{
	"name":"cfo01001",
	"children":[
	{
		"name":"Serine\/threonine kinases: AGC group",
		"children":[
		{
			"name":"PKA family",
			"children":[
			{
				"name":"105249574 cAMP-dependent protein kinase catalytic subunit\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
			},
			{
				"name":"109610490 cAMP-dependent protein kinase catalytic subunit-like\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
			},
			{
				"name":"105254691 cAMP-dependent protein kinase catalytic subunit PRKX\tK19584 PRKX; protein kinase X [EC:2.7.11.11]"
			}
			]
		},
		{
			"name":"PKG family",
			"children":[
			{
				"name":"105255628 cGMP-dependent protein kinase, isozyme 2 forms cD4\/T1\/T3A\/T3B isoform X1\tK07376 PRKG1; cGMP-dependent protein kinase 1 [EC:2.7.11.12]"
			}
			]
		},
		{
			"name":"PKC family [OT]",
			"children":[
			{
				"name":"105256106 protein kinase C, brain isozyme isoform X1\tK02677 PRKCA; classical protein kinase C alpha type [EC:2.7.11.13]"
			},
			{
				"name":"105252927 protein kinase C isoform X1\tK18050 PRKCE; novel protein kinase C epsilon type [EC:2.7.11.13]"
			},
			{
				"name":"105255087 atypical protein kinase C isoform X1\tK06069 PRKCI; atypical protein kinase C iota type [EC:2.7.11.13]"
			}
			]
		},
		{
			"name":"PKN family",
			"children":[
			{
				"name":"105252719 serine\/threonine-protein kinase N isoform X1\tK23691 PKN2; serine\/threonine-protein kinase N2 [EC:2.7.11.13]"
			}
			]
		},
		{
			"name":"AUR family [OT]",
			"children":[
			{
				"name":"105257414 aurora kinase C\tK11481 AURKA; aurora kinase A [EC:2.7.11.1]"
			},
			{
				"name":"105251484 aurora kinase B isoform X1\tK11479 AURKB; aurora kinase B [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"PDK1 family",
			"children":[
			{
				"name":"105258854 3-phosphoinositide-dependent protein kinase 1 isoform X1\tK06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"AKT\/PKB family",
			"children":[
			{
				"name":"105251500 RAC-beta serine\/threonine-protein kinase B\tK04456 AKT; RAC serine\/threonine-protein kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"SGK family [OT]"
		},
		{
			"name":"RSK family [OT]",
			"children":[
			{
				"name":"105248577 ribosomal protein S6 kinase 2 beta\tK04373 RPS6KA; ribosomal protein S6 kinase alpha-1\/2\/3\/6 [EC:2.7.11.1]"
			},
			{
				"name":"105256569 ribosomal protein S6 kinase alpha-5 isoform X1\tK04445 RPS6KA5; ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]"
			},
			{
				"name":"105253503 ribosomal protein S6 kinase beta-1\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]"
			},
			{
				"name":"105253504 ribosomal protein S6 kinase beta-1\tK04688 RPS6KB; ribosomal protein S6 kinase beta [EC:2.7.11.1]"
			},
			{
				"name":"105254607 ribosomal protein S6 kinase delta-1\tK20839 RSKL; ribosomal protein S6 kinase-like"
			}
			]
		},
		{
			"name":"NDR family",
			"children":[
			{
				"name":"105248897 serine\/threonine-protein kinase tricorner\tK08790 STK38; serine\/threonine kinase 38 [EC:2.7.11.1]"
			},
			{
				"name":"105254961 serine\/threonine-protein kinase Warts\tK08791 LATS1_2; serine\/threonine-protein kinase LATS1\/2 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"MAST family [OT]",
			"children":[
			{
				"name":"105259053 microtubule-associated serine\/threonine-protein kinase 3 isoform X1\tK08789 MAST; MAST-subfamily protein kinase [EC:2.7.11.37]"
			},
			{
				"name":"105255213 serine\/threonine-protein kinase greatwall\tK16309 MASTL; serine\/threonine-protein kinase greatwall [EC:2.7.11.36]"
			}
			]
		},
		{
			"name":"YANK family",
			"children":[
			{
				"name":"105258110 serine\/threonine-protein kinase 32A isoform X2\tK08793 STK32; serine\/threonine kinase 32 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"DMPK family [OT]",
			"children":[
			{
				"name":"105249459 rho-associated protein kinase 2 isoform X1\tK04514 ROCK1; Rho-associated protein kinase 1 [EC:2.7.11.39]"
			},
			{
				"name":"105254585 serine\/threonine-protein kinase Genghis Khan isoform X1\tK16307 CDC42BP; serine\/threonine-protein kinase MRCK [EC:2.7.11.1]"
			},
			{
				"name":"105251212 citron Rho-interacting kinase-like\tK16308 CIT; citron Rho-interacting kinase [EC:2.7.11.35]"
			}
			]
		},
		{
			"name":"GRK family [OT]",
			"children":[
			{
				"name":"105258109 G protein-coupled receptor kinase 1\tK00910 ADRBK; beta-adrenergic-receptor kinase [EC:2.7.11.15]"
			},
			{
				"name":"105252842 G protein-coupled receptor kinase 2\tK08291 GRK4_5_6; G protein-coupled receptor kinase [EC:2.7.11.16]"
			}
			]
		},
		{
			"name":"Other",
			"children":[
			{
				"name":"105248022 serine\/threonine-protein kinase S6KL\tK17529 SGK494; uncharacterized serine\/threonine-protein kinase SgK494 [EC:2.7.11.1]"
			}
			]
		}
		]
	},
	{
		"name":"Serine\/threonine kinases: CAMK group",
		"children":[
		{
			"name":"CAMK1 family [OT]",
			"children":[
			{
				"name":"105251255 LOW QUALITY PROTEIN: calcium\/calmodulin-dependent protein kinase type 1\tK08794 CAMK1; calcium\/calmodulin-dependent protein kinase I [EC:2.7.11.17]"
			}
			]
		},
		{
			"name":"CAMK2 family",
			"children":[
			{
				"name":"105254953 calcium\/calmodulin-dependent protein kinase type II alpha chain isoform X2\tK04515 CAMK2; calcium\/calmodulin-dependent protein kinase (CaM kinase) II [EC:2.7.11.17]"
			}
			]
		},
		{
			"name":"CAMKL family",
			"children":[
			{
				"name":"105248306 serine\/threonine-protein kinase BRSK2 isoform X1\tK08796 BRSK; BR serine\/threonine kinase [EC:2.7.11.1]"
			},
			{
				"name":"105249949 serine\/threonine-protein kinase grp\tK02216 CHEK1; serine\/threonine-protein kinase CHEK1 [EC:2.7.11.1]"
			},
			{
				"name":"105256551 serine\/threonine-protein kinase MARK2 isoform X2\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]"
			},
			{
				"name":"105257681 MAP\/microtubule affinity-regulating kinase 3\tK08798 MARK; MAP\/microtubule affinity-regulating kinase [EC:2.7.11.1]"
			},
			{
				"name":"105253944 maternal embryonic leucine zipper kinase\tK08799 MELK; maternal embryonic leucine zipper kinase [EC:2.7.11.1]"
			},
			{
				"name":"105252990 5'-AMP-activated protein kinase catalytic subunit alpha-2\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]"
			},
			{
				"name":"105255902 MAP\/microtubule affinity-regulating kinase 4\tK16311 SIK2; serine\/threonine-protein kinase SIK2 [EC:2.7.11.1]"
			},
			{
				"name":"105254816 serine\/threonine-protein kinase SIK3 isoform X1\tK19009 SIK3; serine\/threonine-protein kinase SIK3 [EC:2.7.11.1]"
			},
			{
				"name":"105255723 maternal embryonic leucine zipper kinase\tK08802 SNRK; SNF related kinase [EC:2.7.11.1]"
			},
			{
				"name":"105253099 serine\/threonine-protein kinase STK11 isoform X1\tK07298 STK11; serine\/threonine-protein kinase 11 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"DAPK family",
			"children":[
			{
				"name":"105248856 death-associated protein kinase 1-like isoform X1\tK08803 DAPK; death-associated protein kinase [EC:2.7.11.1]"
			},
			{
				"name":"105249947 death-associated protein kinase related\tK08804 STK17; serine\/threonine kinase 17 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"DCAMKL family",
			"children":[
			{
				"name":"105252524 serine\/threonine-protein kinase GG21441 isoform X1\tK08805 DCLK1_2; doublecortin-like kinase 1\/2 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"MAPKAPK family [OT]",
			"children":[
			{
				"name":"105250864 MAP kinase-activated protein kinase 2 isoform X1\tK04443 MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1]"
			},
			{
				"name":"105253114 MAP kinase-interacting serine\/threonine-protein kinase 1\tK04372 MKNK; MAP kinase interacting serine\/threonine kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"MLCK family",
			"children":[
			{
				"name":"105256936 myosin light chain kinase, smooth muscle\tK00907 MYLK; myosin-light-chain kinase [EC:2.7.11.18]"
			},
			{
				"name":"105251526 titin isoform X10\tK12567 TTN; titin [EC:2.7.11.1]"
			},
			{
				"name":"105255184 Titin; titin homolog\tK12567 TTN; titin [EC:2.7.11.1]"
			},
			{
				"name":"105255188 titin homolog isoform X1\tK12567 TTN; titin [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"PHK family",
			"children":[
			{
				"name":"105255564 phosphorylase b kinase gamma catalytic chain, skeletal muscle\/heart isoform isoform X1\tK00871 PHKG; phosphorylase kinase gamma subunit [EC:2.7.11.19]"
			}
			]
		},
		{
			"name":"PIM family [OT]"
		},
		{
			"name":"PKD family",
			"children":[
			{
				"name":"105252354 serine\/threonine-protein kinase D3 isoform X1\tK06070 PKD; protein kinase D [EC:2.7.11.13]"
			}
			]
		},
		{
			"name":"PSK family"
		},
		{
			"name":"RAD53 family",
			"children":[
			{
				"name":"105258386 serine\/threonine-protein kinase Chk2\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"Trio family [OT]"
		},
		{
			"name":"TSSK family",
			"children":[
			{
				"name":"105251326 testis-specific serine\/threonine-protein kinase 4\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]"
			},
			{
				"name":"105252356 testis-specific serine\/threonine-protein kinase 3\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]"
			},
			{
				"name":"105259197 testis-specific serine\/threonine-protein kinase 1 isoform X2\tK08811 TSSK; testis-specific serine kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"CDPK family"
		},
		{
			"name":"CASK family",
			"children":[
			{
				"name":"105255597 peripheral plasma membrane protein CASK isoform X2\tK06103 CASK; calcium\/calmodulin-dependent serine protein kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"Trbl family",
			"children":[
			{
				"name":"105248052 tribbles homolog 2\tK08814 TRIB1_2; tribbles homolog 1\/2"
			}
			]
		},
		{
			"name":"Other"
		}
		]
	},
	{
		"name":"Serine\/threonine kinases: CK1 group",
		"children":[
		{
			"name":"CK1 family [OT]",
			"children":[
			{
				"name":"105247876 casein kinase I isoform X2\tK08957 CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]"
			},
			{
				"name":"105251108 casein kinase I isoform X1\tK08958 CSNK1G; casein kinase 1, gamma [EC:2.7.11.1]"
			},
			{
				"name":"105255207 casein kinase I isoform X2\tK08960 CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"TTBK family",
			"children":[
			{
				"name":"105248090 uncharacterized protein LOC105248090 isoform X1\tK08815 TTBK; tau tubulin kinase [EC:2.7.11.26]"
			}
			]
		},
		{
			"name":"VRK family",
			"children":[
			{
				"name":"105255214 serine\/threonine-protein kinase VRK1 isoform X1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]"
			},
			{
				"name":"105255937 serine\/threonine-protein kinase VRK1\tK08816 VRK; vaccinia related kinase [EC:2.7.11.1]"
			}
			]
		}
		]
	},
	{
		"name":"Serine\/threonine kinases: CMGC group",
		"children":[
		{
			"name":"CDK family",
			"children":[
			{
				"name":"105255798 cyclin-dependent kinase 20\tK08817 CDK20; cyclin-dependent kinase 20 [EC:2.7.11.22]"
			},
			{
				"name":"105254980 cyclin-dependent kinase 11B isoform X1\tK08818 CDC2L; cell division cycle 2-like [EC:2.7.11.22]"
			},
			{
				"name":"105253176 cyclin-dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]"
			},
			{
				"name":"105253817 cyclin-dependent kinase 2\tK02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]"
			},
			{
				"name":"105249672 cyclin-dependent kinase 4\tK02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]"
			},
			{
				"name":"105248046 cyclin-dependent-like kinase 5\tK02090 CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]"
			},
			{
				"name":"105258436 cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
			},
			{
				"name":"105250707 cyclin-dependent kinase 8\tK02208 CDK8_11; cyclin-dependent kinase 8\/11 [EC:2.7.11.22 2.7.11.23]"
			},
			{
				"name":"105253591 cyclin-dependent kinase 9\tK02211 CDK9; cyclin-dependent kinase 9 [EC:2.7.11.22 2.7.11.23]"
			},
			{
				"name":"105252634 cyclin-dependent kinase 10\tK02449 CDK10; cyclin-dependent kinase 10 [EC:2.7.11.22]"
			},
			{
				"name":"105253932 cyclin-dependent kinase 12 isoform X1\tK08819 CDK12_13; cyclin-dependent kinase 12\/13 [EC:2.7.11.22 2.7.11.23]"
			},
			{
				"name":"105248762 cyclin-dependent kinase 14 isoform X1\tK08821 CDK14; cyclin-dependent kinase 14 [EC:2.7.11.22]"
			}
			]
		},
		{
			"name":"MAPK family [OT]",
			"children":[
			{
				"name":"105258670 mitogen-activated protein kinase 1\tK04371 ERK; mitogen-activated protein kinase 1\/3 [EC:2.7.11.24]"
			},
			{
				"name":"105249889 mitogen-activated protein kinase 15 isoform X1\tK19603 MAPK15; mitogen-activated protein kinase 15 [EC:2.7.11.24]"
			},
			{
				"name":"105253069 stress-activated protein kinase JNK isoform X1\tK04440 JNK; mitogen-activated protein kinase 8\/9\/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]"
			},
			{
				"name":"105252862 mitogen-activated protein kinase p38b isoform X3\tK04441 P38; p38 MAP kinase [EC:2.7.11.24]"
			},
			{
				"name":"105248529 serine\/threonine-protein kinase NLK\tK04468 NLK; nemo like kinase [EC:2.7.11.24]"
			}
			]
		},
		{
			"name":"GSK family [OT]",
			"children":[
			{
				"name":"105258655 glycogen synthase kinase-3 beta isoform X1\tK03083 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]"
			}
			]
		},
		{
			"name":"CLK family",
			"children":[
			{
				"name":"105254017 dual specificity protein kinase CLK2 isoform X1\tK08823 CLK2_3; dual specificity protein kinase CLK2\/3 [EC:2.7.12.1]"
			}
			]
		},
		{
			"name":"CDKL family",
			"children":[
			{
				"name":"105254503 cyclin-dependent kinase-like 4\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]"
			},
			{
				"name":"105255755 cyclin-dependent kinase-like 4 isoform X1\tK08824 CDKL; cyclin-dependent kinase-like [EC:2.7.11.22]"
			}
			]
		},
		{
			"name":"DYRK family [OT]",
			"children":[
			{
				"name":"105251087 serine\/threonine-protein kinase minibrain isoform X1\tK08825 DYRK1; dual specificity tyrosine-phosphorylation-regulated kinase 1 [EC:2.7.12.1]"
			},
			{
				"name":"105250867 dual specificity tyrosine-phosphorylation-regulated kinase 2\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]"
			},
			{
				"name":"105257216 uncharacterized protein LOC105257216 isoform X2\tK18669 DYRK2_3_4; dual specificity tyrosine-phosphorylation-regulated kinase 2\/3\/4 [EC:2.7.12.1]"
			},
			{
				"name":"105258547 homeodomain-interacting protein kinase 2 isoform X1\tK08826 HIPK; homeodomain interacting protein kinase [EC:2.7.11.1]"
			},
			{
				"name":"105254875 serine\/threonine-protein kinase PRP4 homolog isoform X1\tK08827 PRPF4B; serine\/threonine-protein kinase PRP4 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"RCK family [OT]",
			"children":[
			{
				"name":"105250560 serine\/threonine-protein kinase MAK isoform X1\tK08828 ICK; intestinal cell (MAK-like) kinase [EC:2.7.11.22]"
			}
			]
		},
		{
			"name":"SRPK family [OT]",
			"children":[
			{
				"name":"105259402 SRSF protein kinase 3\tK15409 SRPK1; serine\/threonine-protein kinase SRPK1 [EC:2.7.11.1]"
			}
			]
		}
		]
	},
	{
		"name":"Serine\/threonine kinases: STE group",
		"children":[
		{
			"name":"STE7 family",
			"children":[
			{
				"name":"105255739 dual specificity mitogen-activated protein kinase kinase dSOR1\tK04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]"
			},
			{
				"name":"105257778 dual specificity mitogen-activated protein kinase kinase 6\tK04432 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]"
			},
			{
				"name":"105249095 dual specificity mitogen-activated protein kinase kinase 4\tK04430 MAP2K4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]"
			},
			{
				"name":"105252678 dual specificity mitogen-activated protein kinase kinase 7\tK04431 MAP2K7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]"
			}
			]
		},
		{
			"name":"STE20 family",
			"children":[
			{
				"name":"105255940 mitogen-activated protein kinase kinase kinase kinase 5 isoform X1\tK08833 MAP4K5; mitogen-activated protein kinase kinase kinase kinase 5 [EC:2.7.11.1]"
			},
			{
				"name":"105258630 serine\/threonine-protein kinase mig-15 isoform X1\tK08840 TNIK; TRAF2 and NCK interacting kinase [EC:2.7.11.1]"
			},
			{
				"name":"105257790 myosin-IIIb isoform X1\tK08834 MYO3; myosin III [EC:2.7.11.1]"
			},
			{
				"name":"105258971 neither inactivation nor afterpotential protein C\tK08834 MYO3; myosin III [EC:2.7.11.1]"
			},
			{
				"name":"105255992 serine\/threonine-protein kinase OSR1 isoform X2\tK08835 OXSR1; serine\/threonine-protein kinase OSR1\/STK39 [EC:2.7.11.1]"
			},
			{
				"name":"105249243 serine\/threonine-protein kinase PAK mbt\tK05736 PAK5; p21-activated kinase 5 [EC:2.7.11.1]"
			},
			{
				"name":"105250141 serine\/threonine-protein kinase 10 isoform X1\tK08836 SLK; STE20-like kinase [EC:2.7.11.1]"
			},
			{
				"name":"105253054 serine\/threonine-protein kinase 3 isoform X1\tK04412 STK3; serine\/threonine kinase 3"
			},
			{
				"name":"105254613 serine\/threonine-protein kinase svkA isoform X1\tK08838 STK24_25_MST4; serine\/threonine-protein kinase 24\/25\/MST4 [EC:2.7.11.1]"
			},
			{
				"name":"105254289 serine\/threonine-protein kinase Tao\tK04429 TAO; thousand and one amino acid protein kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"STE11 family",
			"children":[
			{
				"name":"105252125 mitogen-activated protein kinase kinase kinase 4 isoform X1\tK04428 MAP3K4; mitogen-activated protein kinase kinase kinase 4 [EC:2.7.11.25]"
			},
			{
				"name":"105257525 mitogen-activated protein kinase kinase kinase 15 isoform X1\tK04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]"
			}
			]
		},
		{
			"name":"Other"
		}
		]
	},
	{
		"name":"Serine\/threonine kinases: TKL group",
		"children":[
		{
			"name":"IRAK family",
			"children":[
			{
				"name":"105256733 serine\/threonine-protein kinase pelle\tK04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]"
			},
			{
				"name":"105259295 uncharacterized protein LOC105259295\tK04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"LISK family [OT]",
			"children":[
			{
				"name":"105253178 LIM domain kinase 1 isoform X1\tK05743 LIMK1; LIM domain kinase 1 [EC:2.7.11.1]"
			},
			{
				"name":"105254113 probable serine\/threonine-protein kinase roco5\tK08842 TESK2; testis-specific kinase 2 [EC:2.7.12.1]"
			}
			]
		},
		{
			"name":"LRRK family"
		},
		{
			"name":"MLK family",
			"children":[
			{
				"name":"105256050 mitogen-activated protein kinase kinase kinase 7\tK04427 MAP3K7; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]"
			},
			{
				"name":"105247832 mitogen-activated protein kinase kinase kinase 11 isoform X1\tK04417 MAP3K9; mitogen-activated protein kinase kinase kinase 9 [EC:2.7.11.25]"
			},
			{
				"name":"105258073 LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13\tK04422 MAP3K13; mitogen-activated protein kinase kinase kinase 13 [EC:2.7.11.25]"
			},
			{
				"name":"105256339 integrin-linked protein kinase homolog pat-4\tK06272 ILK; integrin-linked kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"RAF family [OT]",
			"children":[
			{
				"name":"105253402 raf homolog serine\/threonine-protein kinase Raf\tK04365 BRAF; B-Raf proto-oncogene serine\/threonine-protein kinase [EC:2.7.11.1]"
			},
			{
				"name":"105257033 kinase suppressor of Ras 2\tK18529 KSR2; kinase suppressor of Ras 2 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"RIPK family [OT]"
		},
		{
			"name":"Other"
		}
		]
	},
	{
		"name":"Serine\/threonine kinases: Other",
		"children":[
		{
			"name":"RGC family [OT]",
			"children":[
			{
				"name":"105254646 atrial natriuretic peptide receptor 1 isoform X1\tK12323 NPR1; atrial natriuretic peptide receptor 1 [EC:4.6.1.2]"
			},
			{
				"name":"105256501 atrial natriuretic peptide receptor 1 isoform X1\tK12323 NPR1; atrial natriuretic peptide receptor 1 [EC:4.6.1.2]"
			},
			{
				"name":"105250130 retinal guanylyl cyclase 2\tK12322 GUCY2F; guanylate cyclase 2F [EC:4.6.1.2]"
			}
			]
		},
		{
			"name":"BUB family",
			"children":[
			{
				"name":"105249225 uncharacterized protein LOC105249225 isoform X1\tK02178 BUB1; checkpoint serine\/threonine-protein kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"Bud32 family",
			"children":[
			{
				"name":"105252736 EKC\/KEOPS complex subunit Tp53rk\tK08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"CAMKK family",
			"children":[
			{
				"name":"105257380 calcium\/calmodulin-dependent protein kinase kinase 2 isoform X1\tK07359 CAMKK2; calcium\/calmodulin-dependent protein kinase kinase 2 [EC:2.7.11.17]"
			}
			]
		},
		{
			"name":"CDC7 family",
			"children":[
			{
				"name":"105258726 cell division cycle 7-related protein kinase isoform X1\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"CK2 family",
			"children":[
			{
				"name":"105256631 casein kinase II subunit alpha isoform X1\tK03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"Haspin family",
			"children":[
			{
				"name":"105250493 uncharacterized protein LOC105250493 isoform X1\tK16315 GSG2; serine\/threonine-protein kinase haspin [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"IKK family [OT]",
			"children":[
			{
				"name":"105251219 inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1\tK07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]"
			},
			{
				"name":"105250722 inhibitor of nuclear factor kappa-B kinase subunit epsilon\tK05410 TBK1; TANK-binding kinase 1 [EC:2.7.11.10]"
			}
			]
		},
		{
			"name":"IRE family",
			"children":[
			{
				"name":"105250660 serine\/threonine-protein kinase\/endoribonuclease IRE1 isoform X1\tK08852 ERN1; serine\/threonine-protein kinase\/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]"
			}
			]
		},
		{
			"name":"MOS family",
			"children":[
			{
				"name":"105252645 serine\/threonine-protein kinase mos\tK04367 MOS; proto-oncogene serine\/threonine-protein kinase mos [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"NAK family [OT]",
			"children":[
			{
				"name":"105249285 uncharacterized protein LOC105249285 isoform X1\tK08853 AAK; AP2-associated kinase [EC:2.7.11.1]"
			},
			{
				"name":"105249432 cyclin-G-associated kinase\tK08855 GAK; cyclin G-associated kinase [EC:2.7.11.1]"
			},
			{
				"name":"105250700 serine\/threonine-protein kinase 16\tK08856 STK16; serine\/threonine kinase 16 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"NEK family"
		},
		{
			"name":"NKF1 family",
			"children":[
			{
				"name":"105255722 serine\/threonine-protein kinase 10\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]"
			},
			{
				"name":"105258287 serine\/threonine-protein kinase SBK1\tK08858 SBK; serine\/threonine-protein kinase SBK [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"NKF2 family",
			"children":[
			{
				"name":"105250504 serine\/threonine-protein kinase PINK1, mitochondrial\tK05688 PINK1; PTEN induced putative kinase 1 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"NKF3 family"
		},
		{
			"name":"NKF4 family"
		},
		{
			"name":"NKF5 family",
			"children":[
			{
				"name":"105254410 uncharacterized protein LOC105254410 isoform X3\tK17540 TEX14; inactive serine\/threonine-protein kinase TEX14"
			}
			]
		},
		{
			"name":"NRBP family",
			"children":[
			{
				"name":"105250970 nuclear receptor-binding protein homolog isoform X1\tK08875 NRBP; nuclear receptor-binding protein"
			}
			]
		},
		{
			"name":"PEK family [OT]",
			"children":[
			{
				"name":"105259077 eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1\tK16194 EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [EC:2.7.11.1]"
			},
			{
				"name":"105250501 eIF-2-alpha kinase GCN2\tK16196 EIF2AK4; eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"PLK family [OT]",
			"children":[
			{
				"name":"105249967 serine\/threonine-protein kinase polo\tK06631 PLK1; polo-like kinase 1 [EC:2.7.11.21]"
			},
			{
				"name":"105251234 serine\/threonine-protein kinase PLK1\tK08861 PLK2; polo-like kinase 2 [EC:2.7.11.21]"
			},
			{
				"name":"105250345 serine\/threonine-protein kinase PLK4 isoform X1\tK08863 PLK4; polo-like kinase 4 [EC:2.7.11.21]"
			}
			]
		},
		{
			"name":"SCY1 family [OT]",
			"children":[
			{
				"name":"105253788 N-terminal kinase-like protein\tK08876 SCYL1; SCY1-like protein 1"
			},
			{
				"name":"105255228 SCY1-like protein 2\tK17541 SCYL2; SCY1-like protein 2"
			},
			{
				"name":"105256392 SCY1-like protein 2 isoform X1\tK17541 SCYL2; SCY1-like protein 2"
			},
			{
				"name":"105253365 protein-associating with the carboxyl-terminal domain of ezrin\tK17542 SCYL3; SCY1-like protein 3"
			}
			]
		},
		{
			"name":"Slob family",
			"children":[
			{
				"name":"105249470 PX domain-containing protein kinase-like protein isoform X1\tK17543 PXK; PX domain-containing protein kinase-like protein"
			},
			{
				"name":"105254939 slowpoke-binding protein isoform X1\tK17543 PXK; PX domain-containing protein kinase-like protein"
			}
			]
		},
		{
			"name":"TBCK family",
			"children":[
			{
				"name":"105256543 TBC domain-containing protein kinase-like protein isoform X1\tK17544 TBCK; TBC domain-containing protein kinase-like protein"
			}
			]
		},
		{
			"name":"TLK family",
			"children":[
			{
				"name":"105251342 serine\/threonine-protein kinase tousled-like 2 isoform X4\tK08864 TLK; tousled-like kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"TOPK family",
			"children":[
			{
				"name":"105251070 lymphokine-activated killer T-cell-originated protein kinase isoform X1\tK08865 PBK; PDZ-binding kinase [EC:2.7.12.2]"
			}
			]
		},
		{
			"name":"TTK family",
			"children":[
			{
				"name":"105257250 serine\/threonine-protein kinase MPS1\tK08866 TTK; serine\/threonine-protein kinase TTK\/MPS1 [EC:2.7.12.1]"
			}
			]
		},
		{
			"name":"ULK family [OT]",
			"children":[
			{
				"name":"105249769 serine\/threonine-protein kinase fused isoform X1\tK06228 FU; fused [EC:2.7.11.1]"
			},
			{
				"name":"105257917 serine\/threonine-protein kinase ULK2 isoform X1\tK08269 ULK2; serine\/threonine-protein kinase ULK2 [EC:2.7.11.1]"
			},
			{
				"name":"105250500 serine\/threonine-protein kinase ULK3\tK21358 ULK3; serine\/threonine-protein kinase ULK3 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"VPS15 family",
			"children":[
			{
				"name":"105258125 phosphoinositide 3-kinase regulatory subunit 4 isoform X1\tK08333 PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"WEE family",
			"children":[
			{
				"name":"105258895 wee1-like protein kinase isoform X1\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"Wnk family",
			"children":[
			{
				"name":"105254082 serine\/threonine-protein kinase WNK1 isoform X1\tK08867 WNK; WNK lysine deficient protein kinase [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"ABC1 family",
			"children":[
			{
				"name":"105250733 uncharacterized aarF domain-containing protein kinase 2\tK08869 ADCK; aarF domain-containing kinase"
			},
			{
				"name":"105252829 uncharacterized aarF domain-containing protein kinase 5 isoform X2\tK08869 ADCK; aarF domain-containing kinase"
			},
			{
				"name":"105254561 uncharacterized aarF domain-containing protein kinase 1\tK08869 ADCK; aarF domain-containing kinase"
			},
			{
				"name":"105257560 atypical kinase COQ8B, mitochondrial isoform X2\tK08869 ADCK; aarF domain-containing kinase"
			}
			]
		},
		{
			"name":"Alpha family [OT]"
		},
		{
			"name":"BCR family"
		},
		{
			"name":"BRD family [OT]",
			"children":[
			{
				"name":"105250086 homeotic protein female sterile isoform X1\tK11722 BRD4; bromodomain-containing protein 4"
			}
			]
		},
		{
			"name":"FAST family"
		},
		{
			"name":"G11 family"
		},
		{
			"name":"H11 family"
		},
		{
			"name":"PDHK family [OT]",
			"children":[
			{
				"name":"105254566 pyruvate dehydrogenase (acetyl-transferring) kinase, mitochondrial\tK00898 PDK2_3_4; pyruvate dehydrogenase kinase 2\/3\/4 [EC:2.7.11.2]"
			}
			]
		},
		{
			"name":"PIKK family [OT]",
			"children":[
			{
				"name":"105248156 serine-protein kinase ATM isoform X1\tK04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]"
			},
			{
				"name":"105257424 serine\/threonine-protein kinase ATR\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
			},
			{
				"name":"105256945 serine\/threonine-protein kinase mTOR isoform X1\tK07203 MTOR; serine\/threonine-protein kinase mTOR [EC:2.7.11.1]"
			},
			{
				"name":"105258805 DNA-dependent protein kinase catalytic subunit-like\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
			},
			{
				"name":"105259055 serine\/threonine-protein kinase SMG1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]"
			},
			{
				"name":"105256300 transformation\/transcription domain-associated protein isoform X1\tK08874 TRRAP; transformation\/transcription domain-associated protein"
			}
			]
		},
		{
			"name":"RIO family [OT]",
			"children":[
			{
				"name":"105255794 serine\/threonine-protein kinase RIO1 isoform X1\tK07178 RIOK1; RIO kinase 1 [EC:2.7.11.1]"
			},
			{
				"name":"105248293 serine\/threonine-protein kinase RIO2\tK07179 RIOK2; RIO kinase 2 [EC:2.7.11.1]"
			}
			]
		},
		{
			"name":"TAF1 family",
			"children":[
			{
				"name":"105250712 transcription initiation factor TFIID subunit 1\tK03125 TAF1; transcription initiation factor TFIID subunit 1 [EC:2.3.1.48 2.7.11.1]"
			}
			]
		},
		{
			"name":"TIF1 family [OT]",
			"children":[
			{
				"name":"105251551 E3 ubiquitin-protein ligase TRIM33\tK08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"Other",
			"children":[
			{
				"name":"105249434 protein mahjong isoform X1\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]"
			},
			{
				"name":"105258811 dual serine\/threonine and tyrosine protein kinase isoform X1\tK16288 DSTYK; dual serine\/threonine and tyrosine protein kinase [EC:2.7.12.1]"
			}
			]
		},
		{
			"name":"Bacterial family"
		}
		]
	},
	{
		"name":"Receptor serine\/threonine kinases (RSTK): TKL group",
		"children":[
		{
			"name":"TGFBR1 family [OT]",
			"children":[
			{
				"name":"105249162 activin receptor type-1\tK04675 ACVR1; activin receptor type-1 [EC:2.7.11.30]"
			},
			{
				"name":"105259212 bone morphogenetic protein receptor type-1B isoform X1\tK13578 BMPR1B; bone morphogenetic protein receptor type-1B [EC:2.7.11.30]"
			},
			{
				"name":"105256068 TGF-beta receptor type-1 isoform X1\tK04674 TGFBR1; TGF-beta receptor type-1 [EC:2.7.11.30]"
			}
			]
		},
		{
			"name":"TGFBR2 family [OT]",
			"children":[
			{
				"name":"105254093 activin receptor type-2A\tK13596 ACVR2B; activin receptor type-2B [EC:2.7.11.30]"
			},
			{
				"name":"105259096 bone morphogenetic protein receptor type-2 isoform X1\tK04671 BMPR2; bone morphogenetic protein receptor type-2 [EC:2.7.11.30]"
			},
			{
				"name":"105252675 inhibin beta C chain isoform X1\tK04669 TGFBRX; TGF-beta receptor, other"
			}
			]
		}
		]
	},
	{
		"name":"Receptor tyrosine kinases (RTK)",
		"children":[
		{
			"name":"EGFR family [OT]",
			"children":[
			{
				"name":"105257833 epidermal growth factor receptor isoform X1\tK04361 EGFR; epidermal growth factor receptor [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"INSR family [OT]"
		},
		{
			"name":"PDGFR family [OT]"
		},
		{
			"name":"FGFR family [OT]",
			"children":[
			{
				"name":"105254933 tyrosine kinase receptor Cad96Ca\tK04362 FGFR1; fibroblast growth factor receptor 1 [EC:2.7.10.1]"
			},
			{
				"name":"105249959 fibroblast growth factor receptor homolog 1 isoform X1\tK05093 FGFR2; fibroblast growth factor receptor 2 [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"VEGFR family [OT]",
			"children":[
			{
				"name":"105257298 vascular endothelial growth factor receptor 1 isoform X1\tK05096 FLT1; FMS-like tyrosine kinase 1 [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"MET family"
		},
		{
			"name":"TRK family [OT]",
			"children":[
			{
				"name":"105252670 high affinity nerve growth factor receptor isoform X1\tK03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"EPH family [OT]",
			"children":[
			{
				"name":"105259214 ephrin type-A receptor 3 isoform X1\tK05110 EPHB1; Eph receptor B1 [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"AXL family"
		},
		{
			"name":"ALK family",
			"children":[
			{
				"name":"105251192 ALK tyrosine kinase receptor isoform X1\tK05119 ALK; anaplastic lymphoma kinase [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"TIE family"
		},
		{
			"name":"ROR family",
			"children":[
			{
				"name":"105248787 tyrosine-protein kinase transmembrane receptor Ror isoform X1\tK05122 ROR1; receptor tyrosine kinase-like orphan receptor 1 [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"DDR family",
			"children":[
			{
				"name":"105254904 uncharacterized protein LOC105254904\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]"
			},
			{
				"name":"105255635 epithelial discoidin domain-containing receptor 1 isoform X1\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]"
			},
			{
				"name":"105255636 discoidin domain-containing receptor 2\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]"
			},
			{
				"name":"105255637 discoidin domain-containing receptor 2\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]"
			},
			{
				"name":"105255638 discoidin domain-containing receptor 2 isoform X1\tK05125 DDR2; discoidin domain receptor family member 2 [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"RET family",
			"children":[
			{
				"name":"105250051 proto-oncogene tyrosine-protein kinase receptor Ret isoform X1\tK05126 RET; proto-oncogene tyrosine-protein kinase Ret [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"ROS family",
			"children":[
			{
				"name":"105258133 proto-oncogene tyrosine-protein kinase ROS isoform X1\tK05088 ROS1; proto-oncogene tyrosine-protein kinase ROS [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"CCK family",
			"children":[
			{
				"name":"105255013 inactive tyrosine-protein kinase 7 isoform X1\tK05127 PTK7; PTK7 protein tyrosine kinase 7 [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"RYK family",
			"children":[
			{
				"name":"105250010 tyrosine-protein kinase Drl isoform X1\tK05128 RYK; RYK receptor-like tyrosine kinase [EC:2.7.10.1]"
			},
			{
				"name":"105250579 tyrosine-protein kinase Dnt\tK05128 RYK; RYK receptor-like tyrosine kinase [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"MUSK family",
			"children":[
			{
				"name":"105250648 tyrosine-protein kinase transmembrane receptor Ror2 isoform X2\tK05129 MUSK; muscle, skeletal, receptor tyrosine kinase [EC:2.7.10.1]"
			}
			]
		},
		{
			"name":"LMR family [OT]",
			"children":[
			{
				"name":"105254590 uncharacterized protein LOC105254590\tK08898 LMTK2; lemur tyrosine kinase 2 [EC:2.7.10.1]"
			}
			]
		}
		]
	},
	{
		"name":"Non-receptor tyrosine kinases",
		"children":[
		{
			"name":"ABL family",
			"children":[
			{
				"name":"105248025 tyrosine-protein kinase Abl isoform X1\tK06619 ABL1; abelson tyrosine-protein kinase 1 [EC:2.7.10.2]"
			}
			]
		},
		{
			"name":"ACK family",
			"children":[
			{
				"name":"105250290 uncharacterized protein LOC105250290\tK08886 TNK2; activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]"
			},
			{
				"name":"105254223 uncharacterized protein LOC105254223 isoform X1\tK08886 TNK2; activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]"
			}
			]
		},
		{
			"name":"CSK family",
			"children":[
			{
				"name":"105252140 tyrosine-protein kinase CSK isoform X1\tK05728 CSK; C-terminal Src kinase [EC:2.7.10.4]"
			}
			]
		},
		{
			"name":"FAK family",
			"children":[
			{
				"name":"105253398 uncharacterized protein LOC105253398 isoform X1\tK05725 PTK2; focal adhesion kinase 1 [EC:2.7.10.2]"
			}
			]
		},
		{
			"name":"FES family",
			"children":[
			{
				"name":"105248318 tyrosine-protein kinase Fer isoform X1\tK08889 FER; tyrosine-protein kinase Fer [EC:2.7.10.2]"
			}
			]
		},
		{
			"name":"JAK family [OT]",
			"children":[
			{
				"name":"105255224 tyrosine-protein kinase hopscotch\tK04447 JAK2; Janus kinase 2 [EC:2.7.10.2]"
			}
			]
		},
		{
			"name":"SRC family",
			"children":[
			{
				"name":"105257753 tyrosine-protein kinase Src42A isoform X1\tK08892 FRK; fyn-related kinase [EC:2.7.10.2]"
			},
			{
				"name":"105252079 tyrosine-protein kinase Src64B isoform X1\tK05704 SRC; tyrosine-protein kinase Src [EC:2.7.10.2]"
			}
			]
		},
		{
			"name":"TEC family",
			"children":[
			{
				"name":"105249778 tyrosine-protein kinase Btk29A isoform X2\tK07364 TEC; tyrosine-protein kinase Tec [EC:2.7.10.2]"
			}
			]
		},
		{
			"name":"SYK family"
		},
		{
			"name":"Other"
		},
		{
			"name":"Bacterial"
		}
		]
	},
	{
		"name":"Histidine kinases",
		"children":[
		{
			"name":"OmpR family"
		},
		{
			"name":"NarL family"
		},
		{
			"name":"Spo family [OT]"
		},
		{
			"name":"CitB family [OT]"
		},
		{
			"name":"LytTR family [OT]"
		},
		{
			"name":"NtrC family"
		},
		{
			"name":"CheA family [OT]"
		},
		{
			"name":"Cell cycle family [OT]"
		},
		{
			"name":"Lux family [OT]"
		},
		{
			"name":"LuxR family [OT]"
		},
		{
			"name":"Other"
		}
		]
	}
	]
}