{
	"name":"bsl02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins"
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins"
			},
			{
				"name":"Subtype I-A factors"
			},
			{
				"name":"Subtype I-B factors"
			},
			{
				"name":"Subtype I-C factors"
			},
			{
				"name":"Subtype I-D factors"
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors"
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"A7A1_1718 Type I restriction-modification system R subunit HsdR\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"A7A1_1717 Restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"A7A1_1716 Type I restriction-modification system methyltransferase subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"A7A1_0732 Hypothetical protein YtxK\tK00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]"
				},
				{
					"name":"A7A1_1060 Modification methylase BamHI\tK00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"A7A1_0315 Hypothetical protein YisB\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"A7A1_1303 Hypothetical protein\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"A7A1_1399 Endoribonuclease EndoA\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"A7A1_1398 Antitoxin EndoAI\tK07723 ndoAI; CopG family transcriptional regulator \/ antitoxin EndoAI"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM"
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK",
				"children":[
				{
					"name":"A7A1_0844 TopI - like protein YobL\tK21487 yobL; toxin YobL [EC:3.1.-.-]"
				},
				{
					"name":"A7A1_2771 TopI - like protein YobL\tK21487 yobL; toxin YobL [EC:3.1.-.-]"
				},
				{
					"name":"A7A1_0843 Hypothetical protein YobK\tK21488 yobK; antitoxin YobK"
				},
				{
					"name":"A7A1_2770 Hypothetical protein YobK\tK21488 yobK; antitoxin YobK"
				}
				]
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB",
				"children":[
				{
					"name":"A7A1_1426 Stage II sporulation protein spoIISA\tK06388 spoIISA; stage II sporulation protein SA"
				},
				{
					"name":"A7A1_1425 Stage II sporulation protein spoIISB\tK06389 spoIISB; stage II sporulation protein SB"
				}
				]
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"A7A1_0496 Cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"A7A1_0444 Septum protein MreB\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"A7A1_0581 Cell-shape determining rotein MreBH\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"A7A1_1074 MreB-like Mbl protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"A7A1_0698 Gram positive topoisomerase IV, subunit A\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"A7A1_0697 DNA topoisomerase IV subunit B\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA"
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"A7A1_0393 Hypothetical protein YrvO\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"A7A1_0429 Cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"A7A1_0721 NifS - like protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}