{
	"name":"cot01009",
	"children":[
	{
		"name":"Protein serine\/threonine phosphatases",
		"children":[
		{
			"name":"Phosphoprotein phosphatases (PPPs)",
			"children":[
			{
				"name":"Protein phosphatase-1",
				"children":[
				{
					"name":"Catalytic subunits",
					"children":[
					{
						"name":"CORT_0G01970 Glc7 serine\/threonine phosphatase\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"CORT_0G02360 Ppz1 protein phosphatase\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"CORT_0H02080 Sal6 protein phosphatase\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"PP1-interacting proteins (PIPs)",
					"children":[
					{
						"name":"CORT_0E00790 Glc8 protein\tK16833 PPP1R2; protein phosphatase inhibitor 2"
					},
					{
						"name":"CORT_0A08580 Sds22 serine-threonine phosphatase\tK17550 PPP1R7; protein phosphatase 1 regulatory subunit 7"
					},
					{
						"name":"CORT_0G00550 Ypi1 protein\tK17553 PPP1R11; protein phosphatase 1 regulatory subunit 11"
					},
					{
						"name":"CORT_0F01770 Bud27 protein\tK17560 URI1; unconventional prefoldin RPB5 interactor 1"
					},
					{
						"name":"CORT_0H00460 Dbp7 ATP-dependent DEAD-box RNA helicase\tK14806 DDX31; ATP-dependent RNA helicase DDX31\/DBP7 [EC:5.6.2.7]"
					},
					{
						"name":"CORT_0D05540 Lin1 protein\tK13099 CD2BP2; CD2 antigen cytoplasmic tail-binding protein 2"
					},
					{
						"name":"CORT_0C05270 Kip2 protein\tK11498 CENPE; centromeric protein E"
					},
					{
						"name":"CORT_0G03000 Sui3 translation initiation factor\tK03238 EIF2S2; translation initiation factor 2 subunit 2"
					},
					{
						"name":"CORT_0B08550 Pol32 protein\tK03504 POLD3; DNA polymerase delta subunit 3"
					},
					{
						"name":"CORT_0A00760 Hda1 hypothetical proteinistone deacetylase\tK11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]"
					},
					{
						"name":"CORT_0F01110 Sah1 S-adenosyl-L-homocysteine hydrolase\tK01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]"
					},
					{
						"name":"CORT_0E02260 Jhd2 protein\tK11446 KDM5; [histone H3]-trimethyl-L-lysine4 demethylase [EC:1.14.11.67]"
					},
					{
						"name":"CORT_0G02680 Rpl5 ribosomal protein L5\tK02932 RP-L5e; large subunit ribosomal protein L5e"
					},
					{
						"name":"CORT_0C04100 hypothetical protein\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
					},
					{
						"name":"CORT_0A13040 Mpp10 SSU processome and 90S preribosome component\tK14559 MPP10; U3 small nucleolar RNA-associated protein MPP10"
					},
					{
						"name":"CORT_0E03020 Myo5 Class I myosin\tK10356 MYO1; myosin I"
					},
					{
						"name":"CORT_0B00280 Kin3 protein\tK20872 NEK2; serine\/threonine-protein kinase Nek2 [EC:2.7.11.1]"
					},
					{
						"name":"CORT_0A01970 Sgd1 protein\tK17583 NOM1; nucleolar MIF4G domain-containing protein 1"
					},
					{
						"name":"CORT_0D05530 Orc5 protein\tK02607 ORC5; origin recognition complex subunit 5"
					},
					{
						"name":"CORT_0F01160 Pfk1 phosphofructokinase alpha subinit\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					},
					{
						"name":"CORT_0G03170 Pfk2 phosphofructokinase beta subunit, Pfk1p-Pfk2p heteromultimer\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					},
					{
						"name":"CORT_0C00620 Rrp1 protein\tK14849 RRP1; ribosomal RNA-processing protein 1"
					},
					{
						"name":"CORT_0C03300 Snf5 protein\tK11648 SMARCB1; SWI\/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1"
					},
					{
						"name":"CORT_0A13140 Vps54 protein\tK17600 VPS54; vacuolar protein sorting-associated protein 54"
					}
					]
				}
				]
			},
			{
				"name":"Protein phosphatase-2 (PP2A)",
				"children":[
				{
					"name":"Catalytic subunits",
					"children":[
					{
						"name":"CORT_0D07100 Pph21 protein phosphatase\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Regulatory subunits",
					"children":[
					{
						"name":"CORT_0C00440 Tpd3 protein\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A"
					},
					{
						"name":"CORT_0A07080 Cdc55 protein\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B"
					},
					{
						"name":"CORT_0B05790 Rts1 serine\/threonine-protein phosphatase B-type regulatory subunit\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					}
					]
				},
				{
					"name":"Other PP2-interacting proteins",
					"children":[
					{
						"name":"CORT_0A00650 Rrd1 peptidyl-prolyl cis\/trans-isomerase\tK17605 PPP2R4; serine\/threonine-protein phosphatase 2A activator"
					},
					{
						"name":"CORT_0D06770 Rrd2 protein\tK17605 PPP2R4; serine\/threonine-protein phosphatase 2A activator"
					},
					{
						"name":"CORT_0E02710 Tap42 protein\tK17606 IGBP1; immunoglobulin-binding protein 1"
					},
					{
						"name":"CORT_0F00900 Tip41 protein\tK17607 TIPRL; type 2A phosphatase activator TIP41"
					},
					{
						"name":"CORT_0G03280 Far11 protein\tK27960 STRIP; striatin-interacting protein"
					},
					{
						"name":"CORT_0G02390 Ppm1 protein\tK18203 LCMT1; [phosphatase 2A protein]-leucine-carboxy methyltransferase [EC:2.1.1.233]"
					}
					]
				}
				]
			},
			{
				"name":"Calcineurin (PPP3\/ PP2B)",
				"children":[
				{
					"name":"Catalytic subunits",
					"children":[
					{
						"name":"CORT_0B11330 Cmp1 catalytic subunit of calcineurin (Ca[2+]-calmodulin-regulated S\/T protein phosphatase)\tK04348 PPP3C; serine\/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Regulatory subunits",
					"children":[
					{
						"name":"CORT_0B02900 Cnb1 regulatory subunit of calcineurin B (Ca[2+]-calmodulin-regulated S\/T protein phosphatase)\tK06268 PPP3R; serine\/threonine-protein phosphatase 2B regulatory subunit"
					},
					{
						"name":"CORT_0B01610 Cmd1 calmodulin\tK02183 CALM; calmodulin"
					},
					{
						"name":"CORT_0B02170 hypothetical protein\tK02183 CALM; calmodulin"
					}
					]
				},
				{
					"name":"Other calcineurin-interacting proteins"
				}
				]
			},
			{
				"name":"Protein phosphatase-4",
				"children":[
				{
					"name":"Catalytic subunits",
					"children":[
					{
						"name":"CORT_0D02580 Pph3 protein\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Regulatory subunits",
					"children":[
					{
						"name":"CORT_0B07510 Psy2 protein phosphatase PP4 complex subunit\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				}
				]
			},
			{
				"name":"Protein phosphatase-5",
				"children":[
				{
					"name":"Catalytic subunits",
					"children":[
					{
						"name":"CORT_0D06590 Ppt1 serine\/threonine phosphatase\tK04460 PPP5C; serine\/threonine-protein phosphatase 5 [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"PP5-interacting proteins",
					"children":[
					{
						"name":"CORT_0A03180 Cdc27 ubiquitin-protein ligase\tK03350 APC3; anaphase-promoting complex subunit 3"
					},
					{
						"name":"CORT_0B00950 hypothetical protein\tK03353 APC6; anaphase-promoting complex subunit 6"
					},
					{
						"name":"CORT_0G03310 Hsp90 chaperone of Hsp90 family\tK04079 HSP90A; molecular chaperone HtpG"
					},
					{
						"name":"CORT_0D05790 Ssb1 heat shock protein\tK03283 HSPA1_6_8; heat shock 70kDa protein 1\/6\/8"
					}
					]
				}
				]
			},
			{
				"name":"Protein phosphatase-6",
				"children":[
				{
					"name":"Catalytic subunits",
					"children":[
					{
						"name":"CORT_0B06380 Sit4 serine\/threonine protein phosphatase catalytic subunit\tK15427 SIT4; serine\/threonine-protein phosphatase PP1-1 [EC:3.1.3.16]"
					},
					{
						"name":"CORT_0E03070 Ppg1 protein phosphatase\tK17615 PPG1; serine\/threonine-protein phosphatase PPG1 [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Regulatory subunits"
				}
				]
			},
			{
				"name":"PPEF\/PP7 protein phosphatases"
			}
			]
		},
		{
			"name":"Mg2+- or Mn2+- dependent protein phosphatases (PPMs)",
			"children":[
			{
				"name":"PPM1 phosphatases (PP2C)",
				"children":[
				{
					"name":"CORT_0D03840 Ptc1 protein phosphatase\tK19704 PTC1; protein phosphatase PTC1 [EC:3.1.3.16]"
				},
				{
					"name":"CORT_0A03050 Ptc2 phosphatase\tK14803 PTC2_3; protein phosphatase PTC2\/3 [EC:3.1.3.16]"
				},
				{
					"name":"CORT_0D05480 Ptc4 Type PP2C serine\/threonine phosphatase\tK19705 PTC4; protein phosphatase PTC4 [EC:3.1.3.16]"
				},
				{
					"name":"CORT_0G02130 Ptc6 protein phosphatase\tK19708 PTC6; protein phosphatase PTC6 [EC:3.1.3.16 3.1.3.43]"
				},
				{
					"name":"CORT_0E00120 Ptc8 type 2C protein phosphatase\tK17508 PTC7; protein phosphatase PTC7 [EC:3.1.3.16]"
				},
				{
					"name":"CORT_0E02830 Ptc7 protein phosphatase, type 2C\tK17508 PTC7; protein phosphatase PTC7 [EC:3.1.3.16]"
				}
				]
			},
			{
				"name":"Pyruvate dehydrogenase phosphatases",
				"children":[
				{
					"name":"Catalytic subunit",
					"children":[
					{
						"name":"CORT_0D05910 Ptc5 protein phosphatase\tK01102 PDP; pyruvate dehydrogenase phosphatase [EC:3.1.3.43]"
					},
					{
						"name":"CORT_0G02130 Ptc6 protein phosphatase\tK19708 PTC6; protein phosphatase PTC6 [EC:3.1.3.16 3.1.3.43]"
					}
					]
				},
				{
					"name":"Regulatory subunit"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Protein tyrosine phosphatases (PTPs)",
		"children":[
		{
			"name":"Class I PTPs (Classical)",
			"children":[
			{
				"name":"Receptor PTPs"
			},
			{
				"name":"Non-receptor PTPs",
				"children":[
				{
					"name":"CORT_0E03910 hypothetical protein\tK19806 PTP2_3; tyrosine-protein phosphatase 2\/3 [EC:3.1.3.48]"
				}
				]
			}
			]
		},
		{
			"name":"Class I PTPs (Dual specificity phosphatases)",
			"children":[
			{
				"name":"MAPK phosphatases",
				"children":[
				{
					"name":"CORT_0H00910 dual specificity protein phosphatase\tK04459 DUSP; dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]"
				},
				{
					"name":"CORT_0A04470 Cpp1 MAPK phosphatase\tK11240 MSG5; tyrosine-protein phosphatase MSG5 [EC:3.1.3.48]"
				}
				]
			},
			{
				"name":"Slingshots"
			},
			{
				"name":"Phosphatase of regenerating liver (PRL)"
			},
			{
				"name":"Atypical DSPs",
				"children":[
				{
					"name":"CORT_0A02130 Yvh1 dual specificity phosphatase (phosphoserine\/threonine and phosphotyrosine phosphatase)\tK14819 DUSP12; dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48]"
				},
				{
					"name":"CORT_0C06720 Oca1 protein phosphatase\tK18043 OCA1; tyrosine-protein phosphatase OCA1 [EC:3.1.3.48]"
				},
				{
					"name":"CORT_0C06470 Oca2 protein\tK18044 OCA2; tyrosine-protein phosphatase-like protein OCA2"
				},
				{
					"name":"CORT_0D03330 Siw14 protein phosphatase\tK18045 SIW14; tyrosine-protein phosphatase SIW14 [EC:3.1.3.48]"
				},
				{
					"name":"CORT_0G00380 Oca6 protein phosphatase\tK18046 OCA6; tyrosine-protein phosphatase OCA6 [EC:3.1.3.48]"
				}
				]
			},
			{
				"name":"CDC14",
				"children":[
				{
					"name":"CORT_0F03840 Cdc14 protein\tK06639 CDC14; cell division cycle 14 [EC:3.1.3.16 3.1.3.48]"
				}
				]
			},
			{
				"name":"Phosphatase and Tensin homologs (PTEN)",
				"children":[
				{
					"name":"CORT_0G03260 Tep1 protein phosphatase\tK01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]"
				}
				]
			},
			{
				"name":"Myotubularins",
				"children":[
				{
					"name":"CORT_0A05240 phosphatidylinositol 3-phosphate (PI3P) phosphatase\tK18083 MTMR6_7_8; myotubularin-related protein 6\/7\/8 [EC:3.1.3.64 3.1.3.95]"
				}
				]
			},
			{
				"name":"Suppressors of T-cell receptor signaling"
			}
			]
		},
		{
			"name":"Class II PTPs",
			"children":[
			{
				"name":"Low molecular weight PTPs (LMWPTPs)",
				"children":[
				{
					"name":"CORT_0A04720 Ltp1 protein phosphatase\tK14394 ACP1; low molecular weight phosphotyrosine protein phosphatase [EC:3.1.3.2 3.1.3.48]"
				}
				]
			}
			]
		},
		{
			"name":"Class III PTPs",
			"children":[
			{
				"name":"CDC25s",
				"children":[
				{
					"name":"CORT_0D06510 Mih1 protein phosphatase\tK02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"HAD phosphatases",
		"children":[
		{
			"name":"Fcp\/Scp phosphatases",
			"children":[
			{
				"name":"CORT_0C01190 Fcp1 protein\tK15732 CTDP1; RNA polymerase II subunit A C-terminal domain phosphatase [EC:3.1.3.16]"
			},
			{
				"name":"CORT_0D06800 hypothetical protein\tK15731 CTDSP; carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase [EC:3.1.3.16]"
			},
			{
				"name":"CORT_0E00610 Nem1 protein\tK17617 CTDNEP1; CTD nuclear envelope phosphatase 1 [EC:3.1.3.16]"
			},
			{
				"name":"CORT_0F03870 Rtr1 protein\tK20827 RPAP2; RNA polymerase II-associated protein 2 [EC:3.1.3.16]"
			}
			]
		},
		{
			"name":"MDP-1",
			"children":[
			{
				"name":"CORT_0D06330 hypothetical protein\tK17619 MDP1; magnesium-dependent phosphatase 1 [EC:3.1.3.48 3.1.3.-]"
			}
			]
		},
		{
			"name":"EYAs"
		},
		{
			"name":"Other HAD phosphatases",
			"children":[
			{
				"name":"CORT_0A11650 Ser2 protein\tK01079 serB; phosphoserine phosphatase [EC:3.1.3.3]"
			},
			{
				"name":"CORT_0A05700 hypothetical protein\tK17623 PUDP; pseudouridine 5'-phosphatase [EC:3.1.3.96]"
			},
			{
				"name":"CORT_0A13480 Smp2 Mg2+-dependent phosphatidate phosphatase\tK15728 LPIN; phosphatidate phosphatase LPIN [EC:3.1.3.4]"
			}
			]
		}
		]
	}
	]
}