{
	"name":"cuo03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"CUROG_04165 adaB; Methylated-DNA--protein-cysteine methyltransferase, inducible\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"CUROG_02815 phrB; Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"CUROG_06240 ung; Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"CUROG_09720 pdg; Ultraviolet N-glycosylase\/AP lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex"
					},
					{
						"name":"DNA polymerase epsilon complex"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex"
					},
					{
						"name":"Cul4-DDB2 complex"
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex"
					},
					{
						"name":"Cul4-CSA complex"
					},
					{
						"name":"Other TCR factor"
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"CUROG_02265 Type III restriction enzyme, res subunit\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Other NER factors"
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"MutL homologs"
				},
				{
					"name":"DNA polymerase delta complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other MMR factors"
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex"
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex"
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins"
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins"
				},
				{
					"name":"RecQ family DNA helicases"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Protein phosphatase 4"
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex"
				},
				{
					"name":"Other HR factors"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex"
				},
				{
					"name":"DNA Ligase 4 complex"
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors"
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors"
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group"
			},
			{
				"name":"Other TLS factors"
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex"
			},
			{
				"name":"HRAD17(Rad24)-RFC complex"
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex"
			},
			{
				"name":"FPC (fork protection complex)"
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex"
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"CUROG_06550 hypothetical protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"CUROG_05535 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"CUROG_04165 adaB; Methylated-DNA--protein-cysteine methyltransferase, inducible\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"CUROG_02815 phrB; Deoxyribodipyrimidine photo-lyase\tK01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"CUROG_06240 ung; Uracil-DNA glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"CUROG_00715 tag; DNA-3-methyladenine glycosylase 1\tK01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]"
					},
					{
						"name":"CUROG_02005 nei1; Endonuclease 8 1\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"CUROG_06195 fpg1; Formamidopyrimidine-DNA glycosylase 1\tK10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]"
					},
					{
						"name":"CUROG_02460 nei2; Endonuclease 8 1\tK05522 nei; endonuclease VIII [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"CUROG_09720 pdg; Ultraviolet N-glycosylase\/AP lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"CUROG_01615 xthA; Exodeoxyribonuclease III\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]"
					},
					{
						"name":"CUROG_08345 exoA; Exodeoxyribonuclease\tK01142 xthA; exodeoxyribonuclease III [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"CUROG_06630 ligA2; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"DNA polymerase I",
					"children":[
					{
						"name":"CUROG_04195 polA; DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"CUROG_04285 uvrA1; UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"CUROG_05625 uvrA2; UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"CUROG_04260 uvrB; UvrABC system protein B\tK03702 uvrB; excinuclease ABC subunit B"
					},
					{
						"name":"CUROG_05110 uvrC; UvrABC system protein C\tK03703 uvrC; excinuclease ABC subunit C"
					},
					{
						"name":"CUROG_07835 uvrD1; ATP-dependent DNA helicase UvrD1\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_07900 uvrD2; ATP-dependent DNA helicase UvrD2\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_07910 uvrD3; ATP-dependent DNA helicase UvrD1\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_04195 polA; DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_06630 ligA2; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)",
						"children":[
						{
							"name":"CUROG_08945 rpoB; DNA-directed RNA polymerase subunit beta\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]"
						},
						{
							"name":"CUROG_08940 rpoC; DNA-directed RNA polymerase subunit beta'\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]"
						},
						{
							"name":"CUROG_08675 rpoA; DNA-directed RNA polymerase subunit alpha\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]"
						},
						{
							"name":"CUROG_05175 rpoZ; DNA-directed RNA polymerase subunit omega\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]"
						}
						]
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases",
					"children":[
					{
						"name":"CUROG_07190 xseA; Exodeoxyribonuclease 7 large subunit\tK03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]"
					},
					{
						"name":"CUROG_07195 exodeoxyribonuclease VII small subunit\tK03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]"
					}
					]
				},
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"CUROG_03960 dnaE1; DNA polymerase III subunit alpha\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_00010 dnaN; DNA polymerase III subunit beta\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_03105 hypothetical protein\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_09625 dnaX1; DNA polymerase III subunit tau\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_04010 ligA1; DNA ligase\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_06410 polC2; DNA polymerase III PolC-type\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_06590 polC3; DNA polymerase III PolC-type\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_09885 DNA polymerase III subunit epsilon\tK02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]"
					},
					{
						"name":"CUROG_09920 dnaX2; DNA polymerase III subunit tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"CUROG_06630 ligA2; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"CUROG_07835 uvrD1; ATP-dependent DNA helicase UvrD1\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_07900 uvrD2; ATP-dependent DNA helicase UvrD2\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_07910 uvrD3; ATP-dependent DNA helicase UvrD1\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_02885 ssb1; Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
					},
					{
						"name":"CUROG_10340 ssb2; Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins",
					"children":[
					{
						"name":"CUROG_05735 recombinase A\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"CUROG_05365 ruvA; Holliday junction ATP-dependent DNA helicase RuvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"CUROG_05360 ruvB; Holliday junction ATP-dependent DNA helicase RuvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_05370 ruvC; Crossover junction endodeoxyribonuclease RuvC\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					},
					{
						"name":"CUROG_05160 priA2; Primosomal protein N'\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"RecFOR pathway proteins",
					"children":[
					{
						"name":"CUROG_05735 recombinase A\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"CUROG_01865 hypothetical protein\tK04485 radA; DNA repair protein RadA\/Sms"
					},
					{
						"name":"CUROG_00015 recF; DNA replication and repair protein RecF\tK03629 recF; DNA replication and repair protein RecF"
					},
					{
						"name":"CUROG_06230 recG; ATP-dependent DNA helicase RecG\tK03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_03300 DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
					},
					{
						"name":"CUROG_09910 recR; Recombination protein RecR\tK06187 recR; recombination protein RecR"
					},
					{
						"name":"CUROG_04420 recN; DNA repair protein RecN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
					},
					{
						"name":"CUROG_05365 ruvA; Holliday junction ATP-dependent DNA helicase RuvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"CUROG_05360 ruvB; Holliday junction ATP-dependent DNA helicase RuvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"CUROG_05370 ruvC; Crossover junction endodeoxyribonuclease RuvC\tK01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]"
					}
					]
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"CUROG_00055 gyrA; DNA gyrase subunit A\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
						},
						{
							"name":"CUROG_00035 gyrB; DNA gyrase subunit B\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
						},
						{
							"name":"CUROG_09640 topA; DNA topoisomerase 1\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						}
						]
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway",
						"children":[
						{
							"name":"CUROG_03300 DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
						},
						{
							"name":"CUROG_09910 recR; Recombination protein RecR\tK06187 recR; recombination protein RecR"
						},
						{
							"name":"CUROG_06630 ligA2; DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
						}
						]
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"CUROG_04285 uvrA1; UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"CUROG_05625 uvrA2; UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"CUROG_04260 uvrB; UvrABC system protein B\tK03702 uvrB; excinuclease ABC subunit B"
						}
						]
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"CUROG_03905 dinB; DNA polymerase IV\tK02346 dinB; DNA polymerase IV [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"CUROG_05735 recombinase A\tK03553 recA; recombination protein RecA"
				},
				{
					"name":"CUROG_05655 lexA; LexA repressor\tK01356 lexA; repressor LexA [EC:3.4.21.88]"
				},
				{
					"name":"CUROG_04420 recN; DNA repair protein RecN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
				},
				{
					"name":"CUROG_08485 DNA polymerase IV\tK14161 imuB; protein ImuB"
				},
				{
					"name":"CUROG_08450 dnaE2; Error-prone DNA polymerase\tK14162 dnaE2; error-prone DNA polymerase [EC:2.7.7.7]"
				},
				{
					"name":"CUROG_02885 ssb1; Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"CUROG_10340 ssb2; Single-stranded DNA-binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"CUROG_05730 recX; Regulatory protein RecX\tK03565 recX; regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases",
				"children":[
				{
					"name":"CUROG_02730 dinG; putative ATP-dependent helicase DinG\tK03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]"
				},
				{
					"name":"CUROG_02455 putative ATP-dependent helicase Lhr\tK03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"CUROG_06550 hypothetical protein\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"CUROG_06265 mutT1; Putative mutator protein MutT4\tK23258 mutT1; 8-oxo-(d)GTP phosphatase [EC:3.6.1.69]"
				},
				{
					"name":"CUROG_04450 nudF; ADP-ribose pyrophosphatase\tK01554 K01554; 8-oxo-dGDP phosphatase [EC:3.6.1.58]"
				},
				{
					"name":"CUROG_05535 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"CUROG_02680 nrdE2; Ribonucleoside-diphosphate reductase subunit alpha 2\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]"
				},
				{
					"name":"CUROG_02690 nrdF2; Ribonucleoside-diphosphate reductase subunit beta nrdF2\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}