{
	"name":"chd02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"Calhy_2489 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Calhy_2542 CRISPR-associated protein Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Calhy_2488 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Calhy_2541 CRISPR-associated protein Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"Calhy_2491 CRISPR-associated helicase Cas3\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"Calhy_2544 metal dependent phosphohydrolase\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"Calhy_2494 CRISPR-associated CXXC_CXXC protein Cst1\tK19088 cst1; CRISPR-associated protein Cst1"
				},
				{
					"name":"Calhy_2493 CRISPR-associated regulatory protein, DevR family\tK19075 cst2; CRISPR-associated protein Cst2"
				},
				{
					"name":"Calhy_2490 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2543 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2492 CRISPR-associated protein Cas5 family\tK19090 cas5t; CRISPR-associated protein Cas5t"
				},
				{
					"name":"Calhy_2191 CRISPR-associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				},
				{
					"name":"Calhy_2495 CRISPR-associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"Calhy_2547 CRISPR-associated protein, Csh1 family\tK19114 csh1; CRISPR-associated protein Csh1"
				},
				{
					"name":"Calhy_2546 CRISPR-associated protein, Csh2 family\tK19115 csh2; CRISPR-associated protein Csh2"
				},
				{
					"name":"Calhy_2490 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2543 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2545 CRISPR-associated protein Cas5\tK19116 cas5h; CRISPR-associated protein Cas5h"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"Calhy_2490 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2543 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"Calhy_2490 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2543 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2191 CRISPR-associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				},
				{
					"name":"Calhy_2495 CRISPR-associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"Calhy_2490 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Calhy_2543 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins",
				"children":[
				{
					"name":"Calhy_2561 CRISPR-associated protein, Csm1 family\tK07016 csm1; CRISPR-associated protein Csm1"
				}
				]
			},
			{
				"name":"Subtype III-A factors",
				"children":[
				{
					"name":"Calhy_2560 CRISPR-associated protein, Csm2 family\tK19138 csm2; CRISPR-associated protein Csm2"
				},
				{
					"name":"Calhy_2559 CRISPR-associated RAMP protein, Csm3 family\tK09002 csm3; CRISPR-associated protein Csm3"
				},
				{
					"name":"Calhy_2558 CRISPR-associated RAMP protein, Csm4 family\tK19139 csm4; CRISPR-associated protein Csm4"
				},
				{
					"name":"Calhy_2557 CRISPR-associated RAMP protein, Csm5 family\tK19140 csm5; CRISPR-associated protein Csm5"
				}
				]
			},
			{
				"name":"Subtype III-B factors",
				"children":[
				{
					"name":"Calhy_2579 protein of unknown function DUF324\tK07061 cmr1; CRISPR-associated protein Cmr1"
				},
				{
					"name":"Calhy_2578 protein of unknown function DUF324\tK19076 cmr2; CRISPR-associated protein Cmr2"
				}
				]
			},
			{
				"name":"Subtype III-U factors",
				"children":[
				{
					"name":"Calhy_2564 CRISPR-associated protein, MJ1666 family\tK19143 csx1; CRISPR-associated protein Csx1"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"Calhy_1820 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Calhy_0372 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Calhy_1821 restriction modification system DNA specificity domain protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Calhy_0371 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"Calhy_0409 D12 class N6 adenine-specific DNA methyltransferase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"Calhy_2464 DNA methylase N-4\/N-6 domain protein\tK24451 zim; modification methylase"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system"
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"Calhy_0362 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Calhy_0883 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Calhy_2420 transcriptional modulator of MazE\/toxin, MazF\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Calhy_0295 transcriptional regulator, AbrB family\tK07172 mazE; antitoxin MazE"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"Calhy_0481 addiction module toxin, RelE\/StbE family\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"Calhy_0525 plasmid stabilization system\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"Calhy_2170 addiction module toxin, Txe\/YoeB family\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"Calhy_2171 prevent-host-death family protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"Calhy_1905 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Calhy_0187 cell shape determining protein, MreB\/Mrl family\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Calhy_1425 cell shape determining protein, MreB\/Mrl family\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Calhy_1765 glutamyl-tRNA synthetase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"Calhy_0182 protein of unknown function DUF86\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"Calhy_1079 protein of unknown function DUF86\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"Calhy_2394 protein of unknown function DUF86\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"Calhy_0181 DNA polymerase beta domain protein region\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"Calhy_0479 DNA polymerase beta domain protein region\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"Calhy_1078 DNA polymerase beta domain protein region\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"Calhy_2393 DNA polymerase beta domain protein region\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"Calhy_1036 cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"Calhy_1190 aminotransferase class V\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}