"EKO05_0000487 DNA-dependent ATPase protein rad54\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"EKO05_0006855 helicase\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"EKO05_0004590 uncharacterized protein\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0005191 uncharacterized protein\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0005195 uncharacterized protein\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0008463 uncharacterized protein\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0008902 uncharacterized protein\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0009852 DNA helicase\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"EKO05_0009852 DNA helicase\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0003229 DNA topoisomerase\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"EKO05_0009625 uncharacterized protein\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"EKO05_0000568 Replication factor A protein 1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"EKO05_0001517 Replication factor A protein 2\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"EKO05_0007608 uncharacterized protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"EKO05_0011236 Platinum sensitivity protein\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"EKO05_0006270 Structural maintenance of chromosomes protein 5\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"EKO05_0009620 RNA helicase\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"EKO05_0004632 uncharacterized protein\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"EKO05_0010590 uncharacterized protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"EKO05_0011505 uncharacterized protein\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"EKO05_0001716 26S proteasome complex subunit\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"EKO05_0003758 uncharacterized protein\tK10992 SFR1; Swi5-dependent recombination DNA repair protein 1"
					},
					{
						"name":"EKO05_0010045 Slx4p interacting protein\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"EKO05_0005822 uncharacterized protein\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"EKO05_0006194 Esa1p-associated factor\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"EKO05_0009431 uncharacterized protein\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"EKO05_0002041 uncharacterized protein\tK22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]"
					},
					{
						"name":"EKO05_0002127 DNA helicase\tK14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"EKO05_0011440 ATP-dependent DNA helicase II subunit 1\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"EKO05_0003357 ATP-dependent DNA helicase yku80\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"EKO05_0001401 meiotic recombination\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"EKO05_0003639 DNA repair protein rad50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"EKO05_0007846 DNA ligase (ATP)\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					},
					{
						"name":"EKO05_0010155 DNA ligase (ATP)\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"EKO05_0001709 DNA-directed DNA polymerase\tK10981 POL4; DNA polymerase IV [EC:2.7.7.7]"
					},
					{
						"name":"EKO05_0011353 DNA-directed DNA polymerase\tK10981 POL4; DNA polymerase IV [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"EKO05_0005527 uncharacterized protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"EKO05_0003734 uncharacterized protein\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"EKO05_0006241 MHF histone-fold complex component\tK11511 APITD1; centromere protein S"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"EKO05_0009852 DNA helicase\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"EKO05_0003229 DNA topoisomerase\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"EKO05_0009625 uncharacterized protein\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"EKO05_0001928 Phosphodiesterase I\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"EKO05_0001365 RecA recombinase Rhp51\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"EKO05_0002063 telomere binding protein\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"EKO05_0001542 uncharacterized protein\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"EKO05_0001540 uncharacterized protein\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"EKO05_0002977 uncharacterized protein\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"EKO05_0000621 uncharacterized protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"EKO05_0001198 DNA-directed DNA polymerase\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"EKO05_0006188 DNA-directed DNA polymerase\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"EKO05_0004144 DNA-directed DNA polymerase\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				},
				{
					"name":"EKO05_0001019 deoxycytidyl transferase\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"EKO05_0004404 DNA-directed DNA polymerase\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"EKO05_0005762 E2 ubiquitin-conjugating enzyme\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"EKO05_0009314 RING-type E3 ubiquitin transferase\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"EKO05_0005297 DNA helicase rad5\tK15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]"
				},
				{
					"name":"EKO05_0008210 RING-type E3 ubiquitin transferase\tK15711 SMARCA3; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]"
				},
				{
					"name":"EKO05_0001594 E2 ubiquitin-conjugating protein mms2\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"EKO05_0006498 E2 ubiquitin-conjugating enzyme\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"EKO05_0001863 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"EKO05_0009544 uncharacterized protein\tK26957 GCNA; germ cell nuclear acidic protein"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"EKO05_0005134 Exodeoxyribonuclease III\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"EKO05_0008753 Checkpoint protein hus1\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"EKO05_0003811 Exodeoxyribonuclease III\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"EKO05_0002093 RFC checkpoint protein Rad17\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"EKO05_0001940 Subunit of heteropentameric Replication factor C (RF-C)\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"EKO05_0008604 replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"EKO05_0002854 Subunit of heteropentameric Replication factor C (RF-C)\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"EKO05_0006307 Replication factor C (RF-C) subunit\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"EKO05_0003811 Exodeoxyribonuclease III\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"EKO05_0004823 Topoisomerase 1-associated factor 1\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"EKO05_0004810 chromosome segregation in meiosis-protein\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"EKO05_0005624 uncharacterized protein\tK11272 MRC1; mediator of replication checkpoint protein 1"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"EKO05_0002063 telomere binding protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"EKO05_0011520 uncharacterized protein\tK20403 TTI1; TELO2-interacting protein 1"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"EKO05_0002949 uncharacterized protein\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"EKO05_0003173 uncharacterized protein\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"EKO05_0004835 Non-specific serine\/threonine protein kinase\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"EKO05_0005209 Non-specific serine\/threonine protein kinase\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"EKO05_0007208 Non-specific serine\/threonine protein kinase\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"EKO05_0008103 Non-specific serine\/threonine protein kinase\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"EKO05_0000571 Protein-tyrosine-phosphatase\tK02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]"
				},
				{
					"name":"EKO05_0003576 14-3-3 protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"EKO05_0008348 uncharacterized protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"EKO05_0000498 Non-specific serine\/threonine protein kinase\tK03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]"
				},
				{
					"name":"EKO05_0003452 transcription factor, variant 2\tK24664 FKH; forkhead protein FKH"
				},
				{
					"name":"EKO05_0009670 Vacuolar protein sorting-associated protein 4\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"EKO05_0006368 uncharacterized protein\tK25059 SDE2; replication stress response regulator SDE2"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"EKO05_0000572 DNA-directed DNA polymerase\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"EKO05_0001875 DNA cross-link repair protein PSO2\/SNM1\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"EKO05_0000477 uncharacterized protein\tK17815 EXO5; exonuclease V [EC:3.1.-.-]"
				},
				{
					"name":"EKO05_0002743 uncharacterized protein\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				},
				{
					"name":"EKO05_0003648 uncharacterized protein\tK05986 NUCS; nuclease S1 [EC:3.1.30.1]"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"EKO05_0002521 uncharacterized protein\tK20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"EKO05_0005534 RING-type E3 ubiquitin transferase\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"EKO05_0001507 Pre-mRNA-splicing factor cef1\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"EKO05_0010287 uncharacterized protein\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"EKO05_0001770 pre-mRNA-splicing factor prp46\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"EKO05_0011172 8-oxo-dGTP diphosphatase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"EKO05_0001861 dUTP diphosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"EKO05_0007520 Ribonucleoside-diphosphate reductase\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"EKO05_0005452 Ribonucleoside-diphosphate reductase\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"EKO05_0004162 Methylated-DNA--[protein]-cysteine S-methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"EKO05_0002622 Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				},
				{
					"name":"EKO05_0004572 Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"EKO05_0009513 Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"EKO05_0007244 DNA-3-methyladenine glycosylase II\tK01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]"
					},
					{
						"name":"EKO05_0000870 uncharacterized protein\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"EKO05_0001375 uncharacterized protein\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"EKO05_0000847 DNA-(apurinic or apyrimidinic site) lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"EKO05_0007632 DNA-(apurinic or apyrimidinic site) lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"EKO05_0004046 DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"EKO05_0004046 DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"EKO05_0011172 8-oxo-dGTP diphosphatase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"EKO05_0001861 dUTP diphosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}