{
	"name":"ckr02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"CKR_2445 hypothetical protein\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"CKR_2444 hypothetical protein\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"CKR_2447 hypothetical protein\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"CKR_2446 hypothetical protein\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"CKR_2451 hypothetical protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"CKR_2450 hypothetical protein\tK19114 csh1; CRISPR-associated protein Csh1"
				},
				{
					"name":"CKR_2449 hypothetical protein\tK19115 csh2; CRISPR-associated protein Csh2"
				},
				{
					"name":"CKR_2446 hypothetical protein\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"CKR_2448 hypothetical protein\tK19116 cas5h; CRISPR-associated protein Cas5h"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"CKR_2446 hypothetical protein\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"CKR_2446 hypothetical protein\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"CKR_2451 hypothetical protein\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"CKR_2446 hypothetical protein\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"CKR_2302 hypothetical protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"CKR_2301 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"CKR_2605 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"CKR_2604 hypothetical protein\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"CKR_1751 hypothetical protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"CKR_2036 hypothetical protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"CKR_2910 hypothetical protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"CKR_3440 hypothetical protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"CKR_P10 hypothetical protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"CKR_P33 hypothetical protein\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"CKR_2796 hypothetical protein\tK07317 K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"CKR_2367 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"CKR_2908 hypothetical protein\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"CKR_2272 hypothetical protein\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"CKR_2866 hypothetical protein\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"CKR_2865 hypothetical protein\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"CKR_2350 hypothetical protein\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"CKR_P43 hypothetical protein\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"CKR_3158 hypothetical protein\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"CKR_3393 hypothetical protein\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD"
			},
			{
				"name":"YafQ-dinJ"
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"CKR_1816 hypothetical protein\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"CKR_1817 hypothetical protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB"
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"CKR_1235 hypothetical protein\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"CKR_0779 hypothetical protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"CKR_3246 hypothetical protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"CKR_1882 hypothetical protein\tK02621 parC; topoisomerase IV subunit A [EC:5.6.2.2]"
				},
				{
					"name":"CKR_1883 hypothetical protein\tK02622 parE; topoisomerase IV subunit B [EC:5.6.2.2]"
				},
				{
					"name":"CKR_1351 hypothetical protein\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"CKR_1141 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"CKR_1796 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"CKR_1142 hypothetical protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"CKR_1797 hypothetical protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"CKR_0732 hypothetical protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"CKR_0989 hypothetical protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"CKR_1214 hypothetical protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}