{
	"name":"bstg01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]"
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases"
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases"
			},
			{
				"name":"O-Phosphotransferases"
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters",
				"children":[
				{
					"name":"WT74_03715 MFS transporter\tK08151 tetA; MFS transporter, DHA1 family, tetracycline resistance protein"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters"
			},
			{
				"name":"Others"
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases"
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"WT74_27960 class A beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				},
				{
					"name":"WT74_29835 class A beta-lactamase\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]",
				"children":[
				{
					"name":"WT74_17600 histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"WT74_24430 histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"WT74_25880 histidine kinase\tK07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]"
				},
				{
					"name":"WT74_17605 two-component system response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"WT74_24435 two-component system response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				},
				{
					"name":"WT74_25885 two-component system response regulator\tK07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR"
				}
				]
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"WT74_18245 hypothetical protein\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				},
				{
					"name":"WT74_27915 D-alanyl-D-alanine dipeptidase\tK08641 vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22]"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"WT74_26325 hypothetical protein\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"WT74_27425 hypothetical protein\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]",
				"children":[
				{
					"name":"WT74_13860 hemolysin D\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_16885 hypothetical protein\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_25895 RND transporter MFP subunit\tK03585 acrA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_13855 multidrug transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"WT74_16880 hypothetical protein\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"WT74_25900 RND transporter\tK18138 acrB; multidrug efflux pump"
				},
				{
					"name":"WT74_00400 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_06285 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_07310 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_07605 MarR family transcriptional regulator\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_08385 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_13850 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_26530 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_26695 hypothetical protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_29915 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]",
				"children":[
				{
					"name":"WT74_28800 RND transporter\tK18300 oprN; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]",
				"children":[
				{
					"name":"WT74_09170 RND transporter MFP subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_18990 RND transporter MFP subunit\tK18302 mexJ; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_09175 multidrug transporter AcrB\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"WT74_18995 multidrug transporter AcrB\tK18303 mexK; multidrug efflux pump"
				},
				{
					"name":"WT74_00400 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_06285 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_07310 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_07605 MarR family transcriptional regulator\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_08385 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_13850 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_26530 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_26695 hypothetical protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_29915 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]",
				"children":[
				{
					"name":"WT74_08370 TetR family transcriptional regulator\tK18129 mexZ; TetR\/AcrR family transcriptional regulator, mexXY operon repressor"
				},
				{
					"name":"WT74_08375 multidrug transporter\tK18094 mexX; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_08380 multidrug transporter\tK18095 mexY; multidrug efflux pump"
				},
				{
					"name":"WT74_00400 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_06285 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_07310 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_07605 MarR family transcriptional regulator\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_08385 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_13850 multidrug transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_26530 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_26695 hypothetical protein\tK18139 oprM; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_29915 RND transporter\tK18139 oprM; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]",
				"children":[
				{
					"name":"WT74_11700 MerR family transcriptional regulator\tK19591 cueR; MerR family transcriptional regulator, copper efflux regulator"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]",
				"children":[
				{
					"name":"WT74_06250 histidine kinase\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"WT74_06265 histidine kinase\tK18143 adeS; two-component system, OmpR family, sensor histidine kinase AdeS [EC:2.7.13.3]"
				},
				{
					"name":"WT74_06270 two-component system response regulator\tK18144 adeR; two-component system, OmpR family, response regulator AdeR"
				},
				{
					"name":"WT74_06275 RND transporter\tK18145 adeA; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_06280 acriflavine resistance protein B\tK18146 adeB; multidrug efflux pump"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]",
				"children":[
				{
					"name":"WT74_25300 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"WT74_28690 RND transporter\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"WT74_31200 histidine kinase\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"WT74_31985 anibiotic ABC transporter\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]",
				"children":[
				{
					"name":"WT74_25300 hypothetical protein\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"WT74_28690 RND transporter\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"WT74_31200 histidine kinase\tK12340 tolC; outer membrane protein"
				},
				{
					"name":"WT74_31985 anibiotic ABC transporter\tK12340 tolC; outer membrane protein"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]",
				"children":[
				{
					"name":"WT74_14105 transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"WT74_19680 transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"WT74_27985 transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"WT74_31595 LysR family transcriptional regulator\tK18900 bpeT; LysR family transcriptional regulator, regulator for bpeEF and oprC"
				},
				{
					"name":"WT74_27450 hemolysin secretion protein D\tK18901 bpeE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_31585 hemolysin secretion protein D\tK18901 bpeE; membrane fusion protein, multidrug efflux system"
				},
				{
					"name":"WT74_27445 transporter\tK18902 bpeF; multidrug efflux pump"
				},
				{
					"name":"WT74_31580 transporter\tK18902 bpeF; multidrug efflux pump"
				},
				{
					"name":"WT74_25890 RND transporter\tK18903 oprC; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_27440 RND transporter\tK18903 oprC; outer membrane protein, multidrug efflux system"
				},
				{
					"name":"WT74_31575 RND transporter\tK18903 oprC; outer membrane protein, multidrug efflux system"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]"
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]"
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}