{
	"name":"chig03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors",
					"children":[
					{
						"name":"CH63R_08096 mRNA capping enzyme\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]"
					},
					{
						"name":"CH63R_08119 Cell division control protein 2\tK04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]"
					},
					{
						"name":"CH63R_04402 Serine threonine-protein kinase\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"CH63R_02262 mRNA capping enzyme\tK00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]"
					}
					]
				},
				{
					"name":"Cap binding complex",
					"children":[
					{
						"name":"CH63R_04225 Cap binding protein\tK12882 NCBP1; nuclear cap-binding protein subunit 1"
					},
					{
						"name":"CH63R_02273 RNA recognition domain-containing protein\tK12883 NCBP2; nuclear cap-binding protein subunit 2"
					}
					]
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)",
					"children":[
					{
						"name":"CH63R_02495 Cleavage and polyadenylation specificity factor subunit 5\tK14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5"
					}
					]
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)",
					"children":[
					{
						"name":"CH63R_13749 mRNA cleavage and polyadenylation factor CLP1\tK14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]"
					},
					{
						"name":"CH63R_12749 mRNA cleavage factor complex component pcf11\tK14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11"
					}
					]
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex",
					"children":[
					{
						"name":"CH63R_05827 CPSF A subunit region\tK14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1"
					},
					{
						"name":"CH63R_12197 RNA-metabolising metallo-beta-lactamase\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"CH63R_10390 Endoribonuclease YSH1\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"CH63R_06055 Zinc finger ccch type domain containing protein\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4"
					},
					{
						"name":"CH63R_05199 Pre-mRNA polyadenylation factor FIP1\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1"
					},
					{
						"name":"CH63R_09203 Retinoblastoma-binding protein\tK15541 MPE1; protein MPE1"
					},
					{
						"name":"CH63R_02762 WD domain-containing protein\tK15542 PFS2; polyadenylation factor subunit 2"
					},
					{
						"name":"CH63R_02545 WD repeat domain-containing protein\tK14962 WDR82; COMPASS component SWD2"
					},
					{
						"name":"CH63R_02723 Serine\/threonine-protein phosphatase\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"CH63R_05692 Serine\/threonine-protein phosphatase\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"CH63R_05979 RNA polymerase II subunit A domain phosphatase SSU72\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex",
					"children":[
					{
						"name":"CH63R_00434 RNA recognition domain-containing protein\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"CH63R_01279 mRNA 3'-end-processing protein RNA14\tK14408 CSTF3; cleavage stimulation factor subunit 3"
					},
					{
						"name":"CH63R_11631 mRNA cleavage and polyadenylation specificity factor complex subunit\tK06100 SYMPK; symplekin"
					}
					]
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors",
					"children":[
					{
						"name":"CH63R_11366 SMB protein\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"CH63R_03852 LSM domain-containing protein\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"CH63R_10320 Small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"CH63R_05382 LSM domain-containing protein\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"CH63R_12197 RNA-metabolising metallo-beta-lactamase\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"CH63R_10390 Endoribonuclease YSH1\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"CH63R_00434 RNA recognition domain-containing protein\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"CH63R_11631 mRNA cleavage and polyadenylation specificity factor complex subunit\tK06100 SYMPK; symplekin"
					}
					]
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex",
					"children":[
					{
						"name":"CH63R_04415 Transcription elongation factor SPT4\tK15171 SUPT4H1; transcription elongation factor SPT4"
					},
					{
						"name":"CH63R_14182 Transcription elongation factor SPT5\tK15172 SUPT5H; transcription elongation factor SPT5"
					}
					]
				},
				{
					"name":"N6-methyltransferase complex",
					"children":[
					{
						"name":"CH63R_05184 Methyltransferase-like protein\tK11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]"
					},
					{
						"name":"CH63R_07637 Zinc finger protein\tK22909 ZC3H13; zinc finger CCCH domain-containing protein 13"
					}
					]
				},
				{
					"name":"Poly(A) addition factors",
					"children":[
					{
						"name":"CH63R_02575 Poly polymerase\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]"
					}
					]
				},
				{
					"name":"Negative regulators of mRNA 3' end processing"
				}
				]
			},
			{
				"name":"Other processing factors",
				"children":[
				{
					"name":"CH63R_04414 Zinc finger protein rts2\tK13102 KIN; DNA\/RNA-binding protein KIN17"
				},
				{
					"name":"CH63R_00783 Arsenite resistance protein Ars2\tK27103 SRRT; serrate RNA effector molecule"
				},
				{
					"name":"CH63R_00486 Nuclear polyadenylated rna-binding protein nab2\tK23039 NAB2; nuclear polyadenylated RNA-binding protein NAB2"
				}
				]
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex",
					"children":[
					{
						"name":"CH63R_05931 RNA recognition domain-containing protein\tK12876 RBM8A; RNA-binding protein 8A"
					},
					{
						"name":"CH63R_00110 Mago nashi\tK12877 MAGOH; protein mago nashi"
					},
					{
						"name":"CH63R_00696 RNA binding protein\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"CH63R_10187 RNA recognition domain-containing protein containing protein\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"CH63R_07376 ATP-dependent RNA helicase SUB2\tK12812 DDX39B; ATP-dependent RNA helicase UAP56\/SUB2 [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_03697 DEAD\/DEAH box helicase\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_14155 hypothetical protein\tK25178 CCDC174; coiled-coil domain-containing protein 174"
					},
					{
						"name":"CH63R_02982 Sin3 associated polypeptide p18\tK14324 SAP18; histone deacetylase complex subunit SAP18"
					},
					{
						"name":"CH63R_06981 RNA-binding protein with serine-rich domain 1\tK14325 RNPS1; RNA-binding protein with serine-rich domain 1"
					}
					]
				},
				{
					"name":"TREX complex",
					"children":[
					{
						"name":"CH63R_02539 guanylate kinase\tK12878 THOC1; THO complex subunit 1"
					},
					{
						"name":"CH63R_07898 THO complex subunit 2\tK12879 THOC2; THO complex subunit 2"
					},
					{
						"name":"CH63R_11850 WD domain-containing protein\tK12880 THOC3; THO complex subunit 3"
					},
					{
						"name":"CH63R_00696 RNA binding protein\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"CH63R_10187 RNA recognition domain-containing protein containing protein\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"CH63R_01067 Fms interacting\tK13174 THOC5; THO complex subunit 5"
					}
					]
				},
				{
					"name":"TREX-2 complex",
					"children":[
					{
						"name":"CH63R_00037 DSS1\/SEM1 family protein\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"CH63R_06421 Cell division control protein 31\tK16466 CETN3; centrin-3"
					},
					{
						"name":"CH63R_04265 GANP\/Nin1\/mts3\/eIF-3 p25 family protein\tK23719 SAC3; nuclear mRNA export protein SAC3"
					}
					]
				},
				{
					"name":"Nuclear pore complex",
					"children":[
					{
						"name":"CH63R_08349 TPR\/MLP1\/MLP2-like protein\tK09291 TPR; nucleoprotein TPR"
					},
					{
						"name":"CH63R_08521 WD repeat domain-containing protein\tK14298 RAE1; mRNA export factor"
					},
					{
						"name":"CH63R_14171 Protein transporter sec-13\tK14004 SEC13; protein transport protein SEC13"
					},
					{
						"name":"CH63R_07065 Nucleoporin nup44\tK14308 NUP54; nuclear pore complex protein Nup54"
					},
					{
						"name":"CH63R_00791 Nuclear pore glycoprotein p62\tK14306 NUP62; nuclear pore complex protein Nup62"
					},
					{
						"name":"CH63R_12716 Nuclear pore protein\tK14309 NUP93; nuclear pore complex protein Nup93"
					},
					{
						"name":"CH63R_06389 Nucleoporin autopeptidase\tK14297 NUP98; nuclear pore complex protein Nup98-Nup96"
					},
					{
						"name":"CH63R_01125 Nuclear pore complex protein nup107\tK14301 NUP107; nuclear pore complex protein Nup107"
					},
					{
						"name":"CH63R_09331 Nuclear pore complex subunit nup133\tK14300 NUP133; nuclear pore complex protein Nup133"
					},
					{
						"name":"CH63R_02366 Nucleoporin\tK14311 NUP188; nuclear pore complex protein Nup188"
					},
					{
						"name":"CH63R_13893 Non-repetitive\/WGA-negative nucleoporin\tK14312 NUP155; nuclear pore complex protein Nup155"
					},
					{
						"name":"CH63R_02406 Nuclear pore complex subunit\tK14310 NUP205; nuclear pore complex protein Nup205"
					},
					{
						"name":"CH63R_05200 Nucleoporin NUP49\/NSP49\tK14307 NUPL1; nucleoporin p58\/p45"
					},
					{
						"name":"CH63R_10051 nucleoporin protein Ndc1-Nup\tK14315 NDC1; nucleoporin NDC1"
					},
					{
						"name":"CH63R_00430 Nuclear pore complex subunit\tK18715 NUP159; nucleoporin NUP159"
					},
					{
						"name":"CH63R_12095 CCCH zinc finger domain protein\tK18716 NUP42; nucleoporin NUP42"
					},
					{
						"name":"CH63R_02274 Nuclear pore complex protein An-Nup82\tK18719 NUP82; nucleoporin NUP82"
					},
					{
						"name":"CH63R_06421 Cell division control protein 31\tK16466 CETN3; centrin-3"
					},
					{
						"name":"CH63R_04166 GLE1-like protein\tK18723 GLE1; nucleoporin GLE1"
					},
					{
						"name":"CH63R_00950 TAP domain-containing protein\tK14284 NXF; nuclear RNA export factor"
					},
					{
						"name":"CH63R_04032 Nuclear transport factor 2 domain-containing protein\tK14285 NXT1_2; NTF2-related export protein 1\/2"
					},
					{
						"name":"CH63R_04297 Nuclear pore complex component\tK18724 POM34; nucleoporin POM34"
					},
					{
						"name":"CH63R_01177 Nucleoporin pom152\tK18725 POM152; nucleoporin POM152"
					}
					]
				},
				{
					"name":"Ran-mediated transport factors",
					"children":[
					{
						"name":"CH63R_01116 GTP-binding nuclear protein GSP1\/Ran\tK07936 RAN; GTP-binding nuclear protein Ran"
					},
					{
						"name":"CH63R_10001 UBX domain-containing protein\tK18726 FAF2; FAS-associated factor 2"
					},
					{
						"name":"CH63R_02383 AAA family ATPase\tK13525 VCP; transitional endoplasmic reticulum ATPase"
					},
					{
						"name":"CH63R_12790 Exportin\tK14290 XPO1; exportin-1"
					},
					{
						"name":"CH63R_00597 Ran GTPase activating protein 1\tK14319 RANGAP1; Ran GTPase-activating protein 1"
					},
					{
						"name":"CH63R_06396 Nuclear transport factor 2\tK28773 NUTF2; nuclear transport factor 2"
					}
					]
				},
				{
					"name":"eIF4F and regulatory proteins",
					"children":[
					{
						"name":"CH63R_04087 Eukaryotic initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"CH63R_05846 Eukaryotic initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"CH63R_00652 DEAD\/DEAH box helicase\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"CH63R_02537 Translation initiation factor 4F\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"CH63R_02142 RNA recognition domain-containing protein\tK03258 EIF4B; translation initiation factor 4B"
					},
					{
						"name":"CH63R_04144 DEAD\/DEAH box helicase\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_07538 DEAD\/DEAH box helicase\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_05092 GYF domain-containing protein\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein"
					},
					{
						"name":"CH63R_14066 Polyadenylate-binding protein\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"CH63R_07677 DSHCT domain-containing protein\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]"
					},
					{
						"name":"CH63R_04628 Sec63 Brl domain-containing protein\tK18664 SLH1; antiviral helicase SLH1 [EC:5.6.2.6]"
					},
					{
						"name":"CH63R_11475 Translation machinery-associated protein 20\tK07575 MCTS; malignant T-cell-amplified sequence"
					},
					{
						"name":"CH63R_11830 Translation machinery-associated protein 22\tK24272 DENR; density-regulated protein"
					}
					]
				},
				{
					"name":"APOBEC1-ACF complex"
				},
				{
					"name":"Other transport factors",
					"children":[
					{
						"name":"CH63R_00961 RNA binding protein pym\tK14294 WIBG; partner of Y14 and mago"
					},
					{
						"name":"CH63R_09182 Nuclear polyadenylated RNA-binding protein\tK14411 MSI; RNA-binding protein Musashi"
					},
					{
						"name":"CH63R_08152 Elongation factor Tu GTP binding domain-containing protein\tK14416 HBS1; elongation factor 1 alpha-like protein"
					},
					{
						"name":"CH63R_01812 Protein DOM34-like protein\tK06965 PELO; protein pelota"
					},
					{
						"name":"CH63R_09085 RNA recognition domain-containing protein\tK14396 PABPN1; polyadenylate-binding protein 2"
					},
					{
						"name":"CH63R_08931 ATP-dependent RNA helicase DBP5\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_07690 Pre-mRNA-splicing factor SYF1\tK12867 SYF1; pre-mRNA-splicing factor SYF1"
					},
					{
						"name":"CH63R_13050 Sap domain-containing protein\tK18732 SARNP; SAP domain-containing ribonucleoprotein"
					},
					{
						"name":"CH63R_06495 Ran exchange factor Prp20\/Pim1\tK11493 RCC1; regulator of chromosome condensation"
					},
					{
						"name":"CH63R_08491 RAN exchange factor prp20 pim1\tK11493 RCC1; regulator of chromosome condensation"
					},
					{
						"name":"CH63R_13605 GANP\/Nin1\/mts3\/eIF-3 p25 family protein\tK23802 LENG8; SAC3 family protein LENG8\/THP3"
					}
					]
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex",
					"children":[
					{
						"name":"CH63R_02360 Eukaryotic peptide chain release factor subunit 1\tK03265 ETF1; peptide chain release factor subunit 1"
					},
					{
						"name":"CH63R_06406 Elongation factor Tu GTP binding domain-containing protein\tK03267 ERF3; peptide chain release factor subunit 3"
					},
					{
						"name":"CH63R_09111 RNA helicase\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					},
					{
						"name":"CH63R_04540 MIF4G domain-containing protein\tK14327 UPF2; regulator of nonsense transcripts 2"
					},
					{
						"name":"CH63R_10306 Nonsense-mediated mRNA decay protein\tK14328 UPF3; regulator of nonsense transcripts 3"
					}
					]
				},
				{
					"name":"Protein phosphatase 2A",
					"children":[
					{
						"name":"CH63R_04798 Serine\/threonine-protein phosphatase\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"CH63R_02798 Protein phosphatase pp2a regulatory subunit a\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A"
					},
					{
						"name":"CH63R_11868 Protein phosphatase PP2A regulatory subunit B\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B"
					},
					{
						"name":"CH63R_04056 Protein phosphatase 2A regulatory B subunit\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					}
					]
				},
				{
					"name":"Other surveillance factors",
					"children":[
					{
						"name":"CH63R_05092 GYF domain-containing protein\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein"
					},
					{
						"name":"CH63R_01940 Elongation factor Tu GTP binding domain-containing protein\tK24887 GTPBP1; GTP-binding protein 1"
					}
					]
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex",
					"children":[
					{
						"name":"CH63R_11824 CPL domain-containing protein\tK14844 PUF6; pumilio homology domain family member 6"
					},
					{
						"name":"CH63R_00628 KH domain-containing protein\tK18738 HEK; heterogeneous nuclear rnp K-like protein"
					},
					{
						"name":"CH63R_02829 KH domain-containing protein\tK18738 HEK; heterogeneous nuclear rnp K-like protein"
					},
					{
						"name":"CH63R_04483 Class v myosin\tK10357 MYO5; myosin V"
					}
					]
				},
				{
					"name":"Factors that have mRNA localization signals"
				},
				{
					"name":"Trans-acting binding proteins",
					"children":[
					{
						"name":"CH63R_07902 KH domain-containing protein\tK13210 FUBP; far upstream element-binding protein"
					},
					{
						"name":"CH63R_07477 translation elongation factor EF-1 alpha\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"CH63R_01688 Elongation factor 1-gamma\tK03233 EEF1G; elongation factor 1-gamma"
					},
					{
						"name":"CH63R_04422 glutathione S-transferase domain-containing protein\tK03233 EEF1G; elongation factor 1-gamma"
					}
					]
				},
				{
					"name":"Other mRNA localization factors",
					"children":[
					{
						"name":"CH63R_04165 RNB domain-containing protein\tK18748 SSD1; protein SSD1"
					}
					]
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule",
					"children":[
					{
						"name":"CH63R_04140 5'-3' exoribonuclease 1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]"
					},
					{
						"name":"CH63R_01278 Protein argonaute\tK11593 ELF2C; eukaryotic translation initiation factor 2C"
					},
					{
						"name":"CH63R_04087 Eukaryotic initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"CH63R_05846 Eukaryotic initiation factor 4E\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"CH63R_09111 RNA helicase\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					},
					{
						"name":"CH63R_04144 DEAD\/DEAH box helicase\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_07538 DEAD\/DEAH box helicase\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_12123 ATP-dependent RNA helicase DHH1\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_10415 G2 m phase checkpoint control protein\tK18749 LSM14; protein LSM14"
					},
					{
						"name":"CH63R_13029 Importin beta-2\tK18752 TNPO1; transportin-1"
					},
					{
						"name":"CH63R_02689 Catalytic subunit of cAMP-dependent protein kinase\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
					},
					{
						"name":"CH63R_07193 Serine threonine-protein kinase prkx\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
					},
					{
						"name":"CH63R_11839 La domain-containing protein\tK18757 LARP1; la-related protein 1"
					}
					]
				},
				{
					"name":"P-body specific factors",
					"children":[
					{
						"name":"CH63R_02550 Decapping enzyme dcp2\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"CH63R_12765 LSM domain-containing protein\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"CH63R_00447 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"CH63R_01939 LSM domain-containing protein\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					},
					{
						"name":"CH63R_04219 U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5"
					},
					{
						"name":"CH63R_11718 LSM domain-containing protein\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"CH63R_10003 LSM domain-containing protein\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					},
					{
						"name":"CH63R_00935 LSM domain-containing protein\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8"
					},
					{
						"name":"CH63R_04483 Class v myosin\tK10357 MYO5; myosin V"
					},
					{
						"name":"CH63R_11627 Tubulin\/FtsZ family protein\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"CH63R_12878 tubulin alpha-B chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"CH63R_06376 CCR4-Not complex component\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"CH63R_04735 NOT2\/NOT3\/NOT5 family protein\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"CH63R_09105 Not1 domain-containing protein\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"CH63R_08224 RNA recognition domain-containing protein\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"CH63R_13147 endonuclease\/Exonuclease\/phosphatase\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"CH63R_02694 CAF1 family ribonuclease\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"CH63R_06415 PAB-dependent poly(A)-specific ribonuclease subunit PAN2\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]"
					},
					{
						"name":"CH63R_10002 PAB-dependent poly(A)-specific ribonuclease subunit PAN3\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3"
					},
					{
						"name":"CH63R_13593 Topoisomerase II-associated protein PAT1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1"
					},
					{
						"name":"CH63R_02381 DFDF domain-containing protein\tK12615 EDC3; enhancer of mRNA-decapping protein 3"
					},
					{
						"name":"CH63R_04540 MIF4G domain-containing protein\tK14327 UPF2; regulator of nonsense transcripts 2"
					},
					{
						"name":"CH63R_10306 Nonsense-mediated mRNA decay protein\tK14328 UPF3; regulator of nonsense transcripts 3"
					},
					{
						"name":"CH63R_00572 RNA polymerase ii subunit 7\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
					}
					]
				},
				{
					"name":"Stress granule specific factors",
					"children":[
					{
						"name":"CH63R_02530 RNA recognition domain-containing protein\tK13201 TIA1; nucleolysin TIA-1\/TIAR"
					},
					{
						"name":"CH63R_14066 Polyadenylate-binding protein\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"CH63R_02331 NTF2 and RRM domain-containing protein\tK24983 G3BP2; Ras GTPase-activating protein-binding protein 2"
					},
					{
						"name":"CH63R_01232 Eukaryotic translation initiation factor eIF2A\tK15026 EIF2A; translation initiation factor 2A"
					},
					{
						"name":"CH63R_11056 Eukaryotic translation initiation factor 3 subunit B\tK03253 EIF3B; translation initiation factor 3 subunit B"
					},
					{
						"name":"CH63R_00652 DEAD\/DEAH box helicase\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"CH63R_03697 DEAD\/DEAH box helicase\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_02142 RNA recognition domain-containing protein\tK03258 EIF4B; translation initiation factor 4B"
					},
					{
						"name":"CH63R_02537 Translation initiation factor 4F\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"CH63R_09446 WD domain-containing protein\tK14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein"
					},
					{
						"name":"CH63R_00950 TAP domain-containing protein\tK14284 NXF; nuclear RNA export factor"
					},
					{
						"name":"CH63R_12688 Histone deacetylase\tK11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex",
					"children":[
					{
						"name":"CH63R_02550 Decapping enzyme dcp2\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"CH63R_12123 ATP-dependent RNA helicase DHH1\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					},
					{
						"name":"CH63R_02381 DFDF domain-containing protein\tK12615 EDC3; enhancer of mRNA-decapping protein 3"
					},
					{
						"name":"CH63R_13593 Topoisomerase II-associated protein PAT1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1"
					}
					]
				},
				{
					"name":"Lsm complex",
					"children":[
					{
						"name":"CH63R_12765 LSM domain-containing protein\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"CH63R_00447 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"CH63R_01939 LSM domain-containing protein\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					},
					{
						"name":"CH63R_04219 U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5"
					},
					{
						"name":"CH63R_11718 LSM domain-containing protein\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"CH63R_10003 LSM domain-containing protein\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					},
					{
						"name":"CH63R_00935 LSM domain-containing protein\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8"
					}
					]
				},
				{
					"name":"5' exonucleases",
					"children":[
					{
						"name":"CH63R_04140 5'-3' exoribonuclease 1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]"
					}
					]
				},
				{
					"name":"Other 5'-3' decay factors",
					"children":[
					{
						"name":"CH63R_13731 Scavenger mRNA decapping enzyme\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					}
					]
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors",
					"children":[
					{
						"name":"CH63R_04153 Exosome component EXOSC1\/CSL4\tK07573 CSL4; exosome complex component CSL4"
					},
					{
						"name":"CH63R_09325 Exosome complex exonuclease RRP4\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"CH63R_07407 Exosome complex exonuclease RRP40\tK03681 RRP40; exosome complex component RRP40"
					},
					{
						"name":"CH63R_05361 3' exoribonuclease\tK11600 RRP41; exosome complex component RRP41"
					},
					{
						"name":"CH63R_01112 Exosome complex subunit Rrp46\tK12590 RRP46; exosome complex component RRP46"
					},
					{
						"name":"CH63R_07696 3' exoribonuclease\tK12587 MTR3; exosome complex component MTR3"
					},
					{
						"name":"CH63R_12794 3' exoribonuclease family protein\tK12589 RRP42; exosome complex component RRP42"
					},
					{
						"name":"CH63R_07318 Exosome complex exonuclease RRP43\tK12586 RRP43; exosome complex component RRP43"
					},
					{
						"name":"CH63R_02429 3' exoribonuclease\tK03678 RRP45; exosome complex component RRP45"
					}
					]
				},
				{
					"name":"Exosome cofactors",
					"children":[
					{
						"name":"CH63R_11736 RNB domain-containing protein\tK12585 DIS3; exosome complex exonuclease DIS3\/RRP44 [EC:3.1.13.-]"
					},
					{
						"name":"CH63R_01346 3'-5' exonuclease\tK12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]"
					},
					{
						"name":"CH63R_09942 Sas10\/Utp3\/C1D family protein\tK12592 C1D; exosome complex protein LRP1"
					}
					]
				},
				{
					"name":"TRAMP complex",
					"children":[
					{
						"name":"CH63R_06501 Topoisomerase family protein\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]"
					},
					{
						"name":"CH63R_09318 Zinc knuckle\tK12597 AIR1_2; protein AIR1\/2"
					},
					{
						"name":"CH63R_10707 DSHCT domain-containing protein\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Ski complex",
					"children":[
					{
						"name":"CH63R_07677 DSHCT domain-containing protein\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]"
					},
					{
						"name":"CH63R_01383 Tetratricopeptide\tK12600 SKI3; superkiller protein 3"
					},
					{
						"name":"CH63R_10875 WD repeat domain-containing protein\tK12601 SKI8; superkiller protein 8"
					}
					]
				},
				{
					"name":"Ccr4-NOT complex",
					"children":[
					{
						"name":"CH63R_13147 endonuclease\/Exonuclease\/phosphatase\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"CH63R_06376 CCR4-Not complex component\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"CH63R_04735 NOT2\/NOT3\/NOT5 family protein\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"CH63R_09105 Not1 domain-containing protein\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"CH63R_08224 RNA recognition domain-containing protein\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"CH63R_02694 CAF1 family ribonuclease\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"CH63R_14166 Cell differentiation family protein\tK12606 RCD1; CCR4-NOT transcription complex subunit 9"
					},
					{
						"name":"CH63R_04027 ABC transporter\tK12608 CAF16; CCR4-NOT complex subunit CAF16"
					},
					{
						"name":"CH63R_11698 PH domain-containing protein\tK12609 CAF120; CCR4-NOT transcriptional complex subunit CAF120"
					}
					]
				},
				{
					"name":"Pan complex",
					"children":[
					{
						"name":"CH63R_06415 PAB-dependent poly(A)-specific ribonuclease subunit PAN2\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]"
					},
					{
						"name":"CH63R_10002 PAB-dependent poly(A)-specific ribonuclease subunit PAN3\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3"
					}
					]
				},
				{
					"name":"Other 3'-5' decay factors",
					"children":[
					{
						"name":"CH63R_03052 Caf1 family ribonuclease\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]"
					},
					{
						"name":"CH63R_13731 Scavenger mRNA decapping enzyme\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					},
					{
						"name":"CH63R_02698 Duf1740 domain containing protein\tK26109 NRDE2; nuclear exosome regulator NRDE2"
					},
					{
						"name":"CH63R_02591 VTS1 protein\tK27407 VTS1; RNA-binding protein VTS1"
					}
					]
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"CH63R_10161 RNase3 domain-containing protein\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"CH63R_10790 RNase\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"CH63R_11618 Exonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases"
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"CH63R_01087 phosphopyruvate hydratase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"CH63R_07580 ATP-dependent 6-phosphofructokinase\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"CH63R_07750 hsp70-like protein\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"CH63R_10172 Heat shock protein 60\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					}
					]
				},
				{
					"name":"Others"
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome",
					"children":[
					{
						"name":"CH63R_09325 Exosome complex exonuclease RRP4\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"CH63R_04153 Exosome component EXOSC1\/CSL4\tK07573 CSL4; exosome complex component CSL4"
					}
					]
				},
				{
					"name":"Cofactors",
					"children":[
					{
						"name":"CH63R_05361 3' exoribonuclease\tK11600 RRP41; exosome complex component RRP41"
					},
					{
						"name":"CH63R_12794 3' exoribonuclease family protein\tK12589 RRP42; exosome complex component RRP42"
					}
					]
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}