{
	"name":"cal03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"CAALFM_C407010CA CaO19.3108; methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"CAALFM_C306400CA CaO19.7425; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"CAALFM_C306530WA CaO19.7442; hypothetical protein\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"CAALFM_C703910WA OGG1; 8-oxoguanine glycosylase\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"CAALFM_C108200WA NTG1; bifunctional N-glycosylase\/AP lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"CAALFM_C306430WA APN1; DNA-(apurinic or apyrimidinic site) lyase\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"CAALFM_C110650WA APN2; DNA-(apurinic or apyrimidinic site) lyase\tK10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"CAALFM_C702790CA POL3; DNA-directed DNA polymerase delta\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"CAALFM_C504740CA HYS2; DNA-directed DNA polymerase delta subunit\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"CAALFM_C105850WA POL32; DNA polymerase delta subunit\tK03504 POLD3; DNA polymerase delta subunit 3"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"CAALFM_CR07000CA POL2; DNA polymerase epsilon catalytic subunit\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"CAALFM_CR09900CA DPB2; DNA polymerase epsilon noncatalytic subunit\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"CAALFM_C200430CA DPB4; DNA polymerase epsilon noncatalytic subunit\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						},
						{
							"name":"CAALFM_C103640CA HFL1; DNA polymerase epsilon noncatalytic subunit\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"CAALFM_C401770WA POL30; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"CAALFM_CR04560CA CaO19.547; multifunctional nuclease\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"CAALFM_C300830CA CaO19.6155; DNA ligase (ATP)\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"CAALFM_CR03440WA CaO19.2376; hypothetical protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"CAALFM_CR03590CA CaO19.4383; DNA 5'-adenosine monophosphate hydrolase\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"CAALFM_C307660WA CaO19.6722; hypothetical protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"CAALFM_C201850WA RAD23; Rad23p\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"CAALFM_C302450WA HRT1; SCF ubiquitin ligase complex subunit\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"CAALFM_C106040WA RTT101; cullin\tK10609 CUL4; cullin 4"
						}
						]
					},
					{
						"name":"NER4 complex",
						"children":[
						{
							"name":"CAALFM_C201840CA RAD7; UV-damaged DNA-binding protein\tK15082 RAD7; DNA repair protein RAD7"
						},
						{
							"name":"CAALFM_C102810WA RAD16; DNA repair protein\tK15083 RAD16; DNA repair protein RAD16"
						}
						]
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"CAALFM_CR10680WA RPO21; DNA-directed RNA polymerase II core subunit\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"CAALFM_C101590CA CaO19.3349; DNA-directed RNA polymerase II core subunit\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"CAALFM_C405630WA CaO19.1248; DNA-directed RNA polymerase II core subunit\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"CAALFM_C204650CA RPB4; DNA-directed RNA polymerase II subunit\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"CAALFM_C112820CA CaO19.6340; DNA-directed RNA polymerase core subunit\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"CAALFM_C503360WA RPO26; DNA-directed RNA polymerase core subunit\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"CAALFM_C101570CA RPB7; DNA-directed RNA polymerase II subunit\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"CAALFM_CR04780WA RPB8; DNA-directed RNA polymerase core subunit\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"CAALFM_C207200WA CaO19.2276; DNA-directed RNA polymerase II core subunit\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"CAALFM_C403040WA DNA-directed RNA polymerase core subunit\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"CAALFM_C100940WA RPB11; DNA-directed RNA polymerase II core subunit\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"CAALFM_C114390WA RPC10; DNA-directed RNA polymerase core subunit\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"CAALFM_C302450WA HRT1; SCF ubiquitin ligase complex subunit\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"CAALFM_C106040WA RTT101; cullin\tK10609 CUL4; cullin 4"
						},
						{
							"name":"CAALFM_C302770CA CaO19.268; hypothetical protein\tK10570 ERCC8; DNA excision repair protein ERCC-8"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"CAALFM_CR07910CA CaO19.607; DNA-dependent ATPase\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"CAALFM_CR05910WA CaO19.6623; hypothetical protein\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"CAALFM_CR02970CA CaO19.2857; TFIIH\/NER complex ATPase\/helicase subunit\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"CAALFM_C700050CA RAD3; TFIIH\/NER complex ATP-dependent 5'-3' DNA helicase subunit\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"CAALFM_C404120CA CaO19.5297; TFIIH\/NER complex subunit\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"CAALFM_C201490CA CaO19.1457; TFIIH\/NER complex subunit\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"CAALFM_C600640CA CaO19.4194; TFIIH\/NER complex subunit\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"CAALFM_CR05560WA CaO19.5846; TFIIH\/NER complex subunit\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"CAALFM_C107280CA TFIIH complex subunit\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"CAALFM_C106710WA CaO19.6239; TFIIH complex serine\/threonine-protein kinase subunit\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"CAALFM_C101820CA CaO19.4542; TFIIH complex kinase subunit\tK06634 CCNH; cyclin H"
					},
					{
						"name":"CAALFM_C500690CA TFB3; TFIIH\/NER complex subunit\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"CAALFM_C200380CA RFA1; replication factor A subunit protein\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"CAALFM_C207120WA RFA2; Rfa2p\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"CAALFM_C109670CA CaO19.4830; hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"CAALFM_C702020WA RAD14; Rad14p\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"CAALFM_C105820CA RAD10; Rad10p\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"CAALFM_C210440CA RAD1; ssDNA endodeoxyribonuclease\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"CAALFM_C403550WA RAD2; ssDNA endodeoxyribonuclease\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"CAALFM_C300830CA CaO19.6155; DNA ligase (ATP)\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"CAALFM_C301450CA MET18; Met18p\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"CAALFM_C502730CA CaO19.4293; iron-sulfur cluster assembly protein\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"CAALFM_C702550CA CaO19.6455; iron-sulfur cluster assembly protein\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"CAALFM_CR00370WA CaO19.7497; cullin\tK03869 CUL3; cullin 3"
					},
					{
						"name":"CAALFM_C104550WA ELC1; elongin C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"CAALFM_C103810CA ELA1; elongin A\tK15077 ELA1; elongin-A"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"CAALFM_C407120CA MSH2; mismatch repair ATPase\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"CAALFM_C208680WA MSH3; mismatch repair protein\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"CAALFM_C113170CA MSH6; mismatch repair ATPase\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"CAALFM_C400790CA MLH1; mismatch repair ATPase\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"CAALFM_C209470CA PMS1; ATP-binding mismatch repair protein\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"CAALFM_C114400CA MLH3; mismatch repair protein\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"CAALFM_C702790CA POL3; DNA-directed DNA polymerase delta\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"CAALFM_C504740CA HYS2; DNA-directed DNA polymerase delta subunit\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"CAALFM_C105850WA POL32; DNA polymerase delta subunit\tK03504 POLD3; DNA polymerase delta subunit 3"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"CAALFM_C200380CA RFA1; replication factor A subunit protein\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"CAALFM_C207120WA RFA2; Rfa2p\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"CAALFM_C109670CA CaO19.4830; hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"CAALFM_C205790CA RFC1; replication factor C subunit 1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"CAALFM_C700820WA RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"CAALFM_CR10700WA RFC4; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"CAALFM_C200950CA RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"CAALFM_C504000WA RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"CAALFM_C401770WA POL30; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"CAALFM_C500630CA EXO1; Rad2 family nuclease\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"CAALFM_C300830CA CaO19.6155; DNA ligase (ATP)\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"CAALFM_C701270CA CaO19.6907; hypothetical protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"CAALFM_C701340WA MRE11; MRX complex nuclease subunit\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"CAALFM_C302000WA RAD50; MRX complex DNA-binding subunit\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"CAALFM_C701340WA MRE11; MRX complex nuclease subunit\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"CAALFM_C302000WA RAD50; MRX complex DNA-binding subunit\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"CAALFM_CR02200CA RAD51; recombinase\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"CAALFM_CR02200CA RAD51; recombinase\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"CAALFM_C208110WA RAD57; putative DNA-dependent ATPase\tK10958 RAD57; DNA repair protein RAD57"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"CAALFM_C600510CA RAD52; recombinase\tK10873 RAD52; DNA repair and recombination protein RAD52"
					},
					{
						"name":"CAALFM_C405270CA RAD59; Rad59p\tK10959 RAD59; DNA repair protein RAD59"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"CAALFM_C113660WA RAD54; DNA-dependent ATPase\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"CAALFM_C210840WA RDH54; DNA-dependent ATPase\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"CAALFM_C210570WA SGS1; ATP-dependent DNA helicase\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"CAALFM_C210570WA SGS1; ATP-dependent DNA helicase\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"CAALFM_C304740CA CaO19.5934; DNA topoisomerase 3\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"CAALFM_C210450WA NCE4; Nce4p\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"CAALFM_C200380CA RFA1; replication factor A subunit protein\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"CAALFM_C207120WA RFA2; Rfa2p\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"CAALFM_C109670CA CaO19.4830; hypothetical protein\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"CAALFM_CR03800CA PPH3; phosphoprotein phosphatase PP4 catalytic subunit\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"CAALFM_C102280CA PSY2; Psy2p\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"CAALFM_CR03100WA SMC5; DNA repair ATPase\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"CAALFM_C701580WA SMC6; DNA repair protein\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"CAALFM_C504790CA CaO19.3965; hypothetical protein\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"CAALFM_C306200CA MMS21; SUMO ligase\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"CAALFM_C403170WA CaO19.2673; Smc5-Smc6 complex subunit\tK22823 NSMCE3; non-structural maintenance of chromosomes element 3"
					},
					{
						"name":"CAALFM_C400800WA CaO19.4161; Smc5-Smc6 complex subunit\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"CAALFM_C600770CA CaO19.3648; hypothetical protein\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"CAALFM_C600540WA CaO19.4206; hypothetical protein\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"CAALFM_C406880CA proteasome regulatory particle lid subunit\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"CAALFM_C107980CA CaO19.5069; hypothetical protein\tK10991 SWI5; DNA repair protein Swi5\/Sae3"
					},
					{
						"name":"CAALFM_CR05580CA CaO19.5844; hypothetical protein\tK10992 SFR1; Swi5-dependent recombination DNA repair protein 1"
					},
					{
						"name":"CAALFM_C500230CA CaO19.972; endonuclease\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"CAALFM_C402590CA CaO19.2740; hypothetical protein\tK15079 SLX4; structure-specific endonuclease subunit SLX4"
					},
					{
						"name":"CAALFM_CR05010WA CaO19.652; crossover junction endodeoxyribonuclease\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"CAALFM_C208280WA EAF3; Eaf3p\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"CAALFM_CR09860WA YTA6; putative AAA family ATPase\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"CAALFM_C302970CA CaO19.291; metalloendopeptidase\tK22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]"
					},
					{
						"name":"CAALFM_C406190CA MPH1; 3'-5' DNA helicase\tK14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]"
					},
					{
						"name":"CAALFM_CR00390WA MMS22; Mms22p\tK26122 MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"CAALFM_C111810WA CAS1; ATP-dependent DNA helicase\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"CAALFM_CR03390CA YKU80; ATP-dependent DNA helicase\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"CAALFM_C701340WA MRE11; MRX complex nuclease subunit\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"CAALFM_C302000WA RAD50; MRX complex DNA-binding subunit\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"CAALFM_C203030WA LIG4; DNA ligase (ATP)\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"CAALFM_CR03440WA CaO19.2376; hypothetical protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"CAALFM_CR03590CA CaO19.4383; DNA 5'-adenosine monophosphate hydrolase\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"CAALFM_C210780CA PSO2; Pso2p\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"CAALFM_C112840WA CaO19.4914; hypothetical protein\tK11511 APITD1; centromere protein S"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"CAALFM_C210570WA SGS1; ATP-dependent DNA helicase\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"CAALFM_C304740CA CaO19.5934; DNA topoisomerase 3\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"CAALFM_C210450WA NCE4; Nce4p\tK15364 NCE4; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"CAALFM_CR02200CA RAD51; recombinase\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"CAALFM_C700210CA CaO19.7101; hypothetical protein\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"CAALFM_C112830CA CaO19.4913; hypothetical protein\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"CAALFM_C701270CA CaO19.6907; hypothetical protein\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"CAALFM_C203540WA RAD32; DNA-directed DNA polymerase eta\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"CAALFM_C406020CA CaO19.4412; deoxycytidyl transferase\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"CAALFM_C306080WA REV3; Rev3p\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				},
				{
					"name":"CAALFM_C209480WA CaO19.1406; hypothetical protein\tK03508 POLZ2; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"CAALFM_C703870WA RAD6; E2 ubiquitin-conjugating protein\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"CAALFM_C601770WA RAD18; E3 ubiquitin-protein ligase\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"CAALFM_C200350WA CaO19.2097; DNA helicase\tK15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]"
				},
				{
					"name":"CAALFM_C112650CA CaO19.6358; E2 ubiquitin-conjugating protein\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"CAALFM_C500560WA CaO19.2225; E2 ubiquitin-conjugating protein\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"CAALFM_C401770WA POL30; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"CAALFM_C400030CA CaO19.366; hypothetical protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"CAALFM_C402700WA CaO19.2728; hypothetical protein\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"CAALFM_C700820WA RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"CAALFM_CR10700WA RFC4; replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"CAALFM_C200950CA RFC5; replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"CAALFM_C504000WA RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"CAALFM_C400030CA CaO19.366; hypothetical protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				},
				{
					"name":"CAALFM_C206220CA MEC3; Mec3p\tK02544 MEC3; G2-specific checkpoint protein"
				},
				{
					"name":"CAALFM_C302560WA DDC1; Ddc1p\tK06663 DDC1; DNA damage checkpoint protein"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"CAALFM_C501460WA YBL053; Ybl053p\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"CAALFM_C206130WA CSM3; Csm3p\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"CAALFM_C111440CA GIN1; chromatin-modulating protein\tK11272 MRC1; mediator of replication checkpoint protein 1"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"CAALFM_C700210CA CaO19.7101; hypothetical protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"CAALFM_C103630WA CaO19.3062; hypothetical protein\tK20403 TTI1; TELO2-interacting protein 1"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"CAALFM_C502210WA CaO19.4228; hypothetical protein\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"CAALFM_C603010WA TEL1; DNA-binding protein kinase\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"CAALFM_C505100CA DUN1; serine\/threonine protein kinase\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"CAALFM_C300800WA MIH1; putative tyrosine protein phosphatase\tK02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]"
				},
				{
					"name":"CAALFM_C103220CA BMH1; 14-3-3 family protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"CAALFM_C303810WA RAD53; serine\/threonine\/tyrosine protein kinase\tK02831 RAD53; ser\/thr\/tyr protein kinase RAD53 [EC:2.7.11.-]"
				},
				{
					"name":"CAALFM_C502610CA RAD9; chromatin-binding protein\tK06661 RAD9; DNA repair protein RAD9"
				},
				{
					"name":"CAALFM_C504060CA MEC1; protein kinase\tK02543 MEC1; cell cycle checkpoint protein MEC1"
				},
				{
					"name":"CAALFM_C201950CA AMN1; Amn1p\tK15081 AMN1; antagonist of mitotic exit network protein 1"
				},
				{
					"name":"CAALFM_C110010CA SWE1; tyrosine protein kinase\tK03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]"
				},
				{
					"name":"CAALFM_C300670CA FKH2; forkhead family transcription factor\tK24664 FKH; forkhead protein FKH"
				},
				{
					"name":"CAALFM_C503090WA VPS4; AAA family ATPase\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"CAALFM_C603120WA POL5; DNA-directed DNA polymerase\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"CAALFM_C102390WA CaO19.2926; hypothetical protein\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"CAALFM_CR03490WA DEM1; Dem1p\tK17815 EXO5; exonuclease V [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"CAALFM_C307480WA CaO19.6740; E3 ubiquitin-protein ligase\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"CAALFM_C109370WA CEF1; Cef1p\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"CAALFM_C300500CA CaO19.5413; mRNA splicing protein\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"CAALFM_C104150CA CaO19.1049; hypothetical protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"CAALFM_C101330CA DUT1; bifunctional dITP\/dUTP diphosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"CAALFM_C203160CA RNR1; ribonucleotide-diphosphate reductase subunit\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"CAALFM_CR05570CA RNR3; Rnr3p\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"CAALFM_C203010CA RNR21; ribonucleotide-diphosphate reductase subunit\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				},
				{
					"name":"CAALFM_C207570WA RNR22; Rnr22p\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"CAALFM_C407010CA CaO19.3108; methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"CAALFM_C306400CA CaO19.7425; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"CAALFM_C208420WA CaO19.3639; hypothetical protein\tK01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]"
					},
					{
						"name":"CAALFM_C601820CA FPG1; Fpg1p\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"CAALFM_C108200WA NTG1; bifunctional N-glycosylase\/AP lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"CAALFM_C305010CA CaO19.5970; DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"CAALFM_C305010CA CaO19.5970; DNA helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"CAALFM_C104150CA CaO19.1049; hypothetical protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"CAALFM_C101330CA DUT1; bifunctional dITP\/dUTP diphosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}