{
	"name":"ccrn03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"123303028 activating signal cointegrator 1 complex subunit 3-like\tK18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]"
				},
				{
					"name":"123297639 deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"123299608 putative 3-methyladenine DNA glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"123300543 N-glycosylase\/DNA lyase isoform X1\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"123291978 DNA-(apurinic or apyrimidinic site) endonuclease\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"123297456 DNA polymerase delta catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"123299319 DNA polymerase delta subunit 2-like\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"123302838 DNA polymerase delta subunit 2-like\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"123302842 LOW QUALITY PROTEIN: DNA polymerase delta subunit 2-like\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"123297945 DNA polymerase delta subunit 3-like\tK03504 POLD3; DNA polymerase delta subunit 3"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"123292937 DNA polymerase epsilon catalytic subunit 1\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"123300595 DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"123295781 DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						},
						{
							"name":"123300365 DNA polymerase epsilon subunit C\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						},
						{
							"name":"123305806 DNA polymerase epsilon subunit 4\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"123305888 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"123295742 flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"123299294 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors",
					"children":[
					{
						"name":"123296170 DNA repair protein XRCC1\tK10803 XRCC1; DNA-repair protein XRCC1"
					},
					{
						"name":"123292907 DNA ligase 3\tK10776 LIG3; DNA ligase 3 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"123292047 probable tyrosyl-DNA phosphodiesterase\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"123298483 uncharacterized protein F21D5.5\tK08073 PNKP; bifunctional polynucleotide phosphatase\/kinase [EC:3.1.3.32 2.7.1.78]"
					},
					{
						"name":"123305113 poly [ADP-ribose] polymerase isoform X1\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"123300389 UV excision repair protein RAD23 homolog B\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"123293855 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"123298473 cullin-4B\tK10609 CUL4; cullin 4"
						},
						{
							"name":"123292286 DNA damage-binding protein 1 isoform X1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"123306033 DNA-directed RNA polymerase II subunit RPB1\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"123296821 DNA-directed RNA polymerase II subunit RPB2 isoform X1\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"123302555 DNA-directed RNA polymerase II subunit RPB3\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"123296771 DNA-directed RNA polymerase II subunit Rpb4\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"123298267 DNA-directed RNA polymerases I, II, and III subunit RPABC1\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"123305650 DNA-directed RNA polymerases I, II, and III subunit RPABC2\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"123295757 DNA-directed RNA polymerase II subunit RPB7\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"123292426 DNA-directed RNA polymerases I, II, and III subunit RPABC3 isoform X1\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"123300929 DNA-directed RNA polymerase II subunit RPB9\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"123295554 DNA-directed RNA polymerases I, II, and III subunit RPABC5\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"123295263 DNA-directed RNA polymerase II subunit RPB11\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"123298443 DNA-directed RNA polymerases I, II, and III subunit RPABC4\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"123293855 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"123298473 cullin-4B\tK10609 CUL4; cullin 4"
						},
						{
							"name":"123292286 DNA damage-binding protein 1 isoform X1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"123298666 DNA excision repair protein ERCC-6-like\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"123290465 general transcription and DNA repair factor IIH helicase subunit XPB\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"123293955 general transcription and DNA repair factor IIH helicase subunit XPD\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"123299105 general transcription factor IIH subunit 1\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"123296315 general transcription factor IIH subunit 2\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"123305304 general transcription factor IIH subunit 3\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"123300045 general transcription factor IIH subunit 4\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"123299816 general transcription factor IIH subunit 5\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"123298234 cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"123300568 cyclin-H\tK06634 CCNH; cyclin H"
					},
					{
						"name":"123299332 CDK-activating kinase assembly factor MAT1\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"123305254 replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"123295556 replication protein A 32 kDa subunit-B\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"123301634 replication protein A 14 kDa subunit-like\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"123295441 DNA repair protein complementing XP-A cells homolog isoform X1\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"123305644 DNA excision repair protein ERCC-1\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"123296332 DNA repair endonuclease XPF\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"123299294 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"123295108 probable cytosolic iron-sulfur protein assembly protein Ciao1\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"123294051 MIP18 family protein galla-2\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"123298396 MIP18 family protein galla-1\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"123302744 cullin-3\tK03869 CUL3; cullin 3"
					},
					{
						"name":"123300973 cullin-5\tK10612 CUL5; cullin 5"
					},
					{
						"name":"123303421 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"123292144 elongin-B\tK03873 ELOB; elongin-B"
					},
					{
						"name":"123297631 transcription elongation factor B polypeptide 3-like\tK15076 ELOA; elongin-A"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"123301480 DNA mismatch repair protein Msh2\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"123302197 DNA mismatch repair protein Msh6\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"123300974 DNA mismatch repair protein Mlh1\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"123297612 mismatch repair endonuclease PMS2\tK10858 PMS2; DNA mismatch repair protein PMS2"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"123297456 DNA polymerase delta catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"123299319 DNA polymerase delta subunit 2-like\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"123302838 DNA polymerase delta subunit 2-like\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"123302842 LOW QUALITY PROTEIN: DNA polymerase delta subunit 2-like\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"123297945 DNA polymerase delta subunit 3-like\tK03504 POLD3; DNA polymerase delta subunit 3"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"123305254 replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"123295556 replication protein A 32 kDa subunit-B\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"123301634 replication protein A 14 kDa subunit-like\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"123293528 replication factor C subunit 1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"123290501 replication factor C subunit 4 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"123296099 replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"123294063 replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"123300280 replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"123305888 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"123300904 exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"123299294 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"123291081 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"123299130 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA1-core complex",
					"children":[
					{
						"name":"123295369 BRCA1-associated RING domain protein 1-like\tK10683 BARD1; BRCA1-associated RING domain protein 1"
					}
					]
				},
				{
					"name":"BRCA1-A complex",
					"children":[
					{
						"name":"123300663 BRCA1-A complex subunit Abraxas 1-like\tK20774 FAM175A; BRCA1-A complex subunit Abraxas"
					},
					{
						"name":"123305681 BRISC and BRCA1-A complex member 1-like\tK20776 BABAM; BRISC and BRCA1-A complex member 1"
					},
					{
						"name":"123295044 BRISC and BRCA1-A complex member 2-like\tK12173 BRE; BRCA1-A complex subunit BRE"
					},
					{
						"name":"123295658 lys-63-specific deubiquitinase BRCC36-like\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
					}
					]
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"123291081 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"123299130 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"123292240 DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"123292240 DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"123303073 DNA repair protein RAD51 homolog 3-like\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"123296002 DNA repair protein RAD51 homolog 4\tK10871 RAD51L3; RAD51-like protein 3"
					},
					{
						"name":"123293750 DNA repair protein XRCC2-like\tK10879 XRCC2; DNA-repair protein XRCC2"
					},
					{
						"name":"123297305 DNA repair protein XRCC3\tK10880 XRCC3; DNA-repair protein XRCC3"
					}
					]
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"123298277 DNA repair and recombination protein RAD54-like\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"123306077 DNA repair and recombination protein RAD54B-like\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"123294908 ATP-dependent DNA helicase Q1-like\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"123305872 Werner syndrome ATP-dependent helicase-like isoform X1\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
					},
					{
						"name":"123291551 Bloom syndrome protein homolog\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"123295996 ATP-dependent DNA helicase Q4\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
					},
					{
						"name":"123301445 ATP-dependent DNA helicase Q5-like\tK10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"123291551 Bloom syndrome protein homolog\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"123294916 DNA topoisomerase 3-alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"123297290 DNA topoisomerase 3-beta-1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"123300250 recQ-mediated genome instability protein 1-like\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"123305254 replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"123295556 replication protein A 32 kDa subunit-B\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"123301634 replication protein A 14 kDa subunit-like\tK10740 RPA3; replication factor A3"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"123299679 serine\/threonine-protein phosphatase 4 catalytic subunit\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"123296623 serine\/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"123292100 serine\/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"123293049 serine\/threonine-protein phosphatase 4 regulatory subunit 4-like\tK15426 PPP4R4; serine\/threonine-protein phosphatase 4 regulatory subunit 4"
					}
					]
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"123296234 structural maintenance of chromosomes protein 5\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"123299807 structural maintenance of chromosomes protein 6\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"123292654 non-structural maintenance of chromosomes element 1 homolog\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"123303706 melanoma-associated antigen B16-like\tK22823 NSMCE3; non-structural maintenance of chromosomes element 3"
					},
					{
						"name":"123290832 EP300-interacting inhibitor of differentiation 3-like\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					},
					{
						"name":"123294577 EP300-interacting inhibitor of differentiation 3-like isoform X1\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"123298806 crossover junction endonuclease EME1\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"123299782 exonuclease 3'-5' domain-containing protein 2 isoform X1\tK20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]"
					},
					{
						"name":"123298253 26S proteasome complex subunit SEM1\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"123300277 structure-specific endonuclease subunit slx1\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"123294901 flap endonuclease GEN\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"123297312 mortality factor 4-like protein 1\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"123292984 fidgetin-like protein 1\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"123296236 uncharacterized protein LOC123296236\tK23112 BRAT1; BRCA1-associated ATM activator 1"
					},
					{
						"name":"123299780 uncharacterized protein LOC123299780 isoform X1\tK23456 CFAP410; cilla- and flagella-associated protein"
					},
					{
						"name":"123300938 zinc finger SWIM domain-containing protein 7-like\tK25770 ZSWIM7; zinc finger SWIM domain-containing protein 7"
					},
					{
						"name":"123290455 protein MMS22-like\tK26125 MMS22L; protein MMS22-like"
					},
					{
						"name":"123292702 tonsoku-like protein\tK09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2"
					},
					{
						"name":"123292713 tonsoku-like protein\tK09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2"
					},
					{
						"name":"123306219 probable serine\/threonine-protein kinase DDB_G0276461\tK27803 HROB; homologous recombination OB-fold protein"
					},
					{
						"name":"123300627 DNA helicase MCM8-like\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
					},
					{
						"name":"123298171 DNA helicase MCM9-like\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
					},
					{
						"name":"123292948 MRN complex-interacting protein\tK28623 MRNIP; MRN complex-interacting protein"
					},
					{
						"name":"123297499 Werner Syndrome-like exonuclease\tK22807 WRNexo; werner syndrome-like exonuclease [EC:3.1.11.-]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"123291081 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"123299130 DNA repair protein RAD50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"123291904 DNA ligase 4\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"123296869 protein artemis\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex",
					"children":[
					{
						"name":"123300544 E3 ubiquitin-protein ligase FANCL\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
					}
					]
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"123296546 centromere protein S-like\tK11511 APITD1; centromere protein S"
					},
					{
						"name":"123297562 centromere protein X-like\tK15360 STRA13; centromere protein X"
					},
					{
						"name":"123291025 ubiquitin-conjugating enzyme E2 T-like\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"123291551 Bloom syndrome protein homolog\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"123294916 DNA topoisomerase 3-alpha\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"123297290 DNA topoisomerase 3-beta-1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"123300250 recQ-mediated genome instability protein 1-like\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"FANCD2-I complex",
					"children":[
					{
						"name":"123306052 Fanconi anemia group D2 protein homolog\tK10891 FANCD2; fanconi anemia group D2 protein"
					},
					{
						"name":"123298805 Fanconi anemia group I protein homolog\tK10895 FANCI; fanconi anemia group I protein"
					}
					]
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"123292240 DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"123303073 DNA repair protein RAD51 homolog 3-like\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"123291582 WD repeat-containing protein 48 homolog\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6",
					"children":[
					{
						"name":"123291778 serine\/threonine-protein phosphatase 6 catalytic subunit\tK15498 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"123295451 serine\/threonine-protein phosphatase 6 regulatory subunit 3\tK15501 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3"
					}
					]
				},
				{
					"name":"Ubiquitin ligases",
					"children":[
					{
						"name":"123292373 E3 ubiquitin-protein ligase rnf8-like\tK10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]"
					},
					{
						"name":"123292737 E3 ubiquitin-protein ligase HERC2\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"123297785 telomerase Cajal body protein 1 homolog\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"123294685 gastrulation defective protein 1 homolog\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"123291597 DNApol-eta\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"123292180 DNA polymerase iota\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"123294027 LOW QUALITY PROTEIN: DNA repair protein Rev1\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"123292446 ubiquitin-conjugating enzyme E2-17 kDa\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"123302985 ubiquitin-conjugating enzyme E2 2-like\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"123306013 ubiquitin-conjugating enzyme E2 2-like\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"123297795 ubiquitin-conjugating enzyme E2 variant 2\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"123290937 ubiquitin-conjugating enzyme E2 N-like\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				},
				{
					"name":"123302531 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"123305888 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"123303579 DNA-dependent metalloprotease SPRTN-like\tK24051 SPRTN; SprT-like domain-contaning protein Spartan"
				},
				{
					"name":"123305079 DNA-dependent metalloprotease dvc-1-like\tK24051 SPRTN; SprT-like domain-contaning protein Spartan"
				},
				{
					"name":"123295847 inner centromere protein A-like\tK26957 GCNA; germ cell nuclear acidic protein"
				},
				{
					"name":"123306111 dentin sialophosphoprotein-like\tK26957 GCNA; germ cell nuclear acidic protein"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"123300517 cell cycle checkpoint control protein RAD9A-like\tK10995 RAD9B; cell cycle checkpoint control protein RAD9B"
				},
				{
					"name":"123298476 checkpoint protein HUS1\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"123300772 cell cycle checkpoint protein RAD1-like\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"123293313 cell cycle checkpoint protein RAD17\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"123290501 replication factor C subunit 4 isoform X1\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"123296099 replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"123294063 replication factor C subunit 5\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"123300280 replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"123300772 cell cycle checkpoint protein RAD1-like\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"123305050 protein timeless homolog\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"123299041 TIMELESS-interacting protein\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				}
				]
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"123300600 uncharacterized protein LOC123300600\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"123294590 Golgi to ER traffic protein 4 homolog\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex",
				"children":[
				{
					"name":"123301880 integrator complex subunit 3\tK13140 INTS3; integrator complex subunit 3 (SOSS complex subunit A)"
				},
				{
					"name":"123295588 SOSS complex subunit B homolog\tK28889 NABP; SOSS complex subunit B"
				}
				]
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"123298863 serine\/threonine-protein kinase ATR\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"123300496 serine-protein kinase ATM\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"123291117 serine\/threonine-protein kinase grp isoform X1\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"123291965 ovarian-specific serine\/threonine-protein kinase Lok\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"123293371 M-phase inducer phosphatase-like\tK05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]"
				},
				{
					"name":"123294738 14-3-3 protein zeta-like\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"123302157 14-3-3 protein zeta\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"123301798 14-3-3 protein epsilon isoform X1\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"123300020 wee1-like protein kinase\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"123302346 plastin-2\tK17336 PLS3; plastin-3"
				},
				{
					"name":"123291929 protein downstream neighbor of son homolog\tK22422 DONSON; protein downstream neighbor of Son"
				},
				{
					"name":"123294983 vacuolar protein sorting-associated protein 4\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"123301270 protein SUPPRESSOR OF K(+) TRANSPORT GROWTH DEFECT 1-like\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"123293320 abscission\/NoCut checkpoint regulator\tK24778 ZFYVE19; abscission\/NoCut checkpoint regulator"
				},
				{
					"name":"123292294 replication stress response regulator SDE2\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"123298448 bladder cancer-associated protein\tK29062 BLCAP; apoptosis inducing factor BLCAP"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"123306097 DNA polymerase theta-like\tK02349 POLQ; DNA polymerase theta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"123295380 uncharacterized protein LOC123295380\tK10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]"
				},
				{
					"name":"123295947 uncharacterized protein LOC123295947\tK10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"123292185 helicase POLQ-like\tK19178 HELQ; POLQ-like helicase [EC:5.6.2.4]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"123296724 pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"123290464 cell division cycle 5-like protein\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"123300641 pre-mRNA-splicing factor SPF27\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"123300036 pleiotropic regulator 1 isoform X1\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"123294562 7,8-dihydro-8-oxoguanine triphosphatase-like\tK17816 NUDT1; 8-oxo-dGTP diphosphatase \/ 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]"
				},
				{
					"name":"123300234 8-oxo-dGDP phosphatase NUDT18\tK17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]"
				},
				{
					"name":"123300005 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"123301396 deoxyuridine 5'-triphosphate nucleotidohydrolase-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"123301417 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"123302813 deoxyuridine 5'-triphosphate nucleotidohydrolase-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"123295515 ribonucleoside-diphosphate reductase large subunit isoform X1\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"123298625 ribonucleoside-diphosphate reductase subunit M2 B\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"123297639 deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"123299608 putative 3-methyladenine DNA glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors"
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"123298350 single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"123298350 single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"123300005 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"123301396 deoxyuridine 5'-triphosphate nucleotidohydrolase-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"123301417 deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"123302813 deoxyuridine 5'-triphosphate nucleotidohydrolase-like\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}