{
	"name":"bay01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS"
				},
				{
					"name":"Polyene macrolide PKS"
				},
				{
					"name":"Pimaricinolide synthase"
				},
				{
					"name":"Candicidin PKS"
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS"
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS",
					"children":[
					{
						"name":"RBAM_014330 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_016930 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_022080 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_016920 acyltransferase domain-containing protein\tK15328 pksD; bacillaene synthase trans-acting acyltransferase"
					},
					{
						"name":"RBAM_016980 non-ribosomal peptide synthetase\tK13611 pksJ; bacillaene biosynthesis, polyketide synthase \/ nonribosomal peptide synthetase PksJ\/BaeJ"
					},
					{
						"name":"RBAM_016990 SDR family NAD(P)-dependent oxidoreductase\tK13612 pksL; bacillaene polyketide synthase PksL\/BaeL"
					},
					{
						"name":"RBAM_017000 SDR family NAD(P)-dependent oxidoreductase\tK13613 pksM; bacillaene polyketide synthase PksM\/BaeM"
					},
					{
						"name":"RBAM_017010 non-ribosomal peptide synthetase\tK13614 pksN; bacillaene biosynthesis, polyketide synthase \/ nonribosomal peptide synthetase PksN\/BaeN"
					},
					{
						"name":"RBAM_017020 methyltransferase\tK13615 pksR; bacillaene polyketide synthase PksR\/BaeR"
					}
					]
				},
				{
					"name":"Macrolactin PKS",
					"children":[
					{
						"name":"RBAM_014330 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_016930 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_022080 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_014340 SDR family NAD(P)-dependent oxidoreductase\tK25842 mlnB; macrolactin polyketide synthase MlnB"
					},
					{
						"name":"RBAM_014350 SDR family NAD(P)-dependent oxidoreductase\tK25843 mlnC; macrolactin polyketide synthase MlnC"
					},
					{
						"name":"RBAM_014360 SDR family NAD(P)-dependent oxidoreductase\tK25844 mlnD; macrolactin polyketide synthase MlnD"
					},
					{
						"name":"RBAM_014370 SDR family NAD(P)-dependent oxidoreductase\tK25845 mlnE; macrolactin polyketide synthase MlnE"
					},
					{
						"name":"RBAM_014380 SDR family NAD(P)-dependent oxidoreductase\tK25846 mlnF; macrolactin polyketide synthase MlnF"
					},
					{
						"name":"RBAM_014390 SDR family NAD(P)-dependent oxidoreductase\tK25847 mlnG; macrolactin polyketide synthase MlnG"
					},
					{
						"name":"RBAM_014400 alpha\/beta fold hydrolase\tK25848 mlnH; macrolactin polyketide synthase MlnH"
					}
					]
				},
				{
					"name":"Difficidin PKS",
					"children":[
					{
						"name":"RBAM_014330 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_016930 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_022080 fabD; ACP S-malonyltransferase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"RBAM_022030 SDR family NAD(P)-dependent oxidoreductase\tK25849 dfnD; difficidin synthase DfnD"
					},
					{
						"name":"RBAM_022020 KR domain-containing protein\tK25850 dfnE; difficidin synthase DfnE"
					},
					{
						"name":"RBAM_022010 SDR family NAD(P)-dependent oxidoreductase\tK25851 dfnF; difficidin synthase DfnF"
					},
					{
						"name":"RBAM_022000 SDR family NAD(P)-dependent oxidoreductase\tK25852 dfnG; difficidin synthase DfnG"
					},
					{
						"name":"RBAM_021990 SDR family NAD(P)-dependent oxidoreductase\tK25853 dfnH; difficidin synthase DfnH"
					},
					{
						"name":"RBAM_021980 SDR family NAD(P)-dependent oxidoreductase\tK25854 dfnI; difficidin synthase DfnI"
					},
					{
						"name":"RBAM_021970 zinc-binding dehydrogenase\tK25855 dfnJ; difficidin synthase DfnJ"
					}
					]
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type"
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS"
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS"
				},
				{
					"name":"Nonaketide PKS"
				},
				{
					"name":"Decaketide PKS"
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type",
				"children":[
				{
					"name":"RBAM_020200 type III polyketide synthase\tK16167 bpsA; alkylresorcinol\/alkylpyrone synthase"
				}
				]
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase"
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase",
				"children":[
				{
					"name":"RBAM_003650 srfAA; surfactin non-ribosomal peptide synthetase SrfAA\tK15654 srfAA; surfactin\/lichenysin synthetase A"
				},
				{
					"name":"RBAM_003660 srfAB; surfactin non-ribosomal peptide synthetase SrfAB\tK15655 srfAB; surfactin\/lichenysin synthetase B"
				},
				{
					"name":"RBAM_003680 srfAC; surfactin non-ribosomal peptide synthetase SrfAC\tK15656 srfAC; surfactin\/lichenysin synthetase C"
				}
				]
			},
			{
				"name":"Iturin family lipopeptide synthetase",
				"children":[
				{
					"name":"RBAM_018180 non-ribosomal peptide synthetase\tK15661 ituA; iturin family lipopeptide synthetase A"
				},
				{
					"name":"RBAM_018170 non-ribosomal peptide synthetase\tK15662 ituB; iturin family lipopeptide synthetase B"
				},
				{
					"name":"RBAM_018160 non-ribosomal peptide synthetase\tK15663 ituC; iturin family lipopeptide synthetase C"
				}
				]
			},
			{
				"name":"Fengycin family lipopeptide synthetase",
				"children":[
				{
					"name":"RBAM_018460 non-ribosomal peptide synthetase\tK15664 ppsA; plipastatin\/fengycin lipopeptide synthetase A"
				},
				{
					"name":"RBAM_018450 non-ribosomal peptide synthetase\tK15665 ppsB; plipastatin\/fengycin lipopeptide synthetase B"
				},
				{
					"name":"RBAM_018440 non-ribosomal peptide synthetase\tK15666 ppsC; plipastatin\/fengycin lipopeptide synthetase C"
				},
				{
					"name":"RBAM_018430 non-ribosomal peptide synthetase\tK15667 ppsD; plipastatin\/fengycin lipopeptide synthetase D"
				},
				{
					"name":"RBAM_018420 non-ribosomal peptide synthase\tK15668 ppsE; plipastatin\/fengycin lipopeptide synthetase E"
				}
				]
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase"
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"RBAM_029000 MbtH family NRPS accessory protein\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"RBAM_029020 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"RBAM_029030 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase",
				"children":[
				{
					"name":"RBAM_029020 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"RBAM_029030 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"RBAM_029010 amino acid adenylation domain-containing protein\tK04780 dhbF; glyine---[glycyl-carrier protein] ligase [EC:6.2.1.66]"
				}
				]
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase"
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase",
				"children":[
				{
					"name":"RBAM_029020 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"RBAM_029030 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Myxochelin synthetase",
				"children":[
				{
					"name":"RBAM_029030 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"RBAM_029020 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				}
				]
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase",
				"children":[
				{
					"name":"RBAM_029020 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"RBAM_029030 (2,3-dihydroxybenzoyl)adenylate synthase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase"
		},
		{
			"name":"Ketoreductase"
		},
		{
			"name":"Oxygenase",
			"children":[
			{
				"name":"RBAM_017030 cytochrome P450\tK15468 pksS; cytochrome P450 family 107 subfamily K polypeptide 1"
			}
			]
		},
		{
			"name":"Methylase",
			"children":[
			{
				"name":"RBAM_020190 hypothetical protein\tK16168 bpsB; methyltransferase"
			}
			]
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Halogenase"
		},
		{
			"name":"beta-Branched incorporating proteins",
			"children":[
			{
				"name":"RBAM_016910 fabD; ACP S-malonyltransferase\tK15327 pksC; polyketide biosynthesis malonyl-CoA-[acyl-carrier-protein] transacylase"
			},
			{
				"name":"RBAM_009810 polyketide beta-ketoacyl:ACP synthase\tK00646 pksF; malonyl-[acp] decarboxylase [EC:4.1.1.124]"
			},
			{
				"name":"RBAM_016940 acyl carrier protein\tK15337 acpK; polyketide biosynthesis acyl carrier protein"
			},
			{
				"name":"RBAM_016950 hydroxymethylglutaryl-CoA synthase family protein\tK15311 pksG; 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase [EC:2.3.3.22]"
			},
			{
				"name":"RBAM_021950 hydroxymethylglutaryl-CoA synthase family protein\tK15311 pksG; 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase [EC:2.3.3.22]"
			},
			{
				"name":"RBAM_016960 enoyl-CoA hydratase\/isomerase\tK15312 pksH; 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase [EC:4.2.1.181]"
			},
			{
				"name":"RBAM_016970 enoyl-CoA hydratase\tK15313 pksI; 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]"
			},
			{
				"name":"RBAM_021940 enoyl-CoA hydratase\tK15313 pksI; 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]"
			}
			]
		},
		{
			"name":"Others"
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase"
		},
		{
			"name":"Thioesterase",
			"children":[
			{
				"name":"RBAM_003690 srfAD; surfactin biosynthesis thioesterase SrfAD\tK15657 srfATE; external thioesterase TEII"
			}
			]
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Aminotransferase"
		},
		{
			"name":"Others"
		}
		]
	}
	]
}