{
	"name":"clos03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins"
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family",
				"children":[
				{
					"name":"DMR38_00210 AraC family transcriptional regulator\tK13653 K13653; AraC family transcriptional regulator"
				},
				{
					"name":"DMR38_16395 hypothetical protein\tK13653 K13653; AraC family transcriptional regulator"
				}
				]
			},
			{
				"name":"LysR family"
			},
			{
				"name":"DeoR family",
				"children":[
				{
					"name":"DMR38_10550 DeoR family transcriptional regulator\tK03436 fruR2; DeoR family transcriptional regulator, fructose operon transcriptional repressor"
				},
				{
					"name":"DMR38_01140 spoIIID; sporulation transcriptional regulator SpoIIID\tK06283 spoIIID; putative DeoR family transcriptional regulator, stage III sporulation protein D"
				},
				{
					"name":"DMR38_08065 DeoR\/GlpR transcriptional regulator\tK06608 iolR; DeoR family transcriptional regulator, myo-inositol catabolism operon repressor"
				},
				{
					"name":"DMR38_03880 transcriptional regulator\tK23774 ccpN; DeoR family transcriptional regulator, catabolite repression regulator"
				}
				]
			},
			{
				"name":"LacI family",
				"children":[
				{
					"name":"DMR38_00845 LacI family transcriptional regulator\tK02529 galR; LacI family transcriptional regulator, galactose operon repressor"
				},
				{
					"name":"DMR38_15035 LacI family DNA-binding transcriptional regulator\tK02525 kdgR; LacI family transcriptional regulator, kdg operon repressor"
				}
				]
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"DMR38_00535 GntR family transcriptional regulator\tK02103 araR; GntR family transcriptional regulator, arabinose operon transcriptional repressor"
				},
				{
					"name":"DMR38_12005 GntR family transcriptional regulator\tK24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator"
				},
				{
					"name":"DMR38_03220 GntR family transcriptional regulator\tK03710 K03710; GntR family transcriptional regulator"
				},
				{
					"name":"DMR38_08860 aminotransferase class I\/II-fold pyridoxal phosphate-dependent enzyme\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				},
				{
					"name":"DMR38_21410 aminotransferase class I\/II-fold pyridoxal phosphate-dependent enzyme\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				}
				]
			},
			{
				"name":"TetR\/AcrR family"
			},
			{
				"name":"Lrp\/AsnC family",
				"children":[
				{
					"name":"DMR38_03205 AsnC family transcriptional regulator\tK03718 asnC; Lrp\/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA"
				},
				{
					"name":"DMR38_01700 Lrp\/AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"DMR38_10785 Lrp\/AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				}
				]
			},
			{
				"name":"LuxR family"
			},
			{
				"name":"MarR family"
			},
			{
				"name":"MerR family"
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"DMR38_06160 transcriptional repressor\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"DMR38_09910 transcriptional repressor\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"DMR38_17850 transcriptional repressor\tK09825 perR; Fur family transcriptional regulator, peroxide stress response regulator"
				}
				]
			},
			{
				"name":"IclR family",
				"children":[
				{
					"name":"DMR38_06845 IclR family transcriptional regulator\tK13641 iclR; IclR family transcriptional regulator, acetate operon repressor"
				}
				]
			},
			{
				"name":"CRP\/FNR family",
				"children":[
				{
					"name":"DMR38_05095 cyclic nucleotide-binding domain-containing protein\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"DMR38_15070 Crp\/Fnr family transcriptional regulator\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"DMR38_17485 yeiL; transcriptional regulator YeiL\tK16326 yeiL; CRP\/FNR family transcriptional regulator, putaive post-exponential-phase nitrogen-starvation regulator"
				}
				]
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"DMR38_06115 Rrf2 family transcriptional regulator\tK17472 cymR; Rrf2 family transcriptional regulator, cysteine metabolism repressor"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"DMR38_07925 metalloregulator ArsR\/SmtB family transcription factor\tK03892 arsR; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor"
				},
				{
					"name":"DMR38_00825 metalloregulator ArsR\/SmtB family transcription factor\tK21903 cadC; ArsR family transcriptional regulator, lead\/cadmium\/zinc\/bismuth-responsive transcriptional repressor"
				},
				{
					"name":"DMR38_15060 metalloregulator ArsR\/SmtB family transcription factor\tK22042 hlyU; ArsR family transcriptional regulator, virulence genes transcriptional regulator"
				}
				]
			},
			{
				"name":"XRE family",
				"children":[
				{
					"name":"DMR38_06885 helix-turn-helix domain-containing protein\tK23779 sutR; XRE family transcriptional regulator, regulator of sulfur utilization"
				}
				]
			},
			{
				"name":"PadR family",
				"children":[
				{
					"name":"DMR38_15215 PadR family transcriptional regulator\tK26739 padR; PadR family transcriptional regulator, phenolic acid-responsive transcriptional regulator"
				},
				{
					"name":"DMR38_08185 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				},
				{
					"name":"DMR38_13925 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				},
				{
					"name":"DMR38_16475 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				},
				{
					"name":"DMR38_17165 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				},
				{
					"name":"DMR38_17175 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				},
				{
					"name":"DMR38_19335 PadR family transcriptional regulator\tK10947 K10947; PadR family transcriptional regulator"
				}
				]
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"DMR38_17185 mntR; transcriptional regulator MntR\tK11924 mntR; DtxR family transcriptional regulator, manganese transport regulator"
				},
				{
					"name":"DMR38_06820 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"DMR38_09725 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"DMR38_10500 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"DMR38_13005 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"DMR38_19325 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"DMR38_13795 biotin--[acetyl-CoA-carboxylase] ligase\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"DMR38_14210 PAS domain-containing protein\tK02688 prpR; transcriptional regulator, propionate catabolism operon regulatory protein"
				},
				{
					"name":"DMR38_04385 TrmB family transcriptional regulator\tK23356 trmB; HTH-type transcriptional regulator, sugar sensing transcriptional regulator"
				},
				{
					"name":"DMR38_20730 purR; pur operon repressor\tK09685 purR; HTH-type transcriptional regulator, purine operon repressor"
				},
				{
					"name":"DMR38_10300 PAS domain S-box protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_10305 PAS domain S-box protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_10325 PAS domain-containing protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_10345 AAA family ATPase\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_12055 AAA family ATPase\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_12310 PAS domain-containing protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_12350 PAS domain S-box protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_12390 PAS domain S-box protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_12845 PAS domain-containing protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_12855 PAS domain-containing protein\tK21405 acoR; sigma-54 dependent transcriptional regulator, acetoin dehydrogenase operon transcriptional activator AcoR"
				},
				{
					"name":"DMR38_14345 sugar diacid utilization regulator\tK02647 cdaR; carbohydrate diacid regulator"
				},
				{
					"name":"DMR38_10840 PAS domain S-box protein\tK06714 rocR; arginine utilization regulatory protein"
				},
				{
					"name":"DMR38_12445 transcriptional regulator\tK06714 rocR; arginine utilization regulatory protein"
				},
				{
					"name":"DMR38_09830 transporter\tK02019 modE; molybdate transport system regulatory protein"
				},
				{
					"name":"DMR38_18565 redox-sensing transcriptional repressor Rex\tK01926 rex; redox-sensing transcriptional repressor"
				},
				{
					"name":"DMR38_06590 codY; GTP-sensing pleiotropic transcriptional regulator CodY\tK03706 codY; transcriptional pleiotropic repressor"
				},
				{
					"name":"DMR38_12830 helix-turn-helix transcriptional regulator\tK07727 K07727; putative transcriptional regulator"
				},
				{
					"name":"DMR38_08725 helix-turn-helix transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				},
				{
					"name":"DMR38_09195 helix-turn-helix transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				},
				{
					"name":"DMR38_09315 transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				},
				{
					"name":"DMR38_09895 transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				},
				{
					"name":"DMR38_16445 helix-turn-helix domain-containing protein\tK07729 K07729; putative transcriptional regulator"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family"
			},
			{
				"name":"Other families"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"DMR38_05770 metal-sensing transcriptional repressor\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor"
				},
				{
					"name":"DMR38_07135 metal-sensing transcriptional repressor\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor"
				},
				{
					"name":"DMR38_12880 metal-sensing transcriptional repressor\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor"
				},
				{
					"name":"DMR38_16135 metal-sensing transcriptional repressor\tK21600 csoR; CsoR family transcriptional regulator, copper-sensing transcriptional repressor"
				},
				{
					"name":"DMR38_12630 hypothetical protein\tK09684 pucR; PucR family transcriptional regulator, purine catabolism regulatory protein"
				},
				{
					"name":"DMR38_00685 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK06284 abrB; AbrB family transcriptional regulator, transcriptional pleiotropic regulator of transition state genes"
				},
				{
					"name":"DMR38_20680 spoVT; stage V sporulation protein T\tK04769 spoVT; AbrB family transcriptional regulator, stage V sporulation protein T"
				},
				{
					"name":"DMR38_09285 chromosome partitioning protein ParB\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"DMR38_21620 ParB\/RepB\/Spo0J family partition protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"DMR38_21630 noc; nucleoid occlusion protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"DMR38_04350 arginine repressor\tK03402 argR; transcriptional regulator of arginine metabolism"
				},
				{
					"name":"DMR38_05625 arginine repressor\tK03402 argR; transcriptional regulator of arginine metabolism"
				},
				{
					"name":"DMR38_03790 hrcA; heat-inducible transcriptional repressor HrcA\tK03705 hrcA; heat-inducible transcriptional repressor"
				},
				{
					"name":"DMR38_13170 tenA; thiaminase II\tK03707 tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]"
				},
				{
					"name":"DMR38_20505 CtsR family transcriptional regulator\tK03708 ctsR; transcriptional regulator of stress and heat shock response"
				},
				{
					"name":"DMR38_19525 sugar-binding transcriptional regulator\tK05311 cggR; central glycolytic genes regulator"
				},
				{
					"name":"DMR38_09050 sugar-binding transcriptional regulator\tK05346 deoR; deoxyribonucleoside regulator"
				},
				{
					"name":"DMR38_05010 pyrR; bifunctional pyr operon transcriptional regulator\/uracil phosphoribosyltransferase PyrR\tK02825 pyrR; pyrimidine operon attenuation protein \/ uracil phosphoribosyltransferase [EC:2.4.2.9]"
				},
				{
					"name":"DMR38_06245 nrdR; transcriptional repressor NrdR\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"DMR38_04905 mraZ; division\/cell wall cluster transcriptional repressor MraZ\tK03925 mraZ; transcriptional regulator MraZ"
				}
				]
			}
			]
		}
		]
	}
	]
}