{
	"name":"bmic03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III",
				"children":[
				{
					"name":"B661_mgp03 cob; apocytochrome b\tK00412 CYTB; ubiquinol-cytochrome c reductase cytochrome b subunit"
				}
				]
			},
			{
				"name":"Cytochrome c oxidase",
				"children":[
				{
					"name":"B661_mgp02 cox1; cytochrome c oxidase subunit I\tK02256 COX1; cytochrome c oxidase subunit 1 [EC:7.1.1.9]"
				},
				{
					"name":"BMR1_03g03415 cytochrome c oxidase subunit II\tK02261 COX2; cytochrome c oxidase subunit 2"
				}
				]
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase",
				"children":[
				{
					"name":"BmR1_04g09005 DNA-directed RNA polymerase, mitochondrial\tK10908 POLRMT; DNA-directed RNA polymerase, mitochondrial [EC:2.7.7.6]"
				}
				]
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors",
				"children":[
				{
					"name":"BMR1_02g04235 translation initiation factor IF-2\tK02519 infB; translation initiation factor IF-2"
				},
				{
					"name":"BMR1_02g01720 elongation factor EF-Tu\tK02358 tuf; elongation factor Tu"
				},
				{
					"name":"BMR1_02g01065 Elongation factor Tu GTP binding domain\tK02355 fusA; elongation factor G"
				},
				{
					"name":"BmR1_04g09525 elongation factor EF-G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"RNase MRP",
				"children":[
				{
					"name":"BmR1_04g09640 POP1, ribonuclease P\/MRP protein subunit POP1\tK01164 POP1; ribonuclease P\/MRP protein subunit POP1 [EC:3.1.26.5]"
				},
				{
					"name":"BmR1_04g09205 POP4, RPP29, ribonuclease P protein subunit POP4\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"BmR1_04g07330 hypothetical protein\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				}
				]
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"BmR1_04g08550 Lactation elevated protein 1\tK18798 AFG1; peroxisome-assembly ATPase [EC:3.6.4.7]"
				},
				{
					"name":"BMR1_03g04575 splicing factor 1\tK17675 SUPV3L1; ATP-dependent RNA helicase SUPV3L1\/SUV3 [EC:5.6.2.6]"
				},
				{
					"name":"BMR1_01G02590 solute carrier family 25 (mitochondrial carrier, adenine nucleotide)\tK05863 SLC25A4S; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4\/5\/6\/31"
				},
				{
					"name":"BmR1_04g09410 mitochondrial carrier protein, MC family\tK15113 SLC25A28_37; solute carrier family 25 (mitochondrial iron transporter), member 28\/37"
				},
				{
					"name":"BmR1_04g06780 GTPase Era\tK03595 era; GTPase"
				},
				{
					"name":"BMR1_01G00295 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"BMR1_01G01655 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"BmR1_04g06445 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"BMR1_03g00240 glycyl-tRNA synthetase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"BMR1_01G00100 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"BMR1_03g02600 arginyl-tRNA synthetase\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"BmR1_04g09180 GatB\/GatE catalytic domain\tK02434 gatB; aspartyl-tRNA(Asn)\/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]"
				},
				{
					"name":"BmR1_04g09945 2'5'-phosphodiesterase 12\tK19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]"
				},
				{
					"name":"BMR1_01G00535 Ribosome biogenesis GTPase A\tK19828 MTG1; mitochondrial GTPase 1"
				},
				{
					"name":"BmR1_04g07090 Mitochondrial ribosome-associated GTPase 1\tK19828 MTG1; mitochondrial GTPase 1"
				},
				{
					"name":"BMR1_02g00533 Probable peptide chain release factor C12orf65 mitochondrial\tK23498 COXPD7; peptide chain release factor"
				},
				{
					"name":"BmR1_04g06530 UPF0160 protein MYG1 mitochondrial\tK25877 MYG1; MYG1 exonuclease [EC:3.1.-.-]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase"
			},
			{
				"name":"Mitochondrial DNA maintenance factors"
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"BMR1_01G03165 Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"BMR1_02g01695 ATPase family AAA domain-containing protein 3\tK17681 ATAD3A_B; ATPase family AAA domain-containing protein 3A\/B"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors",
				"children":[
				{
					"name":"BMR1_03g00965 DnaJ homolog subfamily A member 2\tK09503 DNAJA2; DnaJ homolog subfamily A member 2"
				},
				{
					"name":"BMR1_01G02545 HSPA1_8, heat shock 70kDa protein 1\/8\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
				}
				]
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex",
				"children":[
				{
					"name":"BMR1_01G02355 mitochondrial import receptor subunit TOM22, putative (TOM22)\tK17769 TOM22; mitochondrial import receptor subunit TOM22"
				},
				{
					"name":"BmR1_04g09755 mitochondrial import receptor subunit TOM40\tK11518 TOM40; mitochondrial import receptor subunit TOM40"
				}
				]
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"BmR1_04g09565 Sorting and assembly machinery component 50 homolog A\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex",
				"children":[
				{
					"name":"BMR1_03g03835 Mitochondrial import inner membrane translocase subunit Tim9\tK17777 TIM9; mitochondrial import inner membrane translocase subunit TIM9"
				},
				{
					"name":"BMR1_03g00835 Mitochondrial import inner membrane translocase subunit Tim10\tK17778 TIM10; mitochondrial import inner membrane translocase subunit TIM10"
				}
				]
			},
			{
				"name":"TIM8\/13 complex",
				"children":[
				{
					"name":"BMR1_02g01668 mitochondrial import inner membrane translocase subunit TIM13, putative (TIM13)\tK17780 TIM8; mitochondrial import inner membrane translocase subunit TIM8"
				},
				{
					"name":"BMR1_02g03802 mitochondrial inner membrane TIM10 associated protein, putative\tK17781 TIM13; mitochondrial import inner membrane translocase subunit TIM13"
				}
				]
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex",
				"children":[
				{
					"name":"BMR1_02g02015 conserved Plasmodium protein, unknown function\tK17783 ERV1; mitochondrial FAD-linked sulfhydryl oxidase [EC:1.8.3.2]"
				},
				{
					"name":"BMR1_03g02000 Mitochondrial FAD-linked sulfhydryl oxidase ERV1\tK17783 ERV1; mitochondrial FAD-linked sulfhydryl oxidase [EC:1.8.3.2]"
				}
				]
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex",
				"children":[
				{
					"name":"BmR1_04g05165 Mitochondrial import inner membrane translocase subunit tim22\tK17790 TIM22; mitochondrial import inner membrane translocase subunit TIM22"
				}
				]
			},
			{
				"name":"TIM23 complex",
				"children":[
				{
					"name":"BMR1_03g03535 mitochondrial import inner membrane translocase subunit TIM23, putative (TIM23)\tK17794 TIM23; mitochondrial import inner membrane translocase subunit TIM23"
				},
				{
					"name":"BMR1_03g00755 Tim17\/Tim22\/Tim23\/Pmp24 family\tK17795 TIM17; mitochondrial import inner membrane translocase subunit TIM17"
				},
				{
					"name":"BMR1_02g02090 NLI interacting factor-like phosphatase\tK17496 TIM50; mitochondrial import inner membrane translocase subunit TIM50"
				}
				]
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors",
				"children":[
				{
					"name":"BMR1_02g03905 LETM1-like protein\tK17800 LETM1; mitochondrial proton\/calcium exchanger protein"
				},
				{
					"name":"BMR1_02g03240 mitochondrial inner membrane protease subunit 1\tK09647 IMP1; mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-]"
				},
				{
					"name":"BmR1_04g05170 Uncharacterized methyltransferase C3B9.04 mitochondrial\tK17803 OMS1; methyltransferase OMS1, mitochondrial [EC:2.1.1.-]"
				},
				{
					"name":"BMR1_03g04355 Uncharacterised protein family (UPF0041)\tK22138 MPC1; mitochondrial pyruvate carrier 1"
				},
				{
					"name":"BMR1_02g01667 Mitochondrial pyruvate carrier 2\tK22139 MPC2; mitochondrial pyruvate carrier 2"
				}
				]
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"BMR1_03g00750 Mitochondrial import inner membrane translocase subunit TIM44\tK17804 TIM44; mitochondrial import inner membrane translocase subunit TIM44"
				},
				{
					"name":"BmR1_04g08040 molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"BMR1_03g00730 molecular chaperone GrpE\tK03687 GRPE; molecular chaperone GrpE"
				},
				{
					"name":"BMR1_03g02315 protein pelota\tK09539 DNAJC19; DnaJ homolog subfamily C member 19"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"BmR1_04g08505 mitochondrial processing peptidase\tK01412 PMPCA; mitochondrial-processing peptidase subunit alpha [EC:3.4.24.64]"
				},
				{
					"name":"BMR1_02g00260 mitochondrial processing peptidase\tK17732 PMPCB; mitochondrial-processing peptidase subunit beta [EC:3.4.24.64]"
				},
				{
					"name":"BMR1_03g00560 mitochondrial intermediate peptidase\tK01410 MIPEP; mitochondrial intermediate peptidase [EC:3.4.24.59]"
				},
				{
					"name":"BMR1_03g03315 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"BMR1_03g04270 chaperonin GroEL\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"BMR1_02g00395 chaperonin GroES\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"BMR1_01G02830 molecular chaperone DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				},
				{
					"name":"BMR1_02g02565 Chaperone protein DnaJ\tK03686 dnaJ; molecular chaperone DnaJ"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors",
				"children":[
				{
					"name":"BMR1_02g01065 Elongation factor Tu GTP binding domain\tK02355 fusA; elongation factor G"
				},
				{
					"name":"BmR1_04g09525 elongation factor EF-G\tK02355 fusA; elongation factor G"
				}
				]
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"BMR1_03g04230 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"BMR1_02g00446 nitrogen fixation protein NifU and related proteins\tK22068 ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial"
				},
				{
					"name":"BMR1_02g01335 protein ISD11, putative (ISD11)\tK22069 LYRM4; LYR motif-containing protein 4"
				},
				{
					"name":"BMR1_02g00365 2Fe-2S ferredoxin\tK22071 FDX2; ferredoxin-2, mitochondrial"
				},
				{
					"name":"BMR1_03g00286 ferredoxin--NADP+ reductase\tK18914 FDXR; adrenodoxin-NADP+ reductase [EC:1.18.1.6]"
				},
				{
					"name":"BmR1_04g08040 molecular chaperone DnaK\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"BMR1_01G02321 Iron-sulfur cluster co-chaperone protein HscB mitochondrial\tK04082 hscB; molecular chaperone HscB"
				},
				{
					"name":"BMR1_02g02145 Monothiol glutaredoxin-S11\tK07390 grxD; monothiol glutaredoxin"
				},
				{
					"name":"BmR1_04g06260 iron-sulfur cluster assembly protein\tK22063 ISCA1; iron-sulfur cluster assembly 1"
				},
				{
					"name":"BmR1_04g07630 Iron-sulfur assembly protein IscA-like 2 mitochondrial\tK22072 ISCA2; iron-sulfur cluster assembly 2"
				},
				{
					"name":"BMR1_03g04682 Putative transferase CAF17 mitochondrial\tK22073 IBA57; transferase CAF17, mitochondrial [EC:2.1.-.-]"
				},
				{
					"name":"BmR1_04g06390 NifU-like protein C1709.19c\tK22074 NFU1; NFU1 iron-sulfur cluster scaffold homolog, mitochondrial"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis",
				"children":[
				{
					"name":"BmR1_04g06650 Protein tyrosine kinase\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]"
				},
				{
					"name":"BMR1_03g02710 Protein SERAC1\tK23504 SERAC1; protein SERAC1"
				},
				{
					"name":"BMR1_03g00230 DDX47, RRP3, ATP-dependent RNA helicase DDX47\/RRP3\tK14777 DDX47; ATP-dependent RNA helicase DDX47\/RRP3 [EC:5.6.2.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors"
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors",
				"children":[
				{
					"name":"BMR1_02g00285 BCS1 N terminal\tK08900 BCS1; mitochondrial chaperone BCS1"
				}
				]
			},
			{
				"name":"Complex-IV assembly factors",
				"children":[
				{
					"name":"BMR1_02g03022 cytochrome c oxidase assembly protein, putative\tK18178 COA5; cytochrome c oxidase assembly factor 5"
				},
				{
					"name":"BmR1_04g08725 ATP-dependent RNA helicase DDX23\/PRP28\tK02257 COX10; heme o synthase [EC:2.5.1.141]"
				},
				{
					"name":"BMR1_02g00065 cytochrome c oxidase subunit XI assembly protein\tK02258 COX11; cytochrome c oxidase assembly protein subunit 11"
				},
				{
					"name":"BmR1_04g05520 cytochrome c oxidase subunit XV assembly protein\tK02259 COX15; heme a synthase [EC:1.17.99.9]"
				},
				{
					"name":"BMR1_01G01250 cytochrome c oxidase subunit XVII assembly protein\tK02260 COX17; cytochrome c oxidase assembly protein subunit 17"
				},
				{
					"name":"BMR1_03g01435 Cytochrome c oxidase assembly protein COX19\tK18183 COX19; cytochrome c oxidase assembly protein subunit 19"
				},
				{
					"name":"BmR1_04g09135 hypothetical protein\tK18183 COX19; cytochrome c oxidase assembly protein subunit 19"
				},
				{
					"name":"BMR1_01G01645 preprotein translocase subunit YidC\tK03217 yidC; YidC\/Oxa1 family membrane protein insertase"
				},
				{
					"name":"BMR1_02g03835 SURF1 family\tK14998 SURF1; surfeit locus 1 family protein"
				},
				{
					"name":"BmR1_04g08740 sco1\/2-like protein\tK07152 SCO1; protein SCO1"
				}
				]
			},
			{
				"name":"Complex-V assembly factors",
				"children":[
				{
					"name":"BMR1_03g00305 ATP synthase mitochondrial F1 complex assembly factor 1\tK07555 ATPeAF1; ATP synthase mitochondrial F1 complex assembly factor 1"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors",
				"children":[
				{
					"name":"BmR1_04g09231 Optic atrophy 3 protein (OPA3)\tK23166 OPA3; optic atrophy 3 protein"
				},
				{
					"name":"BMR1_01G02575 dynamin GTPase\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]"
				},
				{
					"name":"BMR1_02g02560 mitochondrial fission 1 protein, putative (FIS1)\tK17969 FIS1; mitochondrial fission 1 protein"
				}
				]
			},
			{
				"name":"Actin cytoskeleton organization",
				"children":[
				{
					"name":"BmR1_04g06305 peptide alpha-N-acetyltransferase\tK17972 NAA20; N-terminal acetyltransferase B complex catalytic subunit [EC:2.3.1.254]"
				}
				]
			},
			{
				"name":"Mitochondrial movement",
				"children":[
				{
					"name":"BMR1_01G01640 Prohibitin-4 mitochondrial\tK17080 PHB1; prohibitin 1"
				},
				{
					"name":"BMR1_02g00405 Prohibitin-2\tK17081 PHB2; prohibitin 2"
				}
				]
			},
			{
				"name":"Retention of mitochondria",
				"children":[
				{
					"name":"BMR1_01G02575 dynamin GTPase\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]"
				},
				{
					"name":"BMR1_03g01547 Myosin-13\tK10357 MYO5; myosin V"
				},
				{
					"name":"BMR1_03g03720 myosin ATPase\tK10357 MYO5; myosin V"
				}
				]
			},
			{
				"name":"Morphogenesis factors",
				"children":[
				{
					"name":"BMR1_02g00230 Mitochondrial ribosomal death-associated protein 3\tK17408 DAP3; small subunit ribosomal protein S29"
				}
				]
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins",
				"children":[
				{
					"name":"BMR1_01G01105 autophagy-related protein 3, putative (ATG3)\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
				},
				{
					"name":"BMR1_03g00700 autophagy-related protein 7\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7"
				},
				{
					"name":"BMR1_03g03150 GABA(A) receptor-associated protein (autophagy-related protein 8)\tK08341 GABARAP; GABA(A) receptor-associated protein"
				}
				]
			},
			{
				"name":"Parkin-dependent mechanism factors",
				"children":[
				{
					"name":"BMR1_02g03135 conserved Plasmodium protein, unknown function\tK19513 CLEC16A; protein CLEC16A"
				}
				]
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"BmR1_04g08775 molecular chaperone HtpG\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors",
				"children":[
				{
					"name":"BmR1_04g06650 Protein tyrosine kinase\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]"
				}
				]
			}
			]
		}
		]
	}
	]
}