{
	"name":"cho03029",
	"children":[
	{
		"name":"Mitochondrial DNA transcription, translation, and replication factors",
		"children":[
		{
			"name":"Mitochondrial DNA-encoded proteins",
			"children":[
			{
				"name":"Mitochondrial respiratory chain complex I"
			},
			{
				"name":"Mitochondrial respiratory chain complex III"
			},
			{
				"name":"Cytochrome c oxidase"
			},
			{
				"name":"F-type ATPase"
			}
			]
		},
		{
			"name":"Mitochondrial transcription and translation factors",
			"children":[
			{
				"name":"Mitochondrial RNA polymerase"
			},
			{
				"name":"Mitochondrial transcription factors"
			},
			{
				"name":"Mitochondrial translation factors"
			},
			{
				"name":"RNase MRP",
				"children":[
				{
					"name":"Chro.30109 POP4 (processing of precursor, S. cerevisiae)\tK03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]"
				},
				{
					"name":"Chro.30196 ribonuclease P (30kD)\tK03539 RPP1; ribonuclease P\/MRP protein subunit RPP1 [EC:3.1.26.5]"
				}
				]
			},
			{
				"name":"Mitochondrial ribonuclease P"
			},
			{
				"name":"Other mitochondrial DNA transcription and translation factors",
				"children":[
				{
					"name":"Chro.80141 ADP\/ATP carrier\tK05863 SLC25A4S; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4\/5\/6\/31"
				},
				{
					"name":"Chro.20115 mitochondrial carrier protein\tK15113 SLC25A28_37; solute carrier family 25 (mitochondrial iron transporter), member 28\/37"
				},
				{
					"name":"Chro.60344 tyrosyl-tRNA synthetase\tK01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]"
				},
				{
					"name":"Chro.50330 leucyl-tRNA synthetase\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"Chro.50331 KIAA1352 protein\tK01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]"
				},
				{
					"name":"Chro.80123 glycyl-tRNA synthetase\tK01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]"
				},
				{
					"name":"Chro.50402 RIKEN cDNA 2610011N19 gene\tK01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]"
				},
				{
					"name":"Chro.40208 C0850c\tK19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial DNA replication factors",
			"children":[
			{
				"name":"Mitochondrial DNA polymerase",
				"children":[
				{
					"name":"Chro.30314 hypothetical protein\tK22761 PRIMPOL; DNA-directed primase\/polymerase protein [EC:2.7.7.102 2.7.7.7]"
				}
				]
			},
			{
				"name":"Mitochondrial DNA maintenance factors",
				"children":[
				{
					"name":"Chro.50161 endonuclease G-like 1\tK01173 ENDOG; endonuclease G, mitochondrial"
				}
				]
			},
			{
				"name":"Other Mitochondrial DNA replication factors",
				"children":[
				{
					"name":"Chro.70168 26S proteosome regulatory subunit\tK17681 ATAD3A_B; ATPase family AAA domain-containing protein 3A\/B"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial protein import machinery",
		"children":[
		{
			"name":"Endoplasmic reticulum membrane and cytosol",
			"children":[
			{
				"name":"ER-mitochondria encounter structure (ERMES) complex"
			},
			{
				"name":"Other ER-memrane and cytosol factors",
				"children":[
				{
					"name":"Chro.80434 DNAJ domain protein\tK09503 DNAJA2; DnaJ homolog subfamily A member 2"
				},
				{
					"name":"Chro.20010 heat shock protein\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
				}
				]
			}
			]
		},
		{
			"name":"Outer membrane",
			"children":[
			{
				"name":"Transporter outer membrane (TOM) complex",
				"children":[
				{
					"name":"Chro.10287 mitochondrial import receptor subunit tom40\tK11518 TOM40; mitochondrial import receptor subunit TOM40"
				}
				]
			},
			{
				"name":"TOB\/SAM complex",
				"children":[
				{
					"name":"Chro.20088 hypothetical protein\tK07277 SAM50; outer membrane protein insertion porin family"
				}
				]
			},
			{
				"name":"MIM complex"
			},
			{
				"name":"Porin"
			},
			{
				"name":"Other outer membrane factor"
			}
			]
		},
		{
			"name":"Inter membrane space",
			"children":[
			{
				"name":"Transporter inner membrane (TIM) 9\/10 complex"
			},
			{
				"name":"TIM8\/13 complex",
				"children":[
				{
					"name":"Chro.60510 hypothetical protein\tK17780 TIM8; mitochondrial import inner membrane translocase subunit TIM8"
				}
				]
			},
			{
				"name":"Mitochondrial intermembrane space assembly (MIA) complex"
			}
			]
		},
		{
			"name":"Inner mambrane",
			"children":[
			{
				"name":"MICOS complex"
			},
			{
				"name":"MICOS complex (yeast)"
			},
			{
				"name":"TIM22 complex"
			},
			{
				"name":"TIM23 complex",
				"children":[
				{
					"name":"Chro.20443 mitochondrial import inner membrane translocase subunit tim17\tK17795 TIM17; mitochondrial import inner membrane translocase subunit TIM17"
				},
				{
					"name":"Chro.80393 hypothetical protein\tK17496 TIM50; mitochondrial import inner membrane translocase subunit TIM50"
				}
				]
			},
			{
				"name":"Mitochondrial calcium uniporter complex"
			},
			{
				"name":"Other inner membrane factors",
				"children":[
				{
					"name":"Chro.50194 hypothetical protein\tK17800 LETM1; mitochondrial proton\/calcium exchanger protein"
				},
				{
					"name":"Chro.40078 hypothetical protein\tK09647 IMP1; mitochondrial inner membrane protease subunit 1 [EC:3.4.21.-]"
				}
				]
			}
			]
		},
		{
			"name":"Matrix",
			"children":[
			{
				"name":"MMC\/PAM proteins",
				"children":[
				{
					"name":"Chro.30332 mitochondrial import inner membrane translocase\tK17804 TIM44; mitochondrial import inner membrane translocase subunit TIM44"
				},
				{
					"name":"Chro.30389 dnaK-type molecular chaperone hsp70, organellar\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"Chro.50021 co-chaperone GrpE\tK03687 GRPE; molecular chaperone GrpE"
				},
				{
					"name":"Chro.50020 chaperone\tK09539 DNAJC19; DnaJ homolog subfamily C member 19"
				}
				]
			},
			{
				"name":"Other matrix factors",
				"children":[
				{
					"name":"Chro.70239 mitochondrial processing peptidase alpha subunit\tK01412 PMPCA; mitochondrial-processing peptidase subunit alpha [EC:3.4.24.64]"
				},
				{
					"name":"Chro.50031 mitochondrial processing peptidase beta subunit\tK17732 PMPCB; mitochondrial-processing peptidase subunit beta [EC:3.4.24.64]"
				},
				{
					"name":"Chro.60573 Hsp60\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
				},
				{
					"name":"Chro.70275 hypothetical protein\tK04078 groES; chaperonin GroES"
				},
				{
					"name":"Chro.50487 hypothetical protein\tK17808 ZIM17; mitochondrial protein import protein ZIM17"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Mitochondrial quality control factors",
		"children":[
		{
			"name":"Regulator of mitochondrial biogenesis",
			"children":[
			{
				"name":"Ubiquitas transcription factors"
			},
			{
				"name":"Nuclear respiratory factors"
			},
			{
				"name":"Coactivators"
			},
			{
				"name":"Proteins involved in Fe-S cluster biogenesis",
				"children":[
				{
					"name":"Chro.40346 NifS-like protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
				},
				{
					"name":"Chro.60135 IscU-like protein\tK22068 ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial"
				},
				{
					"name":"Chro.50410 hypothetical protein\tK19054 FXN; frataxin [EC:1.16.3.1]"
				},
				{
					"name":"Chro.80316 NADPH:ferredoxin oxidoreductase\tK18914 FDXR; adrenodoxin-NADP+ reductase [EC:1.18.1.6]"
				},
				{
					"name":"Chro.30389 dnaK-type molecular chaperone hsp70, organellar\tK04043 dnaK; molecular chaperone DnaK"
				},
				{
					"name":"Chro.30319 chaperone protein - related\tK04082 hscB; molecular chaperone HscB"
				}
				]
			},
			{
				"name":"Other regulator of mitochondrial biogenesis",
				"children":[
				{
					"name":"Chro.60086 OSK4\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]"
				},
				{
					"name":"Chro.40362 DEAD box protein\tK14777 DDX47; ATP-dependent RNA helicase DDX47\/RRP3 [EC:5.6.2.7]"
				}
				]
			}
			]
		},
		{
			"name":"Mitochondrial respiratory chain complex assembly factors",
			"children":[
			{
				"name":"Complex-I assembly factors"
			},
			{
				"name":"Complex-II assembly factors"
			},
			{
				"name":"Complex-III assembly factors"
			},
			{
				"name":"Complex-IV assembly factors"
			},
			{
				"name":"Complex-V assembly factors"
			}
			]
		},
		{
			"name":"Mitochondrial dynamics",
			"children":[
			{
				"name":"Fission and Fusion factors",
				"children":[
				{
					"name":"Chro.50144 hypothetical protein\tK17968 TRIAP1; TRIAP1\/MDM35 family protein"
				},
				{
					"name":"Chro.20357 dynamin-related protein\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]"
				}
				]
			},
			{
				"name":"Actin cytoskeleton organization",
				"children":[
				{
					"name":"Chro.10300 ENSANGP00000020842\tK17972 NAA20; N-terminal acetyltransferase B complex catalytic subunit [EC:2.3.1.254]"
				}
				]
			},
			{
				"name":"Mitochondrial movement",
				"children":[
				{
					"name":"Chro.70468 prohibitin\tK17080 PHB1; prohibitin 1"
				},
				{
					"name":"Chro.50147 SPFH domain \/ Band 7 family\tK17081 PHB2; prohibitin 2"
				}
				]
			},
			{
				"name":"Retention of mitochondria",
				"children":[
				{
					"name":"Chro.20357 dynamin-related protein\tK17065 DNM1L; dynamin 1-like protein [EC:3.6.5.5]"
				},
				{
					"name":"Chro.60497 myosin-related protein\tK10357 MYO5; myosin V"
				},
				{
					"name":"Chro.70483 myosin B\tK10357 MYO5; myosin V"
				}
				]
			},
			{
				"name":"Morphogenesis factors"
			}
			]
		},
		{
			"name":"Mitophagy factors",
			"children":[
			{
				"name":"Autophagy-related proteins",
				"children":[
				{
					"name":"Chro.80308 autophagocytosis protein\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
				},
				{
					"name":"Chro.60035 beclin1-like protein\tK08334 BECN; beclin"
				},
				{
					"name":"Chro.40017 hypothetical protein\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7"
				},
				{
					"name":"Chro.70444 autophagy 8i\tK08341 GABARAP; GABA(A) receptor-associated protein"
				}
				]
			},
			{
				"name":"Parkin-dependent mechanism factors",
				"children":[
				{
					"name":"Chro.70140 ENSANGP00000022085\tK19513 CLEC16A; protein CLEC16A"
				}
				]
			},
			{
				"name":"Parkin-independent mechanism factors",
				"children":[
				{
					"name":"Chro.30427 heat shock protein 83\tK04079 HSP90A; molecular chaperone HtpG"
				}
				]
			},
			{
				"name":"Other mitophagy factors",
				"children":[
				{
					"name":"Chro.60086 OSK4\tK07198 PRKAA; 5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]"
				}
				]
			}
			]
		}
		]
	}
	]
}