{
	"name":"ccrn03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors",
					"children":[
					{
						"name":"123306061 mRNA cap guanine-N7 methyltransferase\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]"
					},
					{
						"name":"123305033 mRNA-capping enzyme\tK13917 RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74]"
					},
					{
						"name":"123298234 cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"123293050 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1\tK14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57]"
					},
					{
						"name":"123294053 RNA guanine-N7 methyltransferase activating subunit\tK18708 FAM103A1; RNMT-activating mini protein"
					}
					]
				},
				{
					"name":"Cap binding complex",
					"children":[
					{
						"name":"123297478 nuclear cap-binding protein subunit 1 isoform X1\tK12882 NCBP1; nuclear cap-binding protein subunit 1"
					},
					{
						"name":"123306139 nuclear cap-binding protein subunit 2 isoform X1\tK12883 NCBP2; nuclear cap-binding protein subunit 2"
					}
					]
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)",
					"children":[
					{
						"name":"123294492 cleavage and polyadenylation specificity factor subunit 5-like\tK14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5"
					},
					{
						"name":"123295650 cleavage and polyadenylation specificity factor subunit 5-like isoform X1\tK14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5"
					},
					{
						"name":"123298508 cleavage and polyadenylation specificity factor subunit 6 isoform X1\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7"
					}
					]
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)",
					"children":[
					{
						"name":"123292132 protein CLP1 homolog\tK14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]"
					}
					]
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex",
					"children":[
					{
						"name":"123292298 cleavage and polyadenylation specificity factor subunit 1\tK14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1"
					},
					{
						"name":"123294067 probable cleavage and polyadenylation specificity factor subunit 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"123301080 cleavage and polyadenylation specificity factor 73\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"123297435 cleavage and polyadenylation specificity factor subunit 4\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4"
					},
					{
						"name":"123291835 pre-mRNA 3'-end-processing factor FIP1\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1"
					},
					{
						"name":"123303304 pre-mRNA 3' end processing protein WDR33\tK15542 PFS2; polyadenylation factor subunit 2"
					},
					{
						"name":"123300007 WD repeat-containing protein 82\tK14962 WDR82; COMPASS component SWD2"
					},
					{
						"name":"123293926 serine\/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"123301547 serine\/threonine-protein phosphatase alpha-2 isoform\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"123305404 RNA polymerase II subunit A C-terminal domain phosphatase SSU72\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex",
					"children":[
					{
						"name":"123292215 cleavage stimulation factor subunit 1\tK14406 CSTF1; cleavage stimulation factor subunit 1"
					},
					{
						"name":"123292114 cleavage stimulation factor subunit 2 isoform X1\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"123299696 protein suppressor of forked\tK14408 CSTF3; cleavage stimulation factor subunit 3"
					},
					{
						"name":"123294088 symplekin\tK06100 SYMPK; symplekin"
					}
					]
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors",
					"children":[
					{
						"name":"123304183 small nuclear ribonucleoprotein-associated protein B\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"123300417 small nuclear ribonucleoprotein Sm D3 isoform X1\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"123297583 probable small nuclear ribonucleoprotein E\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"123298368 small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"123291051 probable small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"123298548 U7 snRNA-associated Sm-like protein LSm10\tK25591 LSM10; U7 snRNA-associated Sm-like protein LSm10"
					},
					{
						"name":"123293370 U7 snRNA-associated Sm-like protein LSm11\tK25592 LSM11; U7 snRNA-associated Sm-like protein LSm11"
					},
					{
						"name":"123294067 probable cleavage and polyadenylation specificity factor subunit 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"123301080 cleavage and polyadenylation specificity factor 73\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"123292114 cleavage stimulation factor subunit 2 isoform X1\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"123294088 symplekin\tK06100 SYMPK; symplekin"
					}
					]
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex",
					"children":[
					{
						"name":"123293659 transcription elongation factor SPT4-A\tK15171 SUPT4H1; transcription elongation factor SPT4"
					},
					{
						"name":"123304923 transcription elongation factor SPT5 isoform X1\tK15172 SUPT5H; transcription elongation factor SPT5"
					}
					]
				},
				{
					"name":"N6-methyltransferase complex",
					"children":[
					{
						"name":"123299948 N6-adenosine-methyltransferase subunit METTL3\tK05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]"
					},
					{
						"name":"123299988 N6-adenosine-methyltransferase non-catalytic subunit\tK23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit"
					},
					{
						"name":"123298582 N(6)-adenine-specific methyltransferase METTL4\tK24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]"
					},
					{
						"name":"123295083 U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase\tK11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]"
					},
					{
						"name":"123301575 pre-mRNA-splicing regulator WTAP isoform X1\tK22824 WTAP; pre-mRNA-splicing regulator WTAP"
					},
					{
						"name":"123297574 protein virilizer\tK22910 VIRMA; protein virilizer"
					},
					{
						"name":"123297542 RNA-binding protein spenito\tK13190 RBM15; RNA-binding protein 15"
					},
					{
						"name":"123296691 E3 ubiquitin-protein ligase Hakai\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]"
					}
					]
				},
				{
					"name":"Poly(A) addition factors",
					"children":[
					{
						"name":"123291951 poly(A) polymerase type 3\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]"
					},
					{
						"name":"123298567 poly(A) RNA polymerase gld-2 homolog A-like isoform X1\tK14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]"
					}
					]
				},
				{
					"name":"Negative regulators of mRNA 3' end processing",
					"children":[
					{
						"name":"123295369 BRCA1-associated RING domain protein 1-like\tK10683 BARD1; BRCA1-associated RING domain protein 1"
					},
					{
						"name":"123299127 TAR DNA-binding protein 43-like\tK23600 TARDBP; TAR DNA-binding protein 43"
					},
					{
						"name":"123299128 TAR DNA-binding protein 43-like\tK23600 TARDBP; TAR DNA-binding protein 43"
					},
					{
						"name":"123302347 TAR DNA-binding protein 43-like isoform X1\tK23600 TARDBP; TAR DNA-binding protein 43"
					}
					]
				}
				]
			},
			{
				"name":"Other processing factors",
				"children":[
				{
					"name":"123297905 DNA\/RNA-binding protein KIN17\tK13102 KIN; DNA\/RNA-binding protein KIN17"
				},
				{
					"name":"123297273 methyltransferase-like protein 22\tK23040 METTL22; methyltransferase-like protein 22 [EC:2.1.1.-]"
				},
				{
					"name":"123305194 terminal nucleotidyltransferase 5C isoform X1\tK23034 TENT5C; terminal nucleotidyltransferase 5C [EC:2.7.7.19]"
				},
				{
					"name":"123294565 serrate RNA effector molecule homolog\tK27103 SRRT; serrate RNA effector molecule"
				}
				]
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex",
					"children":[
					{
						"name":"123305287 RNA-binding protein 8A\tK12876 RBM8A; RNA-binding protein 8A"
					},
					{
						"name":"123292378 protein mago nashi\tK12877 MAGOH; protein mago nashi"
					},
					{
						"name":"123296979 THO complex subunit 4\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"123304917 ATP-dependent RNA helicase WM6\tK12812 DDX39B; ATP-dependent RNA helicase UAP56\/SUB2 [EC:5.6.2.7]"
					},
					{
						"name":"123291826 eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]"
					},
					{
						"name":"123290478 coiled-coil domain-containing protein 174\tK25178 CCDC174; coiled-coil domain-containing protein 174"
					},
					{
						"name":"123300645 histone deacetylase complex subunit SAP18\tK14324 SAP18; histone deacetylase complex subunit SAP18"
					},
					{
						"name":"123292097 pinin\tK13114 PNN; pinin"
					},
					{
						"name":"123291619 RNA-binding protein with serine-rich domain 1-B\tK14325 RNPS1; RNA-binding protein with serine-rich domain 1"
					}
					]
				},
				{
					"name":"TREX complex",
					"children":[
					{
						"name":"123297647 THO complex subunit 1\tK12878 THOC1; THO complex subunit 1"
					},
					{
						"name":"123291524 THO complex subunit 2\tK12879 THOC2; THO complex subunit 2"
					},
					{
						"name":"123305835 THO complex subunit 3\tK12880 THOC3; THO complex subunit 3"
					},
					{
						"name":"123296979 THO complex subunit 4\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"123297544 THO complex subunit 5 homolog isoform X1\tK13174 THOC5; THO complex subunit 5"
					},
					{
						"name":"123296097 THO complex subunit 6 homolog\tK13175 THOC6; THO complex subunit 6"
					},
					{
						"name":"123300233 THO complex subunit 7 homolog\tK13176 THOC7; THO complex subunit 7"
					}
					]
				},
				{
					"name":"TREX-2 complex",
					"children":[
					{
						"name":"123294021 PCI domain-containing protein 2\tK23801 PCID2; nuclear mRNA export protein PCID2\/THP1"
					},
					{
						"name":"123298253 26S proteasome complex subunit SEM1\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"123305856 transcription and mRNA export factor ENY2\tK11368 ENY2; enhancer of yellow 2 transcription factor"
					}
					]
				},
				{
					"name":"Nuclear pore complex",
					"children":[
					{
						"name":"123299048 nucleoprotein TPR isoform X1\tK09291 TPR; nucleoprotein TPR"
					},
					{
						"name":"123290895 protein Rae1\tK14298 RAE1; mRNA export factor"
					},
					{
						"name":"123293947 protein SEC13 homolog\tK14004 SEC13; protein transport protein SEC13"
					},
					{
						"name":"123299144 nucleoporin Nup37\tK14302 NUP37; nuclear pore complex protein Nup37"
					},
					{
						"name":"123295022 nuclear pore complex protein Nup75\tK14304 NUP85; nuclear pore complex protein Nup85"
					},
					{
						"name":"123301773 nucleoporin Nup43\tK14305 NUP43; nuclear pore complex protein Nup43"
					},
					{
						"name":"123291615 nuclear pore complex protein Nup50\tK14295 NUP50; nuclear pore complex protein Nup50"
					},
					{
						"name":"123292116 probable nucleoporin Nup54\tK14308 NUP54; nuclear pore complex protein Nup54"
					},
					{
						"name":"123297376 nuclear pore glycoprotein p62\tK14306 NUP62; nuclear pore complex protein Nup62"
					},
					{
						"name":"123300516 nuclear pore complex protein Nup88\tK14318 NUP88; nuclear pore complex protein Nup88"
					},
					{
						"name":"123301581 nuclear pore complex protein Nup93-like\tK14309 NUP93; nuclear pore complex protein Nup93"
					},
					{
						"name":"123302691 nuclear pore complex protein Nup98-Nup96\tK14297 NUP98; nuclear pore complex protein Nup98-Nup96"
					},
					{
						"name":"123305686 nuclear pore complex protein Nup107\tK14301 NUP107; nuclear pore complex protein Nup107"
					},
					{
						"name":"123294265 nuclear pore complex protein Nup133\tK14300 NUP133; nuclear pore complex protein Nup133"
					},
					{
						"name":"123296146 nucleoporin Nup188\tK14311 NUP188; nuclear pore complex protein Nup188"
					},
					{
						"name":"123296620 nuclear pore complex protein Nup153-like isoform X1\tK14296 NUP153; nuclear pore complex protein Nup153"
					},
					{
						"name":"123297851 nuclear pore complex protein Nup154\tK14312 NUP155; nuclear pore complex protein Nup155"
					},
					{
						"name":"123305095 nuclear pore complex protein Nup160 homolog\tK14303 NUP160; nuclear pore complex protein Nup160"
					},
					{
						"name":"123301169 nucleoporin Nup35\tK14313 NUP35; nuclear pore complex protein Nup53"
					},
					{
						"name":"123295445 nuclear pore complex protein Nup205\tK14310 NUP205; nuclear pore complex protein Nup205"
					},
					{
						"name":"123299655 nuclear pore membrane glycoprotein 210\tK14314 NUP210; nuclear pore complex protein Nup210"
					},
					{
						"name":"123292117 nucleoporin NDC1\tK14315 NDC1; nucleoporin NDC1"
					},
					{
						"name":"123297585 nucleoporin SEH1-A\tK14299 SEH1; nucleoporin SEH1"
					},
					{
						"name":"123300158 aladin\tK14320 AAAS; aladin"
					},
					{
						"name":"123301541 nucleoporin NUP100\/NSP100-like\tK18716 NUP42; nucleoporin NUP42"
					},
					{
						"name":"123294043 nucleoporin GLE1\tK18723 GLE1; nucleoporin GLE1"
					},
					{
						"name":"123293139 nuclear RNA export factor 1-like\tK14284 NXF; nuclear RNA export factor"
					},
					{
						"name":"123294000 nuclear RNA export factor 1-like\tK14284 NXF; nuclear RNA export factor"
					},
					{
						"name":"123296389 NTF2-related export protein isoform X1\tK14285 NXT1_2; NTF2-related export protein 1\/2"
					}
					]
				},
				{
					"name":"Ran-mediated transport factors",
					"children":[
					{
						"name":"123296934 GTP-binding nuclear protein Ran\tK07936 RAN; GTP-binding nuclear protein Ran"
					},
					{
						"name":"123305495 acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1\tK18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A\/C\/D"
					},
					{
						"name":"123296278 ELAV-like protein 3\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4"
					},
					{
						"name":"123302519 ELAV-like protein 3 isoform X1\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4"
					},
					{
						"name":"123301712 FAS-associated factor 2\tK18726 FAF2; FAS-associated factor 2"
					},
					{
						"name":"123297427 transitional endoplasmic reticulum ATPase TER94 isoform X1\tK13525 VCP; transitional endoplasmic reticulum ATPase"
					},
					{
						"name":"123295161 exportin-1\tK14290 XPO1; exportin-1"
					},
					{
						"name":"123297641 exportin-7 isoform X1\tK18460 XPO7; exportin-7"
					},
					{
						"name":"123295170 ran GTPase-activating protein 1\tK14319 RANGAP1; Ran GTPase-activating protein 1"
					},
					{
						"name":"123295336 probable nuclear transport factor 2 isoform X1\tK28773 NUTF2; nuclear transport factor 2"
					}
					]
				},
				{
					"name":"eIF4F and regulatory proteins",
					"children":[
					{
						"name":"123290408 eukaryotic translation initiation factor 4E type 2\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"123300586 eukaryotic translation initiation factor 4E-1A-like isoform X1\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"123306192 eukaryotic initiation factor 4A-I\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"123290381 eukaryotic translation initiation factor 4 gamma 1-like isoform X1\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"123299164 eukaryotic translation initiation factor 4 gamma 2\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"123293911 eukaryotic translation initiation factor 4B\tK03258 EIF4B; translation initiation factor 4B"
					},
					{
						"name":"123301672 eukaryotic translation initiation factor 4H-like\tK24086 EIF4H; translation initiation factor 4H"
					},
					{
						"name":"123300220 eukaryotic translation initiation factor 4E-binding protein\tK18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2"
					},
					{
						"name":"123292156 protein angel homolog 2\tK18729 ANGEL; protein angel"
					},
					{
						"name":"123298457 synaptic functional regulator FMR1 isoform X1\tK15516 FMR; fragile X mental retardation protein"
					},
					{
						"name":"123302714 cytoplasmic FMR1-interacting protein\tK05749 CYFIP; cytoplasmic FMR1 interacting protein"
					},
					{
						"name":"123302238 cytoplasmic polyadenylation element-binding protein 2 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"123304951 cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"123290469 ATP-dependent RNA helicase DDX3X\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"123291666 polyadenylate-binding protein 1 isoform X1\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"123295662 uncharacterized protein LOC123295662\tK14322 PAIP1; polyadenylate-binding protein-interacting protein 1"
					},
					{
						"name":"123302671 polyadenylate-binding protein-interacting protein 2\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2"
					},
					{
						"name":"123291381 helicase SKI2W\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]"
					},
					{
						"name":"123295375 deformed epidermal autoregulatory factor 1 isoform X1\tK23041 DEAF1; deformed epidermal autoregulatory factor 1"
					},
					{
						"name":"123298381 malignant T-cell-amplified sequence 1 homolog\tK07575 MCTS; malignant T-cell-amplified sequence"
					},
					{
						"name":"123292626 density-regulated protein homolog\tK24272 DENR; density-regulated protein"
					}
					]
				},
				{
					"name":"APOBEC1-ACF complex",
					"children":[
					{
						"name":"123292865 probable RNA-binding protein 46\tK24978 A1CF; APOBEC1 complementation factor"
					}
					]
				},
				{
					"name":"Other transport factors",
					"children":[
					{
						"name":"123293517 partner of Y14 and mago\tK14294 WIBG; partner of Y14 and mago"
					},
					{
						"name":"123304965 heterogeneous nuclear ribonucleoprotein A1, A2\/B1 homolog isoform X1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3"
					},
					{
						"name":"123296455 RNA-binding protein Musashi homolog Rbp6 isoform X1\tK14411 MSI; RNA-binding protein Musashi"
					},
					{
						"name":"123298365 RNA-binding protein Musashi homolog 2 isoform X1\tK14411 MSI; RNA-binding protein Musashi"
					},
					{
						"name":"123298572 heterogeneous nuclear ribonucleoprotein 27C isoform X1\tK14411 MSI; RNA-binding protein Musashi"
					},
					{
						"name":"123294453 HBS1-like protein isoform X1\tK14416 HBS1; elongation factor 1 alpha-like protein"
					},
					{
						"name":"123294673 protein pelota\tK06965 PELO; protein pelota"
					},
					{
						"name":"123300029 polyadenylate-binding protein 2\tK14396 PABPN1; polyadenylate-binding protein 2"
					},
					{
						"name":"123291654 DEAD-box helicase Dbp80\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]"
					},
					{
						"name":"123298688 pre-mRNA-splicing factor syf1 homolog\tK12867 SYF1; pre-mRNA-splicing factor SYF1"
					},
					{
						"name":"123298634 SAP domain-containing ribonucleoprotein\tK18732 SARNP; SAP domain-containing ribonucleoprotein"
					},
					{
						"name":"123296752 regulator of chromosome condensation\tK11493 RCC1; regulator of chromosome condensation"
					},
					{
						"name":"123299633 la-related protein 6-like\tK18733 LARP6; la-related protein 6"
					},
					{
						"name":"123291593 transcriptional activator protein Pur-beta\tK21772 PURA; transcriptional activator protein Pur-alpha"
					},
					{
						"name":"123297340 leukocyte receptor cluster member 8 homolog\tK23802 LENG8; SAC3 family protein LENG8\/THP3"
					}
					]
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex",
					"children":[
					{
						"name":"123299219 eukaryotic peptide chain release factor subunit 1\tK03265 ETF1; peptide chain release factor subunit 1"
					},
					{
						"name":"123296747 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1\tK03267 ERF3; peptide chain release factor subunit 3"
					},
					{
						"name":"123298559 regulator of nonsense transcripts 1 homolog isoform X1\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					},
					{
						"name":"123293406 regulator of nonsense transcripts 2\tK14327 UPF2; regulator of nonsense transcripts 2"
					}
					]
				},
				{
					"name":"Protein phosphatase 2A",
					"children":[
					{
						"name":"123300899 serine\/threonine-protein phosphatase 2A catalytic subunit alpha isoform\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"123295131 serine\/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A"
					},
					{
						"name":"123298495 protein phosphatase PP2A 55 kDa regulatory subunit isoform X1\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B"
					},
					{
						"name":"123290894 serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma-like\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''"
					},
					{
						"name":"123300788 uncharacterized protein LOC123300788 isoform X1\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''"
					},
					{
						"name":"123291374 serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					},
					{
						"name":"123291376 serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like isoform X1\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					},
					{
						"name":"123292337 serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					}
					]
				},
				{
					"name":"Other surveillance factors",
					"children":[
					{
						"name":"123298144 serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]"
					},
					{
						"name":"123296956 uncharacterized protein LOC123296956\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
					},
					{
						"name":"123299184 protein SMG8\tK18734 SMG8; protein SMG8"
					},
					{
						"name":"123294010 protein SMG9-like\tK18735 SMG9; protein SMG9"
					},
					{
						"name":"123294126 probable ATP-dependent RNA helicase DHX34\tK20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6]"
					},
					{
						"name":"123295517 GTP-binding protein 1\tK24887 GTPBP1; GTP-binding protein 1"
					}
					]
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex",
					"children":[
					{
						"name":"123294922 protein penguin\tK14844 PUF6; pumilio homology domain family member 6"
					},
					{
						"name":"123300288 unconventional myosin-Va isoform X1\tK10357 MYO5; myosin V"
					},
					{
						"name":"123297321 protein bicaudal D isoform X1\tK18739 BICD; protein bicaudal D"
					},
					{
						"name":"123290891 uncharacterized protein LOC123290891\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					}
					]
				},
				{
					"name":"Factors that have mRNA localization signals",
					"children":[
					{
						"name":"123292243 actin, clone 403-like\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"123294873 actin-5C\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"123295327 actin, cytoplasmic A3a-like\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"123297559 actin, muscle-like\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"123297690 actin, muscle\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"123294616 protein hairy\tK09090 HESN; hairy and enhancer of split, invertebrate"
					},
					{
						"name":"123295495 protein deadpan-like\tK09090 HESN; hairy and enhancer of split, invertebrate"
					},
					{
						"name":"123300228 enhancer of split mgamma protein-like\tK09090 HESN; hairy and enhancer of split, invertebrate"
					},
					{
						"name":"123300258 enhancer of split mbeta protein-like\tK09090 HESN; hairy and enhancer of split, invertebrate"
					}
					]
				},
				{
					"name":"Trans-acting binding proteins",
					"children":[
					{
						"name":"123305510 far upstream element-binding protein 2 isoform X1\tK13210 FUBP; far upstream element-binding protein"
					},
					{
						"name":"123291898 elongation factor 1-alpha\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"123300658 elongation factor 1-alpha-like\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"123292160 elongation factor 1-gamma\tK03233 EEF1G; elongation factor 1-gamma"
					},
					{
						"name":"123301523 arf-GAP domain and FG repeat-containing protein 1\tK15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1"
					},
					{
						"name":"123302488 double-stranded RNA-binding protein Staufen homolog 2 isoform X1\tK17597 STAU; double-stranded RNA-binding protein Staufen"
					},
					{
						"name":"123290557 polypyrimidine tract-binding protein 1 isoform X1\tK13218 PTBP1; polypyrimidine tract-binding protein 1"
					},
					{
						"name":"123290699 RNA-binding protein squid isoform X1\tK03102 SQD; squid"
					},
					{
						"name":"123302238 cytoplasmic polyadenylation element-binding protein 2 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"123304951 cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					}
					]
				},
				{
					"name":"Other mRNA localization factors",
					"children":[
					{
						"name":"123298457 synaptic functional regulator FMR1 isoform X1\tK15516 FMR; fragile X mental retardation protein"
					},
					{
						"name":"123302714 cytoplasmic FMR1-interacting protein\tK05749 CYFIP; cytoplasmic FMR1 interacting protein"
					},
					{
						"name":"123291546 poly(rC)-binding protein 2 isoform X1\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4"
					},
					{
						"name":"123296741 CUGBP Elav-like family member 2 isoform X1\tK02177 BRU; bruno"
					},
					{
						"name":"123299034 maternal protein exuperantia\tK18745 EXU; maternal protein exuperantia"
					},
					{
						"name":"123305532 Y-box factor homolog\tK09276 YBX1; Y-box-binding protein 1"
					}
					]
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule",
					"children":[
					{
						"name":"123291873 5'-3' exoribonuclease 1 isoform X1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]"
					},
					{
						"name":"123297019 protein argonaute-2-like\tK11593 ELF2C; eukaryotic translation initiation factor 2C"
					},
					{
						"name":"123299050 protein argonaute-2\tK11593 ELF2C; eukaryotic translation initiation factor 2C"
					},
					{
						"name":"123300711 protein argonaute-2-like isoform X1\tK11593 ELF2C; eukaryotic translation initiation factor 2C"
					},
					{
						"name":"123290408 eukaryotic translation initiation factor 4E type 2\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"123300586 eukaryotic translation initiation factor 4E-1A-like isoform X1\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"123298559 regulator of nonsense transcripts 1 homolog isoform X1\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					},
					{
						"name":"123290469 ATP-dependent RNA helicase DDX3X\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"123306123 ATP-dependent RNA helicase me31b\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					},
					{
						"name":"123299733 RNA-binding protein MEX3B\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]"
					},
					{
						"name":"123305532 Y-box factor homolog\tK09276 YBX1; Y-box-binding protein 1"
					},
					{
						"name":"123300918 LIM domain-containing protein jub\tK16682 AJUBA; LIM domain-containing protein"
					},
					{
						"name":"123291473 putative helicase mov-10-B.2\tK18422 MOV10; helicase MOV-10 [EC:5.6.2.5]"
					},
					{
						"name":"123298670 proline-rich nuclear receptor coactivator 2-like\tK18751 PNRC2; proline-rich nuclear receptor coactivator 2"
					},
					{
						"name":"123296939 transportin-2\tK18752 TNPO1; transportin-1"
					},
					{
						"name":"123302330 transportin-1-like isoform X1\tK18752 TNPO1; transportin-1"
					},
					{
						"name":"123298144 serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]"
					},
					{
						"name":"123296956 uncharacterized protein LOC123296956\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
					},
					{
						"name":"123291849 mRNA decay activator protein ZFP36L1\tK18753 ZFP36L; butyrate response factor"
					},
					{
						"name":"123290864 protein lin-28 homolog\tK18754 LIN28; protein lin-28"
					},
					{
						"name":"123290919 huntingtin\tK04533 HD; huntingtin"
					},
					{
						"name":"123299960 protein bicaudal C\tK18756 BICC1; protein bicaudal C"
					},
					{
						"name":"123304965 heterogeneous nuclear ribonucleoprotein A1, A2\/B1 homolog isoform X1\tK12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1\/A3"
					},
					{
						"name":"123291515 cAMP-dependent protein kinase catalytic subunit alpha-like\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
					},
					{
						"name":"123292845 cAMP-dependent protein kinase catalytic subunit alpha-like\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
					},
					{
						"name":"123301774 cAMP-dependent protein kinase catalytic subunit 1\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
					},
					{
						"name":"123302568 la-related protein 1B isoform X1\tK18757 LARP1; la-related protein 1"
					}
					]
				},
				{
					"name":"P-body specific factors",
					"children":[
					{
						"name":"123298581 m7GpppN-mRNA hydrolase\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"123294773 mRNA-decapping enzyme 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]"
					},
					{
						"name":"123300686 U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"123296838 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"123302243 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"123301638 U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					},
					{
						"name":"123305564 U6 snRNA-associated Sm-like protein LSm4\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4"
					},
					{
						"name":"123296683 U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5"
					},
					{
						"name":"123298289 U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"123300756 U6 snRNA-associated Sm-like protein LSm7\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					},
					{
						"name":"123305900 U6 snRNA-associated Sm-like protein LSm8\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8"
					},
					{
						"name":"123293901 kinesin light chain isoform X1\tK10407 KLC; kinesin light chain"
					},
					{
						"name":"123300288 unconventional myosin-Va isoform X1\tK10357 MYO5; myosin V"
					},
					{
						"name":"123290855 tubulin alpha-1 chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123290994 tubulin alpha-1 chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123291066 tubulin alpha-1 chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123291067 tubulin alpha-8 chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123291069 tubulin alpha chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123295740 tubulin alpha chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123298194 tubulin alpha-4 chain-like isoform X1\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123298213 tubulin alpha chain-like isoform X1\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123298426 tubulin alpha-1 chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123300797 tubulin alpha-8 chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123301165 tubulin alpha-1 chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123303107 tubulin alpha-1 chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123305062 tubulin alpha-3 chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"123302238 cytoplasmic polyadenylation element-binding protein 2 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"123304951 cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"123296720 protein Gawky isoform X1\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein"
					},
					{
						"name":"123295443 CCR4-NOT transcription complex subunit 1 isoform X1\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"123297533 regulator of gene activity isoform X1\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"123293408 CCR4-NOT transcription complex subunit 3 isoform X1\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"123290863 putative uncharacterized protein DDB_G0286901\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"123292164 CCR4-NOT transcription complex subunit 6-like isoform X1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"123293582 CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"123303077 CCR4-NOT transcription complex subunit 8-like\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"123298759 DIS3-like exonuclease 2\tK18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]"
					},
					{
						"name":"123293954 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]"
					},
					{
						"name":"123294829 PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3"
					},
					{
						"name":"123292347 protein BTG3-like\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"123295069 protein Tob1-like\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"123298506 protein PAT1 homolog 1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1"
					},
					{
						"name":"123298086 enhancer of mRNA-decapping protein 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3"
					},
					{
						"name":"123298808 uncharacterized protein LOC123298808\tK18760 NANOS2; protein nanos 2"
					},
					{
						"name":"123293406 regulator of nonsense transcripts 2\tK14327 UPF2; regulator of nonsense transcripts 2"
					},
					{
						"name":"123301491 E3 ubiquitin-protein ligase TRIM71 isoform X1\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]"
					},
					{
						"name":"123295757 DNA-directed RNA polymerase II subunit RPB7\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
					}
					]
				},
				{
					"name":"Stress granule specific factors",
					"children":[
					{
						"name":"123294285 nucleolysin TIAR\tK13201 TIA1; nucleolysin TIA-1\/TIAR"
					},
					{
						"name":"123291666 polyadenylate-binding protein 1 isoform X1\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"123302488 double-stranded RNA-binding protein Staufen homolog 2 isoform X1\tK17597 STAU; double-stranded RNA-binding protein Staufen"
					},
					{
						"name":"123298457 synaptic functional regulator FMR1 isoform X1\tK15516 FMR; fragile X mental retardation protein"
					},
					{
						"name":"123305157 eukaryotic translation initiation factor 2A\tK15026 EIF2A; translation initiation factor 2A"
					},
					{
						"name":"123295594 eukaryotic translation initiation factor 3 subunit B\tK03253 EIF3B; translation initiation factor 3 subunit B"
					},
					{
						"name":"123306192 eukaryotic initiation factor 4A-I\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"123291826 eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]"
					},
					{
						"name":"123293911 eukaryotic translation initiation factor 4B\tK03258 EIF4B; translation initiation factor 4B"
					},
					{
						"name":"123290381 eukaryotic translation initiation factor 4 gamma 1-like isoform X1\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"123299164 eukaryotic translation initiation factor 4 gamma 2\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"123300898 guanine nucleotide-binding protein subunit beta-like protein\tK14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein"
					},
					{
						"name":"123293139 nuclear RNA export factor 1-like\tK14284 NXF; nuclear RNA export factor"
					},
					{
						"name":"123294000 nuclear RNA export factor 1-like\tK14284 NXF; nuclear RNA export factor"
					},
					{
						"name":"123302324 histone deacetylase 6 isoform X1\tK11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]"
					},
					{
						"name":"123295355 mucin-5AC isoform X1\tK18763 LARP4; la-related protein 4"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex",
					"children":[
					{
						"name":"123294773 mRNA-decapping enzyme 1B\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]"
					},
					{
						"name":"123298581 m7GpppN-mRNA hydrolase\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"123306123 ATP-dependent RNA helicase me31b\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					},
					{
						"name":"123298086 enhancer of mRNA-decapping protein 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3"
					},
					{
						"name":"123298506 protein PAT1 homolog 1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1"
					}
					]
				},
				{
					"name":"Lsm complex",
					"children":[
					{
						"name":"123300686 U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"123296838 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"123302243 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"123301638 U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					},
					{
						"name":"123305564 U6 snRNA-associated Sm-like protein LSm4\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4"
					},
					{
						"name":"123296683 U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5"
					},
					{
						"name":"123298289 U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"123300756 U6 snRNA-associated Sm-like protein LSm7\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					},
					{
						"name":"123305900 U6 snRNA-associated Sm-like protein LSm8\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8"
					}
					]
				},
				{
					"name":"5' exonucleases",
					"children":[
					{
						"name":"123291873 5'-3' exoribonuclease 1 isoform X1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]"
					},
					{
						"name":"123294103 5'-3' exoribonuclease 2 homolog\tK12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]"
					}
					]
				},
				{
					"name":"Other 5'-3' decay factors",
					"children":[
					{
						"name":"123291584 m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					},
					{
						"name":"123299285 probable helicase with zinc finger domain\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]"
					}
					]
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors",
					"children":[
					{
						"name":"123293307 exosome complex component CSL4\tK07573 CSL4; exosome complex component CSL4"
					},
					{
						"name":"123293061 exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"123293852 exosome complex component RRP40\tK03681 RRP40; exosome complex component RRP40"
					},
					{
						"name":"123291015 exosome complex component RRP41 isoform X1\tK11600 RRP41; exosome complex component RRP41"
					},
					{
						"name":"123293491 exosome complex component RRP46\tK12590 RRP46; exosome complex component RRP46"
					},
					{
						"name":"123303876 exosome complex component MTR3\tK12587 MTR3; exosome complex component MTR3"
					},
					{
						"name":"123293284 exosome complex component RRP42-like\tK12589 RRP42; exosome complex component RRP42"
					},
					{
						"name":"123292684 exosome complex component RRP43-like\tK12586 RRP43; exosome complex component RRP43"
					},
					{
						"name":"123292191 exosome complex component rrp45\tK03678 RRP45; exosome complex component RRP45"
					}
					]
				},
				{
					"name":"Exosome cofactors",
					"children":[
					{
						"name":"123302598 exosome complex exonuclease RRP44\tK12585 DIS3; exosome complex exonuclease DIS3\/RRP44 [EC:3.1.13.-]"
					},
					{
						"name":"123305599 exosome component 10\tK12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]"
					},
					{
						"name":"123305891 nuclear nucleic acid-binding protein C1D-like\tK12592 C1D; exosome complex protein LRP1"
					},
					{
						"name":"123305462 M-phase phosphoprotein 6\tK12593 MPHOSPH6; M-phase phosphoprotein 6, animal type"
					}
					]
				},
				{
					"name":"TRAMP complex",
					"children":[
					{
						"name":"123303594 uncharacterized protein LOC123303594\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]"
					},
					{
						"name":"123303104 exosome RNA helicase MTR4\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Ski complex",
					"children":[
					{
						"name":"123291381 helicase SKI2W\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]"
					},
					{
						"name":"123301081 tetratricopeptide repeat protein 37\tK12600 SKI3; superkiller protein 3"
					},
					{
						"name":"123305140 WD repeat-containing protein 61-like\tK12602 WDR61; WD repeat-containing protein 61"
					}
					]
				},
				{
					"name":"Ccr4-NOT complex",
					"children":[
					{
						"name":"123292164 CCR4-NOT transcription complex subunit 6-like isoform X1\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"123295443 CCR4-NOT transcription complex subunit 1 isoform X1\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"123297533 regulator of gene activity isoform X1\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"123293408 CCR4-NOT transcription complex subunit 3 isoform X1\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"123290863 putative uncharacterized protein DDB_G0286901\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"123293582 CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"123303077 CCR4-NOT transcription complex subunit 8-like\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"123304961 CCR4-NOT transcription complex subunit 9\tK12606 RCD1; CCR4-NOT transcription complex subunit 9"
					},
					{
						"name":"123300459 CCR4-NOT transcription complex subunit 10\tK12607 CNOT10; CCR4-NOT transcription complex subunit 10"
					}
					]
				},
				{
					"name":"Pan complex",
					"children":[
					{
						"name":"123293954 PAN2-PAN3 deadenylation complex catalytic subunit PAN2 isoform X1\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]"
					},
					{
						"name":"123294829 PAN2-PAN3 deadenylation complex subunit PAN3 isoform X1\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3"
					}
					]
				},
				{
					"name":"Other 3'-5' decay factors",
					"children":[
					{
						"name":"123295628 poly(A)-specific ribonuclease PARN-like\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]"
					},
					{
						"name":"123295738 pre-piRNA 3'-exonuclease trimmer-like\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]"
					},
					{
						"name":"123300489 ATP-dependent DNA\/RNA helicase DHX36-like\tK14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]"
					},
					{
						"name":"123292347 protein BTG3-like\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"123295069 protein Tob1-like\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"123296750 nocturnin isoform X1\tK18764 NOCT; nocturnin [EC:3.1.3.108]"
					},
					{
						"name":"123291584 m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					},
					{
						"name":"123303115 2',5'-phosphodiesterase 12 isoform X1\tK19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]"
					},
					{
						"name":"123299285 probable helicase with zinc finger domain\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]"
					},
					{
						"name":"123293622 protein Smaug\tK27396 SMG; protein Smaug"
					},
					{
						"name":"123298668 focadhesin\tK27498 FOCAD; focadhesin"
					}
					]
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases",
					"children":[
					{
						"name":"123301565 probable ribonuclease ZC3H12D isoform X1\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]"
					}
					]
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"123302469 ribonuclease 3\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"123300087 probable oligoribonuclease isoform X1\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases"
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"123295200 enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"123291388 polyribonucleotide nucleotidyltransferase 1, mitochondrial\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"123297233 ATP-dependent 6-phosphofructokinase\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"123296385 chaperone protein HscA homolog\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"123297832 heat shock 70 kDa protein cognate 5\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"123305519 heat shock protein 60A\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					}
					]
				},
				{
					"name":"Others"
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome",
					"children":[
					{
						"name":"123293061 exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"123293307 exosome complex component CSL4\tK07573 CSL4; exosome complex component CSL4"
					}
					]
				},
				{
					"name":"Cofactors",
					"children":[
					{
						"name":"123291015 exosome complex component RRP41 isoform X1\tK11600 RRP41; exosome complex component RRP41"
					},
					{
						"name":"123293284 exosome complex component RRP42-like\tK12589 RRP42; exosome complex component RRP42"
					}
					]
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}