{
	"name":"cov03000",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"Basic leucine zipper (bZIP)",
			"children":[
			{
				"name":"AP-1(-like) components, Jun"
			},
			{
				"name":"AP-1(-like) components, Fos"
			},
			{
				"name":"AP-1(-like) components, Maf"
			},
			{
				"name":"AP-1(-like) components, NF-E2"
			},
			{
				"name":"AP-1(-like) components, Fungal regulators"
			},
			{
				"name":"AP-1(-like) components, CRE-BP\/ATF"
			},
			{
				"name":"CREB"
			},
			{
				"name":"C\/EBP-like factors"
			},
			{
				"name":"bZIP\/PAR"
			},
			{
				"name":"Plant bZIP factors"
			},
			{
				"name":"ZIP only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix (bHLH)",
			"children":[
			{
				"name":"Ubiquitous (class A) factors"
			},
			{
				"name":"Myogenic transcription factors"
			},
			{
				"name":"Achaete-Scute"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Lymphoid factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesodermal Twist-like factors"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, HEN"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Mesp"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Atonal"
			},
			{
				"name":"Tal\/Twist\/Atonal\/Hen, Pancreatic factors"
			},
			{
				"name":"Hairy, Hairy\/E(SPL)"
			},
			{
				"name":"Hairy, Fungal regulators"
			},
			{
				"name":"Factors with PAS domain"
			},
			{
				"name":"Yabby"
			},
			{
				"name":"INO"
			},
			{
				"name":"HLH domain only"
			}
			]
		},
		{
			"name":"Basic helix-loop-helix\/leucine zipper (bHLH-ZIP)",
			"children":[
			{
				"name":"Ubiquitous bHLH-ZIP factors"
			},
			{
				"name":"Cell cycle controlling factors, Myc"
			},
			{
				"name":"Cell cycle controlling factors, Mad\/Max"
			},
			{
				"name":"Other bHLH-ZIP factors"
			}
			]
		},
		{
			"name":"Other basic domains",
			"children":[
			{
				"name":"NF-1"
			},
			{
				"name":"RF-X"
			},
			{
				"name":"AP-2 (bHSH)"
			}
			]
		},
		{
			"name":"Zinc finger",
			"children":[
			{
				"name":"Cys4 thyroid hormone receptor-like"
			},
			{
				"name":"Cys4 hepatocyte nuclear factor 4-like"
			},
			{
				"name":"Cys4 estrogen receptor-like"
			},
			{
				"name":"Cys4 nerve growth factor IB-like"
			},
			{
				"name":"Cys4 Fushi tarazu-F1-like"
			},
			{
				"name":"Cys4 germ cell nuclear factor"
			},
			{
				"name":"Cys4 Knirps\/DAX1-like"
			},
			{
				"name":"Cys4 GATA-factors"
			},
			{
				"name":"Cys2His2 SP\/KLF family and related proteins"
			},
			{
				"name":"Cys2His2 GLI-like"
			},
			{
				"name":"Cys2His2 Snail"
			},
			{
				"name":"Cys2His2 BTB-ZF factors"
			},
			{
				"name":"Cys2His2 BED"
			},
			{
				"name":"Cys2His2 PRDM"
			},
			{
				"name":"Cys2His2 metabolic regulators in fungi"
			},
			{
				"name":"Cys2His2 others"
			},
			{
				"name":"Cys2HisCys zinc factors"
			},
			{
				"name":"Cys3His zinc factors"
			},
			{
				"name":"Cys2CysHis zinc factors"
			},
			{
				"name":"CXXC CpG-binding proteins"
			},
			{
				"name":"Cys6 metabolic regulators in fungi"
			},
			{
				"name":"Other zinc fingers"
			}
			]
		},
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"Homeo domain ANTP: HOXL"
			},
			{
				"name":"Homeo domain ANTP: NKL"
			},
			{
				"name":"Homeo domain Paired-related"
			},
			{
				"name":"Homeo domain LIM"
			},
			{
				"name":"Homeo domain POU"
			},
			{
				"name":"Homeo domain SINE"
			},
			{
				"name":"Homeo domain ZF"
			},
			{
				"name":"Homeo domain CUT"
			},
			{
				"name":"Homeo domain PROS"
			},
			{
				"name":"Homeo domain TALE"
			},
			{
				"name":"Homeo domain other"
			},
			{
				"name":"Fork head\/winged helix developmental regulators"
			},
			{
				"name":"Fork head\/winged helix tissue-specific regulators"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, E2F"
			},
			{
				"name":"Fork head\/winged helix cell cycle-controlling factors, DP"
			},
			{
				"name":"Fork head\/winged helix other regulators"
			},
			{
				"name":"Stork head\/winged helix factors"
			},
			{
				"name":"Heat shock factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-factors"
			},
			{
				"name":"Tryptophan clusters Myb, Myb-like factors"
			},
			{
				"name":"Tryptophan clusters Ets-type"
			},
			{
				"name":"Tryptophan clusters interferon-regulating factors"
			},
			{
				"name":"TEA domain"
			},
			{
				"name":"ARID"
			}
			]
		},
		{
			"name":"beta-Scaffold factors with minor groove contacts",
			"children":[
			{
				"name":"RHR (Rel homology region) Rel\/Ankyrin"
			},
			{
				"name":"RHR (Rel homology region) Ankyrin only"
			},
			{
				"name":"RHR (Rel homology region) NF-AT"
			},
			{
				"name":"STAT"
			},
			{
				"name":"p53"
			},
			{
				"name":"MADS-box regulators of differentiation, MEF-2"
			},
			{
				"name":"MADS-box regulators of differentiation, Homeotic genes"
			},
			{
				"name":"MADS-box regulators of differentiation, Yeast regulators"
			},
			{
				"name":"MADS-box responders to external signals"
			},
			{
				"name":"SAND domain-containing proteins"
			},
			{
				"name":"TATA-binding proteins"
			},
			{
				"name":"HMG SOX"
			},
			{
				"name":"HMG TCF-1"
			},
			{
				"name":"HMG TOX"
			},
			{
				"name":"HMG2-related"
			},
			{
				"name":"UBF"
			},
			{
				"name":"Other HMG box factors"
			},
			{
				"name":"Heteromeric CCAAT factors"
			},
			{
				"name":"Grainyhead"
			},
			{
				"name":"Cold-shock domain factors, DbpA-like"
			},
			{
				"name":"Cold-shock domain factors, YB-1\/DbpB-like"
			},
			{
				"name":"Cold-shock domain factors, FRG Y2-like"
			},
			{
				"name":"Runt"
			},
			{
				"name":"MYRF"
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"HMGI(Y)"
			},
			{
				"name":"NUPR"
			},
			{
				"name":"Pocket domain Rb"
			},
			{
				"name":"Pocket domain CBP"
			},
			{
				"name":"T-box"
			},
			{
				"name":"DMRT"
			},
			{
				"name":"LRRFIP"
			},
			{
				"name":"TCP"
			},
			{
				"name":"AP2\/ERF"
			},
			{
				"name":"WRKY"
			},
			{
				"name":"LOB"
			},
			{
				"name":"GRAS"
			},
			{
				"name":"NAC"
			},
			{
				"name":"Copper-fist proteins fungal regulators"
			},
			{
				"name":"Others"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Helix-turn-helix",
			"children":[
			{
				"name":"AraC family",
				"children":[
				{
					"name":"EKO29_05195 hypothetical protein\tK19693 tfoS; AraC family transcriptional regulator, chitin signaling transcriptional activator"
				},
				{
					"name":"EKO29_12225 hypothetical protein\tK13652 K13652; AraC family transcriptional regulator"
				},
				{
					"name":"EKO29_15635 DNA-3-methyladenine glycosylase 2 family protein\tK13529 ada-alkA; AraC family transcriptional regulator, regulatory protein of adaptative response \/ DNA-3-methyladenine glycosylase II [EC:3.2.2.21]"
				}
				]
			},
			{
				"name":"LysR family",
				"children":[
				{
					"name":"EKO29_04410 LysR family transcriptional regulator\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"EKO29_08530 gcvA; transcriptional regulator GcvA\tK03566 gcvA; LysR family transcriptional regulator, glycine cleavage system transcriptional activator"
				},
				{
					"name":"EKO29_19695 ilvY; HTH-type transcriptional activator IlvY\tK02521 ilvY; LysR family transcriptional regulator, positive regulator for ilvC"
				},
				{
					"name":"EKO29_10240 LysR family transcriptional regulator\tK03576 metR; LysR family transcriptional regulator, regulator for metE and metH"
				},
				{
					"name":"EKO29_16145 nhaR; transcriptional activator NhaR\tK03717 nhaR; LysR family transcriptional regulator, transcriptional activator of nhaA"
				},
				{
					"name":"EKO29_00865 oxyR; DNA-binding transcriptional regulator OxyR\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator"
				},
				{
					"name":"EKO29_13070 hydrogen peroxide-inducible genes activator\tK04761 oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator"
				},
				{
					"name":"EKO29_08195 LysR family transcriptional regulator ArgP\tK05596 argP; LysR family transcriptional regulator, arginine and lysine transport system\/DNA replication regulator"
				},
				{
					"name":"EKO29_05340 cysB; HTH-type transcriptional regulator CysB\tK13634 cysB; LysR family transcriptional regulator, cys regulon transcriptional activator"
				},
				{
					"name":"EKO29_11095 LysR family transcriptional regulator\tK23773 hdfR; LysR family transcriptional regulator, flagellar master operon regulator"
				}
				]
			},
			{
				"name":"DeoR family"
			},
			{
				"name":"LacI family",
				"children":[
				{
					"name":"EKO29_00245 LacI family DNA-binding transcriptional regulator\tK02529 galR; LacI family transcriptional regulator, galactose operon repressor"
				}
				]
			},
			{
				"name":"GntR family",
				"children":[
				{
					"name":"EKO29_02425 hutC; histidine utilization repressor\tK05836 hutC; GntR family transcriptional regulator, histidine utilization repressor"
				},
				{
					"name":"EKO29_06160 fadR; fatty acid metabolism transcriptional regulator FadR\tK03603 fadR; GntR family transcriptional regulator, negative regulator for fad regulon and positive regulator of fabA"
				},
				{
					"name":"EKO29_05450 FadR family transcriptional regulator\tK19775 exuR; GntR family transcriptional regulator, hexuronate regulon transcriptional repressor"
				},
				{
					"name":"EKO29_02955 PLP-dependent aminotransferase family protein\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				},
				{
					"name":"EKO29_11730 PLP-dependent aminotransferase family protein\tK00375 K00375; GntR family transcriptional regulator \/ MocR family aminotransferase"
				}
				]
			},
			{
				"name":"TetR\/AcrR family",
				"children":[
				{
					"name":"EKO29_15935 betI; transcriptional regulator BetI\tK02167 betI; TetR\/AcrR family transcriptional regulator, transcriptional repressor of bet genes"
				},
				{
					"name":"EKO29_19450 slmA; nucleoid occlusion factor SlmA\tK05501 slmA; TetR\/AcrR family transcriptional regulator"
				},
				{
					"name":"EKO29_11025 TetR\/AcrR family transcriptional regulator\tK09017 rutR; TetR\/AcrR family transcriptional regulator"
				},
				{
					"name":"EKO29_11530 TetR\/AcrR family transcriptional regulator\tK09017 rutR; TetR\/AcrR family transcriptional regulator"
				},
				{
					"name":"EKO29_13145 TetR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"EKO29_13395 TetR\/AcrR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"EKO29_17685 TetR\/AcrR family transcriptional regulator\tK16137 nemR; TetR\/AcrR family transcriptional regulator, transcriptional repressor for nem operon"
				},
				{
					"name":"EKO29_17725 TetR\/AcrR family transcriptional regulator\tK18301 mexL; TetR\/AcrR family transcriptional regulator, mexJK operon transcriptional repressor"
				},
				{
					"name":"EKO29_02840 fabR; HTH-type transcriptional repressor FabR\tK22105 fabR; TetR\/AcrR family transcriptional regulator, fatty acid biosynthesis regulator"
				}
				]
			},
			{
				"name":"Lrp\/AsnC family",
				"children":[
				{
					"name":"EKO29_11365 leucine-responsive transcriptional regulator Lrp\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"EKO29_11795 Lrp\/AsnC family transcriptional regulator\tK03719 lrp; Lrp\/AsnC family transcriptional regulator, leucine-responsive regulatory protein"
				},
				{
					"name":"EKO29_16030 Lrp\/AsnC family transcriptional regulator\tK05800 decR; Lrp\/AsnC family transcriptional regulator, cysteine-sensing transcriptional activator"
				}
				]
			},
			{
				"name":"LuxR family",
				"children":[
				{
					"name":"EKO29_15725 response regulator transcription factor\tK20918 vpsT; LuxR family transcriptional regulator, positive regulator of biofilm formation"
				}
				]
			},
			{
				"name":"MarR family",
				"children":[
				{
					"name":"EKO29_06000 MarR family transcriptional regulator\tK06075 slyA; MarR family transcriptional regulator, transcriptional regulator for hemolysin"
				},
				{
					"name":"EKO29_06020 MarR family transcriptional regulator\tK23775 ohrR; MarR family transcriptional regulator, organic hydroperoxide resistance regulator"
				},
				{
					"name":"EKO29_10010 MarR family transcriptional regulator\tK23775 ohrR; MarR family transcriptional regulator, organic hydroperoxide resistance regulator"
				}
				]
			},
			{
				"name":"MerR family",
				"children":[
				{
					"name":"EKO29_07420 MerR family transcriptional regulator\tK08365 merR; MerR family transcriptional regulator, mercuric resistance operon regulatory protein"
				},
				{
					"name":"EKO29_09355 MerR family transcriptional regulator\tK13638 zntR; MerR family transcriptional regulator, Zn(II)-responsive regulator of zntA"
				},
				{
					"name":"EKO29_13635 soxR; redox-sensitive transcriptional activator SoxR\tK13639 soxR; MerR family transcriptional regulator, redox-sensitive transcriptional activator SoxR"
				}
				]
			},
			{
				"name":"Fur family",
				"children":[
				{
					"name":"EKO29_05560 ferric iron uptake transcriptional regulator\tK03711 fur; Fur family transcriptional regulator, ferric uptake regulator"
				},
				{
					"name":"EKO29_10150 transcriptional repressor\tK09823 zur; Fur family transcriptional regulator, zinc uptake regulator"
				}
				]
			},
			{
				"name":"IclR family"
			},
			{
				"name":"CRP\/FNR family",
				"children":[
				{
					"name":"EKO29_13215 Crp\/Fnr family transcriptional regulator\tK10914 crp; CRP\/FNR family transcriptional regulator, cyclic AMP receptor protein"
				},
				{
					"name":"EKO29_06800 fumarate\/nitrate reduction transcriptional regulator Fnr\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				},
				{
					"name":"EKO29_06845 cyclic nucleotide-binding domain-containing protein\tK01420 fnr; CRP\/FNR family transcriptional regulator, anaerobic regulatory protein"
				}
				]
			},
			{
				"name":"Rrf2 family",
				"children":[
				{
					"name":"EKO29_16245 iscR; Fe-S cluster assembly transcriptional regulator IscR\tK13643 iscR; Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor"
				},
				{
					"name":"EKO29_13285 Rrf2 family transcriptional regulator\tK13771 nsrR; Rrf2 family transcriptional regulator, nitric oxide-sensitive transcriptional repressor"
				}
				]
			},
			{
				"name":"ArsR family",
				"children":[
				{
					"name":"EKO29_06080 ArsR family transcriptional regulator\tK23988 arsR-arsC; ArsR family transcriptional regulator, arsenate\/arsenite\/antimonite-responsive transcriptional repressor \/ arsenate reductase (thioredoxin) [EC:1.20.4.4]"
				},
				{
					"name":"EKO29_18665 ArsR family transcriptional regulator\tK22042 hlyU; ArsR family transcriptional regulator, virulence genes transcriptional regulator"
				}
				]
			},
			{
				"name":"XRE family"
			},
			{
				"name":"PadR family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"EKO29_10790 MurR\/RpiR family transcriptional regulator\tK19337 hexR; RpiR family transcriptional regulator, carbohydrate utilization regulator"
				},
				{
					"name":"EKO29_01795 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"EKO29_16185 BlaI\/MecI\/CopY family transcriptional regulator\tK02171 blaI; BlaI family transcriptional regulator, penicillinase repressor"
				},
				{
					"name":"EKO29_01255 birA; bifunctional biotin--[acetyl-CoA-carboxylase] ligase\/biotin operon repressor BirA\tK03524 birA; BirA family transcriptional regulator, biotin operon repressor \/ biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]"
				},
				{
					"name":"EKO29_02265 DNA-binding transcriptional regulator Fis\tK03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein"
				},
				{
					"name":"EKO29_06745 TrmB family transcriptional regulator\tK23356 trmB; HTH-type transcriptional regulator, sugar sensing transcriptional regulator"
				},
				{
					"name":"EKO29_16860 sigma-54-dependent Fis family transcriptional regulator\tK10941 flrA; sigma-54 dependent transcriptional regulator, flagellar regulatory protein"
				},
				{
					"name":"EKO29_14870 norR; nitric oxide reductase transcriptional regulator NorR\tK12266 norR; anaerobic nitric oxide reductase transcription regulator"
				},
				{
					"name":"EKO29_01910 PAS domain S-box protein\tK15836 fhlA; formate hydrogenlyase transcriptional activator"
				},
				{
					"name":"EKO29_07840 transcriptional regulator\tK07727 K07727; putative transcriptional regulator"
				},
				{
					"name":"EKO29_12940 transcriptional regulator\tK07729 K07729; putative transcriptional regulator"
				}
				]
			}
			]
		},
		{
			"name":"Ribbon-helix-helix",
			"children":[
			{
				"name":"CopG family"
			},
			{
				"name":"Other families",
				"children":[
				{
					"name":"EKO29_01930 metJ; met regulon transcriptional regulator MetJ\tK03764 metJ; MetJ family transcriptional regulator, methionine regulon repressor"
				},
				{
					"name":"EKO29_03475 putA; bifunctional proline dehydrogenase\/L-glutamate gamma-semialdehyde dehydrogenase PutA\tK13821 putA; RHH-type transcriptional regulator, proline utilization regulon repressor \/ proline dehydrogenase \/ delta 1-pyrroline-5-carboxylate dehydrogenase [EC:1.5.5.2 1.2.1.88]"
				}
				]
			}
			]
		},
		{
			"name":"Other transcription factors",
			"children":[
			{
				"name":"BglG family"
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"EKO29_18775 regulatory protein NosR\tK19339 nosR; NosR\/NirI family transcriptional regulator, nitrous oxide reductase regulator"
				},
				{
					"name":"EKO29_15105 BolA\/IbaG family iron-sulfur metabolism protein\tK05527 bolA; BolA family transcriptional regulator, general stress-responsive regulator"
				},
				{
					"name":"EKO29_20335 ParB\/RepB\/Spo0J family partition protein\tK03497 parB; ParB family transcriptional regulator, chromosome partitioning protein"
				},
				{
					"name":"EKO29_03740 argR; transcriptional regulator ArgR\tK03402 argR; transcriptional regulator of arginine metabolism"
				},
				{
					"name":"EKO29_18080 argR; transcriptional regulator ArgR\tK03402 argR; transcriptional regulator of arginine metabolism"
				},
				{
					"name":"EKO29_04905 tyrR; transcriptional regulator TyrR\tK03721 tyrR; transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport"
				},
				{
					"name":"EKO29_13805 AAA family ATPase\tK03721 tyrR; transcriptional regulator of aroF, aroG, tyrA and aromatic amino acid transport"
				},
				{
					"name":"EKO29_12235 transcriptional regulator\tK03567 gcvR; glycine cleavage system transcriptional repressor"
				},
				{
					"name":"EKO29_04860 pspF; phage shock protein operon transcriptional activator\tK03974 pspF; psp operon transcriptional activator"
				},
				{
					"name":"EKO29_04875 pspC; envelope stress response membrane protein PspC\tK03973 pspC; phage shock protein C"
				},
				{
					"name":"EKO29_11000 nucleoside diphosphate kinase regulator\tK06140 rnk; regulator of nucleoside diphosphate kinase"
				},
				{
					"name":"EKO29_15835 AlpA family phage regulatory protein\tK07733 alpA; prophage regulatory protein"
				},
				{
					"name":"EKO29_02965 FMN-binding negative transcriptional regulator\tK07734 paiB; transcriptional regulator"
				},
				{
					"name":"EKO29_13550 YqgE\/AlgH family protein\tK07735 algH; putative transcriptional regulator"
				},
				{
					"name":"EKO29_03355 dksA; RNA polymerase-binding protein DksA\tK06204 dksA; RNA polymerase-binding transcription factor"
				},
				{
					"name":"EKO29_20280 TraR\/DksA family transcriptional regulator\tK06204 dksA; RNA polymerase-binding transcription factor"
				},
				{
					"name":"EKO29_17390 nrdR; transcriptional regulator NrdR\tK07738 nrdR; transcriptional repressor NrdR"
				},
				{
					"name":"EKO29_18045 mraZ; transcriptional regulator MraZ\tK03925 mraZ; transcriptional regulator MraZ"
				}
				]
			}
			]
		}
		]
	}
	]
}