{
	"name":"cdk03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"105100088 MGMT; methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"105105353 ALKBH2; DNA oxidative demethylase ALKBH2\tK10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]"
				},
				{
					"name":"105106833 ALKBH3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3\tK10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]"
				},
				{
					"name":"105097145 ASCC3; activating signal cointegrator 1 complex subunit 3 isoform X1\tK18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"105105356 UNG; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"105087162 CCNO; cyclin-O\tK10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]"
					},
					{
						"name":"105097477 TDG; G\/T mismatch-specific thymine DNA glycosylase isoform X1\tK20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]"
					},
					{
						"name":"105098412 MPG; DNA-3-methyladenine glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"105101010 SMUG1; single-strand selective monofunctional uracil DNA glycosylase\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"105090875 MUTYH; adenine DNA glycosylase isoform X1\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"105093094 MBD4; methyl-CpG-binding domain protein 4 isoform X2\tK10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]"
					},
					{
						"name":"105093137 OGG1; N-glycosylase\/DNA lyase isoform X1\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"105087244 NEIL1; endonuclease 8-like 1 isoform X1\tK10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"105101910 NEIL2; endonuclease 8-like 2\tK10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"105084418 NEIL3; endonuclease 8-like 3 isoform X1\tK10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"105099716 NTHL1; endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"105097645 APEX1; DNA-(apurinic or apyrimidinic site) lyase\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"105103538 APEX2; DNA-(apurinic or apyrimidinic site) lyase 2\tK10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"105100171 POLD1; DNA polymerase delta catalytic subunit isoform X1\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"105092328 POLD2; DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
						},
						{
							"name":"105097069 POLD3; DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
						},
						{
							"name":"105104431 POLD4; DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"105104087 POLE; DNA polymerase epsilon catalytic subunit A\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"105091463 POLE2; DNA polymerase epsilon subunit 2 isoform X1\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"105103758 POLE3; DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						},
						{
							"name":"105085173 POLE4; LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 4\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"105101416 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"105094873 FEN1; flap endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"105098930 LIG1; DNA ligase 1 isoform X1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors",
					"children":[
					{
						"name":"105086432 POLB; DNA polymerase beta\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"105090267 XRCC1; DNA repair protein XRCC1 isoform X1\tK10803 XRCC1; DNA-repair protein XRCC1"
					},
					{
						"name":"105088231 LIG3; DNA ligase 3 isoform X1\tK10776 LIG3; DNA ligase 3 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"105096024 TDP1; tyrosyl-DNA phosphodiesterase 1\tK10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]"
					},
					{
						"name":"105085570 APTX; aprataxin isoform X2\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"105088922 APLF; aprataxin and PNK-like factor isoform X1\tK13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]"
					},
					{
						"name":"105100187 PNKP; LOW QUALITY PROTEIN: bifunctional polynucleotide phosphatase\/kinase\tK08073 PNKP; bifunctional polynucleotide phosphatase\/kinase [EC:3.1.3.32 2.7.1.78]"
					},
					{
						"name":"105086594 HMGB1; high mobility group protein B1 isoform X1\tK10802 HMGB1; high mobility group protein B1"
					},
					{
						"name":"105084339 POLL; DNA polymerase lambda isoform X1\tK03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"105099605 PARP1; poly [ADP-ribose] polymerase 1\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
					},
					{
						"name":"105097681 PARP2; poly [ADP-ribose] polymerase 2 isoform X1\tK28005 PARP2; poly [ADP-ribose] polymerase 2 [EC:2.4.2.30]"
					},
					{
						"name":"105093612 PARP3; LOW QUALITY PROTEIN: protein mono-ADP-ribosyltransferase PARP3\tK10798 PARP3_4; protein mono-ADP-ribosyltransferase 3\/4 [EC:2.4.2.-]"
					},
					{
						"name":"105096386 PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1\tK10798 PARP3_4; protein mono-ADP-ribosyltransferase 3\/4 [EC:2.4.2.-]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"105093167 XPC; DNA repair protein complementing XP-C cells isoform X1\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"105087923 RAD23B; UV excision repair protein RAD23 homolog B\tK10839 RAD23; UV excision repair protein RAD23"
						},
						{
							"name":"105100759 RAD23A; UV excision repair protein RAD23 homolog A isoform X1\tK10839 RAD23; UV excision repair protein RAD23"
						},
						{
							"name":"105104052 CETN2; centrin-2 isoform X1\tK10840 CETN2; centrin-2"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"105091911 RBX1; E3 ubiquitin-protein ligase RBX1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"105091340 CUL4A; cullin-4A\tK10609 CUL4; cullin 4"
						},
						{
							"name":"105098890 CUL4B; cullin-4B isoform X1\tK10609 CUL4; cullin 4"
						},
						{
							"name":"105094885 DDB1; DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"105106872 DDB2; DNA damage-binding protein 2 isoform X1\tK10140 DDB2; DNA damage-binding protein 2"
						}
						]
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"105103024 POLR2A; DNA-directed RNA polymerase II subunit RPB1\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"105091802 POLR2B; DNA-directed RNA polymerase II subunit RPB2\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"105093814 POLR2C; DNA-directed RNA polymerase II subunit RPB3\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"105084493 POLR2D; DNA-directed RNA polymerase II subunit RPB4\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"105104119 POLR2E; DNA-directed RNA polymerases I, II, and III subunit RPABC1 isoform X1\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"105091959 POLR2F; DNA-directed RNA polymerases I, II, and III subunit RPABC2\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"105091505 POLR2G; DNA-directed RNA polymerase II subunit RPB7 isoform X1\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"105085875 POLR2H; DNA-directed RNA polymerases I, II, and III subunit RPABC3\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"105088075 DNA-directed RNA polymerase II subunit RPB9 isoform X1\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"105105448 POLR2L; DNA-directed RNA polymerases I, II, and III subunit RPABC5\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"105089639 POLR2J; DNA-directed RNA polymerase II subunit RPB11-a\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"116148901 POLR2K; DNA-directed RNA polymerases I, II, and III subunit RPABC4\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"105091911 RBX1; E3 ubiquitin-protein ligase RBX1\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"105091340 CUL4A; cullin-4A\tK10609 CUL4; cullin 4"
						},
						{
							"name":"105098890 CUL4B; cullin-4B isoform X1\tK10609 CUL4; cullin 4"
						},
						{
							"name":"105094885 DDB1; DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"105084729 ERCC8; DNA excision repair protein ERCC-8 isoform X1\tK10570 ERCC8; DNA excision repair protein ERCC-8"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"105093440 ERCC6; DNA excision repair protein ERCC-6 isoform X1\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"105100856 UVSSA; UV-stimulated scaffold protein A isoform X1\tK23720 UVSSA; UV-stimulated scaffold protein A"
						},
						{
							"name":"105087594 ELOF1; transcription elongation factor 1 homolog isoform X1\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"105084486 ERCC3; general transcription and DNA repair factor IIH helicase subunit XPB\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"105095454 ERCC2; general transcription and DNA repair factor IIH helicase subunit XPD isoform X1\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"105095328 GTF2H1; general transcription factor IIH subunit 1\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"105084772 general transcription factor IIH subunit 2\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"105094332 GTF2H3; general transcription factor IIH subunit 3 isoform X1\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"105087489 GTF2H4; general transcription factor IIH subunit 4 isoform X1\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"105084765 CDK7; cyclin-dependent kinase 7 isoform X1\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"105099633 CCNH; cyclin-H isoform X1\tK06634 CCNH; cyclin H"
					},
					{
						"name":"105086218 MNAT1; CDK-activating kinase assembly factor MAT1\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"105088108 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"105103319 RPA2; replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"105088708 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"105085508 RPA4; replication protein A 30 kDa subunit\tK10741 RPA4; replication factor A4"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"105102245 XPA; DNA repair protein complementing XP-A cells\tK10847 XPA; DNA-repair protein complementing XP-A cells"
					},
					{
						"name":"105095452 ERCC1; DNA excision repair protein ERCC-1 isoform X1\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"105089061 ERCC4; DNA repair endonuclease XPF\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"105094093 DNA repair protein complementing XP-G cells isoform X3\tK10846 ERCC5; DNA excision repair protein ERCC-5"
					},
					{
						"name":"105098930 LIG1; DNA ligase 1 isoform X1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"105084283 MMS19; MMS19 nucleotide excision repair protein homolog isoform X1\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"105099474 CCDC117; coiled-coil domain-containing protein 117 isoform X1\tK27967 CCDC117; coiled-coil domain-containing protein 117"
					},
					{
						"name":"105092809 CIAO1; probable cytosolic iron-sulfur protein assembly protein CIAO1\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"105088468 CIAO2B; cytosolic iron-sulfur assembly component 2B\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"105100520 CIAO2A; cytosolic iron-sulfur assembly component 2A\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"105088294 CUL3; cullin-3 isoform X1\tK03869 CUL3; cullin 3"
					},
					{
						"name":"105096606 CUL5; cullin-5\tK10612 CUL5; cullin 5"
					},
					{
						"name":"105088550 ELOC; elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"105099696 ELOB; elongin-B\tK03873 ELOB; elongin-B"
					},
					{
						"name":"105097294 ELOA; elongin-A\tK15076 ELOA; elongin-A"
					},
					{
						"name":"105085582 UBAP2; ubiquitin-associated protein 2\tK26545 UBAP2; ubiquitin-associated protein 2"
					},
					{
						"name":"105089178 UBAP2L; ubiquitin-associated protein 2-like isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"105092361 MSH2; DNA mismatch repair protein Msh2\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"105084838 MSH3; DNA mismatch repair protein Msh3 isoform X1\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"105092358 MSH6; DNA mismatch repair protein Msh6\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"105099129 PMS1; PMS1 protein homolog 1 isoform X2\tK10864 PMS1; DNA mismatch repair protein PMS1"
					},
					{
						"name":"105090699 MLH1; DNA mismatch repair protein Mlh1 isoform X2\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"105099374 PMS2; mismatch repair endonuclease PMS2 isoform X4\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"105086091 MLH3; DNA mismatch repair protein Mlh3 isoform X2\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"105100171 POLD1; DNA polymerase delta catalytic subunit isoform X1\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"105092328 POLD2; DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
					},
					{
						"name":"105097069 POLD3; DNA polymerase delta subunit 3 isoform X1\tK03504 POLD3; DNA polymerase delta subunit 3"
					},
					{
						"name":"105104431 POLD4; DNA polymerase delta subunit 4\tK03505 POLD4; DNA polymerase delta subunit 4"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"105088108 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"105103319 RPA2; replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"105088708 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"105085508 RPA4; replication protein A 30 kDa subunit\tK10741 RPA4; replication factor A4"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"105089341 RFC1; replication factor C subunit 1 isoform X1\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"105085846 RFC4; replication factor C subunit 4 isoform X2\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"105089732 RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"105100941 RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"105104910 RFC5; replication factor C subunit 5 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"105101416 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"105099269 EXO1; exonuclease 1\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"105086594 HMGB1; high mobility group protein B1 isoform X1\tK10802 HMGB1; high mobility group protein B1"
					},
					{
						"name":"105098930 LIG1; DNA ligase 1 isoform X1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"105101709 WDR76; WD repeat-containing protein 76 isoform X2\tK24755 WDR76; WD repeat-containing protein 76"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"105096542 MRE11; double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"105090110 RAD50; DNA repair protein RAD50 isoform X1\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"105087540 NBN; nibrin isoform X1\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA1-core complex",
					"children":[
					{
						"name":"105090493 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"105099625 BARD1; BRCA1-associated RING domain protein 1 isoform X1\tK10683 BARD1; BRCA1-associated RING domain protein 1"
					}
					]
				},
				{
					"name":"BRCA1-A complex",
					"children":[
					{
						"name":"105090493 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"105092198 ABRAXAS1; BRCA1-A complex subunit Abraxas 1\tK20774 FAM175A; BRCA1-A complex subunit Abraxas"
					},
					{
						"name":"105099580 UIMC1; BRCA1-A complex subunit RAP80 isoform X1\tK20775 UIMC1; BRCA1-A complex subunit RAP80"
					},
					{
						"name":"105101839 BABAM1; BRISC and BRCA1-A complex member 1 isoform X2\tK20776 BABAM; BRISC and BRCA1-A complex member 1"
					},
					{
						"name":"105098560 BABAM2; BRISC and BRCA1-A complex member 2 isoform X7\tK12173 BRE; BRCA1-A complex subunit BRE"
					},
					{
						"name":"105096837 BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X3\tK11864 BRCC3; BRCA1\/BRCA2-containing complex subunit 3 [EC:3.4.19.-]"
					}
					]
				},
				{
					"name":"BRCA1-B complex",
					"children":[
					{
						"name":"105090493 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"105097835 BRIP1; LOW QUALITY PROTEIN: Fanconi anemia group J protein\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					},
					{
						"name":"105104808 TOPBP1; DNA topoisomerase 2-binding protein 1 isoform X3\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
					}
					]
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"105090493 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"105086431 RBBP8; DNA endonuclease RBBP8 isoform X1\tK20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]"
					},
					{
						"name":"105096542 MRE11; double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"105090110 RAD50; DNA repair protein RAD50 isoform X1\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					},
					{
						"name":"105087540 NBN; nibrin isoform X1\tK10867 NBN; nibrin"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"105090493 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"105101018 BRCA2; breast cancer type 2 susceptibility protein\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"105094829 PALB2; partner and localizer of BRCA2 isoform X1\tK10897 PALB2; partner and localizer of BRCA2"
					},
					{
						"name":"105096876 RAD51; DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"105096876 RAD51; DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"105086162 RAD51B; DNA repair protein RAD51 homolog 2 isoform X5\tK10869 RAD51L1; RAD51-like protein 1"
					},
					{
						"name":"105097813 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"105106565 RAD51D; DNA repair protein RAD51 homolog 4 isoform X1\tK10871 RAD51L3; RAD51-like protein 3"
					},
					{
						"name":"105098698 XRCC2; DNA repair protein XRCC2\tK10879 XRCC2; DNA-repair protein XRCC2"
					},
					{
						"name":"105105986 XRCC3; DNA repair protein XRCC3 isoform X1\tK10880 XRCC3; DNA-repair protein XRCC3"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"105102954 RAD52; DNA repair protein RAD52 homolog isoform X1\tK10873 RAD52; DNA repair and recombination protein RAD52"
					},
					{
						"name":"105090441 LOW QUALITY PROTEIN: RAD52 motif-containing protein 1-like\tK10874 RDM1; RAD52 motif-containing protein 1"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"105092920 RAD54L; DNA repair and recombination protein RAD54-like\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"105087252 RAD54L2; helicase ARIP4\tK10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]"
					},
					{
						"name":"105085753 RAD54B; DNA repair and recombination protein RAD54B\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"105096487 RECQL; ATP-dependent DNA helicase Q1 isoform X1\tK10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]"
					},
					{
						"name":"105095802 WRN; Werner syndrome ATP-dependent helicase isoform X1\tK10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]"
					},
					{
						"name":"105094699 BLM; Bloom syndrome protein isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"105084938 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4-like\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
					},
					{
						"name":"105105019 RECQL4; ATP-dependent DNA helicase Q4 isoform X1\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
					},
					{
						"name":"105104651 RECQL5; ATP-dependent DNA helicase Q5 isoform X1\tK10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"105094699 BLM; Bloom syndrome protein isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"105095212 TOP3B; DNA topoisomerase 3-beta-1 isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"105100571 TOP3A; DNA topoisomerase 3-alpha isoform X2\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"105100475 RMI1; recQ-mediated genome instability protein 1\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					},
					{
						"name":"105089042 RMI2; recQ-mediated genome instability protein 2\tK15365 RMI2; RecQ-mediated genome instability protein 2"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"105088108 RPA1; replication protein A 70 kDa DNA-binding subunit isoform X1\tK07466 RFA1; replication factor A1"
					},
					{
						"name":"105103319 RPA2; replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
					},
					{
						"name":"105088708 RPA3; replication protein A 14 kDa subunit\tK10740 RPA3; replication factor A3"
					},
					{
						"name":"105085508 RPA4; replication protein A 30 kDa subunit\tK10741 RPA4; replication factor A4"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"105102765 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit isoform X1\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"105086500 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"105095273 PPP4R2; serine\/threonine-protein phosphatase 4 regulatory subunit 2\tK15425 PPP4R2; serine\/threonine-protein phosphatase 4 regulatory subunit 2"
					},
					{
						"name":"105095940 PPP4R3A; serine\/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"105097226 PPP4R3B; serine\/threonine-protein phosphatase 4 regulatory subunit 3B isoform X1\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"105099154 serine\/threonine-protein phosphatase 4 regulatory subunit 3B-like\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					},
					{
						"name":"105095673 PPP4R4; serine\/threonine-protein phosphatase 4 regulatory subunit 4 isoform X1\tK15426 PPP4R4; serine\/threonine-protein phosphatase 4 regulatory subunit 4"
					}
					]
				},
				{
					"name":"AP-5 complex",
					"children":[
					{
						"name":"105102590 AP5B1; AP-5 complex subunit beta-1\tK19022 AP5B1; AP-5 complex subunit beta-1"
					},
					{
						"name":"105091457 AP5M1; AP-5 complex subunit mu-1\tK19023 AP5M1; AP-5 complex subunit mu-1"
					},
					{
						"name":"105096016 AP5S1; AP-5 complex subunit sigma-1\tK19024 AP5S1; AP-5 complex subunit sigma-1"
					},
					{
						"name":"105104238 AP5Z1; AP-5 complex subunit zeta-1 isoform X1\tK19025 AP5Z1; AP-5 complex subunit zeta-1"
					}
					]
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"105106033 SMC5; structural maintenance of chromosomes protein 5 isoform X3\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"105097164 SMC6; structural maintenance of chromosomes protein 6 isoform X1\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"105097172 LRATD1; protein LRATD1\tK22805 FAM84A; protein FAM84A"
					},
					{
						"name":"105098258 NSMCE1; non-structural maintenance of chromosomes element 1 homolog\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"105096441 NSMCE2; E3 SUMO-protein ligase NSE2 isoform X1\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"105093464 NSMCE3; non-structural maintenance of chromosomes element 3 homolog\tK22823 NSMCE3; non-structural maintenance of chromosomes element 3"
					},
					{
						"name":"105104029 NSMCE4A; non-structural maintenance of chromosomes element 4 homolog A isoform X1\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					},
					{
						"name":"105097483 EID3; EP300-interacting inhibitor of differentiation 3\tK22826 EID3; EP300-interacting inhibitor of differentiation 3"
					},
					{
						"name":"105095502 SLF1; SMC5-SMC6 complex localization factor protein 1 isoform X1\tK26126 SLF1; SMC5-SMC6 complex localization factor protein 1"
					},
					{
						"name":"105084328 SLF2; SMC5-SMC6 complex localization factor protein 2 isoform X1\tK26127 SLF2; SMC5-SMC6 complex localization factor protein 2"
					},
					{
						"name":"105099612 SIMC1; LOW QUALITY PROTEIN: SUMO-interacting motif-containing protein 1\tK28408 SIMC1; SUMO-interacting motif-containing protein 1"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"105097725 EME1; crossover junction endonuclease EME1\tK10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]"
					},
					{
						"name":"105099785 EME2; probable crossover junction endonuclease EME2 isoform X1\tK10883 EME2; crossover junction endonuclease EME2"
					},
					{
						"name":"105086157 EXD2; exonuclease 3'-5' domain-containing protein 2 isoform X2\tK20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]"
					},
					{
						"name":"105102585 MUS81; crossover junction endonuclease MUS81 isoform X1\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"105092657 SWI5; DNA repair protein SWI5 homolog\tK10991 SWI5; DNA repair protein Swi5\/Sae3"
					},
					{
						"name":"105095028 SFR1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1\tK10992 SFR1; Swi5-dependent recombination DNA repair protein 1"
					},
					{
						"name":"105102773 SLX1A; structure-specific endonuclease subunit SLX1 isoform X2\tK15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]"
					},
					{
						"name":"105099832 SLX4; structure-specific endonuclease subunit SLX4 isoform X1\tK10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB\/POZ domain-containing protein 12)"
					},
					{
						"name":"105105855 GEN1; flap endonuclease GEN homolog 1\tK15338 GEN1; holliday junction resolvase GEN1\/YEN1 [EC:3.1.-.-]"
					},
					{
						"name":"105101702 SPG11; spatacsin isoform X1\tK19026 SPG11; spatacsin"
					},
					{
						"name":"105086163 ZFYVE26; zinc finger FYVE domain-containing protein 26 isoform X1\tK19027 ZFYVE26; zinc finger FYVE domain-containing protein 26"
					},
					{
						"name":"105091323 RAD51AP1; RAD51-associated protein 1\tK20778 RAD51AP1; RAD51-associated protein 1"
					},
					{
						"name":"105098624 NUCKS1; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1\tK28888 NUCKS1; nuclear ubiquitous casein and cyclin-dependent kinase substrate 1"
					},
					{
						"name":"105092230 MORF4L1; mortality factor 4-like protein 1 isoform X2\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"105084989 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 isoform X1\tK22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"
					},
					{
						"name":"105105293 FIGNL1; fidgetin-like protein 1\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"105095927 DNA repair-scaffolding protein\tK22806 SPIDR; DNA repair-scaffolding protein"
					},
					{
						"name":"105096444 LRATD2; protein LRATD2\tK22810 FAM84B; protein FAM84B"
					},
					{
						"name":"105091238 BRAT1; BRCA1-associated ATM activator 1 isoform X1\tK23112 BRAT1; BRCA1-associated ATM activator 1"
					},
					{
						"name":"105103996 CFAP410; cilia- and flagella-associated protein 410 isoform X1\tK23456 CFAP410; cilla- and flagella-associated protein"
					},
					{
						"name":"105105317 HDGFL2; LOW QUALITY PROTEIN: hepatoma-derived growth factor-related protein 2\tK25065 HDGFL2; hepatoma-derived growth factor-related protein 2"
					},
					{
						"name":"105085086 ZSWIM7; zinc finger SWIM domain-containing protein 7\tK25770 ZSWIM7; zinc finger SWIM domain-containing protein 7"
					},
					{
						"name":"105087607 SWSAP1; ATPase SWSAP1\tK25771 SWSAP1; ATPase SWSAP1"
					},
					{
						"name":"105097292 EMSY; BRCA2-interacting transcriptional repressor EMSY isoform X6\tK25790 EMSY; BRCA2-interacting transcriptional repressor EMSY"
					},
					{
						"name":"105105908 HSF2BP; heat shock factor 2-binding protein isoform X1\tK25791 HSF2BP; heat shock factor 2-binding protein"
					},
					{
						"name":"105092252 MMS22L; protein MMS22-like\tK26125 MMS22L; protein MMS22-like"
					},
					{
						"name":"105105020 TONSL; LOW QUALITY PROTEIN: tonsoku-like protein\tK09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2"
					},
					{
						"name":"105085128 BOD1L1; LOW QUALITY PROTEIN: biorientation of chromosomes in cell division protein 1-like 1\tK27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1"
					},
					{
						"name":"105097465 PARPBP; PCNA-interacting partner isoform X1\tK27412 PARPBP; PCNA-interacting partner"
					},
					{
						"name":"105101055 HROB; uncharacterized protein C17orf53 homolog\tK27803 HROB; homologous recombination OB-fold protein"
					},
					{
						"name":"105101348 MCM8; DNA helicase MCM8\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
					},
					{
						"name":"105088349 MCM9; DNA helicase MCM9\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
					},
					{
						"name":"105093365 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1\tK15047 HNRNPUL1; heterogeneous nuclear ribonucleoprotein U-like protein 1"
					},
					{
						"name":"105091503 HNRNPUL2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein U-like protein 2\tK28611 HNRNPUL2; heterogeneous nuclear ribonucleoprotein U-like protein 2"
					},
					{
						"name":"105100631 MRNIP; MRN complex-interacting protein isoform X1\tK28623 MRNIP; MRN complex-interacting protein"
					},
					{
						"name":"105095580 RADX; RPA-related protein RADX\tK29002 RADX; RPA-related protein RADX"
					},
					{
						"name":"105087575 RBM6; RNA-binding protein 6 isoform X1\tK29038 RBM6; RNA-binding protein 6"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"105091894 XRCC6; X-ray repair cross-complementing protein 6\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"105088812 XRCC5; X-ray repair cross-complementing protein 5\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					},
					{
						"name":"105095924 PRKDC; DNA-dependent protein kinase catalytic subunit isoform X1\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"105096542 MRE11; double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"105090110 RAD50; DNA repair protein RAD50 isoform X1\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"105094085 LIG4; DNA ligase 4 isoform X1\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					},
					{
						"name":"105090668 XRCC4; DNA repair protein XRCC4 isoform X1\tK10886 XRCC4; DNA-repair protein XRCC4"
					},
					{
						"name":"105096097 NHEJ1; non-homologous end-joining factor 1 isoform X1\tK10980 NHEJ1; non-homologous end-joining factor 1"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"105084339 POLL; DNA polymerase lambda isoform X1\tK03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"105092342 POLM; DNA-directed DNA\/RNA polymerase mu isoform X1\tK03513 POLM; DNA polymerase mu [EC:2.7.7.7]"
					},
					{
						"name":"105084270 DNTT; DNA nucleotidylexotransferase isoform X1\tK00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]"
					},
					{
						"name":"105086432 POLB; DNA polymerase beta\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"105085570 APTX; aprataxin isoform X2\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"105088922 APLF; aprataxin and PNK-like factor isoform X1\tK13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]"
					},
					{
						"name":"105104520 DCLRE1C; protein artemis isoform X1\tK10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]"
					},
					{
						"name":"105089132 TDP2; tyrosyl-DNA phosphodiesterase 2\tK19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]"
					},
					{
						"name":"105086114 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 isoform X1\tK23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1"
					},
					{
						"name":"105089023 PWWP3B; PWWP domain-containing DNA repair factor 3B\tK23386 PWWP3; PWWP domain-containing DNA repair factor 3"
					},
					{
						"name":"105104130 PWWP3A; PWWP domain-containing DNA repair factor 3A isoform X2\tK23386 PWWP3; PWWP domain-containing DNA repair factor 3"
					},
					{
						"name":"105106310 PWWP domain-containing DNA repair factor 3B-like\tK23386 PWWP3; PWWP domain-containing DNA repair factor 3"
					},
					{
						"name":"105106191 PAXX; protein PAXX isoform X1\tK25772 PAXX; protein PAXX"
					},
					{
						"name":"105091609 CYREN; cell cycle regulator of non-homologous end joining isoform X1\tK26155 CYREN; cell cycle regulator of non-homologous end joining"
					},
					{
						"name":"105098440 JMJD8; jmjC domain-containing protein 8 isoform X1\tK25792 JMJD8; jumonji domain-containing protein 8"
					},
					{
						"name":"105101377 SHLD1; shieldin complex subunit 1 isoform X1\tK26128 SHLD1; shieldin complex subunit 1"
					},
					{
						"name":"105100363 SHLD2; shieldin complex subunit 2 isoform X1\tK26129 SHLD2; shieldin complex subunit 2"
					},
					{
						"name":"105084750 SHLD3; shieldin complex subunit 3\tK26130 SHLD3; shieldin complex subunit 3"
					},
					{
						"name":"105089319 BEND4; BEN domain-containing protein 4 isoform X1\tK27845 BEND4; BEN domain-containing protein 4"
					},
					{
						"name":"105098218 IFFO1; intermediate filament family orphan 1 isoform X1\tK28738 IFFO; non-homologous end joining factor IFFO"
					},
					{
						"name":"105103983 IFFO2; LOW QUALITY PROTEIN: intermediate filament family orphan 2\tK28738 IFFO; non-homologous end joining factor IFFO"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex",
					"children":[
					{
						"name":"105104346 FANCA; Fanconi anemia group A protein isoform X1\tK10888 FANCA; fanconi anemia group A protein"
					},
					{
						"name":"116148490 LOW QUALITY PROTEIN: Fanconi anemia group B protein-like\tK10889 FANCB; fanconi anemia group B protein"
					},
					{
						"name":"105084691 FANCC; Fanconi anemia group C protein isoform X1\tK10890 FANCC; fanconi anemia group C protein"
					},
					{
						"name":"105101349 FANCE; Fanconi anemia group E protein isoform X1\tK10892 FANCE; fanconi anemia group E protein"
					},
					{
						"name":"105095351 FANCF; Fanconi anemia group F protein\tK10893 FANCF; fanconi anemia group F protein"
					},
					{
						"name":"105102311 FANCG; Fanconi anemia group G protein isoform X1\tK10894 FANCG; fanconi anemia group G protein"
					},
					{
						"name":"105097234 FANCL; E3 ubiquitin-protein ligase FANCL isoform X1\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
					},
					{
						"name":"105086459 FANCM; Fanconi anemia group M protein\tK10896 FANCM; fanconi anemia group M protein"
					},
					{
						"name":"105096712 FAAP24; Fanconi anemia core complex-associated protein 24 isoform X1\tK10898 FAAP24; fanconi anemia-associated protein"
					},
					{
						"name":"105105719 FAAP100; LOW QUALITY PROTEIN: Fanconi anemia core complex-associated protein 100\tK10993 FAAP100; fanconi anemia core complex 100 kDa subunit"
					}
					]
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"105101259 HES1; transcription factor HES-1\tK06054 HES1; hairy and enhancer of split 1"
					},
					{
						"name":"105107014 centromere protein S isoform X1\tK11511 APITD1; centromere protein S"
					},
					{
						"name":"105102212 CENPX; centromere protein X isoform X1\tK15360 STRA13; centromere protein X"
					},
					{
						"name":"105105924 UBE2T; ubiquitin-conjugating enzyme E2 T\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"105094699 BLM; Bloom syndrome protein isoform X1\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"105095212 TOP3B; DNA topoisomerase 3-beta-1 isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"105100571 TOP3A; DNA topoisomerase 3-alpha isoform X2\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"105100475 RMI1; recQ-mediated genome instability protein 1\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					},
					{
						"name":"105089042 RMI2; recQ-mediated genome instability protein 2\tK15365 RMI2; RecQ-mediated genome instability protein 2"
					}
					]
				},
				{
					"name":"FANCD2-I complex",
					"children":[
					{
						"name":"105093121 FANCD2; Fanconi anemia group D2 protein isoform X1\tK10891 FANCD2; fanconi anemia group D2 protein"
					},
					{
						"name":"105094668 FANCI; Fanconi anemia group I protein\tK10895 FANCI; fanconi anemia group I protein"
					}
					]
				},
				{
					"name":"Downstream FA components",
					"children":[
					{
						"name":"105090493 BRCA1; breast cancer type 1 susceptibility protein isoform X1\tK10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]"
					},
					{
						"name":"105101018 BRCA2; breast cancer type 2 susceptibility protein\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"105097835 BRIP1; LOW QUALITY PROTEIN: Fanconi anemia group J protein\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					},
					{
						"name":"105094829 PALB2; partner and localizer of BRCA2 isoform X1\tK10897 PALB2; partner and localizer of BRCA2"
					}
					]
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"105093468 FAN1; fanconi-associated nuclease 1\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"105096876 RAD51; DNA repair protein RAD51 homolog 1\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"105097813 RAD51C; DNA repair protein RAD51 homolog 3 isoform X1\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"105099743 TELO2; telomere length regulation protein TEL2 homolog isoform X1\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"105096281 USP1; ubiquitin carboxyl-terminal hydrolase 1\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
					},
					{
						"name":"105084644 WDR48; WD repeat-containing protein 48 isoform X2\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6",
					"children":[
					{
						"name":"105092627 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit\tK15498 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"105098779 PPP6R1; LOW QUALITY PROTEIN: serine\/threonine-protein phosphatase 6 regulatory subunit 1\tK15499 PPP6R1; serine\/threonine-protein phosphatase 6 regulatory subunit 1"
					},
					{
						"name":"105090352 PPP6R2; serine\/threonine-protein phosphatase 6 regulatory subunit 2 isoform X1\tK15500 PPP6R2; serine\/threonine-protein phosphatase 6 regulatory subunit 2"
					},
					{
						"name":"105104402 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3 isoform X1\tK15501 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3"
					},
					{
						"name":"105104359 ANKRD28; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1\tK15502 ANKRD28; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A"
					},
					{
						"name":"105088802 ANKRD44; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B isoform X1\tK15503 ANKRD44; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B"
					},
					{
						"name":"105086367 ANKRD52; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C isoform X1\tK15504 ANKRD52; serine\/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C"
					}
					]
				},
				{
					"name":"Ubiquitin ligases",
					"children":[
					{
						"name":"105087034 RNF8; E3 ubiquitin-protein ligase RNF8 isoform X3\tK10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]"
					},
					{
						"name":"105101287 RNF168; E3 ubiquitin-protein ligase RNF168\tK20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]"
					},
					{
						"name":"105098180 RNF169; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF169\tK20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]"
					},
					{
						"name":"105090766 HERC2; E3 ubiquitin-protein ligase HERC2 isoform X1\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
					}
					]
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"105103010 WRAP53; telomerase Cajal body protein 1 isoform X1\tK23314 WRAP53; telomerase Cajal body protein 1"
					},
					{
						"name":"105106178 TPRN; LOW QUALITY PROTEIN: taperin\tK24164 TPRN; taperin"
					},
					{
						"name":"105106098 ZCWPW1; zinc finger CW-type PWWP domain protein 1 isoform X1\tK24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1"
					},
					{
						"name":"105086988 WDR70; WD repeat-containing protein 70\tK24752 WDR70; WD repeat-containing protein 70"
					},
					{
						"name":"105101709 WDR76; WD repeat-containing protein 76 isoform X2\tK24755 WDR76; WD repeat-containing protein 76"
					},
					{
						"name":"105106376 HMCES; abasic site processing protein HMCES\tK28434 HMCES; abasic site processing protein HMCES"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"105088628 POLH; DNA polymerase eta isoform X1\tK03509 POLH; DNA polymerase eta [EC:2.7.7.7]"
				},
				{
					"name":"105103607 POLI; DNA polymerase iota isoform X1\tK03510 POLI; DNA polymerase iota [EC:2.7.7.7]"
				},
				{
					"name":"105084801 POLK; DNA polymerase kappa isoform X1\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				},
				{
					"name":"105099123 REV1; DNA repair protein REV1 isoform X2\tK03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"105099205 REV3L; DNA polymerase zeta catalytic subunit isoform X1\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"105093933 UBE2A; ubiquitin-conjugating enzyme E2 A\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"105090300 UBE2B; ubiquitin-conjugating enzyme E2 B\tK10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]"
				},
				{
					"name":"105093146 RAD18; E3 ubiquitin-protein ligase RAD18 isoform X1\tK10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]"
				},
				{
					"name":"105089506 HLTF; helicase-like transcription factor isoform X3\tK15711 SMARCA3; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]"
				},
				{
					"name":"105087875 UBE2V1; ubiquitin-conjugating enzyme E2 variant 1 isoform X1\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"105090913 LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 variant 1-like\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"105095921 UBE2V2; ubiquitin-conjugating enzyme E2 variant 2 isoform X3\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"105097410 UBE2N; ubiquitin-conjugating enzyme E2 N isoform X3\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"105101416 PCNA; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"105100546 PCLAF; PCNA-associated factor isoform X1\tK28763 PCLAF; PCNA-associated factor"
				},
				{
					"name":"105097465 PARPBP; PCNA-interacting partner isoform X1\tK27412 PARPBP; PCNA-interacting partner"
				},
				{
					"name":"105102151 SPRTN; sprT-like domain-containing protein Spartan isoform X1\tK24051 SPRTN; SprT-like domain-contaning protein Spartan"
				},
				{
					"name":"105088000 GCNA; acidic repeat-containing protein\tK26957 GCNA; germ cell nuclear acidic protein"
				},
				{
					"name":"105099802 DPPA5; developmental pluripotency-associated 5 protein isoform X1\tK28975 DPPA5; developmental pluripotency-associated protein 5"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"105104429 RAD9A; LOW QUALITY PROTEIN: cell cycle checkpoint control protein RAD9A\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"105102489 RAD9B; cell cycle checkpoint control protein RAD9B isoform X1\tK10995 RAD9B; cell cycle checkpoint control protein RAD9B"
				},
				{
					"name":"105106220 HUS1; checkpoint protein HUS1 isoform X1\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"105087010 RAD1; cell cycle checkpoint protein RAD1 isoform X1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"105084766 RAD17; cell cycle checkpoint protein RAD17 isoform X2\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"105085846 RFC4; replication factor C subunit 4 isoform X2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"105089732 RFC2; replication factor C subunit 2\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"105100941 RFC3; replication factor C subunit 3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"105104910 RFC5; replication factor C subunit 5 isoform X1\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"105087010 RAD1; cell cycle checkpoint protein RAD1 isoform X1\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"105086358 TIMELESS; protein timeless homolog isoform X2\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				},
				{
					"name":"105093265 TIPIN; TIMELESS-interacting protein isoform X1\tK10998 TIPIN; replication fork protection complex subunit TIPIN\/Csm3\/Swi3"
				},
				{
					"name":"105086957 CLSPN; claspin\tK25773 CLSPN; claspin"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"105099743 TELO2; telomere length regulation protein TEL2 homolog isoform X1\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"105085002 TTI1; TELO2-interacting protein 1 homolog\tK20403 TTI1; TELO2-interacting protein 1"
				},
				{
					"name":"105095808 TTI2; TELO2-interacting protein 2\tK23115 TTI2; TELO2-interacting protein 2"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"105087468 BAG6; large proline-rich protein BAG6 isoform X1\tK23390 BAG6; large proline-rich protein BAG6"
				},
				{
					"name":"105085681 UBL4B; ubiquitin-like protein 4B isoform X2\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"105093598 LOW QUALITY PROTEIN: ubiquitin-like protein 4A\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"105106588 UBL4A; ubiquitin-like protein 4A\tK23388 UBL4; ubiquitin-like protein 4"
				},
				{
					"name":"105102057 GET4; Golgi to ER traffic protein 4 homolog isoform X1\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex",
				"children":[
				{
					"name":"105089414 INTS3; integrator complex subunit 3\tK13140 INTS3; integrator complex subunit 3 (SOSS complex subunit A)"
				},
				{
					"name":"105086370 NABP2; SOSS complex subunit B1 isoform X1\tK28889 NABP; SOSS complex subunit B"
				},
				{
					"name":"105088790 NABP1; SOSS complex subunit B2 isoform X2\tK28889 NABP; SOSS complex subunit B"
				},
				{
					"name":"105096259 INIP; SOSS complex subunit C\tK28890 INIP; SOSS complex subunit C"
				}
				]
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"105086328 ATR; serine\/threonine-protein kinase ATR\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"105088009 ATRIP; ATR-interacting protein isoform X1\tK10905 ATRIP; ATR interacting protein"
				},
				{
					"name":"105088929 ETAA1; LOW QUALITY PROTEIN: ewing's tumor-associated antigen 1\tK28856 ETAA1; Ewing's tumor-associated antigen 1"
				},
				{
					"name":"105096603 ATM; serine-protein kinase ATM isoform X1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
				},
				{
					"name":"105103011 TP53; cellular tumor antigen p53\tK04451 TP53; tumor protein p53"
				},
				{
					"name":"105094454 CHEK1; serine\/threonine-protein kinase Chk1\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
				},
				{
					"name":"105099476 CHEK2; serine\/threonine-protein kinase Chk2 isoform X1\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"105103857 CDC25A; M-phase inducer phosphatase 1 isoform X1\tK06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]"
				},
				{
					"name":"105096018 CDC25B; M-phase inducer phosphatase 2 isoform X1\tK05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]"
				},
				{
					"name":"105090655 CDC25C; M-phase inducer phosphatase 3 isoform X1\tK05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]"
				},
				{
					"name":"105087105 YWHAB; 14-3-3 protein beta\/alpha\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"105090535 YWHAZ; 14-3-3 protein zeta\/delta\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"105091237 YWHAQ; 14-3-3 protein theta\tK16197 YWHAB_Q_Z; 14-3-3 protein beta\/theta\/zeta"
				},
				{
					"name":"105086861 LOW QUALITY PROTEIN: 14-3-3 protein eta-like\tK16198 YWHAG_H; 14-3-3 protein gamma\/eta"
				},
				{
					"name":"105089727 YWHAG; 14-3-3 protein gamma\tK16198 YWHAG_H; 14-3-3 protein gamma\/eta"
				},
				{
					"name":"105099415 YWHAH; 14-3-3 protein eta\tK16198 YWHAG_H; 14-3-3 protein gamma\/eta"
				},
				{
					"name":"105088124 YWHAE; 14-3-3 protein epsilon isoform X1\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"105095342 NAV2; neuron navigator 2 isoform X1\tK19483 NAV2; neuron navigator 2 [EC:5.6.2.4]"
				},
				{
					"name":"105093996 WEE1; LOW QUALITY PROTEIN: wee1-like protein kinase\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"105097323 WEE2; wee1-like protein kinase 2\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"105102995 PER1; period circadian protein homolog 1 isoform X1\tK21944 PER1; period circadian protein 1"
				},
				{
					"name":"105105762 PER2; period circadian protein homolog 2 isoform X1\tK02633 PER2; period circadian protein 2"
				},
				{
					"name":"105107088 PER3; LOW QUALITY PROTEIN: period circadian protein homolog 3\tK21945 PER3; period circadian protein 3"
				},
				{
					"name":"105087495 MDC1; mediator of DNA damage checkpoint protein 1 isoform X1\tK20780 MDC1; mediator of DNA damage checkpoint protein 1"
				},
				{
					"name":"105104259 PLS3; plastin-3\tK17336 PLS3; plastin-3"
				},
				{
					"name":"105085462 AEN; apoptosis-enhancing nuclease\tK18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]"
				},
				{
					"name":"105090883 serine\/threonine-protein kinase PLK3 isoform X4\tK08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]"
				},
				{
					"name":"105106529 PLK5; inactive serine\/threonine-protein kinase PLK5 isoform X1\tK19596 PLK5; inactive serine\/threonine-protein kinase PLK5"
				},
				{
					"name":"105090995 NEK5; serine\/threonine-protein kinase Nek5\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"105093308 NEK4; serine\/threonine-protein kinase Nek4 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"105101615 NEK1; serine\/threonine-protein kinase Nek1 isoform X1\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"105087213 NEK10; serine\/threonine-protein kinase Nek10 isoform X1\tK20879 NEK10; serine\/threonine-protein kinase Nek10 [EC:2.7.11.1]"
				},
				{
					"name":"105088765 NEK11; serine\/threonine-protein kinase Nek11 isoform X1\tK20880 NEK11; serine\/threonine-protein kinase Nek11 [EC:2.7.11.1]"
				},
				{
					"name":"105089887 DONSON; protein downstream neighbor of Son\tK22422 DONSON; protein downstream neighbor of Son"
				},
				{
					"name":"105087615 KANK2; KN motif and ankyrin repeat domain-containing protein 2\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"105087673 KANK3; KN motif and ankyrin repeat domain-containing protein 3 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"105096294 KANK4; LOW QUALITY PROTEIN: KN motif and ankyrin repeat domain-containing protein 4\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"105105867 KANK1; KN motif and ankyrin repeat domain-containing protein 1 isoform X1\tK22808 KANK; KN motif and ankyrin repeat domain-containing protein"
				},
				{
					"name":"105097877 schlafen family member 11-like isoform X1\tK24458 SLFN11; schlafen family member 11 [EC:3.6.-.-]"
				},
				{
					"name":"105088515 CHMP4C; charged multivesicular body protein 4c\tK24782 CHMP4C; charged multivesicular body protein 4C"
				},
				{
					"name":"105088403 VPS4A; vacuolar protein sorting-associated protein 4A isoform X1\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"105089002 VPS4B; vacuolar protein sorting-associated protein 4B\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				},
				{
					"name":"105096871 ZFYVE19; abscission\/NoCut checkpoint regulator\tK24778 ZFYVE19; abscission\/NoCut checkpoint regulator"
				},
				{
					"name":"105099640 SDE2; replication stress response regulator SDE2\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"105104176 KRCC1; lysine-rich coiled-coil protein 1 isoform X1\tK29003 KRCC1; lysine-rich coiled-coil protein 1"
				},
				{
					"name":"105084998 BLCAP; bladder cancer-associated protein\tK29062 BLCAP; apoptosis inducing factor BLCAP"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"105090311 POLQ; DNA polymerase theta isoform X1\tK02349 POLQ; DNA polymerase theta [EC:2.7.7.7]"
				},
				{
					"name":"105095737 MYBBP1A; myb-binding protein 1A\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				},
				{
					"name":"105084435 PRIMPOL; DNA-directed primase\/polymerase protein isoform X1\tK22761 PRIMPOL; DNA-directed primase\/polymerase protein [EC:2.7.7.102 2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"105087958 TREX1; three-prime repair exonuclease 1 isoform X1\tK10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2]"
				},
				{
					"name":"105103901 TREX2; three prime repair exonuclease 2\tK10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]"
				},
				{
					"name":"105091683 DCLRE1A; DNA cross-link repair 1A protein\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"105085962 DCLRE1B; 5' exonuclease Apollo isoform X1\tK15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]"
				},
				{
					"name":"105103380 EXO5; exonuclease V\tK17815 EXO5; exonuclease V [EC:3.1.-.-]"
				},
				{
					"name":"105106255 ENDOV; endonuclease V isoform X5\tK21813 ENDOV; endonuclease V [EC:3.1.26.-]"
				},
				{
					"name":"105092357 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 isoform X1\tK25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]"
				},
				{
					"name":"105101840 ANKLE1; ankyrin repeat and LEM domain-containing protein 1\tK21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1"
				}
				]
			},
			{
				"name":"Helicases",
				"children":[
				{
					"name":"105092033 HELQ; helicase POLQ-like isoform X1\tK19178 HELQ; POLQ-like helicase [EC:5.6.2.4]"
				},
				{
					"name":"105084687 ERCC6L2; DNA excision repair protein ERCC-6-like 2 isoform X1\tK20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]"
				}
				]
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"105094892 PRPF19; pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"105088644 CDC5L; cell division cycle 5-like protein\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"105085949 BCAS2; pre-mRNA-splicing factor SPF27\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"105089289 PLRG1; pleiotropic regulator 1 isoform X1\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"105101806 NUDT15; nucleotide triphosphate diphosphatase NUDT15 isoform X1\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"105105774 NUDT1; 7,8-dihydro-8-oxoguanine triphosphatase\tK17816 NUDT1; 8-oxo-dGTP diphosphatase \/ 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]"
				},
				{
					"name":"105102746 NUDT18; 8-oxo-dGDP phosphatase NUDT18\tK17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]"
				},
				{
					"name":"105104870 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X2\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"105096519 RRM1; ribonucleoside-diphosphate reductase large subunit\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"105090530 RRM2B; ribonucleoside-diphosphate reductase subunit M2 B\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				},
				{
					"name":"105091241 RRM2; ribonucleoside-diphosphate reductase subunit M2\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"105100088 MGMT; methylated-DNA--protein-cysteine methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"105105356 UNG; uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"105101010 SMUG1; single-strand selective monofunctional uracil DNA glycosylase\tK10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]"
					},
					{
						"name":"105098412 MPG; DNA-3-methyladenine glycosylase\tK03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]"
					},
					{
						"name":"105090875 MUTYH; adenine DNA glycosylase isoform X1\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"105099716 NTHL1; endonuclease III-like protein 1 isoform X1\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors"
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"105097324 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"105097324 SSBP1; single-stranded DNA-binding protein, mitochondrial isoform X1\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"105101806 NUDT15; nucleotide triphosphate diphosphatase NUDT15 isoform X1\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"105104870 DUT; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X2\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}