{
	"name":"bmal01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"DM55_3975 acetyltransferase family protein\tK18816 aac6-I; aminoglycoside 6'-N-acetyltransferase I [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"DM55_4549 sugar (and other) transporter family protein\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"DM55_4239 bla; beta-lactamase Toho-1\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"DM55_4631 heavy metal sensor kinase family protein\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"DM55_4630 response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"DM55_4247 ddpX; D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"DM55_1708 efflux transporter, RND family, MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"DM55_1709 RND transporter, hydrophobe\/amphiphile efflux-1 family protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"DM55_1154 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_1710 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_2152 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_3089 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_3570 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_4442 oprM; outer membrane protein oprM\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_4612 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"DM55_2828 efflux transporter, RND family, MFP subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"DM55_2827 acrB\/AcrD\/AcrF family protein\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"DM55_1154 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_1710 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_2152 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_3089 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_3570 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_4442 oprM; outer membrane protein oprM\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_4612 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"DM55_2948 putative transcriptional regulator domain protein\tK18129 mexZ; TetR\/AcrR family transcriptional regulator, mexXY operon repressor"
				},
				{
					"name":"DM55_2949 efflux transporter, RND family, MFP subunit\tK18094 mexX; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"DM55_2950 acrB\/AcrD\/AcrF family protein\tK18095 mexY; multidrug efflux pump"
				},
				{
					"name":"DM55_1154 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_1710 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_2152 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_3089 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_3570 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_4442 oprM; outer membrane protein oprM\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"DM55_4612 efflux transporter, outer membrane factor (OMF) lipo, NodT family protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"DM55_862 outer membrane efflux family protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"DM55_862 outer membrane efflux family protein\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"DM55_2702 bacterial regulatory helix-turn-helix , lysR family protein\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"DM55_4563 bacterial regulatory helix-turn-helix , lysR family protein\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}