{
	"name":"aroo01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS"
				},
				{
					"name":"Polyene macrolide PKS",
					"children":[
					{
						"name":"NQK81_07605 SDR family NAD(P)-dependent oxidoreductase\tK16384 amphC; polyene macrolide polyketide synthase"
					}
					]
				},
				{
					"name":"Pimaricinolide synthase"
				},
				{
					"name":"Candicidin PKS"
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS",
					"children":[
					{
						"name":"NQK81_05420 SDR family NAD(P)-dependent oxidoreductase\tK12443 ppsD; phthiocerol\/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]"
					}
					]
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS"
				},
				{
					"name":"Macrolactin PKS"
				},
				{
					"name":"Difficidin PKS"
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"NQK81_13750 type I polyketide synthase\tK15314 sgcE; enediyne polyketide synthase"
				},
				{
					"name":"NQK81_30350 acyltransferase domain-containing protein\tK20422 ncsB; neocarzinostatin naphthoate synthase [EC:2.3.1.237]"
				}
				]
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS"
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS",
					"children":[
					{
						"name":"NQK81_20770 MBL fold metallo-hydrolase\tK05555 actIV; cyclase [EC:4.-.-.-]"
					}
					]
				},
				{
					"name":"Nonaketide PKS"
				},
				{
					"name":"Decaketide PKS"
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"NQK81_15375 type III polyketide synthase\tK16424 dpgA; 3,5-dihydroxyphenylacetyl-CoA synthase [EC:2.3.1.246]"
				}
				]
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase"
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase"
			},
			{
				"name":"Iturin family lipopeptide synthetase"
			},
			{
				"name":"Fengycin family lipopeptide synthetase"
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase",
				"children":[
				{
					"name":"NQK81_15515 amino acid adenylation domain-containing protein\tK16428 cepA; nonribosomal peptide synthetase CepA"
				},
				{
					"name":"NQK81_15505 amino acid adenylation domain-containing protein\tK16429 cepB; nonribosomal peptide synthetase CepB"
				},
				{
					"name":"NQK81_15500 amino acid adenylation domain-containing protein\tK16430 cepC; nonribosomal peptide synthetase CepC"
				},
				{
					"name":"NQK81_15420 amino acid adenylation domain-containing protein\tK16432 cepK; nonribosomal peptide synthetase CepK"
				}
				]
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"NQK81_04190 MbtH family protein\tK05375 mbtH; MbtH protein"
				},
				{
					"name":"NQK81_15495 MbtH family protein\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"NQK81_04810 isochorismatase family protein\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"NQK81_04815 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"NQK81_41805 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase",
				"children":[
				{
					"name":"NQK81_04810 isochorismatase family protein\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"NQK81_04815 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"NQK81_41805 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase"
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase",
				"children":[
				{
					"name":"NQK81_04810 isochorismatase family protein\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"NQK81_04815 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"NQK81_41805 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Myxochelin synthetase",
				"children":[
				{
					"name":"NQK81_04815 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"NQK81_41805 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"NQK81_04810 isochorismatase family protein\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				}
				]
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase",
				"children":[
				{
					"name":"NQK81_04810 isochorismatase family protein\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"NQK81_04815 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"NQK81_41805 AMP-binding protein\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase",
			"children":[
			{
				"name":"NQK81_13745 acyl-CoA thioesterase\tK15315 sgcE10; enediyne core biosynthesis thioesterase"
			}
			]
		},
		{
			"name":"Ketoreductase",
			"children":[
			{
				"name":"NQK81_11380 3-hydroxyacyl-CoA dehydrogenase NAD-binding domain-containing protein\tK05556 actVI1; ketoreductase RED1 [EC:1.1.1.-]"
			}
			]
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"NQK81_45050 antibiotic biosynthesis monooxygenase\tK14632 actVA6; C-6 monooxygenase"
			},
			{
				"name":"NQK81_30325 cytochrome P450\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"NQK81_44935 cytochrome P450\tK20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]"
			},
			{
				"name":"NQK81_30290 4-hydroxyphenylacetate 3-hydroxylase family protein\tK21184 sgcC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]"
			},
			{
				"name":"NQK81_02920 epoxide hydrolase 1\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_03020 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_05620 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_14025 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_16150 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_26945 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_30265 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_32865 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_38980 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_41990 epoxide hydrolase\tK21159 sgcF; epoxide hydrolase"
			},
			{
				"name":"NQK81_15365 enoyl-CoA hydratase\/isomerase family protein\tK16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"NQK81_33475 methyltransferase\tK20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]"
			}
			]
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Halogenase"
		},
		{
			"name":"beta-Branched incorporating proteins"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"NQK81_12345 cyclase\tK14627 actVI3; dehydratase [EC:4.2.1.-]"
			},
			{
				"name":"NQK81_13650 DUF1702 family protein\tK21160 sgcE2; enediyne biosynthesis protein E2"
			},
			{
				"name":"NQK81_13785 DUF1702 family protein\tK21161 sgcE3; enediyne biosynthesis protein E3"
			},
			{
				"name":"NQK81_13780 CRTAC1 family protein\tK21162 sgcE4; enediyne biosynthesis protein E4"
			},
			{
				"name":"NQK81_13775 enediyne biosynthesis protein\tK21163 sgcE5; enediyne biosynthesis protein E5"
			},
			{
				"name":"NQK81_13770 cytochrome P450\tK21164 sgcE7; enediyne biosynthesis protein E7"
			},
			{
				"name":"NQK81_13765 DUF5987 family protein\tK21165 sgcE8; enediyne biosynthesis protein E8"
			},
			{
				"name":"NQK81_13760 GMC family oxidoreductase\tK21166 sgcE9; enediyne biosynthesis protein E9"
			},
			{
				"name":"NQK81_31275 TIGR03084 family metal-binding protein\tK21167 sgcE11; enediyne biosynthesis protein E11"
			},
			{
				"name":"NQK81_30295 condensation domain-containing protein\tK21186 sgcC5; condensation enzyme"
			},
			{
				"name":"NQK81_13740 flavin reductase family protein\tK21185 sgcE6; flavin reductase"
			},
			{
				"name":"NQK81_30345 AMP-binding protein\tK20423 ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase [EC:6.2.1.43]"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase"
		},
		{
			"name":"Thioesterase",
			"children":[
			{
				"name":"NQK81_15425 alpha\/beta hydrolase\tK16434 cepJ; thioesterase CepJ"
			}
			]
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"NQK81_15485 cytochrome P450\tK16445 cepE; oxidation protein CepE"
			},
			{
				"name":"NQK81_15480 cytochrome P450\tK16446 cepF; oxidation protein CepF"
			},
			{
				"name":"NQK81_15475 cytochrome P450\tK16447 cepG; oxidation protein CepG"
			}
			]
		},
		{
			"name":"Glycosyltransferase",
			"children":[
			{
				"name":"NQK81_15470 glycosyltransferase\tK16440 gtfA; chloroorienticin B synthase [EC:2.4.1.311]"
			},
			{
				"name":"NQK81_15450 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			},
			{
				"name":"NQK81_15460 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			},
			{
				"name":"NQK81_15465 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			},
			{
				"name":"NQK81_33260 glycosyltransferase\tK16444 gtfB; vancomycin aglycone glucosyltransferase [EC:2.4.1.310]"
			}
			]
		},
		{
			"name":"Aminotransferase",
			"children":[
			{
				"name":"NQK81_15430 PLP-dependent aminotransferase family protein\tK16423 hpgT; (S)-3,5-dihydroxyphenylglycine transaminase [EC:2.6.1.103]"
			}
			]
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"NQK81_15415 cytochrome P450\tK16433 cepL; hydroxylation protein CepL"
			},
			{
				"name":"NQK81_15410 hppD; 4-hydroxyphenylpyruvate dioxygenase\tK16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]"
			},
			{
				"name":"NQK81_30300 hppD; 4-hydroxyphenylpyruvate dioxygenase\tK16421 hmaS; 4-hydroxymandelate synthase [EC:1.13.11.46]"
			},
			{
				"name":"NQK81_15405 alpha-hydroxy-acid oxidizing protein\tK16422 hmo; 4-hydroxymandelate oxidase [EC:1.1.3.46]"
			},
			{
				"name":"NQK81_15370 enoyl-CoA hydratase\/isomerase family protein\tK16425 dpgB; isomerase DpgB"
			},
			{
				"name":"NQK81_15365 enoyl-CoA hydratase\/isomerase family protein\tK16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]"
			},
			{
				"name":"NQK81_15360 enoyl-CoA hydratase-related protein\tK16426 dpgD; dehydration protein DpgD"
			}
			]
		}
		]
	}
	]
}