{
	"name":"crg03019",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"mRNA processing factors",
			"children":[
			{
				"name":"5' end processing",
				"children":[
				{
					"name":"Capping factors",
					"children":[
					{
						"name":"105345793 mRNA cap guanine-N7 methyltransferase\tK00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]"
					},
					{
						"name":"105322687 mRNA-capping enzyme\tK13917 RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74]"
					},
					{
						"name":"105317788 cyclin-dependent kinase 7\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"105339251 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1\tK14589 CMTR1; cap1 methyltransferase [EC:2.1.1.57]"
					},
					{
						"name":"105322668 cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1\tK14590 CMTR2; cap2 methyltransferase [EC:2.1.1.296]"
					}
					]
				},
				{
					"name":"Cap binding complex",
					"children":[
					{
						"name":"105318090 nuclear cap-binding protein subunit 1\tK12882 NCBP1; nuclear cap-binding protein subunit 1"
					},
					{
						"name":"105323733 nuclear cap-binding protein subunit 2\tK12883 NCBP2; nuclear cap-binding protein subunit 2"
					}
					]
				}
				]
			},
			{
				"name":"3' end processing",
				"children":[
				{
					"name":"Pre-mRNA cleavage factor Im (CFIm)",
					"children":[
					{
						"name":"105329073 cleavage and polyadenylation specificity factor subunit 5\tK14397 NUDT21; cleavage and polyadenylation specificity factor subunit 5"
					},
					{
						"name":"105325886 cleavage and polyadenylation specificity factor subunit 6 isoform X1\tK14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6\/7"
					}
					]
				},
				{
					"name":"Pre-mRNA cleavage factor IIm (CFIIm)",
					"children":[
					{
						"name":"105326854 polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform X3\tK14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]"
					},
					{
						"name":"105338678 pre-mRNA cleavage complex 2 protein Pcf11\tK14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11"
					}
					]
				},
				{
					"name":"Cleavage and polyadenylation specificity factor (CPSF) complex",
					"children":[
					{
						"name":"105342117 cleavage and polyadenylation specificity factor subunit 1 isoform X1\tK14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1"
					},
					{
						"name":"105319344 cleavage and polyadenylation specificity factor subunit 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"105319722 cleavage and polyadenylation specificity factor subunit 3\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"105338165 cleavage and polyadenylation specificity factor subunit 4\tK14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4"
					},
					{
						"name":"105318324 pre-mRNA 3'-end-processing factor FIP1 isoform X1\tK14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1"
					},
					{
						"name":"105333261 pre-mRNA 3' end processing protein WDR33\tK15542 PFS2; polyadenylation factor subunit 2"
					},
					{
						"name":"105334335 WD repeat-containing protein 82\tK14962 WDR82; COMPASS component SWD2"
					},
					{
						"name":"105318349 serine\/threonine-protein phosphatase PP1-beta catalytic subunit\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"105320999 serine\/threonine-protein phosphatase alpha-2 isoform\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"105326211 serine\/threonine-protein phosphatase PP1-gamma catalytic subunit A\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"105337924 serine\/threonine-protein phosphatase PP1-beta catalytic subunit\tK06269 PPP1C; serine\/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"105333262 RNA polymerase II subunit A C-terminal domain phosphatase SSU72\tK15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]"
					}
					]
				},
				{
					"name":"Cleavage stimulation factor (CSTF) complex",
					"children":[
					{
						"name":"105323009 cleavage stimulation factor subunit 1\tK14406 CSTF1; cleavage stimulation factor subunit 1"
					},
					{
						"name":"105331297 cleavage stimulation factor subunit 2 isoform X1\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"105347665 cleavage stimulation factor subunit 3\tK14408 CSTF3; cleavage stimulation factor subunit 3"
					},
					{
						"name":"105342182 symplekin\tK06100 SYMPK; symplekin"
					}
					]
				},
				{
					"name":"U7-dependent histone pre-mRNA processing factors",
					"children":[
					{
						"name":"105347083 small nuclear ribonucleoprotein E\tK11097 SNRPE; small nuclear ribonucleoprotein E"
					},
					{
						"name":"105328191 small nuclear ribonucleoprotein F\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"105346836 small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					},
					{
						"name":"105347156 U7 snRNA-associated Sm-like protein LSm11\tK25592 LSM11; U7 snRNA-associated Sm-like protein LSm11"
					},
					{
						"name":"105319344 cleavage and polyadenylation specificity factor subunit 2\tK14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2"
					},
					{
						"name":"105319722 cleavage and polyadenylation specificity factor subunit 3\tK14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]"
					},
					{
						"name":"105331297 cleavage stimulation factor subunit 2 isoform X1\tK14407 CSTF2; cleavage stimulation factor subunit 2"
					},
					{
						"name":"105342182 symplekin\tK06100 SYMPK; symplekin"
					},
					{
						"name":"105337739 histone RNA hairpin-binding protein\tK18710 SLBP; histone RNA hairpin-binding protein"
					}
					]
				},
				{
					"name":"DRB sensitivity inducing factor (DSIF) complex",
					"children":[
					{
						"name":"105347027 transcription elongation factor SPT4\tK15171 SUPT4H1; transcription elongation factor SPT4"
					},
					{
						"name":"105323274 transcription elongation factor SPT5\tK15172 SUPT5H; transcription elongation factor SPT5"
					}
					]
				},
				{
					"name":"N6-methyltransferase complex",
					"children":[
					{
						"name":"105329074 N6-adenosine-methyltransferase subunit METTL3\tK05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]"
					},
					{
						"name":"105326041 N6-adenosine-methyltransferase non-catalytic subunit\tK23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit"
					},
					{
						"name":"105333744 N(6)-adenine-specific methyltransferase METTL4\tK24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]"
					},
					{
						"name":"105347004 RNA N6-adenosine-methyltransferase mettl16\tK11393 METTL16; U6 snRNA m6A methyltransferase [EC:2.1.1.346]"
					},
					{
						"name":"105346270 pre-mRNA-splicing regulator WTAP\tK22824 WTAP; pre-mRNA-splicing regulator WTAP"
					},
					{
						"name":"117680637 protein virilizer homolog isoform X1\tK22910 VIRMA; protein virilizer"
					},
					{
						"name":"105342534 RNA-binding protein spenito\tK13190 RBM15; RNA-binding protein 15"
					},
					{
						"name":"105330720 zinc finger CCCH domain-containing protein 13 isoform X1\tK22909 ZC3H13; zinc finger CCCH domain-containing protein 13"
					},
					{
						"name":"105346475 E3 ubiquitin-protein ligase Hakai isoform X1\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]"
					}
					]
				},
				{
					"name":"Poly(A) addition factors",
					"children":[
					{
						"name":"105324541 poly(A) polymerase beta isoform X1\tK14376 PAP; poly(A) polymerase [EC:2.7.7.19]"
					},
					{
						"name":"105328584 poly(A) RNA polymerase GLD2\tK14079 PAPD4; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]"
					},
					{
						"name":"105339907 speckle targeted PIP5K1A-regulated poly(A) polymerase\tK18709 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase [EC:2.7.7.19 2.7.7.52]"
					},
					{
						"name":"105339926 terminal uridylyltransferase 7\tK18709 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase [EC:2.7.7.19 2.7.7.52]"
					}
					]
				},
				{
					"name":"Negative regulators of mRNA 3' end processing",
					"children":[
					{
						"name":"105324607 BRCA1-associated RING domain protein 1 isoform X1\tK10683 BARD1; BRCA1-associated RING domain protein 1"
					},
					{
						"name":"105330918 RNA demethylase ALKBH5\tK10767 ALKBH5; mRNA N6-methyladenine demethylase [EC:1.14.11.53]"
					},
					{
						"name":"105321705 TAR DNA-binding protein 43\tK23600 TARDBP; TAR DNA-binding protein 43"
					},
					{
						"name":"105333799 TAR DNA-binding protein 43\tK23600 TARDBP; TAR DNA-binding protein 43"
					},
					{
						"name":"105348874 TAR DNA-binding protein 43\tK23600 TARDBP; TAR DNA-binding protein 43"
					}
					]
				}
				]
			},
			{
				"name":"Other processing factors",
				"children":[
				{
					"name":"105344782 DNA\/RNA-binding protein KIN17\tK13102 KIN; DNA\/RNA-binding protein KIN17"
				},
				{
					"name":"105322553 methyltransferase-like protein 22\tK23040 METTL22; methyltransferase-like protein 22 [EC:2.1.1.-]"
				},
				{
					"name":"105317409 zinc finger CCCH domain-containing protein 14\tK23038 ZC3H14; zinc finger CCCH domain-containing protein 14"
				},
				{
					"name":"105326707 serrate RNA effector molecule homolog isoform X1\tK27103 SRRT; serrate RNA effector molecule"
				}
				]
			}
			]
		},
		{
			"name":"mRNA surveillance and transport factors",
			"children":[
			{
				"name":"Transport factors",
				"children":[
				{
					"name":"EJC complex",
					"children":[
					{
						"name":"105348755 RNA-binding protein 8A\tK12876 RBM8A; RNA-binding protein 8A"
					},
					{
						"name":"105337940 protein mago nashi homolog 2\tK12877 MAGOH; protein mago nashi"
					},
					{
						"name":"105322560 THO complex subunit 4\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"105319208 spliceosome RNA helicase DDX39B\tK12812 DDX39B; ATP-dependent RNA helicase UAP56\/SUB2 [EC:5.6.2.7]"
					},
					{
						"name":"105319209 spliceosome RNA helicase DDX39B\tK12812 DDX39B; ATP-dependent RNA helicase UAP56\/SUB2 [EC:5.6.2.7]"
					},
					{
						"name":"105335655 eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]"
					},
					{
						"name":"105318756 coiled-coil domain-containing protein 174\tK25178 CCDC174; coiled-coil domain-containing protein 174"
					},
					{
						"name":"105345158 trichohyalin isoform X1\tK14323 CASC3; protein CASC3"
					},
					{
						"name":"105347084 histone deacetylase complex subunit SAP18\tK14324 SAP18; histone deacetylase complex subunit SAP18"
					},
					{
						"name":"105322973 pinin\tK13114 PNN; pinin"
					},
					{
						"name":"105321021 RNA-binding protein with serine-rich domain 1-B\tK14325 RNPS1; RNA-binding protein with serine-rich domain 1"
					},
					{
						"name":"105331448 serine\/arginine repetitive matrix protein 1 isoform X1\tK13171 SRRM1; serine\/arginine repetitive matrix protein 1"
					}
					]
				},
				{
					"name":"TREX complex",
					"children":[
					{
						"name":"105338779 THO complex subunit 1\tK12878 THOC1; THO complex subunit 1"
					},
					{
						"name":"105330153 THO complex subunit 2\tK12879 THOC2; THO complex subunit 2"
					},
					{
						"name":"105345709 THO complex subunit 3\tK12880 THOC3; THO complex subunit 3"
					},
					{
						"name":"105322560 THO complex subunit 4\tK12881 THOC4; THO complex subunit 4"
					},
					{
						"name":"105332689 THO complex subunit 5 homolog isoform X1\tK13174 THOC5; THO complex subunit 5"
					},
					{
						"name":"105346723 THO complex subunit 6 homolog\tK13175 THOC6; THO complex subunit 6"
					},
					{
						"name":"105342267 THO complex subunit 7 homolog\tK13176 THOC7; THO complex subunit 7"
					},
					{
						"name":"109620248 chromatin target of PRMT1 protein isoform X1\tK28424 CHTOP; chromatin target of PRMT1 protein"
					}
					]
				},
				{
					"name":"TREX-2 complex",
					"children":[
					{
						"name":"105331153 PCI domain-containing protein 2\tK23801 PCID2; nuclear mRNA export protein PCID2\/THP1"
					},
					{
						"name":"105322792 26S proteasome complex subunit SEM1\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"105330451 transcription and mRNA export factor ENY2\tK11368 ENY2; enhancer of yellow 2 transcription factor"
					},
					{
						"name":"105331093 uncharacterized protein\tK10840 CETN2; centrin-2"
					},
					{
						"name":"105341222 uncharacterized protein\tK10840 CETN2; centrin-2"
					},
					{
						"name":"117681840 uncharacterized protein\tK10840 CETN2; centrin-2"
					},
					{
						"name":"105336998 centrin-3\tK16466 CETN3; centrin-3"
					},
					{
						"name":"105340178 germinal-center associated nuclear protein isoform X3\tK24317 MCM3AP; germinal-center associated nuclear protein [EC:2.3.1.48]"
					}
					]
				},
				{
					"name":"Nuclear pore complex",
					"children":[
					{
						"name":"105325437 nucleoprotein TPR isoform X1\tK09291 TPR; nucleoprotein TPR"
					},
					{
						"name":"105336642 mRNA export factor\tK14298 RAE1; mRNA export factor"
					},
					{
						"name":"105342784 protein SEC13 homolog\tK14004 SEC13; protein transport protein SEC13"
					},
					{
						"name":"105330288 nucleoporin Nup37\tK14302 NUP37; nuclear pore complex protein Nup37"
					},
					{
						"name":"105347350 nuclear pore complex protein Nup85\tK14304 NUP85; nuclear pore complex protein Nup85"
					},
					{
						"name":"105322538 nucleoporin Nup43\tK14305 NUP43; nuclear pore complex protein Nup43"
					},
					{
						"name":"105343646 nucleoporin p54 isoform X1\tK14308 NUP54; nuclear pore complex protein Nup54"
					},
					{
						"name":"105325291 nuclear pore glycoprotein p62 isoform X1\tK14306 NUP62; nuclear pore complex protein Nup62"
					},
					{
						"name":"105324858 nucleoporin 88\tK14318 NUP88; nuclear pore complex protein Nup88"
					},
					{
						"name":"105334708 nuclear pore complex protein Nup93\tK14309 NUP93; nuclear pore complex protein Nup93"
					},
					{
						"name":"105337474 nuclear pore complex protein Nup98-Nup96\tK14297 NUP98; nuclear pore complex protein Nup98-Nup96"
					},
					{
						"name":"105346252 nuclear pore complex protein Nup107\tK14301 NUP107; nuclear pore complex protein Nup107"
					},
					{
						"name":"105339546 nuclear pore complex protein Nup133\tK14300 NUP133; nuclear pore complex protein Nup133"
					},
					{
						"name":"105334941 nucleoporin NUP188 isoform X1\tK14311 NUP188; nuclear pore complex protein Nup188"
					},
					{
						"name":"105322206 nuclear pore complex protein Nup50 isoform X1\tK14296 NUP153; nuclear pore complex protein Nup153"
					},
					{
						"name":"105338117 uncharacterized protein isoform X2\tK14296 NUP153; nuclear pore complex protein Nup153"
					},
					{
						"name":"105348482 nuclear pore complex protein Nup155\tK14312 NUP155; nuclear pore complex protein Nup155"
					},
					{
						"name":"105341923 nuclear pore complex protein Nup160\tK14303 NUP160; nuclear pore complex protein Nup160"
					},
					{
						"name":"105344637 nucleoporin NUP35\tK14313 NUP35; nuclear pore complex protein Nup53"
					},
					{
						"name":"105340039 nuclear pore complex protein Nup205\tK14310 NUP205; nuclear pore complex protein Nup205"
					},
					{
						"name":"105330354 nuclear pore membrane glycoprotein 210\tK14314 NUP210; nuclear pore complex protein Nup210"
					},
					{
						"name":"105324883 nuclear pore complex protein Nup214 isoform X1\tK14317 NUP214; nuclear pore complex protein Nup214"
					},
					{
						"name":"105344104 nucleoporin p58\/p45 isoform X1\tK14307 NUPL1; nucleoporin p58\/p45"
					},
					{
						"name":"105347373 nucleoporin NUP42 isoform X1\tK14321 NUPL2; nucleoporin-like protein 2"
					},
					{
						"name":"105320638 nucleoporin NDC1\tK14315 NDC1; nucleoporin NDC1"
					},
					{
						"name":"105328593 nucleoporin SEH1 isoform X1\tK14299 SEH1; nucleoporin SEH1"
					},
					{
						"name":"105323093 E3 SUMO-protein ligase RanBP2\tK12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]"
					},
					{
						"name":"105331213 aladin isoform X1\tK14320 AAAS; aladin"
					},
					{
						"name":"136269687 aladin-like\tK14320 AAAS; aladin"
					},
					{
						"name":"105336998 centrin-3\tK16466 CETN3; centrin-3"
					},
					{
						"name":"105329976 mRNA export factor GLE1\tK18723 GLE1; nucleoporin GLE1"
					},
					{
						"name":"105322156 nuclear RNA export factor 1 isoform X1\tK14284 NXF; nuclear RNA export factor"
					}
					]
				},
				{
					"name":"Ran-mediated transport factors",
					"children":[
					{
						"name":"105327885 GTP-binding nuclear protein Ran\tK07936 RAN; GTP-binding nuclear protein Ran"
					},
					{
						"name":"105342498 acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1\tK18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A\/C\/D"
					},
					{
						"name":"105329647 ELAV-like protein 2\tK13088 ELAVL1; ELAV-like protein 1"
					},
					{
						"name":"105329644 ELAV-like protein 3\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4"
					},
					{
						"name":"105335107 ELAV-like protein 1 isoform X1\tK13208 ELAVL2_3_4; ELAV like protein 2\/3\/4"
					},
					{
						"name":"105324082 FAS-associated factor 2 isoform X1\tK18726 FAF2; FAS-associated factor 2"
					},
					{
						"name":"105326153 transitional endoplasmic reticulum ATPase\tK13525 VCP; transitional endoplasmic reticulum ATPase"
					},
					{
						"name":"105325921 protein N-lysine methyltransferase METTL21D isoform X1\tK21806 VCPKMT; protein N-lysine methyltransferase METTL21D [EC:2.1.1.-]"
					},
					{
						"name":"105345320 exportin-1\tK14290 XPO1; exportin-1"
					},
					{
						"name":"105341516 exportin-7 isoform X1\tK18460 XPO7; exportin-7"
					},
					{
						"name":"117685977 LOW QUALITY PROTEIN: exportin-7-like\tK18460 XPO7; exportin-7"
					},
					{
						"name":"105331767 ran GTPase-activating protein 1\tK14319 RANGAP1; Ran GTPase-activating protein 1"
					},
					{
						"name":"105335954 RNA-binding protein FUS isoform X1\tK14651 TAF15; transcription initiation factor TFIID subunit 15"
					},
					{
						"name":"105332288 uncharacterized protein\tK28773 NUTF2; nuclear transport factor 2"
					}
					]
				},
				{
					"name":"eIF4F and regulatory proteins",
					"children":[
					{
						"name":"105327880 eukaryotic translation initiation factor 4E isoform X2\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"105347642 eukaryotic translation initiation factor 4E type 2 isoform X2\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"105323723 eukaryotic initiation factor 4A-I\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"105324495 uncharacterized protein\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"105317347 eukaryotic translation initiation factor 4 gamma 2\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"105345876 eukaryotic translation initiation factor 4 gamma 3 isoform X5\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"109617380 eukaryotic translation initiation factor 4B isoform X1\tK03258 EIF4B; translation initiation factor 4B"
					},
					{
						"name":"105327861 eukaryotic translation initiation factor 4H\tK24086 EIF4H; translation initiation factor 4H"
					},
					{
						"name":"105341698 eukaryotic translation initiation factor 4E-binding protein 1\tK07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1"
					},
					{
						"name":"105325906 eukaryotic translation initiation factor 4E transporter isoform X1\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter"
					},
					{
						"name":"105332122 protein angel homolog 2 isoform X1\tK18729 ANGEL; protein angel"
					},
					{
						"name":"105342998 RNA-binding protein FXR1 isoform X1\tK15516 FMR; fragile X mental retardation protein"
					},
					{
						"name":"105325321 cytoplasmic FMR1-interacting protein isoform X1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein"
					},
					{
						"name":"105329452 cytoplasmic FMR1-interacting protein\tK05749 CYFIP; cytoplasmic FMR1 interacting protein"
					},
					{
						"name":"105339299 cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"105339684 cytoplasmic polyadenylation element-binding protein 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"105341865 ATP-dependent RNA helicase DDX3Y isoform X1\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"105330258 GRB10-interacting GYF protein 2 isoform X1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein"
					},
					{
						"name":"105326555 polyadenylate-binding protein 4\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"105331411 polyadenylate-binding protein-interacting protein 1 isoform X1\tK14322 PAIP1; polyadenylate-binding protein-interacting protein 1"
					},
					{
						"name":"117690339 polyadenylate-binding protein-interacting protein 2\tK27470 PAIP2; polyadenylate-binding protein-interacting protein 2"
					},
					{
						"name":"117680483 superkiller complex protein 2\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]"
					},
					{
						"name":"105343605 deformed epidermal autoregulatory factor 1 homolog isoform X1\tK23041 DEAF1; deformed epidermal autoregulatory factor 1"
					},
					{
						"name":"105340398 malignant T-cell-amplified sequence 1 homolog\tK07575 MCTS; malignant T-cell-amplified sequence"
					},
					{
						"name":"105338124 density-regulated protein homolog\tK24272 DENR; density-regulated protein"
					}
					]
				},
				{
					"name":"APOBEC1-ACF complex",
					"children":[
					{
						"name":"105341857 APOBEC1 complementation factor isoform X1\tK24978 A1CF; APOBEC1 complementation factor"
					}
					]
				},
				{
					"name":"Other transport factors",
					"children":[
					{
						"name":"105330886 partner of Y14 and mago\tK14294 WIBG; partner of Y14 and mago"
					},
					{
						"name":"105326545 DAZ-associated protein 1 isoform X1\tK14411 MSI; RNA-binding protein Musashi"
					},
					{
						"name":"105336239 RNA-binding protein Musashi homolog 2 isoform X1\tK14411 MSI; RNA-binding protein Musashi"
					},
					{
						"name":"105347411 HBS1-like protein isoform X1\tK14416 HBS1; elongation factor 1 alpha-like protein"
					},
					{
						"name":"105338398 protein pelota\tK06965 PELO; protein pelota"
					},
					{
						"name":"105334534 polyadenylate-binding protein 2-B\tK14396 PABPN1; polyadenylate-binding protein 2"
					},
					{
						"name":"105338838 ATP-dependent RNA helicase DDX19A isoform X1\tK18655 DDX19; ATP-dependent RNA helicase DDX19\/DBP5 [EC:5.6.2.7]"
					},
					{
						"name":"105337236 pre-mRNA-splicing factor SYF1\tK12867 SYF1; pre-mRNA-splicing factor SYF1"
					},
					{
						"name":"105335950 SAP domain-containing ribonucleoprotein\tK18732 SARNP; SAP domain-containing ribonucleoprotein"
					},
					{
						"name":"105320914 regulator of chromosome condensation isoform X1\tK11493 RCC1; regulator of chromosome condensation"
					},
					{
						"name":"105317819 la-related protein 6\tK18733 LARP6; la-related protein 6"
					},
					{
						"name":"105322217 transcriptional regulator protein Pur-beta-B isoform X1\tK21772 PURA; transcriptional activator protein Pur-alpha"
					},
					{
						"name":"105329478 polymerase delta-interacting protein 3\tK22414 POLDIP3; polymerase delta-interacting protein 3"
					},
					{
						"name":"105340493 zinc finger CCCH domain-containing protein 11A\tK22415 ZC3H11; zinc finger CCCH domain-containing protein 11"
					},
					{
						"name":"105336386 leukocyte receptor cluster member 8 homolog\tK23802 LENG8; SAC3 family protein LENG8\/THP3"
					}
					]
				}
				]
			},
			{
				"name":"Surveillance factors",
				"children":[
				{
					"name":"Surveillance complex",
					"children":[
					{
						"name":"105325000 eukaryotic peptide chain release factor subunit 1\tK03265 ETF1; peptide chain release factor subunit 1"
					},
					{
						"name":"105339845 eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1\tK03267 ERF3; peptide chain release factor subunit 3"
					},
					{
						"name":"105331061 regulator of nonsense transcripts 1\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					},
					{
						"name":"105344597 regulator of nonsense transcripts 2 isoform X1\tK14327 UPF2; regulator of nonsense transcripts 2"
					},
					{
						"name":"105322817 regulator of nonsense transcripts 3B\tK14328 UPF3; regulator of nonsense transcripts 3"
					}
					]
				},
				{
					"name":"Protein phosphatase 2A",
					"children":[
					{
						"name":"105341231 serine\/threonine-protein phosphatase 2A catalytic subunit beta isoform\tK04382 PPP2C; serine\/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"105343833 serine\/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1\tK03456 PPP2R1; serine\/threonine-protein phosphatase 2A regulatory subunit A"
					},
					{
						"name":"105320707 serine\/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform\tK04354 PPP2R2; serine\/threonine-protein phosphatase 2A regulatory subunit B"
					},
					{
						"name":"105339916 serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''"
					},
					{
						"name":"105345875 serine\/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma\tK11583 PPP2R3; serine\/threonine-protein phosphatase 2A regulatory subunit B''"
					},
					{
						"name":"105324454 serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					},
					{
						"name":"117689403 serine\/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1\tK11584 PPP2R5; serine\/threonine-protein phosphatase 2A regulatory subunit B'"
					}
					]
				},
				{
					"name":"Other surveillance factors",
					"children":[
					{
						"name":"105347393 serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]"
					},
					{
						"name":"105345495 nonsense-mediated mRNA decay factor SMG5 isoform X1\tK11125 SMG5; protein SMG5"
					},
					{
						"name":"105321652 telomerase-binding protein EST1A\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
					},
					{
						"name":"105339479 nonsense-mediated mRNA decay factor SMG7\tK14409 SMG7; protein SMG7"
					},
					{
						"name":"105322808 nonsense-mediated mRNA decay factor SMG8 isoform X4\tK18734 SMG8; protein SMG8"
					},
					{
						"name":"105332655 nonsense-mediated mRNA decay factor SMG9\tK18735 SMG9; protein SMG9"
					},
					{
						"name":"105330258 GRB10-interacting GYF protein 2 isoform X1\tK18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein"
					},
					{
						"name":"117687431 selenocysteine insertion sequence-binding protein 2-like isoform X1\tK19539 SECISBP2; selenocysteine insertion sequence-binding protein 2"
					},
					{
						"name":"105344130 probable ATP-dependent RNA helicase DHX34\tK20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6]"
					},
					{
						"name":"105335507 GTP-binding protein 1\tK24887 GTPBP1; GTP-binding protein 1"
					}
					]
				}
				]
			},
			{
				"name":"Factors involved in mRNA localization",
				"children":[
				{
					"name":"Cargo complex",
					"children":[
					{
						"name":"105336671 pumilio homolog 3\tK14844 PUF6; pumilio homology domain family member 6"
					},
					{
						"name":"105330929 unconventional myosin-Va isoform X1\tK10357 MYO5; myosin V"
					},
					{
						"name":"105340000 protein bicaudal D isoform X2\tK18739 BICD; protein bicaudal D"
					},
					{
						"name":"105320375 uncharacterized protein isoform X1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					},
					{
						"name":"105320376 uncharacterized protein\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					},
					{
						"name":"105326641 uncharacterized protein isoform X1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					},
					{
						"name":"105334795 piRNA biogenesis protein EXD1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					},
					{
						"name":"105340033 uncharacterized protein isoform X1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					},
					{
						"name":"105342861 uncharacterized protein isoform X1\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					},
					{
						"name":"105343835 uncharacterized protein\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					},
					{
						"name":"117681819 uncharacterized protein\tK18740 EXD1; exonuclease 3'-5' domain-containing protein 1"
					}
					]
				},
				{
					"name":"Factors that have mRNA localization signals",
					"children":[
					{
						"name":"105326705 actin, cytoplasmic\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105332192 actin-5\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105332193 actin, cytoplasmic\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105335284 actin, cytoplasmic\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105335713 actin, adductor muscle\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105340468 actin-2\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105340469 actin\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105341705 actin-like\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"117680516 actin, cytoplasmic\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"117690321 actin-like\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"117692766 actin-6 isoform X1\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"136270138 actin-like\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"136275819 actin-1-like\tK05692 ACTB_G1; actin beta\/gamma 1"
					},
					{
						"name":"105339321 T-box transcription factor TBX20\tK10180 TBX6; T-box protein 6"
					},
					{
						"name":"105348851 nanos homolog 1\tK18741 NANOS1; protein nanos 1"
					}
					]
				},
				{
					"name":"Trans-acting binding proteins",
					"children":[
					{
						"name":"105324686 far upstream element-binding protein 1 isoform X1\tK13210 FUBP; far upstream element-binding protein"
					},
					{
						"name":"105338957 elongation factor 1-alpha\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"105345227 elongation factor 1-alpha 1\tK03231 EEF1A; elongation factor 1-alpha"
					},
					{
						"name":"105324050 elongation factor 1-gamma\tK03233 EEF1G; elongation factor 1-gamma"
					},
					{
						"name":"105333434 heterogeneous nuclear ribonucleoprotein A1, A2\/B1 homolog isoform X2\tK13158 HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2\/B1"
					},
					{
						"name":"105340833 HCLS1-associated protein X-1 isoform X1\tK16220 HAX1; HCLS1-associated protein X-1"
					},
					{
						"name":"105331152 arf-GAP domain and FG repeat-containing protein 1 isoform X1\tK15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1"
					},
					{
						"name":"105331923 double-stranded RNA-binding protein Staufen homolog isoform X1\tK17597 STAU; double-stranded RNA-binding protein Staufen"
					},
					{
						"name":"105339299 cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"105339684 cytoplasmic polyadenylation element-binding protein 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					}
					]
				},
				{
					"name":"Other mRNA localization factors",
					"children":[
					{
						"name":"105342998 RNA-binding protein FXR1 isoform X1\tK15516 FMR; fragile X mental retardation protein"
					},
					{
						"name":"105325321 cytoplasmic FMR1-interacting protein isoform X1\tK05749 CYFIP; cytoplasmic FMR1 interacting protein"
					},
					{
						"name":"105329452 cytoplasmic FMR1-interacting protein\tK05749 CYFIP; cytoplasmic FMR1 interacting protein"
					},
					{
						"name":"105333153 poly(rC)-binding protein 3 isoform X1\tK21444 PCBP3_4; poly(rC)-binding protein 3\/4"
					},
					{
						"name":"105340513 caprin-1 isoform X1\tK18743 CAPRIN1; caprin-1"
					},
					{
						"name":"105318040 Y-box factor homolog\tK09276 YBX1; Y-box-binding protein 1"
					}
					]
				}
				]
			},
			{
				"name":"mRNA cycle factors",
				"children":[
				{
					"name":"Common to processing body (P body) and stress granule",
					"children":[
					{
						"name":"105340192 5'-3' exoribonuclease 1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]"
					},
					{
						"name":"105321320 protein argonaute-2 isoform X1\tK11593 ELF2C; eukaryotic translation initiation factor 2C"
					},
					{
						"name":"105329532 protein argonaute-2 isoform X1\tK11593 ELF2C; eukaryotic translation initiation factor 2C"
					},
					{
						"name":"105327880 eukaryotic translation initiation factor 4E isoform X2\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"105347642 eukaryotic translation initiation factor 4E type 2 isoform X2\tK03259 EIF4E; translation initiation factor 4E"
					},
					{
						"name":"105331061 regulator of nonsense transcripts 1\tK14326 UPF1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]"
					},
					{
						"name":"105341865 ATP-dependent RNA helicase DDX3Y isoform X1\tK11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]"
					},
					{
						"name":"105330037 ATP-dependent RNA helicase me31b\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					},
					{
						"name":"105328416 RNA-binding protein MEX3B\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]"
					},
					{
						"name":"105328630 protein LSM14 homolog A isoform X1\tK18749 LSM14; protein LSM14"
					},
					{
						"name":"105318040 Y-box factor homolog\tK09276 YBX1; Y-box-binding protein 1"
					},
					{
						"name":"105326215 LIM domain-containing protein ajuba isoform X1\tK16682 AJUBA; LIM domain-containing protein"
					},
					{
						"name":"105319269 putative helicase MOV-10 isoform X1\tK18422 MOV10; helicase MOV-10 [EC:5.6.2.5]"
					},
					{
						"name":"105318490 transportin-1 isoform X1\tK18752 TNPO1; transportin-1"
					},
					{
						"name":"105347393 serine\/threonine-protein kinase SMG1 isoform X1\tK08873 SMG1; serine\/threonine-protein kinase SMG1 [EC:2.7.11.1]"
					},
					{
						"name":"105345495 nonsense-mediated mRNA decay factor SMG5 isoform X1\tK11125 SMG5; protein SMG5"
					},
					{
						"name":"105321652 telomerase-binding protein EST1A\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
					},
					{
						"name":"105339479 nonsense-mediated mRNA decay factor SMG7\tK14409 SMG7; protein SMG7"
					},
					{
						"name":"105336839 mRNA decay activator protein ZFP36L1\tK18753 ZFP36L; butyrate response factor"
					},
					{
						"name":"105346268 protein lin-28 homolog isoform X1\tK18754 LIN28; protein lin-28"
					},
					{
						"name":"105336135 huntingtin\tK04533 HD; huntingtin"
					},
					{
						"name":"105325916 protein bicaudal C homolog 1-A\tK18756 BICC1; protein bicaudal C"
					},
					{
						"name":"105336635 cAMP-dependent protein kinase catalytic subunit 1 isoform X1\tK04345 PKA; protein kinase A [EC:2.7.11.11]"
					},
					{
						"name":"105331323 la-related protein 1B\tK18757 LARP1; la-related protein 1"
					},
					{
						"name":"105344721 ataxin-2-like protein isoform X3\tK23625 ATXN2; ataxin-2"
					}
					]
				},
				{
					"name":"P-body specific factors",
					"children":[
					{
						"name":"105349067 m7GpppN-mRNA hydrolase\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"105345995 mRNA-decapping enzyme 1A\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]"
					},
					{
						"name":"105346630 U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"105330850 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"105323611 U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					},
					{
						"name":"105348485 U6 snRNA-associated Sm-like protein LSm4\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4"
					},
					{
						"name":"105321817 U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5"
					},
					{
						"name":"105322958 U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"105334675 U6 snRNA-associated Sm-like protein LSm7\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					},
					{
						"name":"105328405 U6 snRNA-associated Sm-like protein LSm8\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8"
					},
					{
						"name":"105340617 kinesin light chain isoform X1\tK10407 KLC; kinesin light chain"
					},
					{
						"name":"105330929 unconventional myosin-Va isoform X1\tK10357 MYO5; myosin V"
					},
					{
						"name":"105329346 tubulin alpha-1A chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"105329348 tubulin alpha-1A chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"105329640 tubulin alpha chain, testis-specific\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"105342358 tubulin alpha-1A chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"105347346 tubulin alpha-3 chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"105347347 tubulin alpha-1A chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"109618881 tubulin alpha-1A chain\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"117682163 tubulin alpha-2\/alpha-4 chain isoform X1\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"117683631 tubulin alpha-1A chain-like\tK07374 TUBA; tubulin alpha"
					},
					{
						"name":"105339299 cytoplasmic polyadenylation element-binding protein 1 isoform X1\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"105339684 cytoplasmic polyadenylation element-binding protein 2\tK02602 CPEB; cytoplasmic polyadenylation element-binding protein"
					},
					{
						"name":"105325598 trinucleotide repeat-containing gene 6C protein isoform X3\tK18412 TNRC6; trinucleotide repeat-containing gene 6 protein"
					},
					{
						"name":"105324909 CCR4-NOT transcription complex subunit 1 isoform X1\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"105320796 CCR4-NOT transcription complex subunit 2 isoform X1\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"105332581 CCR4-NOT transcription complex subunit 3 isoform X3\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"105322221 CCR4-NOT transcription complex subunit 4 isoform X2\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"105348954 uncharacterized protein\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"105337935 CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"105325230 DIS3-like exonuclease 2\tK18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]"
					},
					{
						"name":"105333996 PAN2-PAN3 deadenylation complex catalytic subunit PAN2\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]"
					},
					{
						"name":"105333885 PAN2-PAN3 deadenylation complex subunit pan3 isoform X1\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3"
					},
					{
						"name":"105317912 maternal B9.10 protein\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"105325609 protein Tob1\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"105340066 Btg1; uncharacterized protein LOC105340066\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"105325906 eukaryotic translation initiation factor 4E transporter isoform X1\tK18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter"
					},
					{
						"name":"105343604 protein PAT1 homolog 1 isoform X1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1"
					},
					{
						"name":"105346914 enhancer of mRNA-decapping protein 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3"
					},
					{
						"name":"105322464 enhancer of mRNA-decapping protein 4 isoform X1\tK12616 EDC4; enhancer of mRNA-decapping protein 4"
					},
					{
						"name":"105344597 regulator of nonsense transcripts 2 isoform X1\tK14327 UPF2; regulator of nonsense transcripts 2"
					},
					{
						"name":"105322817 regulator of nonsense transcripts 3B\tK14328 UPF3; regulator of nonsense transcripts 3"
					},
					{
						"name":"105338381 E3 ubiquitin-protein ligase TRIM71\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]"
					},
					{
						"name":"105319613 DNA-directed RNA polymerase II subunit RPB7 isoform X2\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
					},
					{
						"name":"105348558 YTH domain-containing family protein 3\tK20102 YTHDF; YTH domain-containing family protein"
					}
					]
				},
				{
					"name":"Stress granule specific factors",
					"children":[
					{
						"name":"105320706 nucleolysin TIAR\tK13201 TIA1; nucleolysin TIA-1\/TIAR"
					},
					{
						"name":"105326555 polyadenylate-binding protein 4\tK13126 PABPC; polyadenylate-binding protein"
					},
					{
						"name":"105331923 double-stranded RNA-binding protein Staufen homolog isoform X1\tK17597 STAU; double-stranded RNA-binding protein Staufen"
					},
					{
						"name":"105342998 RNA-binding protein FXR1 isoform X1\tK15516 FMR; fragile X mental retardation protein"
					},
					{
						"name":"105329647 ELAV-like protein 2\tK13088 ELAVL1; ELAV-like protein 1"
					},
					{
						"name":"105347201 ras GTPase-activating protein-binding protein 2\tK24983 G3BP2; Ras GTPase-activating protein-binding protein 2"
					},
					{
						"name":"105333810 eukaryotic translation initiation factor 2A isoform X1\tK15026 EIF2A; translation initiation factor 2A"
					},
					{
						"name":"105332194 eukaryotic translation initiation factor 3 subunit B\tK03253 EIF3B; translation initiation factor 3 subunit B"
					},
					{
						"name":"105323723 eukaryotic initiation factor 4A-I\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"105324495 uncharacterized protein\tK03257 EIF4A; translation initiation factor 4A"
					},
					{
						"name":"105335655 eukaryotic initiation factor 4A-III\tK13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]"
					},
					{
						"name":"109617380 eukaryotic translation initiation factor 4B isoform X1\tK03258 EIF4B; translation initiation factor 4B"
					},
					{
						"name":"105317347 eukaryotic translation initiation factor 4 gamma 2\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"105345876 eukaryotic translation initiation factor 4 gamma 3 isoform X5\tK03260 EIF4G; translation initiation factor 4G"
					},
					{
						"name":"105341228 small ribosomal subunit protein RACK1\tK14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein"
					},
					{
						"name":"105332371 TNF receptor-associated factor 2\tK03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]"
					},
					{
						"name":"105344264 TNF receptor-associated factor 2 isoform X1\tK03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]"
					},
					{
						"name":"105322156 nuclear RNA export factor 1 isoform X1\tK14284 NXF; nuclear RNA export factor"
					},
					{
						"name":"105331484 tudor domain-containing protein 3\tK18404 TDRD3; tudor domain-containing protein 3"
					},
					{
						"name":"105325596 la-related protein 4 isoform X1\tK18763 LARP4; la-related protein 4"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"mRNA degradation factors",
			"children":[
			{
				"name":"5'-3' decay",
				"children":[
				{
					"name":"Decapping complex",
					"children":[
					{
						"name":"105345995 mRNA-decapping enzyme 1A\tK12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]"
					},
					{
						"name":"105349067 m7GpppN-mRNA hydrolase\tK12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]"
					},
					{
						"name":"105330037 ATP-dependent RNA helicase me31b\tK12614 DDX6; ATP-dependent RNA helicase DDX6\/DHH1 [EC:5.6.2.7]"
					},
					{
						"name":"105346914 enhancer of mRNA-decapping protein 3\tK12615 EDC3; enhancer of mRNA-decapping protein 3"
					},
					{
						"name":"105322464 enhancer of mRNA-decapping protein 4 isoform X1\tK12616 EDC4; enhancer of mRNA-decapping protein 4"
					},
					{
						"name":"105343604 protein PAT1 homolog 1 isoform X1\tK12617 PATL1; DNA topoisomerase 2-associated protein PAT1"
					}
					]
				},
				{
					"name":"Lsm complex",
					"children":[
					{
						"name":"105346630 U6 snRNA-associated Sm-like protein LSm1\tK12620 LSM1; U6 snRNA-associated Sm-like protein LSm1"
					},
					{
						"name":"105330850 U6 snRNA-associated Sm-like protein LSm2\tK12621 LSM2; U6 snRNA-associated Sm-like protein LSm2"
					},
					{
						"name":"105323611 U6 snRNA-associated Sm-like protein LSm3\tK12622 LSM3; U6 snRNA-associated Sm-like protein LSm3"
					},
					{
						"name":"105348485 U6 snRNA-associated Sm-like protein LSm4\tK12623 LSM4; U6 snRNA-associated Sm-like protein LSm4"
					},
					{
						"name":"105321817 U6 snRNA-associated Sm-like protein LSm5\tK12624 LSM5; U6 snRNA-associated Sm-like protein LSm5"
					},
					{
						"name":"105322958 U6 snRNA-associated Sm-like protein LSm6\tK12625 LSM6; U6 snRNA-associated Sm-like protein LSm6"
					},
					{
						"name":"105334675 U6 snRNA-associated Sm-like protein LSm7\tK12626 LSM7; U6 snRNA-associated Sm-like protein LSm7"
					},
					{
						"name":"105328405 U6 snRNA-associated Sm-like protein LSm8\tK12627 LSM8; U6 snRNA-associated Sm-like protein LSm8"
					}
					]
				},
				{
					"name":"5' exonucleases",
					"children":[
					{
						"name":"105340192 5'-3' exoribonuclease 1\tK12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]"
					},
					{
						"name":"105345357 5'-3' exoribonuclease 2\tK12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]"
					},
					{
						"name":"109618305 U8 snoRNA-decapping enzyme\tK16855 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]"
					}
					]
				},
				{
					"name":"Other 5'-3' decay factors",
					"children":[
					{
						"name":"105342540 m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					},
					{
						"name":"105337397 probable helicase with zinc finger domain isoform X1\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]"
					}
					]
				}
				]
			},
			{
				"name":"3'-5' decay",
				"children":[
				{
					"name":"Core exosome factors",
					"children":[
					{
						"name":"105328567 exosome complex component CSL4\tK07573 CSL4; exosome complex component CSL4"
					},
					{
						"name":"105321222 exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"105331407 exosome complex component RRP40\tK03681 RRP40; exosome complex component RRP40"
					},
					{
						"name":"105331037 exosome complex component RRP41\tK11600 RRP41; exosome complex component RRP41"
					},
					{
						"name":"105339181 exosome complex component RRP46\tK12590 RRP46; exosome complex component RRP46"
					},
					{
						"name":"105330577 exosome complex component MTR3\tK12587 MTR3; exosome complex component MTR3"
					},
					{
						"name":"105329651 exosome complex component RRP42\tK12589 RRP42; exosome complex component RRP42"
					},
					{
						"name":"105327745 exosome complex component RRP43\tK12586 RRP43; exosome complex component RRP43"
					},
					{
						"name":"105348766 exosome complex component RRP45 isoform X1\tK03678 RRP45; exosome complex component RRP45"
					}
					]
				},
				{
					"name":"Exosome cofactors",
					"children":[
					{
						"name":"105341733 exosome complex exonuclease RRP44\tK12585 DIS3; exosome complex exonuclease DIS3\/RRP44 [EC:3.1.13.-]"
					},
					{
						"name":"105322274 DIS3-like exonuclease 1\tK18681 DIS3L; DIS3-like exonuclease 1 [EC:3.1.13.-]"
					},
					{
						"name":"105330593 exosome complex component 10\tK12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]"
					},
					{
						"name":"105324260 nuclear nucleic acid-binding protein C1D\tK12592 C1D; exosome complex protein LRP1"
					},
					{
						"name":"105336031 M-phase phosphoprotein 6\tK12593 MPHOSPH6; M-phase phosphoprotein 6, animal type"
					}
					]
				},
				{
					"name":"TRAMP complex",
					"children":[
					{
						"name":"105345609 terminal nucleotidyltransferase 4B\tK03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5\/7 [EC:2.7.7.19]"
					},
					{
						"name":"117684767 zinc finger CCHC domain-containing protein 7\tK12597 AIR1_2; protein AIR1\/2"
					},
					{
						"name":"105341233 exosome RNA helicase MTR4\tK12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]"
					}
					]
				},
				{
					"name":"Ski complex",
					"children":[
					{
						"name":"117680483 superkiller complex protein 2\tK12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]"
					},
					{
						"name":"105344506 tetratricopeptide repeat protein 37\tK12600 SKI3; superkiller protein 3"
					},
					{
						"name":"105335189 superkiller complex protein 8\tK12602 WDR61; WD repeat-containing protein 61"
					}
					]
				},
				{
					"name":"Ccr4-NOT complex",
					"children":[
					{
						"name":"105348954 uncharacterized protein\tK12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]"
					},
					{
						"name":"105324909 CCR4-NOT transcription complex subunit 1 isoform X1\tK12604 CNOT1; CCR4-NOT transcription complex subunit 1"
					},
					{
						"name":"105320796 CCR4-NOT transcription complex subunit 2 isoform X1\tK12605 CNOT2; CCR4-NOT transcription complex subunit 2"
					},
					{
						"name":"105332581 CCR4-NOT transcription complex subunit 3 isoform X3\tK12580 CNOT3; CCR4-NOT transcription complex subunit 3"
					},
					{
						"name":"105322221 CCR4-NOT transcription complex subunit 4 isoform X2\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
					},
					{
						"name":"105337935 CCR4-NOT transcription complex subunit 7\tK12581 CNOT7_8; CCR4-NOT transcription complex subunit 7\/8"
					},
					{
						"name":"105348977 CCR4-NOT transcription complex subunit 9\tK12606 RCD1; CCR4-NOT transcription complex subunit 9"
					},
					{
						"name":"105338377 CCR4-NOT transcription complex subunit 10 isoform X1\tK12607 CNOT10; CCR4-NOT transcription complex subunit 10"
					}
					]
				},
				{
					"name":"Pan complex",
					"children":[
					{
						"name":"105333996 PAN2-PAN3 deadenylation complex catalytic subunit PAN2\tK12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]"
					},
					{
						"name":"105333885 PAN2-PAN3 deadenylation complex subunit pan3 isoform X1\tK12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3"
					}
					]
				},
				{
					"name":"Other 3'-5' decay factors",
					"children":[
					{
						"name":"105331025 poly(A)-specific ribonuclease PNLDC1 isoform X1\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]"
					},
					{
						"name":"105335764 poly(A)-specific ribonuclease PARN isoform X2\tK01148 PARN; poly(A)-specific ribonuclease [EC:3.1.13.4]"
					},
					{
						"name":"105345676 ATP-dependent DNA\/RNA helicase DHX36\tK14442 DHX36; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]"
					},
					{
						"name":"105317912 maternal B9.10 protein\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"105325609 protein Tob1\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"105340066 Btg1; uncharacterized protein LOC105340066\tK14443 TOB; protein Tob\/BTG"
					},
					{
						"name":"105336378 nocturnin\tK18764 NOCT; nocturnin [EC:3.1.3.108]"
					},
					{
						"name":"105327396 3'-5' exoribonuclease 1\tK18416 THEX1; 3'-5' exoribonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"105340363 ERI1 exoribonuclease 2\tK18417 ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-]"
					},
					{
						"name":"105342540 m7GpppX diphosphatase\tK12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]"
					},
					{
						"name":"105320749 2',5'-phosphodiesterase 12\tK19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]"
					},
					{
						"name":"105337397 probable helicase with zinc finger domain isoform X1\tK25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]"
					},
					{
						"name":"105323546 3'-5' exoribonuclease HELZ2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]"
					},
					{
						"name":"105335192 3'-5' exoribonuclease HELZ2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]"
					},
					{
						"name":"105340096 3'-5' exoribonuclease HELZ2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]"
					},
					{
						"name":"105340146 3'-5' exoribonuclease HELZ2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]"
					},
					{
						"name":"105347778 3'-5' exoribonuclease HELZ2\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]"
					},
					{
						"name":"117684919 3'-5' exoribonuclease HELZ2 isoform X1\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]"
					},
					{
						"name":"136273611 3'-5' exoribonuclease HELZ2-like\tK25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]"
					},
					{
						"name":"105347983 nuclear exosome regulator NRDE2\tK26109 NRDE2; nuclear exosome regulator NRDE2"
					},
					{
						"name":"105318125 protein Smaug homolog 1\tK27396 SMG; protein Smaug"
					},
					{
						"name":"105347554 focadhesin\tK27498 FOCAD; focadhesin"
					}
					]
				}
				]
			},
			{
				"name":"Other degradation factors",
				"children":[
				{
					"name":"RNases",
					"children":[
					{
						"name":"105327943 uncharacterized protein isoform X1\tK18668 ZC3H12; ribonuclease ZC3H12 [EC:3.1.-.-]"
					}
					]
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"Bacterial mRNA degradation factors",
			"children":[
			{
				"name":"RNA degradosome components",
				"children":[
				{
					"name":"Ribonucreases",
					"children":[
					{
						"name":"105327664 ribonuclease 3 isoform X1\tK03685 rnc; ribonuclease III [EC:3.1.26.3]"
					},
					{
						"name":"105338621 probable oligoribonuclease\tK13288 orn; oligoribonuclease [EC:3.1.-.-]"
					}
					]
				},
				{
					"name":"Helicases",
					"children":[
					{
						"name":"105319480 ATP-dependent helicase wrn-1-like isoform X1\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"105328187 bifunctional 3'-5' exonuclease\/ATP-dependent helicase WRN\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"105329363 LOW QUALITY PROTEIN: ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"105348008 probable ATP-dependent DNA helicase RecS\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"109617800 ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"109617963 ATP-dependent DNA helicase RecQ\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"109619424 probable ATP-dependent DNA helicase RecS\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"109621022 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"117680959 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"117685996 bifunctional 3'-5' exonuclease\/ATP-dependent helicase WRN\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"117686899 ATP-dependent DNA helicase RecQ-like\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"117688812 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"117689866 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"117690753 ATP-dependent helicase wrn-1-like\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"117693110 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136270166 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136270697 ATP-dependent DNA helicase RecQ-like\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136273822 ATP-dependent DNA helicase RecQ-like\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136273944 probable ATP-dependent DNA helicase RecS\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136274098 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136274906 probable ATP-dependent DNA helicase RecS\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136275520 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136275701 probable ATP-dependent DNA helicase RecS\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136276317 ATP-dependent helicase wrn-1-like\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					},
					{
						"name":"136276396 uncharacterized protein\tK03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Other RNA degradosome components",
					"children":[
					{
						"name":"105334471 enolase\tK01689 ENO1_2_3; enolase 1\/2\/3 [EC:4.2.1.11]"
					},
					{
						"name":"105328565 polyribonucleotide nucleotidyltransferase 1, mitochondrial\tK00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]"
					},
					{
						"name":"105330927 ATP-dependent 6-phosphofructokinase isoform X1\tK00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]"
					}
					]
				}
				]
			},
			{
				"name":"Other RNA degradation factors",
				"children":[
				{
					"name":"Chaperones",
					"children":[
					{
						"name":"105347255 stress-70 protein, mitochondrial isoform X1\tK04043 dnaK; molecular chaperone DnaK"
					},
					{
						"name":"105348623 heat shock protein 60A\tK04077 groEL; chaperonin GroEL [EC:5.6.1.7]"
					}
					]
				},
				{
					"name":"Others"
				},
				{
					"name":"Bacterial Small RNA Regulators"
				}
				]
			}
			]
		},
		{
			"name":"Archeal mRNA degradation factors",
			"children":[
			{
				"name":"Exosome components",
				"children":[
				{
					"name":"Core exosome",
					"children":[
					{
						"name":"105321222 exosome complex component RRP4\tK03679 RRP4; exosome complex component RRP4"
					},
					{
						"name":"105328567 exosome complex component CSL4\tK07573 CSL4; exosome complex component CSL4"
					}
					]
				},
				{
					"name":"Cofactors",
					"children":[
					{
						"name":"105331037 exosome complex component RRP41\tK11600 RRP41; exosome complex component RRP41"
					},
					{
						"name":"105329651 exosome complex component RRP42\tK12589 RRP42; exosome complex component RRP42"
					}
					]
				},
				{
					"name":"Others"
				}
				]
			}
			]
		}
		]
	}
	]
}