{
	"name":"bbif04031",
	"children":[
	{
		"name":"Heterotrimeric G-proteins",
		"children":[
		{
			"name":"Alpha Subunits",
			"children":[
			{
				"name":"Alpha type 1 (Gi\/o) [OT]",
				"children":[
				{
					"name":"117211492 guanine nucleotide-binding protein G(i) subunit alpha\tK04630 GNAI; guanine nucleotide-binding protein G(i) subunit alpha"
				},
				{
					"name":"117215608 guanine nucleotide-binding protein G(o) subunit alpha\tK04534 GNAO; guanine nucleotide-binding protein G(o) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 2 (Gs)",
				"children":[
				{
					"name":"117212346 guanine nucleotide-binding protein G(s) subunit alpha\tK04632 GNAS; guanine nucleotide-binding protein G(s) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 3 (Gq\/11) [OT]",
				"children":[
				{
					"name":"117214932 guanine nucleotide-binding protein G(q) subunit alpha isoform X1\tK04634 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha"
				}
				]
			},
			{
				"name":"Alpha type 4 (G12\/13)",
				"children":[
				{
					"name":"117210671 guanine nucleotide-binding protein subunit alpha homolog\tK04346 GNA12; guanine nucleotide-binding protein subunit alpha-12"
				}
				]
			},
			{
				"name":"Alpha others - lower eukaryotes"
			}
			]
		},
		{
			"name":"Beta Subunits",
			"children":[
			{
				"name":"Beta [OT]",
				"children":[
				{
					"name":"117207977 guanine nucleotide-binding protein G(I)\/G(S)\/G(T) subunit beta-1\tK04536 GNB1; guanine nucleotide-binding protein G(I)\/G(S)\/G(T) subunit beta-1"
				},
				{
					"name":"117204416 guanine nucleotide-binding protein subunit beta-5\tK04539 GNB5; guanine nucleotide-binding protein subunit beta-5"
				},
				{
					"name":"117217003 guanine nucleotide-binding protein subunit beta-2\tK07972 GNB; guanine nucleotide-binding protein subunit beta, other"
				}
				]
			}
			]
		},
		{
			"name":"Gamma Subunits",
			"children":[
			{
				"name":"Gamma [OT]",
				"children":[
				{
					"name":"117217103 guanine nucleotide-binding protein subunit gamma-e\tK04547 GNG13; guanine nucleotide-binding protein G(I)\/G(S)\/G(O) subunit gamma-13"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Small (monomeric) G-proteins",
		"children":[
		{
			"name":"Ras Family",
			"children":[
			{
				"name":"Ras [OT]",
				"children":[
				{
					"name":"117208409 ras-like protein 1\tK07827 KRAS; GTPase KRas"
				},
				{
					"name":"117217021 ras-like protein 2 isoform X1\tK07830 RRAS2; Ras-related protein R-Ras2"
				},
				{
					"name":"117216579 ras-related protein M-Ras-like\tK07831 MRAS; Ras-related protein M-Ras"
				}
				]
			},
			{
				"name":"Rit"
			},
			{
				"name":"Ral",
				"children":[
				{
					"name":"117211407 ras-related protein Ral-a isoform X1\tK07834 RALA; Ras-related protein Ral-A"
				}
				]
			},
			{
				"name":"Rap [OT]",
				"children":[
				{
					"name":"117216689 ras-related protein Rap1\tK04353 RAP1A; Ras-related protein Rap-1A"
				},
				{
					"name":"117205697 ras-related protein Rap-2a\tK07839 RAP2C; Ras-related protein Rap-2C"
				}
				]
			},
			{
				"name":"Di-Ras [OT]",
				"children":[
				{
					"name":"117214392 GTP-binding protein Di-Ras2\tK07841 DIRAS2; DIRAS family, GTP-binding Ras-like 2"
				}
				]
			},
			{
				"name":"RasD",
				"children":[
				{
					"name":"117204419 dexamethasone-induced Ras-related protein 1\tK07843 RASD1; RAS, dexamethasone-induced Ras-related protein 1"
				}
				]
			},
			{
				"name":"Rad\/Gem\/Kir [OT]",
				"children":[
				{
					"name":"117206605 GTP-binding protein Rit2-like\tK07847 REM1; Rad and Gem related GTP binding protein 1"
				},
				{
					"name":"117209190 uncharacterized protein LOC117209190\tK07847 REM1; Rad and Gem related GTP binding protein 1"
				}
				]
			},
			{
				"name":"Rheb",
				"children":[
				{
					"name":"117210871 GTP-binding protein Rheb homolog\tK07208 RHEB; Ras homolog enriched in brain"
				}
				]
			},
			{
				"name":"Nki-Ras",
				"children":[
				{
					"name":"117212293 NF-kappa-B inhibitor-interacting Ras-like protein isoform X1\tK17197 NKIRAS; NF-kappa-B inhibitor-interacting Ras-like protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"117205490 ras-like protein family member 10B\tK07851 RASL10B; Ras-like protein family member 10B"
				},
				{
					"name":"117209750 ras-related and estrogen-regulated growth inhibitor-like\tK07852 RASL11A; Ras-like protein family member 11A"
				},
				{
					"name":"117205583 ras-related and estrogen-regulated growth inhibitor-like isoform X1\tK17198 RERGL; Ras-related and estrogen-regulated growth inhibitor-like protein"
				}
				]
			}
			]
		},
		{
			"name":"Rho Family",
			"children":[
			{
				"name":"RhoA\/B\/C [OT]",
				"children":[
				{
					"name":"117211567 ras-like GTP-binding protein Rho1 isoform X1\tK04513 RHOA; Ras homolog gene family, member A"
				}
				]
			},
			{
				"name":"Rnd [OT]"
			},
			{
				"name":"Rac\/Cdc42 [OT]",
				"children":[
				{
					"name":"117204118 ras-like GTP-binding protein RhoL\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"117211993 ras-related protein Rac1\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"117214775 ras-related C3 botulinum toxin substrate 1\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1"
				},
				{
					"name":"117205021 cdc42 homolog\tK04393 CDC42; cell division control protein 42"
				},
				{
					"name":"117212444 cdc42 homolog\tK04393 CDC42; cell division control protein 42"
				},
				{
					"name":"117210216 ras-related C3 botulinum toxin substrate 1-like\tK07865 RHOU; Ras homolog gene family, member U"
				}
				]
			},
			{
				"name":"RhoBTB",
				"children":[
				{
					"name":"117210027 rho-related BTB domain-containing protein 1 isoform X1\tK07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1\/2"
				}
				]
			},
			{
				"name":"Miro",
				"children":[
				{
					"name":"117207081 mitochondrial Rho GTPase isoform X1\tK07870 RHOT1; mitochondrial Rho GTPase 1 [EC:3.6.5.-]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Rab Family",
			"children":[
			{
				"name":"Rab1\/35 [OT]",
				"children":[
				{
					"name":"117205347 ras-related protein Rab-1A\tK07874 RAB1A; Ras-related protein Rab-1A"
				},
				{
					"name":"117207266 ras-related protein Rab-35\tK07876 RAB35; Ras-related protein Rab-35"
				}
				]
			},
			{
				"name":"Rab2\/4\/14 [OT]",
				"children":[
				{
					"name":"117215770 ras-related protein Rab-2\tK07877 RAB2A; Ras-related protein Rab-2A"
				},
				{
					"name":"117206319 ras-related protein Rab-14\tK07881 RAB14; Ras-related protein Rab-14"
				}
				]
			},
			{
				"name":"Rab3\/27 [OT]",
				"children":[
				{
					"name":"117214196 ras-related protein Rab-3 isoform X1\tK07883 RAB3C; Ras-related protein Rab-3C"
				},
				{
					"name":"117215806 ras-related protein Rab-27A\tK07885 RAB27A; Ras-related protein Rab-27A"
				}
				]
			},
			{
				"name":"Rab5\/17\/22\/31 [OT]",
				"children":[
				{
					"name":"117204914 ras-related protein Rab-5C\tK07888 RAB5B; Ras-related protein Rab-5B"
				}
				]
			},
			{
				"name":"Rab6\/41 [OT]",
				"children":[
				{
					"name":"117204751 ras-related protein Rab6 isoform X1\tK07893 RAB6A_C_D; Ras-related protein Rab-6A\/C\/D [EC:3.6.5.2]"
				}
				]
			},
			{
				"name":"Rab7\/9 [OT]",
				"children":[
				{
					"name":"117204801 ras-related protein Rab-7a\tK07897 RAB7A; Ras-related protein Rab-7A [EC:3.6.5.2]"
				},
				{
					"name":"117206005 ras-related protein Rab-9A\tK07899 RAB9A; Ras-related protein Rab-9A"
				}
				]
			},
			{
				"name":"Rab8\/10\/13 [OT]",
				"children":[
				{
					"name":"117217094 ras-related protein Rab-8A-like isoform X1\tK07901 RAB8A; Ras-related protein Rab-8A"
				},
				{
					"name":"117209420 ras-related protein Rab-10\tK07903 RAB10; Ras-related protein Rab-10"
				}
				]
			},
			{
				"name":"Rab11\/25 [OT]",
				"children":[
				{
					"name":"117214190 ras-related protein Rab-11A\tK07904 RAB11A; Ras-related protein Rab-11A"
				}
				]
			},
			{
				"name":"Rab12\/18",
				"children":[
				{
					"name":"117215630 ras-related protein Rab-18-like isoform X1\tK07910 RAB18; Ras-related protein Rab-18"
				}
				]
			},
			{
				"name":"Rab15"
			},
			{
				"name":"Rab19\/30\/43 [OT]",
				"children":[
				{
					"name":"117206539 ras-related protein Rab-30-like\tK07917 RAB30; Ras-related protein Rab-30"
				},
				{
					"name":"117213074 ras-related protein Rab-43 isoform X1\tK07930 RAB43; Ras-related protein Rab-43"
				}
				]
			},
			{
				"name":"Rab20\/21\/24 [OT]",
				"children":[
				{
					"name":"117210012 ras-related protein Rab-21\tK07890 RAB21; Ras-related protein Rab-21"
				},
				{
					"name":"117205537 ras-related protein Rab-24-like isoform X1\tK07912 RAB24; Ras-related protein Rab-24"
				}
				]
			},
			{
				"name":"Rab23",
				"children":[
				{
					"name":"117204367 ras-related protein Rab-23\tK06234 RAB23; Ras-related protein Rab-23"
				}
				]
			},
			{
				"name":"Rab26\/37",
				"children":[
				{
					"name":"117209233 ras-related protein Rab-37 isoform X1\tK07914 RAB37; Ras-related protein Rab-37"
				}
				]
			},
			{
				"name":"Rab28",
				"children":[
				{
					"name":"117210922 ras-related protein Rab-28-like\tK07915 RAB28; Ras-related protein Rab-28"
				}
				]
			},
			{
				"name":"Rab29\/32\/38 [OT]",
				"children":[
				{
					"name":"117209536 ras-related protein Rab-32-like\tK07918 RAB32; Ras-related protein Rab-32"
				}
				]
			},
			{
				"name":"Rab33"
			},
			{
				"name":"Rab34\/36",
				"children":[
				{
					"name":"117216960 ras-related protein Rab-34-like\tK07921 RAB34; Ras-related protein Rab-34"
				}
				]
			},
			{
				"name":"Rab39\/42 [OT]",
				"children":[
				{
					"name":"117215845 ras-related protein Rab-39B\tK07925 RAB39B; Ras-related protein Rab-39B"
				}
				]
			},
			{
				"name":"Rab40",
				"children":[
				{
					"name":"117210852 ras-related protein Rab-40C\tK07928 RAB40; Ras-related protein Rab-40"
				}
				]
			},
			{
				"name":"Rab45"
			},
			{
				"name":"Rab-like"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Ran Family",
			"children":[
			{
				"name":"Ran",
				"children":[
				{
					"name":"117214030 GTP-binding nuclear protein Ran\tK07936 RAN; GTP-binding nuclear protein Ran"
				}
				]
			}
			]
		},
		{
			"name":"Arf\/Sar Family",
			"children":[
			{
				"name":"Arf [OT]",
				"children":[
				{
					"name":"117208950 ADP-ribosylation factor 1\tK07937 ARF1_2; ADP-ribosylation factor 1\/2"
				},
				{
					"name":"117208770 ADP-ribosylation factor 2\tK07939 ARF4; ADP-ribosylation factor 4"
				},
				{
					"name":"117212880 ADP-ribosylation factor 6\tK07941 ARF6; ADP-ribosylation factor 6"
				},
				{
					"name":"117216758 ADP-ribosylation factor-like protein 3\tK07941 ARF6; ADP-ribosylation factor 6"
				}
				]
			},
			{
				"name":"Arl1\/Arl5 [OT]",
				"children":[
				{
					"name":"117213693 ADP-ribosylation factor-like protein 1\tK07942 ARL1; ADP-ribosylation factor-like protein 1"
				},
				{
					"name":"117210099 ADP-ribosylation factor-like protein 5B\tK07950 ARL5B; ADP-ribosylation factor-like protein 5B"
				}
				]
			},
			{
				"name":"Arl2\/Arl3",
				"children":[
				{
					"name":"117212792 ADP-ribosylation factor-like protein 2\tK07943 ARL2; ADP-ribosylation factor-like protein 2"
				},
				{
					"name":"117209856 ADP-ribosylation factor-like protein 3\tK07944 ARL3; ADP-ribosylation factor-like protein 3"
				}
				]
			},
			{
				"name":"Arl4\/Arl7",
				"children":[
				{
					"name":"117208924 ADP-ribosylation factor-like protein 4C\tK07945 ARL4; ADP-ribosylation factor-like protein 4"
				}
				]
			},
			{
				"name":"Arl6",
				"children":[
				{
					"name":"117216947 ADP-ribosylation factor-like protein 6 isoform X1\tK07951 ARL6; ADP-ribosylation factor-like protein 6"
				}
				]
			},
			{
				"name":"Arp",
				"children":[
				{
					"name":"117210136 ADP-ribosylation factor-related protein 1\tK07952 ARFRP1; ADP-ribosylation factor related protein 1"
				}
				]
			},
			{
				"name":"Sar",
				"children":[
				{
					"name":"117208853 GTP-binding protein SAR1\tK07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]"
				}
				]
			},
			{
				"name":"Arl8",
				"children":[
				{
					"name":"117208288 ADP-ribosylation factor-like protein 8B-A\tK07955 ARL8; ADP-ribosylation factor-like protein 8"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"117214769 ADP-ribosylation factor-like protein 13B\tK07962 ARL13B; ADP-ribosylation factor-like protein 13B"
				},
				{
					"name":"117217012 E3 ubiquitin-protein ligase TRIM23-like\tK07963 TRIM23; tripartite motif-containing protein 23 [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Unclassified",
			"children":[
			{
				"name":"117209578 rab-like protein 3\tK07933 RABL3; Rab-like protein 3"
			},
			{
				"name":"117209736 intraflagellar transport protein 22 homolog\tK07935 IFT22; intraflagellar transport protein 22"
			},
			{
				"name":"117215642 signal recognition particle receptor subunit beta\tK12272 SRPRB; signal recognition particle receptor subunit beta"
			},
			{
				"name":"117215853 GTP-binding protein 2\tK24888 GTPBP2; GTP-binding protein 2"
			}
			]
		}
		]
	}
	]
}