{ "name":"cdep04131", "children":[ { "name":"Exocytosis", "children":[ { "name":"Calcium ion-dependent exocytosis", "children":[ { "name":"Synaptotagmins" }, { "name":"Septins", "children":[ { "name":"91087417 L203_103206; (RefSeq) uncharacterized protein\tK16944 SEPT7; septin 7" } ] }, { "name":"DOC-2 proteins" }, { "name":"Acrosomal exocytosis proteins", "children":[ { "name":"91085013 L203_100799; (RefSeq) uncharacterized protein\tK06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]" } ] }, { "name":"Phospholipases", "children":[ { "name":"91089767 L203_105558; (RefSeq) uncharacterized protein\tK05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]" }, { "name":"91086340 L203_102128; (RefSeq) uncharacterized protein\tK01115 PLD1_2; phospholipase D1\/2 [EC:3.1.4.4]" }, { "name":"91088152 L203_103942; (RefSeq) uncharacterized protein\tK01115 PLD1_2; phospholipase D1\/2 [EC:3.1.4.4]" } ] }, { "name":"Kinases and associated proteins", "children":[ { "name":"91087865 L203_103655; (RefSeq) uncharacterized protein\tK00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]" }, { "name":"91087456 L203_103245; (RefSeq) uncharacterized protein\tK04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]" }, { "name":"91085412 L203_101198; (RefSeq) uncharacterized protein\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"91089379 L203_105170; (RefSeq) uncharacterized protein\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]" }, { "name":"91086257 L203_102045; (RefSeq) nucleoside diphosphate kinase\tK00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]" }, { "name":"91088919 L203_104709; (RefSeq) uncharacterized protein\tK00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]" }, { "name":"91086777 L203_102565; (RefSeq) uncharacterized protein\tK19852 KIN1_2; serine\/threonine protein kinase KIN1\/2 [EC:2.7.11.1]" } ] }, { "name":"Others", "children":[ { "name":"91085537 L203_101324; (RefSeq) calcium-binding protein NCS-1\tK19932 NCS1; neuronal calcium sensor" } ] } ] }, { "name":"Small GTPases and associated proteins", "children":[ { "name":"Rab GTPases", "children":[ { "name":"91089701 L203_105492; (RefSeq) GTP-binding protein ypt2\tK07901 RAB8A; Ras-related protein Rab-8A" } ] }, { "name":"Rab associated proteins", "children":[ { "name":"91085120 L203_100906; (RefSeq) calmodulin\tK02183 CALM; calmodulin" }, { "name":"91089083 L203_104874; (RefSeq) uncharacterized protein\tK02183 CALM; calmodulin" }, { "name":"91088852 L203_104642; (RefSeq) uncharacterized protein\tK19940 SEC2; Rab guanine nucleotide exchange factor SEC2" }, { "name":"91086820 L203_102609; (RefSeq) uncharacterized protein\tK15292 STXBP1; syntaxin-binding protein 1" }, { "name":"91086401 L203_102189; (RefSeq) uncharacterized protein\tK08518 STXBP5; syntaxin-binding protein 5" }, { "name":"91086939 L203_102728; (RefSeq) uncharacterized protein\tK19952 RABIF; guanine nucleotide exchange factor" }, { "name":"91088197 L203_103987; (RefSeq) uncharacterized protein\tK19952 RABIF; guanine nucleotide exchange factor" }, { "name":"91089531 L203_105322; (RefSeq) uncharacterized protein\tK01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B\/F [EC:3.1.3.36]" }, { "name":"91088795 L203_104585; (RefSeq) uncharacterized protein\tK19951 TBC1D8_9; TBC1 domain family member 8\/9" }, { "name":"91084662 L203_100446; (RefSeq) uncharacterized protein\tK13342 PEX5; peroxin-5" }, { "name":"91086770 L203_102558; (RefSeq) uncharacterized protein\tK13342 PEX5; peroxin-5" }, { "name":"91085080 L203_100866; (RefSeq) uncharacterized protein\tK23460 CHM; Rab proteins geranylgeranyltransferase component A" }, { "name":"91085786 L203_101573; (RefSeq) uncharacterized protein\tK14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]" }, { "name":"91085645 L203_101432; (RefSeq) uncharacterized protein\tK05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]" }, { "name":"91086724 L203_102512; (RefSeq) uncharacterized protein\tK24155 DMXL; rabconnectin-3a" } ] }, { "name":"Rho GTPases", "children":[ { "name":"91086514 L203_102302; (RefSeq) cell division control protein 42\tK04393 CDC42; cell division control protein 42" }, { "name":"91087454 L203_103243; (RefSeq) cell division control protein 42\tK04393 CDC42; cell division control protein 42" }, { "name":"91089773 L203_105564; (RefSeq) uncharacterized protein\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1" } ] }, { "name":"Other small GTPases and associated proteins" } ] }, { "name":"Tethering complex", "children":[ { "name":"Exocyst complex", "children":[ { "name":"91089012 L203_104803; (RefSeq) uncharacterized protein\tK17637 EXOC2; exocyst complex component 2" }, { "name":"91086758 L203_102546; (RefSeq) uncharacterized protein\tK06110 EXOC3; exocyst complex component 3" }, { "name":"91085918 L203_101705; (RefSeq) uncharacterized protein\tK19984 EXOC5; exocyst complex component 5" }, { "name":"91087714 L203_103503; (RefSeq) uncharacterized protein\tK19985 EXOC6; exocyst complex component 6" }, { "name":"91088430 L203_104220; (RefSeq) uncharacterized protein\tK07195 EXOC7; exocyst complex component 7" }, { "name":"91090311 L203_106103; (RefSeq) uncharacterized protein\tK19986 EXOC8; exocyst complex component 8" } ] }, { "name":"Exocyst complex assembly proteins", "children":[ { "name":"91089342 L203_105133; (RefSeq) uncharacterized protein\tK10881 SHFM1; 26 proteasome complex subunit DSS1" }, { "name":"91087200 L203_102989; (RefSeq) uncharacterized protein\tK17945 TPM1_2; tropomyosin, fungi type" } ] } ] }, { "name":"Others", "children":[ { "name":"Exomer complex", "children":[ { "name":"91090294 L203_106086; (RefSeq) uncharacterized protein\tK19877 CHS5; chitin biosynthesis protein CHS5" }, { "name":"91085706 L203_101493; (RefSeq) uncharacterized protein\tK19881 BUD7; Chs5-Arf1p-binding protein BUD7\/BCH1" } ] }, { "name":"ER-PM contacts associated proteins", "children":[ { "name":"91085088 L203_100874; (RefSeq) uncharacterized protein\tK24964 BLTP1; Bridge-like lipid transfer protein family member 1" }, { "name":"91084326 L203_100110; (RefSeq) uncharacterized protein\tK28063 ESYT; extended synaptotagmin" }, { "name":"91086978 L203_102767; (RefSeq) uncharacterized protein\tK28063 ESYT; extended synaptotagmin" }, { "name":"91089244 L203_105035; (RefSeq) uncharacterized protein\tK28063 ESYT; extended synaptotagmin" }, { "name":"91089546 L203_105337; (RefSeq) uncharacterized protein\tK29085 SCS2_22; vesicle-associated membrane protein-associated protein" } ] }, { "name":"Others", "children":[ { "name":"91088738 L203_104528; (RefSeq) uncharacterized protein\tK12481 RBSN; rabenosyn-5" }, { "name":"91085542 L203_101329; (RefSeq) uncharacterized protein\tK19995 SCAMP; secretory carrier-associated membrane protein" } ] } ] } ] }, { "name":"SNARE", "children":[ { "name":"Syntaxin (Qa)", "children":[ { "name":"Stx-PM", "children":[ { "name":"91089938 L203_105729; (RefSeq) uncharacterized protein\tK08486 STX1B_2_3; syntaxin 1B\/2\/3" } ] }, { "name":"Stx-Endo" }, { "name":"Stx-TGN \/ EE", "children":[ { "name":"91086824 L203_102613; (RefSeq) uncharacterized protein\tK08489 STX16; syntaxin 16" } ] }, { "name":"Stx-cisGolgi", "children":[ { "name":"91086798 L203_102586; (RefSeq) uncharacterized protein\tK08490 STX5; syntaxin 5" } ] }, { "name":"Stx-sER" }, { "name":"Stx-rER", "children":[ { "name":"91087292 L203_103081; (RefSeq) uncharacterized protein\tK08492 STX18; syntaxin 18" } ] } ] }, { "name":"SNAP-25[N] (Qb)", "children":[ { "name":"Vti1", "children":[ { "name":"91089351 L203_105142; (RefSeq) uncharacterized protein\tK08493 VTI1; vesicle transport through interaction with t-SNAREs 1" } ] }, { "name":"NPSN" }, { "name":"Gos1 (Gos28)", "children":[ { "name":"91089383 L203_105174; (RefSeq) uncharacterized protein\tK08495 GOSR1; golgi SNAP receptor complex member 1" } ] }, { "name":"Bos1 \/ Membrin", "children":[ { "name":"91087780 L203_103569; (RefSeq) uncharacterized protein\tK08496 GOSR2; golgi SNAP receptor complex member 2" } ] }, { "name":"Sec20", "children":[ { "name":"91089689 L203_105480; (RefSeq) uncharacterized protein\tK08497 SEC20; protein transport protein SEC20" } ] } ] }, { "name":"SNAP-25[C] (Qc)", "children":[ { "name":"STX6" }, { "name":"STX8", "children":[ { "name":"91085832 L203_101619; (RefSeq) uncharacterized protein\tK08501 STX8; syntaxin 8" }, { "name":"91090384 L203_106176; (RefSeq) uncharacterized protein\tK08502 VAM7; regulator of vacuolar morphogenesis" } ] }, { "name":"STX10" }, { "name":"Bet1", "children":[ { "name":"91088899 L203_104689; (RefSeq) uncharacterized protein\tK08504 BET1; blocked early in transport 1" } ] }, { "name":"Sft1" }, { "name":"Syp7" }, { "name":"Use1" } ] }, { "name":"SNAP-25 (Qb,c)", "children":[ { "name":"SNAP-23" }, { "name":"SNAP-25", "children":[ { "name":"91088526 L203_104316; (RefSeq) uncharacterized protein\tK19950 SEC9; protein transport protein SEC9" } ] }, { "name":"SNAP-29" }, { "name":"SNAP-47" } ] }, { "name":"VAMP, Ykt6, Sec22 (R)", "children":[ { "name":"VAMP", "children":[ { "name":"91085397 L203_101183; (RefSeq) uncharacterized protein\tK08513 VAMP4; vesicle-associated membrane protein 4" }, { "name":"91087679 L203_103468; (RefSeq) uncharacterized protein\tK08515 VAMP7; vesicle-associated membrane protein 7" } ] }, { "name":"Ykt6", "children":[ { "name":"91090453 L203_106245; (RefSeq) uncharacterized protein\tK08516 YKT6; synaptobrevin homolog YKT6" } ] }, { "name":"Sec22", "children":[ { "name":"91084413 L203_100197; (RefSeq) uncharacterized protein\tK08517 SEC22; vesicle transport protein SEC22" } ] }, { "name":"Tomosyn", "children":[ { "name":"91086401 L203_102189; (RefSeq) uncharacterized protein\tK08518 STXBP5; syntaxin-binding protein 5" } ] }, { "name":"Putative SNAREs" } ] }, { "name":"SNARE associated proteins", "children":[ { "name":"Syntaxin-binding proteins", "children":[ { "name":"91086820 L203_102609; (RefSeq) uncharacterized protein\tK15292 STXBP1; syntaxin-binding protein 1" }, { "name":"91087442 L203_103231; (RefSeq) uncharacterized protein\tK19998 SCFD1; sec1 family domain-containing protein 1" } ] }, { "name":"Palmitoyltransferases", "children":[ { "name":"91085027 L203_100813; (RefSeq) uncharacterized protein\tK20028 ZDHHC2_15_20; palmitoyltransferase ZDHHC2\/15\/20 [EC:2.3.1.225]" }, { "name":"91087887 L203_103677; (RefSeq) palmitoyltransferase AKR1\tK20032 ZDHHC13_17; palmitoyltransferase ZDHHC13\/17 [EC:2.3.1.225]" } ] }, { "name":"Others", "children":[ { "name":"91088270 L203_104060; (RefSeq) uncharacterized protein\tK06027 NSF; vesicle-fusing ATPase [EC:3.6.4.6]" }, { "name":"91088710 L203_104500; (RefSeq) uncharacterized protein\tK15296 NAPA; alpha-soluble NSF attachment protein" }, { "name":"91085113 L203_100899; (RefSeq) sorting nexin-4\tK17919 SNX4; sorting nexin-4" }, { "name":"91084799 L203_100583; (RefSeq) sorting nexin-41\tK21996 SNX41_42; sorting nexin-41\/42" }, { "name":"91090476 L203_106268; (RefSeq) uncharacterized protein\tK15620 GOLPH3; golgi phosphoprotein 3" }, { "name":"91086648 L203_102436; (RefSeq) uncharacterized protein\tK13525 VCP; transitional endoplasmic reticulum ATPase" }, { "name":"91090622 L203_106414; (RefSeq) uncharacterized protein\tK14012 NSFL1C; UBX domain-containing protein 1" }, { "name":"91088584 L203_104374; (RefSeq) uncharacterized protein\tK27407 VTS1; RNA-binding protein VTS1" } ] } ] } ] }, { "name":"Endocytosis", "children":[ { "name":"Clathrin-mediated endocytosis", "children":[ { "name":"Clathrin", "children":[ { "name":"91086794 L203_102582; (RefSeq) uncharacterized protein\tK04646 CLTC; clathrin heavy chain" } ] }, { "name":"Dynamin", "children":[ { "name":"91089956 L203_105747; (RefSeq) uncharacterized protein\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]" } ] }, { "name":"AP-2 complex", "children":[ { "name":"91085611 L203_101398; (RefSeq) uncharacterized protein\tK11824 AP2A; AP-2 complex subunit alpha" }, { "name":"91086076 L203_101864; (RefSeq) uncharacterized protein\tK11825 AP2B1; AP-2 complex subunit beta-1" }, { "name":"91084612 L203_100396; (RefSeq) uncharacterized protein\tK11826 AP2M1; AP-2 complex subunit mu-1" }, { "name":"91090015 L203_105806; (RefSeq) AP-2 complex subunit sigma\tK11827 AP2S1; AP-2 complex subunit sigma-1" } ] }, { "name":"Other core components", "children":[ { "name":"91090451 L203_106243; (RefSeq) uncharacterized protein\tK20042 FCHO; F-BAR domain only protein" }, { "name":"91085296 L203_101082; (RefSeq) uncharacterized protein\tK12471 EPN; epsin" }, { "name":"91087979 L203_103769; (RefSeq) uncharacterized protein\tK12471 EPN; epsin" }, { "name":"91088690 L203_104480; (RefSeq) uncharacterized protein\tK12472 EPS15; epidermal growth factor receptor substrate 15" }, { "name":"91089501 L203_105292; (RefSeq) uncharacterized protein\tK20044 PICALM; phosphatidylinositol-binding clathrin assembly protein" }, { "name":"91089502 L203_105293; (RefSeq) uncharacterized protein\tK20044 PICALM; phosphatidylinositol-binding clathrin assembly protein" }, { "name":"91087826 L203_103615; (RefSeq) uncharacterized protein\tK12562 AMPH; amphiphysin" }, { "name":"91087357 L203_103146; (RefSeq) uncharacterized protein\tK20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1" }, { "name":"91084747 L203_100531; (RefSeq) heat shock protein HSS1\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8" }, { "name":"91084770 L203_100554; (RefSeq) heat shock protein HSS1\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8" }, { "name":"91087800 L203_103589; (RefSeq) heat shock protein sks2\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8" } ] }, { "name":"Low-density lipoprotein receptor (LDLR) family proteins" }, { "name":"LDLR adaptor proteins", "children":[ { "name":"91087865 L203_103655; (RefSeq) uncharacterized protein\tK00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]" } ] }, { "name":"GPCR adaptor proteins", "children":[ { "name":"91086280 L203_102068; (RefSeq) uncharacterized protein\tK20061 ALY1_2; arrestin-related trafficking adapter 3\/6" }, { "name":"91089739 L203_105530; (RefSeq) uncharacterized protein\tK20062 ART4_5_7; arrestin-related trafficking adapter 4\/5\/7" } ] }, { "name":"Receptor tyrosine kinase (RTK) adaptor proteins" }, { "name":"Inositol 5-phosphatases", "children":[ { "name":"91089531 L203_105322; (RefSeq) uncharacterized protein\tK01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B\/F [EC:3.1.3.36]" }, { "name":"91090187 L203_105979; (RefSeq) uncharacterized protein\tK20279 SYNJ; synaptojanin [EC:3.1.3.36]" } ] }, { "name":"Kinases", "children":[ { "name":"91086156 L203_101944; (RefSeq) uncharacterized protein\tK08853 AAK; AP2-associated kinase [EC:2.7.11.1]" }, { "name":"91084973 L203_100759; (RefSeq) uncharacterized protein\tK17541 SCYL2; SCY1-like protein 2" } ] }, { "name":"Ubiquitin E3 ligases", "children":[ { "name":"91086525 L203_102313; (RefSeq) uncharacterized protein\tK10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]" }, { "name":"91086530 L203_102318; (RefSeq) uncharacterized protein\tK10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]" } ] }, { "name":"Others", "children":[ { "name":"91085324 L203_101110; (RefSeq) uncharacterized protein\tK20040 HIP1R; huntingtin-interacting protein 1-related protein" }, { "name":"91086431 L203_102219; (RefSeq) uncharacterized protein\tK08054 CANX; calnexin" }, { "name":"91084406 L203_100190; (RefSeq) uncharacterized protein\tK11247 SH3GL; endophilin-A" }, { "name":"91087929 L203_103719; (RefSeq) uncharacterized protein\tK20069 NECAP1_2; adaptin ear-binding coat-associated protein 1\/2" }, { "name":"91086025 L203_101812; (RefSeq) uncharacterized protein\tK20031 ZDHHC6; palmitoyltransferase ZDHHC6 [EC:2.3.1.225]" } ] } ] }, { "name":"Lipid raft mediated endocytosis", "children":[ { "name":"Caveolin-mediated endocytosis", "children":[ { "name":"91089956 L203_105747; (RefSeq) uncharacterized protein\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]" }, { "name":"91084834 L203_100619; (RefSeq) uncharacterized protein\tK02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]" } ] }, { "name":"Flotillin-dependent endocytosis" }, { "name":"GRAF1-dependent endocytosis", "children":[ { "name":"91086514 L203_102302; (RefSeq) cell division control protein 42\tK04393 CDC42; cell division control protein 42" }, { "name":"91087454 L203_103243; (RefSeq) cell division control protein 42\tK04393 CDC42; cell division control protein 42" }, { "name":"91085736 L203_101523; (RefSeq) ADP-ribosylation factor\tK07937 ARF1_2; ADP-ribosylation factor 1\/2" } ] }, { "name":"Arf6-dependent endocytosis", "children":[ { "name":"91086843 L203_102632; (RefSeq) ADP-ribosylation factor 6\tK07941 ARF6; ADP-ribosylation factor 6" }, { "name":"91089773 L203_105564; (RefSeq) uncharacterized protein\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1" } ] }, { "name":"RhoA-dependent endocytosis", "children":[ { "name":"91085714 L203_101501; (RefSeq) GTP-binding protein RhoA\tK04513 RHOA; Ras homolog gene family, member A" }, { "name":"91089956 L203_105747; (RefSeq) uncharacterized protein\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]" } ] } ] }, { "name":"Phagocytosis", "children":[ { "name":"Fc receptors" }, { "name":"Integrins (complement receptors)" }, { "name":"Opsonins" }, { "name":"Toll-like receptors" }, { "name":"C-lectin receptors" }, { "name":"Scavenger receptors" }, { "name":"Coronins" }, { "name":"Others", "children":[ { "name":"91090486 L203_106278; (RefSeq) myosin-1\tK10356 MYO1; myosin I" } ] } ] }, { "name":"Macropinocytosis", "children":[ { "name":"Ras GTPases", "children":[ { "name":"91087745 L203_103534; (RefSeq) Ras-like protein\tK07827 KRAS; GTPase KRas" }, { "name":"91088756 L203_104546; (RefSeq) uncharacterized protein\tK07827 KRAS; GTPase KRas" }, { "name":"91089773 L203_105564; (RefSeq) uncharacterized protein\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1" }, { "name":"91086514 L203_102302; (RefSeq) cell division control protein 42\tK04393 CDC42; cell division control protein 42" }, { "name":"91087454 L203_103243; (RefSeq) cell division control protein 42\tK04393 CDC42; cell division control protein 42" } ] }, { "name":"Kinases", "children":[ { "name":"91086183 L203_101971; (RefSeq) uncharacterized protein\tK00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]" }, { "name":"91084433 L203_100217; (RefSeq) uncharacterized protein\tK00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]" }, { "name":"91088473 L203_104263; (RefSeq) uncharacterized protein\tK00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]" }, { "name":"91087456 L203_103245; (RefSeq) uncharacterized protein\tK04409 PAK1; p21-activated kinase 1 [EC:2.7.11.1]" } ] }, { "name":"Phospholipase C", "children":[ { "name":"91089767 L203_105558; (RefSeq) uncharacterized protein\tK05857 PLCD; phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]" } ] }, { "name":"Sorting nexins", "children":[ { "name":"91090036 L203_105827; (RefSeq) uncharacterized protein\tK17917 SNX1_2; sorting nexin-1\/2" } ] }, { "name":"Others" } ] }, { "name":"Bin\/Amphiphysin\/Rvs (BAR) family proteins", "children":[ { "name":"N-BAR proteins", "children":[ { "name":"91087826 L203_103615; (RefSeq) uncharacterized protein\tK12562 AMPH; amphiphysin" }, { "name":"91084406 L203_100190; (RefSeq) uncharacterized protein\tK11247 SH3GL; endophilin-A" } ] }, { "name":"F-BAR proteins", "children":[ { "name":"91090451 L203_106243; (RefSeq) uncharacterized protein\tK20042 FCHO; F-BAR domain only protein" }, { "name":"91087370 L203_103159; (RefSeq) uncharacterized protein\tK20643 RGD1; Rho GTPase-activating protein RGD1" } ] }, { "name":"I-BAR proteins" } ] }, { "name":"Rab GTPases and associated proteins", "children":[ { "name":"Rab GTPases" }, { "name":"Rab associated proteins", "children":[ { "name":"91085711 L203_101498; (RefSeq) uncharacterized protein\tK20131 RABGEF1; Rab5 GDP\/GTP exchange factor" }, { "name":"91088738 L203_104528; (RefSeq) uncharacterized protein\tK12481 RBSN; rabenosyn-5" }, { "name":"91089531 L203_105322; (RefSeq) uncharacterized protein\tK01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B\/F [EC:3.1.3.36]" }, { "name":"91086183 L203_101971; (RefSeq) uncharacterized protein\tK00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]" }, { "name":"91090380 L203_106172; (RefSeq) uncharacterized protein\tK08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]" }, { "name":"91084553 L203_100337; (RefSeq) uncharacterized protein\tK12479 VPS45; vacuolar protein sorting-associated protein 45" } ] } ] }, { "name":"Arf GTPases and associated proteins", "children":[ { "name":"Arf GTPases", "children":[ { "name":"91085736 L203_101523; (RefSeq) ADP-ribosylation factor\tK07937 ARF1_2; ADP-ribosylation factor 1\/2" }, { "name":"91086843 L203_102632; (RefSeq) ADP-ribosylation factor 6\tK07941 ARF6; ADP-ribosylation factor 6" } ] }, { "name":"Arf associated proteins", "children":[ { "name":"91088034 L203_103824; (RefSeq) uncharacterized protein\tK12486 SMAP; stromal membrane-associated protein" }, { "name":"91088974 L203_104764; (RefSeq) uncharacterized protein\tK12486 SMAP; stromal membrane-associated protein" }, { "name":"91088209 L203_103999; (RefSeq) uncharacterized protein\tK12494 PSD; PH and SEC7 domain-containing protein" } ] } ] }, { "name":"Others", "children":[ { "name":"Fucosyltransferase" }, { "name":"EFR3-PI4KIII alpha complex and associated proteins", "children":[ { "name":"91090306 L203_106098; (RefSeq) uncharacterized protein\tK00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]" }, { "name":"91089638 L203_105429; (RefSeq) uncharacterized protein\tK21842 EFR3; protein EFR3" } ] }, { "name":"Insulin-like growth factor-binding proteins" }, { "name":"Others" } ] } ] }, { "name":"Endosome - Lysosome transport", "children":[ { "name":"Rab GTPases and associated proteins", "children":[ { "name":"Rab GTPases", "children":[ { "name":"91088662 L203_104452; (RefSeq) uncharacterized protein\tK07897 RAB7A; Ras-related protein Rab-7A [EC:3.6.5.2]" } ] }, { "name":"FTS\/Hook\/FHIP (FHF) complex", "children":[ { "name":"91089687 L203_105478; (RefSeq) uncharacterized protein\tK16536 HOOK3; protein HOOK3" } ] }, { "name":"FERRY complex" }, { "name":"Rab associated proteins", "children":[ { "name":"91085306 L203_101092; (RefSeq) uncharacterized protein\tK11982 RNF115_126; E3 ubiquitin-protein ligase RNF115\/126 [EC:2.3.2.27]" }, { "name":"91086183 L203_101971; (RefSeq) uncharacterized protein\tK00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]" }, { "name":"91088136 L203_103926; (RefSeq) uncharacterized protein\tK02731 PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]" }, { "name":"91086725 L203_102513; (RefSeq) uncharacterized protein\tK18469 TBC1D5; TBC1 domain family member 5" }, { "name":"91085431 L203_101217; (RefSeq) uncharacterized protein\tK20168 TBC1D15; TBC1 domain family member 15" }, { "name":"91085080 L203_100866; (RefSeq) uncharacterized protein\tK23460 CHM; Rab proteins geranylgeranyltransferase component A" }, { "name":"91085786 L203_101573; (RefSeq) uncharacterized protein\tK14050 RABGGTA; geranylgeranyl transferase type-2 subunit alpha [EC:2.5.1.60]" }, { "name":"91085645 L203_101432; (RefSeq) uncharacterized protein\tK05956 RABGGTB; geranylgeranyl transferase type-2 subunit beta [EC:2.5.1.60]" }, { "name":"91090476 L203_106268; (RefSeq) uncharacterized protein\tK15620 GOLPH3; golgi phosphoprotein 3" } ] } ] }, { "name":"Arf GTPases and associated proteins", "children":[ { "name":"Arf GTPases", "children":[ { "name":"91089655 L203_105446; (RefSeq) uncharacterized protein\tK07955 ARL8; ADP-ribosylation factor-like protein 8" } ] }, { "name":"BLOC-one-related complex (BORC)" }, { "name":"N-acetyl transferase complex C (NatC)", "children":[ { "name":"91088862 L203_104652; (RefSeq) uncharacterized protein\tK00670 NAA30; N-alpha-acetyltransferase 30 [EC:2.3.1.256]" }, { "name":"91086200 L203_101988; (RefSeq) uncharacterized protein\tK20823 NAA35; N-alpha-acetyltransferase 35, NatC auxiliary subunit" } ] }, { "name":"Other Arf associated proteins" } ] }, { "name":"Endosomal sorting complexes required for transport (ESCRT)", "children":[ { "name":"ESCRT-0 complex", "children":[ { "name":"91085250 L203_101036; (RefSeq) uncharacterized protein\tK12182 HGS; hepatocyte growth factor-regulated tyrosine kinase substrate" }, { "name":"91087221 L203_103010; (RefSeq) uncharacterized protein\tK04705 STAM; signal transducing adaptor molecule" } ] }, { "name":"ESCRT-I complex", "children":[ { "name":"91084841 L203_100626; (RefSeq) uncharacterized protein\tK12183 TSG101; ESCRT-I complex subunit TSG101" }, { "name":"91089200 L203_104991; (RefSeq) uncharacterized protein\tK12184 VPS28; ESCRT-I complex subunit VPS28" }, { "name":"91086231 L203_102019; (RefSeq) uncharacterized protein\tK12185 VPS37; ESCRT-I complex subunit VPS37" } ] }, { "name":"ESCRT-II complex", "children":[ { "name":"91087203 L203_102992; (RefSeq) uncharacterized protein\tK12188 SNF8; ESCRT-II complex subunit VPS22" }, { "name":"91086678 L203_102466; (RefSeq) uncharacterized protein\tK12189 VPS25; ESCRT-II complex subunit VPS25" }, { "name":"91087708 L203_103497; (RefSeq) uncharacterized protein\tK12190 VPS36; ESCRT-II complex subunit VPS36" } ] }, { "name":"ESCRT-III complex", "children":[ { "name":"91087935 L203_103725; (RefSeq) uncharacterized protein\tK12197 CHMP1; charged multivesicular body protein 1" }, { "name":"91086637 L203_102425; (RefSeq) uncharacterized protein\tK12191 CHMP2A; charged multivesicular body protein 2A" }, { "name":"91087882 L203_103672; (RefSeq) uncharacterized protein\tK12193 VPS24; charged multivesicular body protein 3" }, { "name":"91085097 L203_100883; (RefSeq) vacuolar-sorting protein SNF7\tK12194 CHMP4A_B; charged multivesicular body protein 4A\/B" }, { "name":"91087278 L203_103067; (RefSeq) uncharacterized protein\tK12198 CHMP5; charged multivesicular body protein 5" }, { "name":"91084505 L203_100289; (RefSeq) uncharacterized protein\tK12195 CHMP6; charged multivesicular body protein 6" }, { "name":"91090284 L203_106076; (RefSeq) uncharacterized protein\tK15053 CHMP7; charged multivesicular body protein 7" }, { "name":"91087091 L203_102880; (RefSeq) uncharacterized protein\tK12196 VPS4; vacuolar protein-sorting-associated protein 4" } ] }, { "name":"ESCRT associated proteins", "children":[ { "name":"91087347 L203_103136; (RefSeq) uncharacterized protein\tK12199 VTA1; vacuolar protein sorting-associated protein VTA1" }, { "name":"91085482 L203_101269; (RefSeq) pH-response regulator protein PalA\/RIM20\tK12200 PDCD6IP; programmed cell death 6-interacting protein" } ] } ] }, { "name":"Tethering complex", "children":[ { "name":"CORVET complex", "children":[ { "name":"91087630 L203_103419; (RefSeq) uncharacterized protein\tK20177 VPS3; vacuolar protein sorting-associated protein 3" }, { "name":"91090543 L203_106335; (RefSeq) uncharacterized protein\tK20178 VPS8; vacuolar protein sorting-associated protein 8" }, { "name":"91085787 L203_101574; (RefSeq) uncharacterized protein\tK20179 VPS11; vacuolar protein sorting-associated protein 11" }, { "name":"91085142 L203_100928; (RefSeq) uncharacterized protein\tK20181 VPS18; vacuolar protein sorting-associated protein 18" }, { "name":"91086306 L203_102094; (RefSeq) uncharacterized protein\tK20182 VPS33A; vacuolar protein sorting-associated protein 33A" } ] }, { "name":"Hops complex", "children":[ { "name":"91085787 L203_101574; (RefSeq) uncharacterized protein\tK20179 VPS11; vacuolar protein sorting-associated protein 11" }, { "name":"91085142 L203_100928; (RefSeq) uncharacterized protein\tK20181 VPS18; vacuolar protein sorting-associated protein 18" }, { "name":"91086306 L203_102094; (RefSeq) uncharacterized protein\tK20182 VPS33A; vacuolar protein sorting-associated protein 33A" }, { "name":"91086590 L203_102378; (RefSeq) uncharacterized protein\tK20183 VPS39; Vam6\/Vps39-like protein vacuolar protein sorting-associated protein 39" }, { "name":"91085860 L203_101647; (RefSeq) uncharacterized protein\tK20184 VPS41; vacuolar protein sorting-associated protein 41" } ] } ] }, { "name":"Acidification regulators", "children":[ { "name":"Rabconnectin-3 complex", "children":[ { "name":"91086724 L203_102512; (RefSeq) uncharacterized protein\tK24155 DMXL; rabconnectin-3a" }, { "name":"91086335 L203_102123; (RefSeq) uncharacterized protein\tK24738 WDR7; rabconnectin-3b" } ] }, { "name":"RAVE complex", "children":[ { "name":"91086724 L203_102512; (RefSeq) uncharacterized protein\tK24155 DMXL; rabconnectin-3a" }, { "name":"91089069 L203_104860; (RefSeq) E3 ubiquitin ligase complex SCF subunit sconC\tK03094 SKP1; S-phase kinase-associated protein 1" } ] } ] }, { "name":"Others", "children":[ { "name":"AP-3 complex", "children":[ { "name":"91086413 L203_102201; (RefSeq) uncharacterized protein\tK12396 AP3D; AP-3 complex subunit delta" }, { "name":"91090210 L203_106002; (RefSeq) uncharacterized protein\tK12397 AP3B; AP-3 complex subunit beta" }, { "name":"91086123 L203_101911; (RefSeq) uncharacterized protein\tK12398 AP3M; AP-3 complex subunit mu" }, { "name":"91087381 L203_103170; (RefSeq) uncharacterized protein\tK12399 AP3S; AP-3 complex subunit sigma" } ] }, { "name":"BLOC-1 complex" }, { "name":"BLOC-1 complex (yeast)" }, { "name":"BLOC-2 complex" }, { "name":"BLOC-3 complex" }, { "name":"Ferlins" }, { "name":"Lysosomal membrane proteins", "children":[ { "name":"91084417 L203_100201; (RefSeq) uncharacterized protein\tK13526 ATP13A2; cation-transporting P-type ATPase 13A2 [EC:7.2.2.-]" } ] }, { "name":"Others", "children":[ { "name":"91088106 L203_103896; (RefSeq) uncharacterized protein\tK20195 MON1; vacuolar fusion protein MON1" }, { "name":"91089020 L203_104811; (RefSeq) uncharacterized protein\tK11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]" }, { "name":"91090358 L203_106150; (RefSeq) uncharacterized protein\tK28212 LEPROT; OB-RGRP\/VPS55 family protein" }, { "name":"91088379 L203_104169; (RefSeq) uncharacterized protein\tK29023 VPS68; vacuolar protein sorting-associated protein 68" }, { "name":"91089912 L203_105703; (RefSeq) uncharacterized protein\tK23481 VPS1; vacuolar protein sorting-associated protein 1" }, { "name":"91088778 L203_104568; (RefSeq) uncharacterized protein\tK28544 SSH4; SSH4 family protein" } ] } ] } ] }, { "name":"Protein recycling", "children":[ { "name":"Rab GTPases and associated proteins", "children":[ { "name":"Rab GTPases", "children":[ { "name":"91086302 L203_102090; (RefSeq) uncharacterized protein\tK07904 RAB11A; Ras-related protein Rab-11A" } ] }, { "name":"Rab4 associated proteins", "children":[ { "name":"91088738 L203_104528; (RefSeq) uncharacterized protein\tK12481 RBSN; rabenosyn-5" }, { "name":"91085113 L203_100899; (RefSeq) sorting nexin-4\tK17919 SNX4; sorting nexin-4" }, { "name":"91086979 L203_102768; (RefSeq) uncharacterized protein\tK10416 DYNC1LI; dynein cytoplasmic 1 light intermediate chain" } ] }, { "name":"Rab11 associated proteins", "children":[ { "name":"91084258 L203_100042; (RefSeq) protein transporter SEC13\tK14004 SEC13; protein transport protein SEC13" }, { "name":"91087714 L203_103503; (RefSeq) uncharacterized protein\tK19985 EXOC6; exocyst complex component 6" }, { "name":"91090456 L203_106248; (RefSeq) uncharacterized protein\tK20242 EVI5; ecotropic viral integration site 5 protein" }, { "name":"91086854 L203_102643; (RefSeq) uncharacterized protein\tK20167 TBC1D14; TBC1 domain family member 14" }, { "name":"91090476 L203_106268; (RefSeq) uncharacterized protein\tK15620 GOLPH3; golgi phosphoprotein 3" } ] }, { "name":"Other Rab GTPase associated proteins", "children":[ { "name":"91089531 L203_105322; (RefSeq) uncharacterized protein\tK01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B\/F [EC:3.1.3.36]" }, { "name":"91085711 L203_101498; (RefSeq) uncharacterized protein\tK20131 RABGEF1; Rab5 GDP\/GTP exchange factor" }, { "name":"91084989 L203_100775; (RefSeq) uncharacterized protein\tK04482 RAD51; DNA repair protein RAD51" }, { "name":"91089048 L203_104839; (RefSeq) DNA repair protein RAD51\tK04482 RAD51; DNA repair protein RAD51" } ] } ] }, { "name":"Others", "children":[ { "name":"Glutamate receptor-interacting proteins (GRIPs)" }, { "name":"GRIP associated proteins" }, { "name":"EARP complex", "children":[ { "name":"91089229 L203_105020; (RefSeq) uncharacterized protein\tK20296 ANG2; vacuolar protein sorting-associated protein 51" }, { "name":"91085707 L203_101494; (RefSeq) uncharacterized protein\tK20298 VPS52; vacuolar protein sorting-associated protein 52" }, { "name":"91087818 L203_103607; (RefSeq) uncharacterized protein\tK20299 VPS53; vacuolar protein sorting-associated protein 53" } ] }, { "name":"WASH complex", "children":[ { "name":"91086028 L203_101815; (RefSeq) uncharacterized protein\tK10364 CAPZA; F-actin-capping protein subunit alpha" }, { "name":"91086098 L203_101886; (RefSeq) uncharacterized protein\tK10365 CAPZB; F-actin-capping protein subunit beta" } ] }, { "name":"Retriever complex", "children":[ { "name":"91087648 L203_103437; (RefSeq) uncharacterized protein\tK18467 VPS29; vacuolar protein sorting-associated protein 29" } ] }, { "name":"CCC complex" }, { "name":"Others", "children":[ { "name":"91085088 L203_100874; (RefSeq) uncharacterized protein\tK24964 BLTP1; Bridge-like lipid transfer protein family member 1" } ] } ] } ] }, { "name":"Endosome - Golgi transport", "children":[ { "name":"Rab GTPases and associated proteins", "children":[ { "name":"Rab GTPases", "children":[ { "name":"91088662 L203_104452; (RefSeq) uncharacterized protein\tK07897 RAB7A; Ras-related protein Rab-7A [EC:3.6.5.2]" } ] }, { "name":"Retromer subcomplex", "children":[ { "name":"91089806 L203_105597; (RefSeq) tubulin beta chain\tK18468 VPS35; vacuolar protein sorting-associated protein 35" }, { "name":"91087648 L203_103437; (RefSeq) uncharacterized protein\tK18467 VPS29; vacuolar protein sorting-associated protein 29" }, { "name":"91090630 L203_106422; (RefSeq) uncharacterized protein\tK18466 VPS26A_B; vacuolar protein sorting-associated protein 26A\/B" } ] }, { "name":"Rab associated proteins", "children":[ { "name":"91090476 L203_106268; (RefSeq) uncharacterized protein\tK15620 GOLPH3; golgi phosphoprotein 3" }, { "name":"91085029 L203_100815; (RefSeq) uncharacterized protein\tK10402 KIF20; kinesin family member 20" }, { "name":"91088795 L203_104585; (RefSeq) uncharacterized protein\tK19951 TBC1D8_9; TBC1 domain family member 8\/9" }, { "name":"91087859 L203_103649; (RefSeq) uncharacterized protein\tK20285 RABEPK; Rab9 effector protein with kelch motifs" }, { "name":"91085035 L203_100821; (RefSeq) uncharacterized protein\tK10419 DYNLRB; dynein light chain roadblock-type" }, { "name":"91085893 L203_101680; (RefSeq) uncharacterized protein\tK04648 DCTN1; dynactin 1" }, { "name":"91089531 L203_105322; (RefSeq) uncharacterized protein\tK01099 INPP5B_F; inositol polyphosphate 5-phosphatase INPP5B\/F [EC:3.1.3.36]" }, { "name":"91084760 L203_100544; (RefSeq) uncharacterized protein\tK19525 VPS13A_C; vacuolar protein sorting-associated protein 13A\/C" } ] } ] }, { "name":"Arf GTPases and associated proteins", "children":[ { "name":"Arf GTPases", "children":[ { "name":"91085736 L203_101523; (RefSeq) ADP-ribosylation factor\tK07937 ARF1_2; ADP-ribosylation factor 1\/2" }, { "name":"91090038 L203_105829; (RefSeq) uncharacterized protein\tK07942 ARL1; ADP-ribosylation factor-like protein 1" }, { "name":"91089935 L203_105726; (RefSeq) uncharacterized protein\tK07952 ARFRP1; ADP-ribosylation factor related protein 1" } ] }, { "name":"Arf GTPase associated proteins", "children":[ { "name":"91086903 L203_102692; (RefSeq) uncharacterized protein\tK12492 ARFGAP1; ADP-ribosylation factor GTPase-activating protein 1" }, { "name":"91090095 L203_105886; (RefSeq) uncharacterized protein\tK12493 ARFGAP2_3; ADP-ribosylation factor GTPase-activating protein 2\/3" }, { "name":"91088034 L203_103824; (RefSeq) uncharacterized protein\tK12486 SMAP; stromal membrane-associated protein" }, { "name":"91088974 L203_104764; (RefSeq) uncharacterized protein\tK12486 SMAP; stromal membrane-associated protein" }, { "name":"91085889 L203_101676; (RefSeq) uncharacterized protein\tK18442 ARFGEF; brefeldin A-inhibited guanine nucleotide-exchange protein" }, { "name":"91089777 L203_105568; (RefSeq) uncharacterized protein\tK18443 GBF1; golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1" } ] } ] }, { "name":"Tethering complex", "children":[ { "name":"Conserved oligomeric Golgi (COG) complex", "children":[ { "name":"91090155 L203_105947; (RefSeq) uncharacterized protein\tK20288 COG1; conserved oligomeric Golgi complex subunit 1" }, { "name":"91086911 L203_102700; (RefSeq) uncharacterized protein\tK20289 COG2; conserved oligomeric Golgi complex subunit 2" }, { "name":"91085275 L203_101061; (RefSeq) uncharacterized protein\tK20290 COG3; conserved oligomeric Golgi complex subunit 3" }, { "name":"91084526 L203_100310; (RefSeq) uncharacterized protein\tK20291 COG4; conserved oligomeric Golgi complex subunit 4" }, { "name":"91084740 L203_100524; (RefSeq) uncharacterized protein\tK20292 COG5; conserved oligomeric Golgi complex subunit 5" }, { "name":"91086533 L203_102321; (RefSeq) uncharacterized protein\tK20293 COG6; conserved oligomeric Golgi complex subunit 6" }, { "name":"91088348 L203_104138; (RefSeq) uncharacterized protein\tK20294 COG7; conserved oligomeric Golgi complex subunit 7" }, { "name":"91089964 L203_105755; (RefSeq) uncharacterized protein\tK20295 COG8; conserved oligomeric Golgi complex subunit 8" } ] }, { "name":"GARP complex", "children":[ { "name":"91089229 L203_105020; (RefSeq) uncharacterized protein\tK20296 ANG2; vacuolar protein sorting-associated protein 51" }, { "name":"91085707 L203_101494; (RefSeq) uncharacterized protein\tK20298 VPS52; vacuolar protein sorting-associated protein 52" }, { "name":"91087818 L203_103607; (RefSeq) uncharacterized protein\tK20299 VPS53; vacuolar protein sorting-associated protein 53" }, { "name":"91090146 L203_105938; (RefSeq) uncharacterized protein\tK17600 VPS54; vacuolar protein sorting-associated protein 54" } ] }, { "name":"TRAPP complex II", "children":[ { "name":"91089933 L203_105724; (RefSeq) uncharacterized protein\tK20300 TRAPPC1; trafficking protein particle complex subunit 1" }, { "name":"91084600 L203_100384; (RefSeq) uncharacterized protein\tK20301 TRAPPC2; trafficking protein particle complex subunit 2" }, { "name":"91090432 L203_106224; (RefSeq) uncharacterized protein\tK20301 TRAPPC2; trafficking protein particle complex subunit 2" }, { "name":"91085557 L203_101344; (RefSeq) uncharacterized protein\tK20302 TRAPPC3; trafficking protein particle complex subunit 3" }, { "name":"91088460 L203_104250; (RefSeq) uncharacterized protein\tK20303 TRAPPC4; trafficking protein particle complex subunit 4" }, { "name":"91084594 L203_100378; (RefSeq) uncharacterized protein\tK20280 TRAPPC5; trafficking protein particle complex subunit 5" }, { "name":"91085256 L203_101042; (RefSeq) uncharacterized protein\tK20304 TRAPPC6; trafficking protein particle complex subunit 6" }, { "name":"91085085 L203_100871; (RefSeq) uncharacterized protein\tK20305 TRAPPC8; trafficking protein particle complex subunit 8" }, { "name":"91090411 L203_106203; (RefSeq) uncharacterized protein\tK20307 TRAPPC10; trafficking protein particle complex subunit 10" }, { "name":"91084670 L203_100454; (RefSeq) uncharacterized protein\tK20308 TRAPPC11; trafficking protein particle complex subunit 11" }, { "name":"91087563 L203_103352; (RefSeq) uncharacterized protein\tK20310 TRAPPC13; trafficking protein particle complex subunit 13" } ] } ] }, { "name":"Others", "children":[ { "name":"AP-1 complex", "children":[ { "name":"91087634 L203_103423; (RefSeq) uncharacterized protein\tK12391 AP1G1; AP-1 complex subunit gamma-1" }, { "name":"91085359 L203_101145; (RefSeq) uncharacterized protein\tK12392 AP1B1; AP-1 complex subunit beta-1" }, { "name":"91085712 L203_101499; (RefSeq) uncharacterized protein\tK12393 AP1M; AP-1 complex subunit mu" } ] }, { "name":"AP-3 complex", "children":[ { "name":"91086413 L203_102201; (RefSeq) uncharacterized protein\tK12396 AP3D; AP-3 complex subunit delta" }, { "name":"91090210 L203_106002; (RefSeq) uncharacterized protein\tK12397 AP3B; AP-3 complex subunit beta" }, { "name":"91086123 L203_101911; (RefSeq) uncharacterized protein\tK12398 AP3M; AP-3 complex subunit mu" }, { "name":"91087381 L203_103170; (RefSeq) uncharacterized protein\tK12399 AP3S; AP-3 complex subunit sigma" } ] }, { "name":"AP-4 complex" }, { "name":"GGA", "children":[ { "name":"91088116 L203_103906; (RefSeq) uncharacterized protein\tK12404 GGA; ADP-ribosylation factor-binding protein GGA" } ] }, { "name":"Aftiphilin\/p200\/gamma-synergin complex", "children":[ { "name":"91088251 L203_104041; (RefSeq) uncharacterized protein\tK24814 HEATR5; HEAT repeat-containing protein 5" } ] }, { "name":"Others", "children":[ { "name":"91086340 L203_102128; (RefSeq) uncharacterized protein\tK01115 PLD1_2; phospholipase D1\/2 [EC:3.1.4.4]" }, { "name":"91088152 L203_103942; (RefSeq) uncharacterized protein\tK01115 PLD1_2; phospholipase D1\/2 [EC:3.1.4.4]" }, { "name":"91090306 L203_106098; (RefSeq) uncharacterized protein\tK00888 PI4KA; phosphatidylinositol 4-kinase A [EC:2.7.1.67]" }, { "name":"91087865 L203_103655; (RefSeq) uncharacterized protein\tK00889 PIP5K; 1-phosphatidylinositol-4-phosphate 5-kinase [EC:2.7.1.68]" }, { "name":"91084433 L203_100217; (RefSeq) uncharacterized protein\tK00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]" }, { "name":"91088473 L203_104263; (RefSeq) uncharacterized protein\tK00921 PIKFYVE; 1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]" }, { "name":"91090427 L203_106219; (RefSeq) uncharacterized protein\tK20316 SCOC; short coiled-coil protein" }, { "name":"91090168 L203_105960; (RefSeq) uncharacterized protein\tK20318 SYS1; protein SYS1" }, { "name":"91088033 L203_103823; (RefSeq) uncharacterized protein\tK23541 TMEM165; Ca2+\/H+ antiporter, TMEM165\/GDT1 family" }, { "name":"91089381 L203_105172; (RefSeq) uncharacterized protein\tK23544 SERINC1; serine incorporator 1" }, { "name":"91087208 L203_102997; (RefSeq) sorting nexin-3\tK17918 SNX3_12; sorting nexin-3\/12" }, { "name":"91090553 L203_106345; (RefSeq) uncharacterized protein\tK17922 SNX8; sorting nexin-8" }, { "name":"91089024 L203_104815; (RefSeq) uncharacterized protein\tK26678 MON2; protein MON2" }, { "name":"91089944 L203_105735; (RefSeq) uncharacterized protein\tK26680 DOP1; protein dopey" }, { "name":"91087488 L203_103277; (RefSeq) uncharacterized protein\tK27894 HID1; protein HID1" }, { "name":"91086051 L203_101839; (RefSeq) uncharacterized protein\tK26750 TVP15; golgi apparatus membrane protein TVP15" }, { "name":"91088583 L203_104373; (RefSeq) uncharacterized protein\tK26752 TVP23; golgi apparatus membrane protein TVP23" }, { "name":"91087291 L203_103080; (RefSeq) uncharacterized protein\tK26753 TVP38; golgi apparatus membrane protein TVP38" }, { "name":"91090270 L203_106062; (RefSeq) uncharacterized protein\tK26753 TVP38; golgi apparatus membrane protein TVP38" }, { "name":"91089912 L203_105703; (RefSeq) uncharacterized protein\tK23481 VPS1; vacuolar protein sorting-associated protein 1" }, { "name":"91085310 L203_101096; (RefSeq) uncharacterized protein\tK28985 PEP1; vacuolar protein sorting\/targeting protein 10" }, { "name":"91087963 L203_103753; (RefSeq) uncharacterized protein\tK28986 VPS17; vacuolar protein sorting-associated protein 17" } ] } ] } ] }, { "name":"Endoplasmic reticulum (ER) - Golgi transport", "children":[ { "name":"Forward pathways", "children":[ { "name":"Coat protein complex II (COP-II)", "children":[ { "name":"91086151 L203_101939; (RefSeq) small COPII coat GTPase\tK07953 SAR1; GTP-binding protein SAR1 [EC:3.6.5.-]" }, { "name":"91084258 L203_100042; (RefSeq) protein transporter SEC13\tK14004 SEC13; protein transport protein SEC13" }, { "name":"91090479 L203_106271; (RefSeq) uncharacterized protein\tK14005 SEC31; protein transport protein SEC31" }, { "name":"91088830 L203_104620; (RefSeq) protein transporter SEC23\tK14006 SEC23; protein transport protein SEC23" }, { "name":"91084521 L203_100305; (RefSeq) uncharacterized protein\tK14007 SEC24; protein transport protein SEC24" }, { "name":"91088392 L203_104182; (RefSeq) protein transporter SEC24\tK14007 SEC24; protein transport protein SEC24" }, { "name":"91086721 L203_102509; (RefSeq) uncharacterized protein\tK14003 PREB; prolactin regulatory element-binding protein" }, { "name":"91087606 L203_103395; (RefSeq) uncharacterized protein\tK20353 SEC16; COPII coat assembly protein SEC16" } ] }, { "name":"TRAPP complex I", "children":[ { "name":"91089933 L203_105724; (RefSeq) uncharacterized protein\tK20300 TRAPPC1; trafficking protein particle complex subunit 1" }, { "name":"91084600 L203_100384; (RefSeq) uncharacterized protein\tK20301 TRAPPC2; trafficking protein particle complex subunit 2" }, { "name":"91090432 L203_106224; (RefSeq) uncharacterized protein\tK20301 TRAPPC2; trafficking protein particle complex subunit 2" }, { "name":"91085557 L203_101344; (RefSeq) uncharacterized protein\tK20302 TRAPPC3; trafficking protein particle complex subunit 3" }, { "name":"91088460 L203_104250; (RefSeq) uncharacterized protein\tK20303 TRAPPC4; trafficking protein particle complex subunit 4" }, { "name":"91084594 L203_100378; (RefSeq) uncharacterized protein\tK20280 TRAPPC5; trafficking protein particle complex subunit 5" }, { "name":"91085256 L203_101042; (RefSeq) uncharacterized protein\tK20304 TRAPPC6; trafficking protein particle complex subunit 6" } ] }, { "name":"p24 family proteins", "children":[ { "name":"91088211 L203_104001; (RefSeq) uncharacterized protein\tK20346 TMED4_9_11; p24 family protein alpha" }, { "name":"91087591 L203_103380; (RefSeq) uncharacterized protein\tK20347 TMED2; p24 family protein beta-1" } ] }, { "name":"PDI family proteins", "children":[ { "name":"91088619 L203_104409; (RefSeq) protein disulfide-isomerase domain\tK09580 PDIA1; protein disulfide-isomerase A1 [EC:5.3.4.1]" }, { "name":"91084820 L203_100605; (RefSeq) uncharacterized protein\tK09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]" }, { "name":"91087541 L203_103330; (RefSeq) protein disulfide-isomerase domain\tK09584 PDIA6; protein disulfide-isomerase A6 [EC:5.3.4.1]" } ] }, { "name":"Rab GTPases", "children":[ { "name":"91086919 L203_102708; (RefSeq) GTP-binding protein ypt1\tK07874 RAB1A; Ras-related protein Rab-1A" } ] }, { "name":"Rab associated proteins", "children":[ { "name":"91086848 L203_102637; (RefSeq) uncharacterized protein\tK20359 RABAC1; PRA1 family protein 1" }, { "name":"91089144 L203_104935; (RefSeq) uncharacterized protein\tK20359 RABAC1; PRA1 family protein 1" }, { "name":"91087752 L203_103541; (RefSeq) uncharacterized protein\tK20360 TBC1D22; TBC1 domain family member 2" }, { "name":"91088670 L203_104460; (RefSeq) uncharacterized protein\tK20360 TBC1D22; TBC1 domain family member 2" }, { "name":"91089270 L203_105061; (RefSeq) uncharacterized protein\tK20362 YIF1; protein transport protein YIF1" }, { "name":"91088570 L203_104360; (RefSeq) uncharacterized protein\tK22939 IER3IP1; immediate early response 3-interacting protein 1" }, { "name":"91087060 L203_102849; (RefSeq) uncharacterized protein\tK20361 USO1; intracellular protein transport protein USO1" } ] }, { "name":"ER-Golgi intermediate compartment (ERGIC) proteins", "children":[ { "name":"91090129 L203_105921; (RefSeq) uncharacterized protein\tK10082 LMAN2; lectin, mannose-binding 2" }, { "name":"91085725 L203_101512; (RefSeq) uncharacterized protein\tK01230 MAN1A_C; mannosyl-oligosaccharide alpha-1,2-mannosidase [EC:3.2.1.113]" }, { "name":"91089619 L203_105410; (RefSeq) uncharacterized protein\tK23741 MAN1B; endoplasmic reticulum Man9GlcNAc2 1,2-alpha-mannosidase [EC:3.2.1.209]" }, { "name":"91086957 L203_102746; (RefSeq) uncharacterized protein\tK20366 ERGIC2; endoplasmic reticulum-Golgi intermediate compartment protein 2" }, { "name":"91085090 L203_100876; (RefSeq) uncharacterized protein\tK20367 ERGIC3; endoplasmic reticulum-Golgi intermediate compartment protein 3" }, { "name":"91084859 L203_100644; (RefSeq) uncharacterized protein\tK20368 CNIH; protein cornichon" }, { "name":"91088871 L203_104661; (RefSeq) uncharacterized protein\tK20369 ERV29; ER-derived vesicles protein" }, { "name":"91089980 L203_105771; (RefSeq) chaperone DnaK\tK09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]" }, { "name":"91087787 L203_103576; (RefSeq) uncharacterized protein\tK29081 RER1; Rer1 family protein" } ] } ] }, { "name":"Retrieval pathways", "children":[ { "name":"Coat protein complex I (COP-I)", "children":[ { "name":"91085501 L203_101288; (RefSeq) uncharacterized protein\tK05236 COPA; coatomer subunit alpha" }, { "name":"91089377 L203_105168; (RefSeq) uncharacterized protein\tK17301 COPB1; coatomer subunit beta" }, { "name":"91085943 L203_101730; (RefSeq) uncharacterized protein\tK17302 COPB2; coatomer subunit beta'" }, { "name":"91084509 L203_100293; (RefSeq) uncharacterized protein\tK17267 COPG; coatomer subunit gamma" }, { "name":"91084434 L203_100218; (RefSeq) uncharacterized protein\tK17268 COPE; coatomer subunit epsilon" }, { "name":"91085931 L203_101718; (RefSeq) uncharacterized protein\tK20472 COPZ; coatomer subunit zeta" } ] }, { "name":"NRZ (DSL1) complex", "children":[ { "name":"91089849 L203_105640; (RefSeq) uncharacterized protein\tK20473 NBAS; neuroblastoma-amplified sequence" }, { "name":"91084677 L203_100461; (RefSeq) uncharacterized protein\tK20474 RINT1; RAD50-interacting protein 1" } ] }, { "name":"Golgi to ER traffic proteins (GET)", "children":[ { "name":"91085562 L203_101349; (RefSeq) uncharacterized protein\tK22384 GET1; tail-anchored protein insertion receptor" }, { "name":"91088221 L203_104011; (RefSeq) uncharacterized protein\tK22386 GET2; GET complex subunit GET2" }, { "name":"91086774 L203_102562; (RefSeq) ATPase GET3\tK01551 arsA; arsenite\/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]" }, { "name":"91089197 L203_104988; (RefSeq) uncharacterized protein\tK23387 GET4; golgi to ER traffic protein 4" }, { "name":"91089838 L203_105629; (RefSeq) uncharacterized protein\tK23388 UBL4; ubiquitin-like protein 4" } ] }, { "name":"Rab GTPases" }, { "name":"Rab associated proteins", "children":[ { "name":"91085485 L203_101272; (RefSeq) uncharacterized protein\tK20476 RIC1; RAB6A-GEF complex partner protein 1" }, { "name":"91086176 L203_101964; (RefSeq) uncharacterized protein\tK20477 RGP1; RAB6A-GEF complex partner protein 2" }, { "name":"91090513 L203_106305; (RefSeq) uncharacterized protein\tK10949 KDELR; ER lumen protein retaining receptor" }, { "name":"91088738 L203_104528; (RefSeq) uncharacterized protein\tK12481 RBSN; rabenosyn-5" }, { "name":"91087752 L203_103541; (RefSeq) uncharacterized protein\tK20360 TBC1D22; TBC1 domain family member 2" }, { "name":"91088670 L203_104460; (RefSeq) uncharacterized protein\tK20360 TBC1D22; TBC1 domain family member 2" } ] } ] }, { "name":"Others", "children":[ { "name":"Oxysterol-binding proteins", "children":[ { "name":"91084295 L203_100079; (RefSeq) uncharacterized protein\tK20456 OSBP; oxysterol-binding protein 1" }, { "name":"91089676 L203_105467; (RefSeq) uncharacterized protein\tK22285 OSBPL8; oxysterol-binding protein-related protein 8" }, { "name":"91087995 L203_103785; (RefSeq) uncharacterized protein\tK20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9\/10\/11" }, { "name":"91088324 L203_104114; (RefSeq) uncharacterized protein\tK20465 OSBPL9_10_11; oxysterol-binding protein-related protein 9\/10\/11" } ] }, { "name":"FXYD proteins" }, { "name":"YIPF proteins", "children":[ { "name":"91088485 L203_104275; (RefSeq) uncharacterized protein\tK22940 YIPF1_2; protein YIPF1\/2" }, { "name":"91085570 L203_101357; (RefSeq) uncharacterized protein\tK20363 YIPF5_7; protein YIPF5\/7" }, { "name":"91085267 L203_101053; (RefSeq) uncharacterized protein\tK22943 YIPF6; protein YIPF6" } ] }, { "name":"ER membrane protein complex", "children":[ { "name":"91088260 L203_104050; (RefSeq) uncharacterized protein\tK23562 EMC1; ER membrane protein complex subunit 1" }, { "name":"91089139 L203_104930; (RefSeq) uncharacterized protein\tK23563 EMC2; ER membrane protein complex subunit 2" }, { "name":"91087267 L203_103056; (RefSeq) uncharacterized protein\tK23564 EMC3; ER membrane protein complex subunit 3" }, { "name":"91087656 L203_103445; (RefSeq) uncharacterized protein\tK23565 EMC4; ER membrane protein complex subunit 4" }, { "name":"91086414 L203_102202; (RefSeq) uncharacterized protein\tK23566 MMGT1; membrane magnesium transporter 1" }, { "name":"91086288 L203_102076; (RefSeq) uncharacterized protein\tK23567 EMC6; ER membrane protein complex subunit 6" }, { "name":"91089900 L203_105691; (RefSeq) uncharacterized protein\tK23568 EMC7; ER membrane protein complex subunit 7" }, { "name":"91085675 L203_101462; (RefSeq) uncharacterized protein\tK23569 EMC8_9; ER membrane protein complex subunit 8\/9" }, { "name":"91084449 L203_100233; (RefSeq) uncharacterized protein\tK23570 EMC10; ER membrane protein complex subunit 10" } ] }, { "name":"SEC61 complex", "children":[ { "name":"91087036 L203_102825; (RefSeq) protein transporter SEC61 subunit alpha\tK10956 SEC61A; protein transport protein SEC61 subunit alpha" }, { "name":"91090244 L203_106036; (RefSeq) uncharacterized protein\tK09481 SEC61B; protein transport protein SEC61 subunit beta" }, { "name":"91087589 L203_103378; (RefSeq) protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic\tK07342 SEC61G; protein transport protein SEC61 subunit gamma and related proteins" } ] }, { "name":"TRAP complex", "children":[ { "name":"91087769 L203_103558; (RefSeq) uncharacterized protein\tK13249 SSR1; translocon-associated protein subunit alpha" } ] }, { "name":"Multi-pass translocon (MPT) complex", "children":[ { "name":"91086040 L203_101827; (RefSeq) uncharacterized protein\tK24962 CCDC47; PAT complex subunit CCDC47" } ] }, { "name":"Post-GPI attachment to proteins factors (PGAP)", "children":[ { "name":"91087480 L203_103269; (RefSeq) uncharacterized protein\tK23553 PGAP3; post-GPI attachment to proteins factor 3" }, { "name":"91090560 L203_106352; (RefSeq) uncharacterized protein\tK23362 MPPE1; ethanolamine phosphate phosphodiesterase [EC:3.1.-.-]" } ] }, { "name":"Others", "children":[ { "name":"91087442 L203_103231; (RefSeq) uncharacterized protein\tK19998 SCFD1; sec1 family domain-containing protein 1" }, { "name":"91089788 L203_105579; (RefSeq) uncharacterized protein\tK20724 TMEM33; transmembrane protein 33" }, { "name":"91089369 L203_105160; (RefSeq) uncharacterized protein\tK21848 ARV1; lipid intermediate transporter" }, { "name":"91086861 L203_102650; (RefSeq) uncharacterized protein\tK21850 KRE6; beta-glucan synthesis-associated protein KRE6" }, { "name":"91087213 L203_103002; (RefSeq) uncharacterized protein\tK21850 KRE6; beta-glucan synthesis-associated protein KRE6" }, { "name":"91088065 L203_103855; (RefSeq) uncharacterized protein\tK21850 KRE6; beta-glucan synthesis-associated protein KRE6" }, { "name":"91089466 L203_105257; (RefSeq) uncharacterized protein\tK21850 KRE6; beta-glucan synthesis-associated protein KRE6" }, { "name":"91090476 L203_106268; (RefSeq) uncharacterized protein\tK15620 GOLPH3; golgi phosphoprotein 3" }, { "name":"91084395 L203_100179; (RefSeq) uncharacterized protein\tK26683 GOLT1; vesicle transport protein GOT1" }, { "name":"91088005 L203_103795; (RefSeq) protein SEY1\tK22698 SEY1; protein SEY1 [EC:3.6.5.-]" }, { "name":"91084352 L203_100136; (RefSeq) uncharacterized protein\tK29087 NVJ2; nucleus-vacuole junction protein 2" } ] } ] } ] }, { "name":"Autophagy", "children":[ { "name":"Autophagosome formation proteins", "children":[ { "name":"ULK complex", "children":[ { "name":"91089037 L203_104828; (RefSeq) uncharacterized protein\tK08331 ATG13; autophagy-related protein 13" }, { "name":"91085318 L203_101104; (RefSeq) uncharacterized protein\tK19730 ATG101; autophagy-related protein 101" } ] }, { "name":"Atg1 complex", "children":[ { "name":"91086881 L203_102670; (RefSeq) serine\/threonine-protein kinase ATG1\tK08269 ULK2; serine\/threonine-protein kinase ULK2 [EC:2.7.11.1]" }, { "name":"91089037 L203_104828; (RefSeq) uncharacterized protein\tK08331 ATG13; autophagy-related protein 13" } ] }, { "name":"PI3K complex", "children":[ { "name":"91086183 L203_101971; (RefSeq) uncharacterized protein\tK00914 PIK3C3; phosphatidylinositol 3-kinase [EC:2.7.1.137]" }, { "name":"91090380 L203_106172; (RefSeq) uncharacterized protein\tK08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]" }, { "name":"91084744 L203_100528; (RefSeq) uncharacterized protein\tK08334 BECN; beclin" } ] }, { "name":"ATG9 transmembrane protein", "children":[ { "name":"91088085 L203_103875; (RefSeq) uncharacterized protein\tK17907 ATG9; autophagy-related protein 9" } ] }, { "name":"Atg18-Atg2 complex", "children":[ { "name":"91086213 L203_102001; (RefSeq) uncharacterized protein\tK17908 WIPI1_2; autophagy-related protein 18" }, { "name":"91088429 L203_104219; (RefSeq) uncharacterized protein\tK17906 ATG2; autophagy-related protein 2" } ] }, { "name":"Atg12 conjugation proteins", "children":[ { "name":"91085316 L203_101102; (RefSeq) ubiquitin-like protein ATG12\tK08336 ATG12; ubiquitin-like protein ATG12" }, { "name":"91087040 L203_102829; (RefSeq) E1-like protein-activating enzyme Gsa7p\/Apg7p\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7" }, { "name":"91084849 L203_100634; (RefSeq) uncharacterized protein\tK08339 ATG5; autophagy-related protein 5" } ] }, { "name":"Atg8 conjugation proteins", "children":[ { "name":"91088963 L203_104753; (RefSeq) uncharacterized protein\tK08341 GABARAP; GABA(A) receptor-associated protein" }, { "name":"91090396 L203_106188; (RefSeq) uncharacterized protein\tK08342 ATG4; cysteine protease ATG4 [EC:3.4.22.-]" }, { "name":"91087040 L203_102829; (RefSeq) E1-like protein-activating enzyme Gsa7p\/Apg7p\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7" }, { "name":"91088635 L203_104425; (RefSeq) uncharacterized protein\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3" } ] } ] }, { "name":"Cytoplasm to vacuolar targeting (CVT) pathway", "children":[ { "name":"Selective cargos", "children":[ { "name":"91084389 L203_100173; (RefSeq) uncharacterized protein\tK01267 DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]" } ] }, { "name":"Cargo receptors" }, { "name":"Scaffold protein", "children":[ { "name":"91088079 L203_103869; (RefSeq) uncharacterized protein\tK08330 ATG11; autophagy-related protein 11" } ] }, { "name":"Other Cvt associated proteins", "children":[ { "name":"91084799 L203_100583; (RefSeq) sorting nexin-41\tK21996 SNX41_42; sorting nexin-41\/42" }, { "name":"91085113 L203_100899; (RefSeq) sorting nexin-4\tK17919 SNX4; sorting nexin-4" }, { "name":"91085134 L203_100920; (RefSeq) uncharacterized protein\tK17900 ATG15; lipase ATG15 [EC:3.1.1.3]" }, { "name":"91088705 L203_104495; (RefSeq) uncharacterized protein\tK21141 ATG27; autophagy-related protein 27" }, { "name":"91087839 L203_103628; (RefSeq) vacuolar protein 8\tK08332 VAC8; vacuolar protein 8" } ] } ] }, { "name":"Mitophagy", "children":[ { "name":"Cargo receptors" }, { "name":"Scaffold proteins", "children":[ { "name":"91088079 L203_103869; (RefSeq) uncharacterized protein\tK08330 ATG11; autophagy-related protein 11" } ] }, { "name":"PINK1-Parkin associated proteins", "children":[ { "name":"91087153 L203_102942; (RefSeq) uncharacterized protein\tK06030 MFN2; mitofusin 2 [EC:3.6.5.-]" }, { "name":"91085247 L203_101033; (RefSeq) uncharacterized protein\tK17987 NBR1; next to BRCA1 gene 1 protein" } ] }, { "name":"Other mitophagy associated proteins", "children":[ { "name":"91084683 L203_100467; (RefSeq) uncharacterized protein\tK00844 HK; hexokinase [EC:2.7.1.1]" }, { "name":"91086639 L203_102427; (RefSeq) uncharacterized protein\tK00844 HK; hexokinase [EC:2.7.1.1]" }, { "name":"91089085 L203_104876; (RefSeq) uncharacterized protein\tK22255 ATPIF1; ATPase inhibitor, mitochondrial" } ] } ] }, { "name":"Pexophagy", "children":[ { "name":"Selective cargos", "children":[ { "name":"91084984 L203_100770; (RefSeq) uncharacterized protein\tK13336 PEX3; peroxin-3" }, { "name":"91085424 L203_101210; (RefSeq) uncharacterized protein\tK13343 PEX14; peroxin-14" } ] }, { "name":"Cargo receptors" }, { "name":"Other pexophagy associated proteins", "children":[ { "name":"91085247 L203_101033; (RefSeq) uncharacterized protein\tK17987 NBR1; next to BRCA1 gene 1 protein" }, { "name":"91088053 L203_103843; (RefSeq) uncharacterized protein\tK13338 PEX1; peroxin-1 [EC:3.6.4.-]" }, { "name":"91084297 L203_100081; (RefSeq) uncharacterized protein\tK13339 PEX6; peroxin-6 [EC:3.6.4.-]" } ] } ] }, { "name":"Aggrephagy", "children":[ { "name":"Cargo receptors", "children":[ { "name":"91085247 L203_101033; (RefSeq) uncharacterized protein\tK17987 NBR1; next to BRCA1 gene 1 protein" } ] }, { "name":"Scaffold proteins" }, { "name":"Other aggrephagy associated proteins", "children":[ { "name":"91086648 L203_102436; (RefSeq) uncharacterized protein\tK13525 VCP; transitional endoplasmic reticulum ATPase" }, { "name":"91090193 L203_105985; (RefSeq) uncharacterized protein\tK11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]" } ] } ] }, { "name":"Xenophagy", "children":[ { "name":"Cargo receptors", "children":[ { "name":"91085247 L203_101033; (RefSeq) uncharacterized protein\tK17987 NBR1; next to BRCA1 gene 1 protein" } ] }, { "name":"Other xenophagy associated proteins" } ] }, { "name":"ER-phagy", "children":[ { "name":"ER-phagy recepters", "children":[ { "name":"91087044 L203_102833; (RefSeq) uncharacterized protein\tK12275 SEC62; translocation protein SEC62" } ] }, { "name":"Other ER-phagy associated proteins", "children":[ { "name":"91086431 L203_102219; (RefSeq) uncharacterized protein\tK08054 CANX; calnexin" }, { "name":"91088567 L203_104357; (RefSeq) uncharacterized protein\tK17278 PGRMC1_2; membrane-associated progesterone receptor component" } ] }, { "name":"ER stress-related proteins", "children":[ { "name":"91089980 L203_105771; (RefSeq) chaperone DnaK\tK09490 HSPA5; endoplasmic reticulum chaperone BiP [EC:5.6.1.10]" }, { "name":"91086381 L203_102169; (RefSeq) uncharacterized protein\tK09487 HSP90B; heat shock protein 90kDa beta" }, { "name":"91087131 L203_102920; (RefSeq) uncharacterized protein\tK03237 EIF2S1; translation initiation factor 2 subunit 1" }, { "name":"91090033 L203_105824; (RefSeq) uncharacterized protein\tK14009 BCAP31; B-cell receptor-associated protein 31" } ] } ] }, { "name":"Chaperone mediated autophagy (CMA)", "children":[ { "name":"Selective cargos", "children":[ { "name":"91087164 L203_102953; (RefSeq) glyceraldehyde-3-phosphate dehydrogenase\tK00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]" }, { "name":"91089245 L203_105036; (RefSeq) pyruvate kinase\tK00873 PK; pyruvate kinase [EC:2.7.1.40]" }, { "name":"91088459 L203_104249; (RefSeq) uncharacterized protein\tK04523 UBQLN; ubiquilin" } ] }, { "name":"Cargo receptors" }, { "name":"Chaperones", "children":[ { "name":"91084747 L203_100531; (RefSeq) heat shock protein HSS1\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8" }, { "name":"91084770 L203_100554; (RefSeq) heat shock protein HSS1\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8" }, { "name":"91087800 L203_103589; (RefSeq) heat shock protein sks2\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8" }, { "name":"91084531 L203_100315; (RefSeq) uncharacterized protein\tK04079 HSP90A; molecular chaperone HtpG" } ] }, { "name":"Co-chaperones" }, { "name":"Other CMA associated proteins", "children":[ { "name":"91088576 L203_104366; (RefSeq) translation elongation factor EF-1 alpha\tK03231 EEF1A; elongation factor 1-alpha" }, { "name":"91086729 L203_102517; (RefSeq) uncharacterized protein\tK13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]" }, { "name":"91090579 L203_106371; (RefSeq) uncharacterized protein\tK13289 CTSA; cathepsin A (carboxypeptidase C) [EC:3.4.16.5]" } ] } ] }, { "name":"Other autophagy associated proteins", "children":[ { "name":"RNautophagy\/DNautophagy" }, { "name":"Micronucleophagy", "children":[ { "name":"91087839 L203_103628; (RefSeq) vacuolar protein 8\tK08332 VAC8; vacuolar protein 8" } ] }, { "name":"Midbophagy", "children":[ { "name":"91085247 L203_101033; (RefSeq) uncharacterized protein\tK17987 NBR1; next to BRCA1 gene 1 protein" } ] }, { "name":"Glycophagy" }, { "name":"TRIM-directed selective autophagy" }, { "name":"ER-mitochondria tethering complex", "children":[ { "name":"91087153 L203_102942; (RefSeq) uncharacterized protein\tK06030 MFN2; mitofusin 2 [EC:3.6.5.-]" } ] }, { "name":"mTORC1 complex", "children":[ { "name":"91090581 L203_106373; (RefSeq) uncharacterized protein\tK07203 MTOR; serine\/threonine-protein kinase mTOR [EC:2.7.11.1]" }, { "name":"91088553 L203_104343; (RefSeq) uncharacterized protein\tK08266 MLST8; target of rapamycin complex subunit LST8" }, { "name":"91087789 L203_103578; (RefSeq) uncharacterized protein\tK07204 RAPTOR; regulatory associated protein of mTOR" }, { "name":"91088185 L203_103975; (RefSeq) uncharacterized protein\tK07204 RAPTOR; regulatory associated protein of mTOR" } ] }, { "name":"mTORC2 complex", "children":[ { "name":"91090581 L203_106373; (RefSeq) uncharacterized protein\tK07203 MTOR; serine\/threonine-protein kinase mTOR [EC:2.7.11.1]" }, { "name":"91088553 L203_104343; (RefSeq) uncharacterized protein\tK08266 MLST8; target of rapamycin complex subunit LST8" }, { "name":"91088820 L203_104610; (RefSeq) uncharacterized protein\tK20410 MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1\/AVO1" }, { "name":"91090080 L203_105871; (RefSeq) uncharacterized protein\tK08267 RICTOR; rapamycin-insensitive companion of mTOR" }, { "name":"91084805 L203_100589; (RefSeq) uncharacterized protein\tK25576 AVO2; target of rapamycin complex 2 subunit AVO2" } ] }, { "name":"SEACIT\/GATOR1 complex", "children":[ { "name":"91085099 L203_100885; (RefSeq) uncharacterized protein\tK20404 DEPDC5; SEA\/GATOR complex protein SEA1\/DEPDC5" }, { "name":"91085221 L203_101007; (RefSeq) uncharacterized protein\tK20405 NPRL2; nitrogen permease regulator 2" }, { "name":"91085222 L203_101008; (RefSeq) uncharacterized protein\tK20405 NPRL2; nitrogen permease regulator 2" }, { "name":"91087422 L203_103211; (RefSeq) uncharacterized protein\tK20406 NPRL3; nitrogen permease regulator 3" } ] }, { "name":"SEACAT\/GATOR2 complex", "children":[ { "name":"91090356 L203_106148; (RefSeq) uncharacterized protein\tK20408 WDR24; SEA\/GATOR complex protein SEA2\/WDR24" }, { "name":"91088112 L203_103902; (RefSeq) uncharacterized protein\tK20409 WDR59; SEA\/GATOR complex protein SEA3\/WDR59" }, { "name":"91088664 L203_104454; (RefSeq) uncharacterized protein\tK20407 MIOS; SEA\/GATOR complex protein SEA4\/MIOS" }, { "name":"91088393 L203_104183; (RefSeq) uncharacterized protein\tK14299 SEH1; nucleoporin SEH1" }, { "name":"91084258 L203_100042; (RefSeq) protein transporter SEC13\tK14004 SEC13; protein transport protein SEC13" } ] }, { "name":"KICSTOR complex" }, { "name":"Rab GTPases", "children":[ { "name":"91086919 L203_102708; (RefSeq) GTP-binding protein ypt1\tK07874 RAB1A; Ras-related protein Rab-1A" }, { "name":"91089701 L203_105492; (RefSeq) GTP-binding protein ypt2\tK07901 RAB8A; Ras-related protein Rab-8A" } ] }, { "name":"Rab associated proteins" }, { "name":"Others", "children":[ { "name":"91085253 L203_101039; (RefSeq) serine\/threonine-protein phosphatase PP2A catalytic subunit\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]" }, { "name":"91085949 L203_101736; (RefSeq) uncharacterized protein\tK17606 IGBP1; immunoglobulin-binding protein 1" }, { "name":"91088469 L203_104259; (RefSeq) uncharacterized protein\tK21249 UVRAG; UV radiation resistance-associated gene protein" }, { "name":"91087426 L203_103215; (RefSeq) uncharacterized protein\tK06902 UMF1; MFS transporter, UMF1 family" }, { "name":"91088059 L203_103849; (RefSeq) uncharacterized protein\tK14209 SLC36A; solute carrier family 36 (proton-coupled amino acid transporter)" }, { "name":"91090333 L203_106125; (RefSeq) uncharacterized protein\tK22991 WDR45; WD repeat-containing protein 45" }, { "name":"91088657 L203_104447; (RefSeq) uncharacterized protein\tK23952 VMA21; vacuolar ATPase assembly integral membrane protein VMA21" }, { "name":"91087782 L203_103571; (RefSeq) uncharacterized protein\tK27411 PHAF1; phagosome assembly factor 1" } ] } ] } ] }, { "name":"Others", "children":[ { "name":"NADPH oxidases (Nox) and associated proteins", "children":[ { "name":"NADPH oxidases" }, { "name":"Nox associated proteins", "children":[ { "name":"91089773 L203_105564; (RefSeq) uncharacterized protein\tK04392 RAC1; Ras-related C3 botulinum toxin substrate 1" } ] } ] }, { "name":"Actin-binding proteins", "children":[ { "name":"Myosins", "children":[ { "name":"91090486 L203_106278; (RefSeq) myosin-1\tK10356 MYO1; myosin I" }, { "name":"91088108 L203_103898; (RefSeq) uncharacterized protein\tK10357 MYO5; myosin V" } ] }, { "name":"Arp2\/3 complex", "children":[ { "name":"91087225 L203_103014; (RefSeq) uncharacterized protein\tK05757 ARPC1A_B; actin related protein 2\/3 complex, subunit 1A\/1B" }, { "name":"91089637 L203_105428; (RefSeq) uncharacterized protein\tK05758 ARPC2; actin related protein 2\/3 complex, subunit 2" }, { "name":"91088752 L203_104542; (RefSeq) uncharacterized protein\tK05756 ARPC3; actin related protein 2\/3 complex, subunit 3" }, { "name":"91084358 L203_100142; (RefSeq) uncharacterized protein\tK05755 ARPC4; actin related protein 2\/3 complex, subunit 4" }, { "name":"91087786 L203_103575; (RefSeq) uncharacterized protein\tK05754 ARPC5; actin related protein 2\/3 complex, subunit 5" }, { "name":"91084318 L203_100102; (RefSeq) uncharacterized protein\tK17260 ACTR2; actin-related protein 2" }, { "name":"91088214 L203_104004; (RefSeq) uncharacterized protein\tK18584 ACTR3; actin-related protein 3" } ] }, { "name":"Nucleation-promoting factors (NPFs)", "children":[ { "name":"91084665 L203_100449; (RefSeq) uncharacterized protein\tK23612 WASL; neural Wiskott-Aldrich syndrome protein" }, { "name":"91088038 L203_103828; (RefSeq) uncharacterized protein\tK23612 WASL; neural Wiskott-Aldrich syndrome protein" }, { "name":"91088744 L203_104534; (RefSeq) uncharacterized protein\tK23612 WASL; neural Wiskott-Aldrich syndrome protein" }, { "name":"91088313 L203_104103; (RefSeq) uncharacterized protein\tK20520 DBNL; drebrin-like protein" }, { "name":"91087826 L203_103615; (RefSeq) uncharacterized protein\tK12562 AMPH; amphiphysin" }, { "name":"91087357 L203_103146; (RefSeq) uncharacterized protein\tK20046 SLA1; actin cytoskeleton-regulatory complex protein SLA1" }, { "name":"91087853 L203_103643; (RefSeq) uncharacterized protein\tK20522 LSB1_2; LAS seventeen-binding protein 1\/2" }, { "name":"91085767 L203_101554; (RefSeq) uncharacterized protein\tK20523 SH3YL1; SH3 domain-containing YSC84-like protein 1" }, { "name":"91087394 L203_103183; (RefSeq) uncharacterized protein\tK20523 SH3YL1; SH3 domain-containing YSC84-like protein 1" }, { "name":"91089323 L203_105114; (RefSeq) uncharacterized protein\tK20523 SH3YL1; SH3 domain-containing YSC84-like protein 1" }, { "name":"91085826 L203_101613; (RefSeq) uncharacterized protein\tK20524 LSB5; LAS seventeen-binding protein 5" } ] }, { "name":"Others", "children":[ { "name":"91087012 L203_102801; (RefSeq) uncharacterized protein\tK05759 PFN; profilin" }, { "name":"91084925 L203_100711; (RefSeq) uncharacterized protein\tK05765 CFL; cofilin" }, { "name":"91085332 L203_101118; (RefSeq) uncharacterized protein\tK17261 CAP1_2; adenylyl cyclase-associated protein" }, { "name":"91088423 L203_104213; (RefSeq) uncharacterized protein\tK10396 KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]" } ] } ] }, { "name":"Mucins", "children":[ { "name":"Membrane bound mucins" }, { "name":"Secretory mucins" } ] }, { "name":"MARVEL domain-containing proteins" }, { "name":"Specific organelles associated proteins", "children":[ { "name":"Melanosome" }, { "name":"Auto phagosome" }, { "name":"Lipid droplets", "children":[ { "name":"91084723 L203_100507; (RefSeq) uncharacterized protein\tK07910 RAB18; Ras-related protein Rab-18" }, { "name":"91089503 L203_105294; (RefSeq) uncharacterized protein\tK28100 FITM2; fat storage-inducing transmembrane protein 2 [EC:3.6.1.-]" } ] }, { "name":"Mitochondrion" } ] }, { "name":"Rho GTPase associated proteins", "children":[ { "name":"Rho GTPase-activating proteins", "children":[ { "name":"91089555 L203_105346; (RefSeq) uncharacterized protein\tK18470 ARHGAP1; Rho GTPase-activating protein 1" }, { "name":"91089165 L203_104956; (RefSeq) uncharacterized protein\tK20649 ARHGAP39; Rho GTPase-activating protein 39" }, { "name":"91087370 L203_103159; (RefSeq) uncharacterized protein\tK20643 RGD1; Rho GTPase-activating protein RGD1" }, { "name":"91086661 L203_102449; (RefSeq) uncharacterized protein\tK08773 RALBP1; RalA-binding protein 1" } ] }, { "name":"Rho guanine nucleotide exchange factors (GEFs)", "children":[ { "name":"91085430 L203_101216; (RefSeq) uncharacterized protein\tK20705 DNMBP; dynamin-binding protein" }, { "name":"91084341 L203_100125; (RefSeq) uncharacterized protein\tK05727 DOCK3; dedicator of cytokinesis protein 3" }, { "name":"91086948 L203_102737; (RefSeq) uncharacterized protein\tK27817 RAP1GDS1; Rap1 GTPase-GDP dissociation stimulator 1" } ] } ] } ] } ] }