{
	"name":"bww01504",
	"children":[
	{
		"name":"Gene variants",
		"children":[
		{
			"name":"beta-Lactamase genes",
			"children":[
			{
				"name":"Class A [MT]",
				"children":[
				{
					"name":"bwei_5861 blaTEM-116; ampicillin resistance protein\tK18698 blaTEM; beta-lactamase class A TEM [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Class D [MT]"
			},
			{
				"name":"Class C [MT]"
			},
			{
				"name":"Class B [MT]"
			}
			]
		},
		{
			"name":"Aminoglycoside resistance genes",
			"children":[
			{
				"name":"N-Acetyltransferases",
				"children":[
				{
					"name":"bwei_2105 yokD; aminoglycoside N(3')-acetyltransferase-like protein yokD\tK00662 aacC; aminoglycoside 3-N-acetyltransferase [EC:2.3.1.81]"
				},
				{
					"name":"bwei_2069 Acetyltransferase, GNAT\tK00663 aacA; aminoglycoside 6'-N-acetyltransferase [EC:2.3.1.82]"
				}
				]
			},
			{
				"name":"Other acetyltransferases"
			},
			{
				"name":"O-Nucleotidyltransferases",
				"children":[
				{
					"name":"bwei_3054 aadK; aminoglycoside 6-adenylyltransferase\tK05593 aadK; aminoglycoside 6-adenylyltransferase [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"O-Phosphotransferases",
				"children":[
				{
					"name":"bwei_3621 Aminoglycoside phosphotransferase\tK17910 aphD; aminoglycoside 2''-phosphotransferase [EC:2.7.1.190]"
				}
				]
			},
			{
				"name":"16S rRNA methyltransferases"
			}
			]
		},
		{
			"name":"Tetracycline resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"bwei_1994 tetP; Tetracycline resistance protein, GTP-binding elongation family\tK18220 tetM; ribosomal protection tetracycline resistance protein"
				}
				]
			}
			]
		},
		{
			"name":"Macrolide resistance genes",
			"children":[
			{
				"name":"23S rRNA methyltransferases"
			},
			{
				"name":"Transporters",
				"children":[
				{
					"name":"bwei_2294 ccmA2; heme ABC exporter, ATP-binding protein CcmA\tK18231 msr; macrolide transport system ATP-binding\/permease protein"
				},
				{
					"name":"bwei_4615 vba; Macrolide efflux pump\tK18231 msr; macrolide transport system ATP-binding\/permease protein"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"bwei_3138 vgb; virginiamycin B lyase\tK18235 vgb; virginiamycin B lyase [EC:4.2.99.-]"
				},
				{
					"name":"bwei_2318 vatD; streptogramin A acetyltransferase\tK18234 vat; virginiamycin A acetyltransferase [EC:2.3.1.-]"
				}
				]
			}
			]
		},
		{
			"name":"Phenicol resistance genes",
			"children":[
			{
				"name":"Transporters"
			},
			{
				"name":"Acetyltransferases",
				"children":[
				{
					"name":"bwei_2533 catB1; Chloramphenicol acetyltransferase\tK00638 catB; chloramphenicol O-acetyltransferase type B [EC:2.3.1.28]"
				}
				]
			},
			{
				"name":"Phosphotransferase"
			},
			{
				"name":"23S rRNA methyltransferase"
			}
			]
		},
		{
			"name":"Sulfonamide resistance genes",
			"children":[
			{
				"name":"Dihydropteroate synthase"
			}
			]
		},
		{
			"name":"Trimethoprim resistance genes",
			"children":[
			{
				"name":"Dihydrofolate reductases"
			}
			]
		},
		{
			"name":"Quinolone resistance genes",
			"children":[
			{
				"name":"Transporter"
			},
			{
				"name":"Other"
			}
			]
		},
		{
			"name":"Rifamycin resistance genes",
			"children":[
			{
				"name":"ADP-ribosyl transferases"
			},
			{
				"name":"Oxygenases"
			}
			]
		},
		{
			"name":"Fosfomycin resistance genes",
			"children":[
			{
				"name":"Transferases"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Gene sets",
		"children":[
		{
			"name":"beta-Lactam resistance modules",
			"children":[
			{
				"name":"Methicillin resistance [MD:M00625]"
			},
			{
				"name":"beta-Lactam resistance, Bla system [MD:M00627]",
				"children":[
				{
					"name":"bwei_1519 mecR1; Methicillin resistance mecR1 protein\tK02172 blaR1; bla regulator protein blaR1"
				},
				{
					"name":"bwei_1518 blaI; penicillinase repressor\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"bwei_2413 blaZ2; beta-lactamase 3\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				},
				{
					"name":"bwei_2507 penPC; beta-lactamase 1\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				},
				{
					"name":"bwei_4089 blaZ1; beta-lactamase 3\tK17836 penP; beta-lactamase class A [EC:3.5.2.6]"
				}
				]
			},
			{
				"name":"Imipenem resistance, repression of porin OprD [MD:M00745]"
			}
			]
		},
		{
			"name":"Vancomycin resistance modules",
			"children":[
			{
				"name":"Vancomycin resistance, D-Ala-D-Lac type [MD:M00651]",
				"children":[
				{
					"name":"bwei_2411 HAMP domain protein\tK18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]"
				},
				{
					"name":"bwei_2410 Two-component response regulator vanRB\tK18344 vanRB; two-component system, OmpR family, response regulator VanR"
				},
				{
					"name":"bwei_4734 vanRB; Two-component response regulator vanRB\tK18344 vanRB; two-component system, OmpR family, response regulator VanR"
				},
				{
					"name":"bwei_0033 vanY; D-alanyl-D-alanine carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"bwei_0383 dacF3; D-alanyl-D-alanine carboxypeptidase DacF\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"bwei_1528 dacA4; D-alanyl-D-alanine carboxypeptidase VanY\/endolysin\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"bwei_1775 vanYB; D-alanyl-D-alanine carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"bwei_2957 dacF1; D-alanyl-D-alanine carboxypeptidase family protein\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"bwei_5334 dacA3; D-alanyl-D-alanine carboxypeptidase\tK07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]"
				},
				{
					"name":"bwei_4026 Vancomycin B-type resistance protein vanW\tK18346 vanW; vancomycin resistance protein VanW"
				}
				]
			},
			{
				"name":"Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]",
				"children":[
				{
					"name":"B  Tetracycline resistance"
				}
				]
			},
			{
				"name":"Tetracycline resistance, efflux pump Tet38 [MD:M00704]"
			}
			]
		},
		{
			"name":"CAMP resistance modules",
			"children":[
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, dltABCD operon [MD:M00725]",
				"children":[
				{
					"name":"bwei_3627 dltA1; D-alanine--poly(phosphoribitol) ligase, subunit 1\tK03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]"
				},
				{
					"name":"bwei_3628 dltB; D-alanyl-lipoteichoic acid biosynthesis protein DltB\tK03739 dltB; membrane protein involved in D-alanine export"
				},
				{
					"name":"bwei_3629 dltC2; D-alanine--poly(phosphoribitol) ligase, subunit 2\tK14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]"
				},
				{
					"name":"bwei_5466 dltC1; D-alanine--poly(phosphoribitol) ligase, subunit 2\tK14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]"
				},
				{
					"name":"bwei_2183 dltD1; D-alanyl-lipoteichoic acid biosynthesis protein DltD\tK03740 dltD; D-alanine transfer protein"
				},
				{
					"name":"bwei_3630 dltD2; D-alanyl-lipoteichoic acid biosynthesis protein DltD\tK03740 dltD; D-alanine transfer protein"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, lysyl-phosphatidylglycerol (L-PG) synthase MprF [MD:M00726]",
				"children":[
				{
					"name":"bwei_3528 mprF; phosphatidylglycerol lysyltransferase\tK14205 mprF; phosphatidylglycerol lysyltransferase [EC:2.3.2.3]"
				}
				]
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, VraFG transporter [MD:M00730]"
			},
			{
				"name":"Cationic antimicrobial peptide (CAMP) resistance, protease PgtE [MD:M00744]"
			}
			]
		},
		{
			"name":"Multipdrug resistance modules",
			"children":[
			{
				"name":"Multidrug resistance, efflux pump MexAB-OprM [MD:M00718]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexCD-OprJ [MD:M00639]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexEF-OprN [MD:M00641]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexJK-OprM [MD:M00642]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexXY-OprM [MD:M00643]"
			},
			{
				"name":"Multidrug resistance, efflux pump MexPQ-OpmE [MD:M00769]"
			},
			{
				"name":"Multidrug resistance, efflux pump AdeABC [PATH:map01501] [MD:M00649]"
			},
			{
				"name":"Multidrug resistance, efflux pump AcrEF-TolC [MD:M00696]"
			},
			{
				"name":"Multidrug resistance, efflux pump MdtEF-TolC [MD:M00697]"
			},
			{
				"name":"Multidrug resistance, efflux pump BpeEF-OprC [MD:M00698]"
			},
			{
				"name":"Multidrug resistance, efflux pump AbcA [MD:M00700]",
				"children":[
				{
					"name":"bwei_2359 Transcriptional regulator, GntR\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				},
				{
					"name":"bwei_3059 bmrA; multidrug resistance ABC transporter ATP-binding\/permease protein BmrA\tK18104 abcA; ATP-binding cassette, subfamily B, bacterial AbcA\/BmrA [EC:7.6.2.2]"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump NorB [MD:M00702]",
				"children":[
				{
					"name":"bwei_2359 Transcriptional regulator, GntR\tK18907 norG; GntR family transcriptional regulator, regulator for abcA and norABC"
				}
				]
			},
			{
				"name":"Multidrug resistance, efflux pump QacA [MD:M00714]"
			},
			{
				"name":"Multidrug resistance, efflux pump MepA [MD:M00705]"
			},
			{
				"name":"Multidrug resistance, repression of porin OmpF [MD:M00746]"
			}
			]
		}
		]
	}
	]
}