{
	"name":"axo03036",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Sister chromatid cohesion proteins",
			"children":[
			{
				"name":"Cohesin complex"
			},
			{
				"name":"Adherin complex"
			},
			{
				"name":"CTF18-RFC complex"
			},
			{
				"name":"Fork protection complex"
			},
			{
				"name":"55LCC heterohexameric ATPase complex"
			},
			{
				"name":"Other sister chromatid cohesion factors"
			}
			]
		},
		{
			"name":"Meiosis-specific proteins",
			"children":[
			{
				"name":"Cohesin complex and associated proteins"
			},
			{
				"name":"Synaptonemal complex"
			},
			{
				"name":"DSB formation-related proteins"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Nucleosome assembly factors",
			"children":[
			{
				"name":"Histones"
			},
			{
				"name":"Histone chaperones",
				"children":[
				{
					"name":"Nucleoplasmins"
				},
				{
					"name":"NAPs (Nucleosome assembly proteins)"
				},
				{
					"name":"CAF-1"
				},
				{
					"name":"FACT complex"
				},
				{
					"name":"Other Histone chaperones and regulators"
				}
				]
			},
			{
				"name":"HMG (high mobility group) proteins"
			}
			]
		},
		{
			"name":"Histone modification proteins",
			"children":[
			{
				"name":"HATs (histone acetyltransferases)"
			},
			{
				"name":"HAT complexes",
				"children":[
				{
					"name":"PCAF complex"
				},
				{
					"name":"STAGA complex"
				},
				{
					"name":"TFTC complex"
				},
				{
					"name":"TIP60 complex"
				},
				{
					"name":"HBO1 complex"
				},
				{
					"name":"MOZ\/MORF complex"
				},
				{
					"name":"SAGA complex"
				},
				{
					"name":"SLIK complex"
				},
				{
					"name":"ADA-HAT complex"
				},
				{
					"name":"HAT-A2 complex"
				},
				{
					"name":"ATAC complex"
				},
				{
					"name":"HATB complex"
				},
				{
					"name":"NSL complex"
				},
				{
					"name":"MSL complex"
				},
				{
					"name":"NuA3 complex"
				},
				{
					"name":"NuA4 complex"
				},
				{
					"name":"SAS complex"
				}
				]
			},
			{
				"name":"HDACs (histone deacetylases)",
				"children":[
				{
					"name":"Class I HDACs"
				},
				{
					"name":"Class II HDACs"
				},
				{
					"name":"SIRTs (sirtuins, class III HDACs)"
				},
				{
					"name":"Class IV HDACs"
				}
				]
			},
			{
				"name":"HDAC complexes",
				"children":[
				{
					"name":"Sin3A-HDAC complex"
				},
				{
					"name":"BRAF-HDAC complex"
				},
				{
					"name":"REST complex"
				},
				{
					"name":"SHIP complex"
				},
				{
					"name":"MiDAC complex"
				},
				{
					"name":"SMART complex"
				},
				{
					"name":"Other HDAC associated proteins"
				}
				]
			},
			{
				"name":"HMTs (histone methyltransferases)",
				"children":[
				{
					"name":"HKMTs (histone lysine methyltransferases)"
				},
				{
					"name":"PRMTs (protein arginine metyltransferases)"
				}
				]
			},
			{
				"name":"HMT complexes",
				"children":[
				{
					"name":"COMPASS\/SET1 complex"
				},
				{
					"name":"COMPASS\/SET1 complex (yeast)"
				},
				{
					"name":"MLL-HCF complex"
				},
				{
					"name":"MLL3\/MLL4 complex"
				},
				{
					"name":"Dot1-containing complex"
				},
				{
					"name":"CHTOP-methylosome complex"
				}
				]
			},
			{
				"name":"Histone demethylases"
			},
			{
				"name":"Polycomb repressive complex (PRC) and associated proteins",
				"children":[
				{
					"name":"Canonical PRC1 (PRC1.2\/1.4)",
					"children":[
					{
						"name":"PRC1.4 specific proteins"
					}
					]
				},
				{
					"name":"Noncanonical PRC1 (PRC1.1)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.3\/1.5)"
				},
				{
					"name":"Noncanonical PRC1 (PRC1.6)"
				},
				{
					"name":"PRC2.1"
				},
				{
					"name":"PRC2.2"
				},
				{
					"name":"PR-DUB complex"
				},
				{
					"name":"Other PRC associated proteins"
				}
				]
			},
			{
				"name":"Sir proteins"
			},
			{
				"name":"Other histone modification proteins"
			}
			]
		},
		{
			"name":"Chromosome condensation proteins",
			"children":[
			{
				"name":"Condensin I"
			},
			{
				"name":"Condensin II"
			},
			{
				"name":"Other regulators of chromosome condensation"
			}
			]
		},
		{
			"name":"Centromeric chromatin formation proteins",
			"children":[
			{
				"name":"Kinetochore proteins",
				"children":[
				{
					"name":"Centromere proteins"
				},
				{
					"name":"CPC (chromosomal passenger complex)"
				},
				{
					"name":"KMN network proteins",
					"children":[
					{
						"name":"MIS12 complex"
					},
					{
						"name":"NDC80 complex"
					}
					]
				},
				{
					"name":"Mis6 complex"
				},
				{
					"name":"COMA complex"
				},
				{
					"name":"NMS complex",
					"children":[
					{
						"name":"NDC80 complex"
					},
					{
						"name":"MIND kinetochore complex"
					}
					]
				},
				{
					"name":"MIS16-MIS18 complex"
				},
				{
					"name":"DASH complex"
				},
				{
					"name":"CBF3 complex"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"SAC (spindle assembly checkpoint) factors",
				"children":[
				{
					"name":"Core SAC proteins"
				},
				{
					"name":"Motor proteins",
					"children":[
					{
						"name":"RZZ complex"
					},
					{
						"name":"Dynein complex"
					}
					]
				},
				{
					"name":"Protein kinases"
				},
				{
					"name":"Others"
				}
				]
			},
			{
				"name":"Other centromeric chromatin formation proteins",
				"children":[
				{
					"name":"Shugoshin"
				},
				{
					"name":"PP2A (protein phosphatase 2A)"
				}
				]
			}
			]
		},
		{
			"name":"Heterochromatin formation proteins",
			"children":[
			{
				"name":"HP1 (heterochromatin protein 1)"
			},
			{
				"name":"MBPs (metylated DNA binding proteins)"
			},
			{
				"name":"Other heterochromatin formation proteins",
				"children":[
				{
					"name":"NH44784_008851 DNA methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Gene silencing",
			"children":[
			{
				"name":"RISC (RNA-induced silencing complex)"
			},
			{
				"name":"piRNA pathway"
			},
			{
				"name":"RNA interference (RNAi) pathway",
				"children":[
				{
					"name":"RITS (RNA-induced transcriptional silencing) complex"
				},
				{
					"name":"RDRC (RNA-directed RNA polymerase complex)"
				},
				{
					"name":"Other RNAi proteins"
				}
				]
			},
			{
				"name":"microRNA pathway",
				"children":[
				{
					"name":"Microprocessor complex",
					"children":[
					{
						"name":"NH44784_005181 Ribonuclease III\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					}
					]
				},
				{
					"name":"RISC loading complex"
				},
				{
					"name":"Other miRNA pathway proteins"
				}
				]
			},
			{
				"name":"Transposable elements"
			}
			]
		},
		{
			"name":"Centrosome formation proteins",
			"children":[
			{
				"name":"Centriole proteins"
			},
			{
				"name":"Pericentriolar materials (PCM)",
				"children":[
				{
					"name":"Centriolar satellite"
				},
				{
					"name":"Other PCM proteins"
				}
				]
			},
			{
				"name":"Cyclins"
			},
			{
				"name":"Kinases and associated factors",
				"children":[
				{
					"name":"Kinase associated protein"
				}
				]
			},
			{
				"name":"Microtubules and associated factors",
				"children":[
				{
					"name":"gamma-tubulin ring complex"
				},
				{
					"name":"Other tubulins"
				},
				{
					"name":"Dynactin complex"
				},
				{
					"name":"BRISC complex"
				},
				{
					"name":"Microtubule-associated proteins"
				}
				]
			},
			{
				"name":"Augmin complex"
			},
			{
				"name":"Centrosome duplication proteins",
				"children":[
				{
					"name":"Centriole replication proteins"
				},
				{
					"name":"Regulators of centriole replication"
				},
				{
					"name":"Other centrosome duplication proteins"
				}
				]
			},
			{
				"name":"Nde1-Su48 complex"
			},
			{
				"name":"LINC complex"
			},
			{
				"name":"3M complex"
			},
			{
				"name":"Gypsy chromatin insulator complex"
			},
			{
				"name":"Other centrosome associated proteins"
			},
			{
				"name":"Spindle formation proteins",
				"children":[
				{
					"name":"NH44784_052131 DinG family ATP-dependent helicase CPE1197\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
				}
				]
			}
			]
		},
		{
			"name":"Sister chromatid separation proteins",
			"children":[
			{
				"name":"Securin and associated proteins"
			},
			{
				"name":"Separase"
			},
			{
				"name":"APC\/C complex"
			},
			{
				"name":"Aurora kinases",
				"children":[
				{
					"name":"Regulators of Aurora kinases"
				}
				]
			},
			{
				"name":"TACC proteins"
			},
			{
				"name":"Polo kinases"
			},
			{
				"name":"Early mitotic inhibitors"
			}
			]
		},
		{
			"name":"Chromatin remodeling factors",
			"children":[
			{
				"name":"BAF complex"
			},
			{
				"name":"PBAF complex"
			},
			{
				"name":"GBAF(ncBAF) complex"
			},
			{
				"name":"CHRAC complex"
			},
			{
				"name":"RSF complex"
			},
			{
				"name":"WICH complex"
			},
			{
				"name":"B-WICH complex"
			},
			{
				"name":"NORC complex"
			},
			{
				"name":"BRF complex"
			},
			{
				"name":"NuRD complex"
			},
			{
				"name":"NuRF complex"
			},
			{
				"name":"NuRF complex (fruit fly)"
			},
			{
				"name":"CERF complex"
			},
			{
				"name":"SRCAP complex"
			},
			{
				"name":"INO80 complex"
			},
			{
				"name":"INO80 complex (yeast)"
			},
			{
				"name":"RSC complex"
			},
			{
				"name":"SWI\/SNF complex"
			},
			{
				"name":"SWR1 complex"
			},
			{
				"name":"ASTRA complex"
			},
			{
				"name":"Other chromatin remodeling factors"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Nucleoid associated proteins",
			"children":[
			{
				"name":"HNS (histone-like nucleoid structuring protein)",
				"children":[
				{
					"name":"NH44784_001921 putative DNA-binding protein (histone\tK03746 hns; DNA-binding protein H-NS"
				}
				]
			},
			{
				"name":"HU (heat unstable protein)",
				"children":[
				{
					"name":"NH44784_001251 DNA-binding protein HU-beta\tK03530 hupB; DNA-binding protein HU-beta"
				}
				]
			},
			{
				"name":"IHF (integration host factor)",
				"children":[
				{
					"name":"NH44784_039051 Integration host factor alpha subunit\tK04764 ihfA; integration host factor subunit alpha"
				},
				{
					"name":"NH44784_003661 Integration host factor beta subunit\tK05788 ihfB; integration host factor subunit beta"
				}
				]
			},
			{
				"name":"Other nucleoid associated proteins",
				"children":[
				{
					"name":"NH44784_034531 DnaJ-class molecular chaperone CbpA\tK05516 cbpA; curved DNA-binding protein"
				},
				{
					"name":"NH44784_034541 FIG00432169: hypothetical protein\tK18997 cbpM; chaperone modulatory protein CbpM"
				},
				{
					"name":"NH44784_022051 Chromosomal replication initiator protein DnaA\tK02313 dnaA; chromosomal replication initiator protein"
				},
				{
					"name":"NH44784_045611 Non-specific DNA-binding protein Dps \/ Iron-binding ferritin-like antioxidant protein \/ Ferroxidase\tK04047 dps; starvation-inducible DNA-binding protein"
				},
				{
					"name":"NH44784_049641 Non-specific DNA-binding protein Dps \/ Iron-binding ferritin-like antioxidant protein \/ Ferroxidase\tK04047 dps; starvation-inducible DNA-binding protein"
				},
				{
					"name":"NH44784_011361 DNA-binding protein Fis\tK03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein"
				},
				{
					"name":"NH44784_037581 RNA-binding protein Hfq\tK03666 hfq; host factor-I protein"
				},
				{
					"name":"NH44784_024951 probable LysR-family transcriptional regulator\tK05596 argP; LysR family transcriptional regulator, arginine and lysine transport system\/DNA replication regulator"
				},
				{
					"name":"NH44784_013581 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_013921 Leucine-responsive regulatory protein, regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_015321 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_019561 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_021411 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_026291 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_039231 Transcriptional regulator BkdR of isoleucine and valine catabolism operon\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_041161 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_043761 Leucine-responsive regulatory protein, regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_044371 leucine-responsive regulatory protein\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_046061 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"NH44784_051951 Transcriptional regulator, AsnC family\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Chromosome partitioning proteins",
			"children":[
			{
				"name":"MukBEF complex"
			},
			{
				"name":"Condensin-like complex",
				"children":[
				{
					"name":"NH44784_005821 Chromosome partition protein smc\tK03529 smc; chromosome segregation protein"
				},
				{
					"name":"NH44784_016301 Segregation and condensation protein A\tK05896 scpA; segregation and condensation protein A"
				},
				{
					"name":"NH44784_003011 Segregation and condensation protein B\tK06024 scpB; segregation and condensation protein B"
				}
				]
			},
			{
				"name":"Divisome proteins",
				"children":[
				{
					"name":"NH44784_013371 Cell division protein FtsA\tK03590 ftsA; cell division protein FtsA"
				},
				{
					"name":"NH44784_004671 Cell division protein FtsB\tK05589 ftsB; cell division protein FtsB"
				},
				{
					"name":"NH44784_016551 Cell division transporter, ATP-binding protein FtsE (TC 3.A.5.1.1\tK09812 ftsE; cell division transport system ATP-binding protein"
				},
				{
					"name":"NH44784_013461 Cell division protein FtsI [Peptidoglycan synthetase]\tK03587 ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]"
				},
				{
					"name":"NH44784_007901 Cell division protein FtsK\tK03466 ftsK; DNA segregation ATPase FtsK\/SpoIIIE, S-DNA-T family"
				},
				{
					"name":"NH44784_013471 Cell division protein FtsL\tK03586 ftsL; cell division protein FtsL"
				},
				{
					"name":"NH44784_013381 Cell division protein FtsQ\tK03589 ftsQ; cell division protein FtsQ"
				},
				{
					"name":"NH44784_013421 Cell division protein FtsW\tK03588 ftsW; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"NH44784_016561 Cell division protein FtsX\tK09811 ftsX; cell division transport system permease protein"
				},
				{
					"name":"NH44784_013361 Cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"NH44784_013651 FIG017670: hypothetical protein\tK09888 zapA; cell division protein ZapA"
				},
				{
					"name":"NH44784_016241 FIG002842: hypothetical protein\tK18778 zapD; cell division protein ZapD"
				},
				{
					"name":"NH44784_004301 ATPase, AFG1 family\tK06916 zapE; cell division protein ZapE"
				},
				{
					"name":"NH44784_012281 N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
				},
				{
					"name":"NH44784_024631 N-acetylmuramoyl-L-alanine amidase\tK01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]"
				},
				{
					"name":"NH44784_014271 Probable Co\/Zn\/Cd efflux system membrane fusion protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"NH44784_042261 RND efflux system, membrane fusion protein CmeA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"NH44784_063681 RND efflux system, membrane fusion protein CmeA\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Inhibitors of FtsZ assembly",
				"children":[
				{
					"name":"NH44784_011501 Septum site-determining protein MinC\tK03610 minC; septum site-determining protein MinC"
				},
				{
					"name":"NH44784_011511 Septum site-determining protein MinD\tK03609 minD; septum site-determining protein MinD"
				},
				{
					"name":"NH44784_011521 Cell division topological specificity factor MinE\tK03608 minE; cell division topological specificity factor"
				},
				{
					"name":"NH44784_025111 Transcriptional regulator, TetR family\tK05501 slmA; TetR\/AcrR family transcriptional regulator"
				}
				]
			},
			{
				"name":"Other chromosome partitioning proteins",
				"children":[
				{
					"name":"NH44784_025041 Rod shape-determining protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"NH44784_025051 Rod shape-determining protein MreC\tK03570 mreC; rod shape-determining protein MreC"
				},
				{
					"name":"NH44784_025061 Rod shape-determining protein MreD\tK03571 mreD; rod shape-determining protein MreD"
				},
				{
					"name":"NH44784_025081 Rod shape-determining protein RodA\tK05837 rodA; peptidoglycan glycosyltransferase [EC:2.4.99.28]"
				},
				{
					"name":"NH44784_022341 Chromosome (plasmid) partitioning protein ParA \/ Sporulation initiation inhibitor protein Soj\tK03496 parA; chromosome partitioning protein"
				},
				{
					"name":"NH44784_009321 putative plasmid stabilization protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"NH44784_022361 Chromosome (plasmid) partitioning protein ParB \/ Stage 0 sporulation protein J\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"NH44784_037741 hypothetical protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"NH44784_055651 hypothetical protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"NH44784_037201 Topoisomerase IV subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"NH44784_037181 Topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"NH44784_022321 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA\tK03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme"
				},
				{
					"name":"NH44784_022331 rRNA small subunit methyltransferase, glucose inhibited division protein GidB\tK03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]"
				},
				{
					"name":"NH44784_024211 putative integrase\/recombinase\tK03733 xerC; integrase\/recombinase XerC"
				},
				{
					"name":"NH44784_035231 ortholog of Bordetella pertussis (BX470248) BP1540\tK04763 xerD; integrase\/recombinase XerD"
				},
				{
					"name":"NH44784_029131 Scaffold protein for [4Fe-4S] cluster assembly ApbC, MRP-like\tK03593 mrp; ATP-binding protein involved in chromosome partitioning"
				},
				{
					"name":"NH44784_023201 GTP-binding protein EngB\tK03978 engB; GTP-binding protein"
				}
				]
			}
			]
		}
		]
	}
	]
}