{
	"name":"bbe01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"BBR47_18430 conserved hypothetical protein\tK00663 aacA; aminoglycoside 6'-N-acetyltransferase [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases",
				"children":[
				{
					"name":"BBR47_31210 probable streptothricin acetyltransferase\tK19273 sat4; streptothricin acetyltransferase [EC:2.3.-.-]"
				}
				]
			},
			{
				"name":"O-Nucleotidyltransferases",
				"children":[
				{
					"name":"BBR47_43230 probable aminoglycoside nucleotidyltransferase\tK17882 aadD; kanamycin nucleotidyltransferase [EC:2.7.7.-]"
				},
				{
					"name":"BBR47_23140 aadK; aminoglycoside 6-adenylyltransferase\tK05593 aadK; aminoglycoside 6-adenylyltransferase [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"BBR47_15510 conserved hypothetical protein\tK17910 aphD; aminoglycoside 2''-phosphotransferase [EC:2.7.1.190]"
				},
				{
					"name":"BBR47_11130 conserved hypothetical protein\tK04343 strB; streptomycin 6-kinase [EC:2.7.1.72]"
				},
				{
					"name":"BBR47_13300 conserved hypothetical protein\tK18844 aph; spectinomycin phosphotransferase"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"BBR47_04340 probable tetracycline resistance protein\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				},
				{
					"name":"BBR47_10140 probable tetracycline resistance protein\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"BBR47_29680 probable tetracycline resistant protein\tK18220 tetM; ribosomal protection tetracycline resistance protein"
				}
				]
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases",
				"children":[
				{
					"name":"BBR47_45040 conserved hypothetical protein\tK15632 cfr; 23S rRNA (adenine-C8)-methyltransferase [EC:2.1.1.224]"
				}
				]
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"BBR47_27680 probable ABC transporter ATP binding protein\tK19350 lsa; lincosamide and streptogramin A transport system ATP-binding\/permease protein"
				},
				{
					"name":"BBR47_37480 conserved hypothetical membrane protein\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				},
				{
					"name":"BBR47_51320 conserved hypothetical membrane protein\tK08217 mef; MFS transporter, DHA3 family, macrolide efflux protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"BBR47_03080 putative macrolide 2-phosphotransferase\tK06979 mph; macrolide phosphotransferase"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"BBR47_14680 cat; chloramphenicol acetyltransferase\tK19271 catA; chloramphenicol O-acetyltransferase type A [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase",
				"children":[
				{
					"name":"BBR47_45040 conserved hypothetical protein\tK15632 cfr; 23S rRNA (adenine-C8)-methyltransferase [EC:2.1.1.224]"
				}
				]
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter",
				"children":[
				{
					"name":"BBR47_49680 putative transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"BBR47_12020 blaR; regulatory protein BlaR1\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"BBR47_30670 hypothetical membrane protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"BBR47_42390 hypothetical membrane protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"BBR47_57600 putative regulatory protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"BBR47_12030 blaI; penicillinase repressor\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"BBR47_30680 putative transcriptional repressor\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"BBR47_42380 probable transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"BBR47_57590 putative penicillinase repressor\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"BBR47_12040 penP; beta-lactamase precursor\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"BBR47_52010 two-component sensor histidine kinase\tK18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
				},
				{
					"name":"BBR47_05860 probable D,D-peptidase\/D,D-carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"BBR47_26840 putative D,D-peptidase\/D,D-carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"BBR47_28030 probable D,D-peptidase\/D,D-carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"BBR47_36730 yodJ; putative D,D-peptidase\/D,D-carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"BBR47_06840 conserved hypothetical protein\tK18346 vanW; vancomycin resistance protein VanW"
				},
				{
					"name":"BBR47_12370 conserved hypothetical protein\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"BBR47_57970 two-component response regulator\tK18349 vanRC; two-component system, OmpR family, response regulator VanR"
				},
				{
					"name":"BBR47_05890 probable amino acid racemase\tK18348 vanT; serine\/alanine racemase [EC:5.1.1.18 5.1.1.1]"
				},
				{
					"name":"BBR47_05870 ligase\tK18856 vanC; D-alanine---D-serine ligase [EC:6.3.2.35]"
				},
				{
					"name":"BBR47_05880 probable D,D-peptidase\/D,D-carboxypeptidase\tK18866 vanXY; zinc D-Ala-D-Ala dipeptidase\/carboxypeptidase [EC:3.4.13.22 3.4.17.14]"
				},
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]",
				"children":[
				{
					"name":"BBR47_04340 probable tetracycline resistance protein\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				},
				{
					"name":"BBR47_10140 probable tetracycline resistance protein\tK08168 tetB; MFS transporter, DHA2 family, metal-tetracycline-proton antiporter"
				}
				]
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"BBR47_14000 conserved hypothetical protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"BBR47_25250 putative efflux system\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"BBR47_28870 putative efflux system\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"BBR47_32120 putative efflux system\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"BBR47_49530 hypothetical protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"BBR47_55220 conserved hypothetical protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"BBR47_07800 putative efflux system\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"BBR47_25260 putative efflux system\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"BBR47_32130 putative efflux system\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"BBR47_49520 hypothetical protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"BBR47_55210 putative efflux system\tK18138 acrB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]"
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]"
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]",
				"children":[
				{
					"name":"BBR47_43340 ydfD; probable transcriptional regulator\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				},
				{
					"name":"BBR47_41950 yvcC; multidrug resistance ABC transporter ATP binding\/permease protein\tK18104 abcA; ATP-binding cassette, subfamily B, bacterial AbcA\/BmrA [EC:7.6.2.2]"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]",
				"children":[
				{
					"name":"BBR47_43340 ydfD; probable transcriptional regulator\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]",
				"children":[
				{
					"name":"BBR47_49680 putative transporter\tK08167 smvA; MFS transporter, DHA2 family, multidrug resistance protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]",
				"children":[
				{
					"name":"BBR47_40610 putative transcriptional regulator\tK18909 mepR; MarR family transcriptional regulator, repressor for mepA"
				}
				]
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}