{
	"name":"ddi03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"DDB_G0275095 mgmt; 6-O-methylguanine-DNA methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				},
				{
					"name":"DDB_G0290389 ascc3; DEAD\/DEAH box helicase\tK18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"DDB_G0277877 uglA; uracil glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"DDB_G0270764 MYH; A\/G-specific adenine DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"DDB_G0292618 ogg1; 8-oxoguanine DNA-glycosylase\tK03660 OGG1; N-glycosylase\/DNA lyase [EC:3.2.2.- 4.2.99.18]"
					},
					{
						"name":"DDB_G0277247 apnB; hypothetical protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"DDB_G0277701 apeA; hypothetical protein\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					},
					{
						"name":"DDB_G0279923 apnA; apurinic\/apyrimidinic endonuclease\tK10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]"
					}
					]
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex",
						"children":[
						{
							"name":"DDB_G0285381 polD1; DNA polymerase delta catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"DDB_G0281641 polD2; DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
						}
						]
					},
					{
						"name":"DNA polymerase epsilon complex",
						"children":[
						{
							"name":"DDB_G0283189 hypothetical protein\tK02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]"
						},
						{
							"name":"DDB_G0278367 hypothetical protein\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
						},
						{
							"name":"DDB_G0272222 ybl1; DNA polymerase epsilon p17 subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
						},
						{
							"name":"DDB_G0272740 hypothetical protein\tK03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]"
						}
						]
					},
					{
						"name":"DDB_G0287607 pcna; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"DDB_G0284987 repG; flap structure specific endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"DDB_G0274493 lig1; DNA ligase I\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				},
				{
					"name":"Short Patch-BER factors",
					"children":[
					{
						"name":"DDB_G0284713 polB; DNA polymerase X family protein\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"DDB_G0284739 gxcFF; IQ calmodulin-binding domain-containing protein\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"DDB_G0275653 xrcc1; BRCT domain-containing protein\tK10803 XRCC1; DNA-repair protein XRCC1"
					}
					]
				},
				{
					"name":"Other BER factors",
					"children":[
					{
						"name":"DDB_G0272839 histidine triad family protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"DDB_G0281229 PNKP; SAP DNA-binding domain-containing protein\tK08073 PNKP; bifunctional polynucleotide phosphatase\/kinase [EC:3.1.3.32 2.7.1.78]"
					},
					{
						"name":"DDB_G0278741 adprt1A; NAD+ ADP-ribosyltransferase\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex",
						"children":[
						{
							"name":"DDB_G0292296 rad4; DNA repair protein Rad4 family protein\tK10838 XPC; xeroderma pigmentosum group C-complementing protein"
						},
						{
							"name":"DDB_G0286357 rcbA; repC-binding protein A\tK10839 RAD23; UV excision repair protein RAD23"
						}
						]
					},
					{
						"name":"Cul4-DDB2 complex",
						"children":[
						{
							"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"DDB_G0292794 culD; hypothetical protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"DDB_G0286013 repE; UV-damaged DNA binding protein1\tK10610 DDB1; DNA damage-binding protein 1"
						}
						]
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex",
						"children":[
						{
							"name":"DDB_G0279193 rpb1; RNA polymerase II core subunit\tK03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]"
						},
						{
							"name":"DDB_G0288257 rpb2; RNA polymerase II core subunit\tK03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]"
						},
						{
							"name":"DDB_G0292244 rpb3; RNA polymerase II core subunit\tK03011 RPB3; DNA-directed RNA polymerase II subunit RPB3"
						},
						{
							"name":"DDB_G0282739 rpb4; DNA-directed RNA polymerase II subunit 4\tK03012 RPB4; DNA-directed RNA polymerase II subunit RPB4"
						},
						{
							"name":"DDB_G0291636 rpb5; RNA polymerase I core subunit\tK03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1"
						},
						{
							"name":"DDB_G0291037 rpb6; RNA polymerase I core subunit\tK03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2"
						},
						{
							"name":"DDB_G0284891 rpb7; DNA-directed RNA polymerase II subunit 7\tK03015 RPB7; DNA-directed RNA polymerase II subunit RPB7"
						},
						{
							"name":"DDB_G0278039 rpb8; RNA polymerase I core subunit\tK03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3"
						},
						{
							"name":"DDB_G0268306 rpb9; RNA polymerase II core subunit\tK03017 RPB9; DNA-directed RNA polymerase II subunit RPB9"
						},
						{
							"name":"DDB_G0272036 rpb10; RNA polymerase I core subunit\tK03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5"
						},
						{
							"name":"DDB_G0277677 rpb11; RNA polymerase II core subunit\tK03008 RPB11; DNA-directed RNA polymerase II subunit RPB11"
						},
						{
							"name":"DDB_G0283365 rpb12; RNA polymerase I core subunit\tK03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4"
						}
						]
					},
					{
						"name":"Cul4-CSA complex",
						"children":[
						{
							"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
						},
						{
							"name":"DDB_G0292794 culD; hypothetical protein\tK10609 CUL4; cullin 4"
						},
						{
							"name":"DDB_G0286013 repE; UV-damaged DNA binding protein1\tK10610 DDB1; DNA damage-binding protein 1"
						},
						{
							"name":"DDB_G0276481 ercc8; DNA excision repair protein 8\tK10570 ERCC8; DNA excision repair protein ERCC-8"
						}
						]
					},
					{
						"name":"Other TCR factor",
						"children":[
						{
							"name":"DDB_G0281441 ercc6; CHR group protein\tK10841 ERCC6; DNA excision repair protein ERCC-6"
						},
						{
							"name":"DDB_G0287203 elof1; elongation factor 1\tK25829 ELOF1; transcription elongation factor 1"
						}
						]
					}
					]
				},
				{
					"name":"TFIIH complex",
					"children":[
					{
						"name":"DDB_G0278729 repB; transcription factor IIH subunit\tK10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]"
					},
					{
						"name":"DDB_G0267414 repD; transcription factor IIH component\tK10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]"
					},
					{
						"name":"DDB_G0268014 gtf2h1; general transcription factor IIH component\tK03141 TFIIH1; transcription initiation factor TFIIH subunit 1"
					},
					{
						"name":"DDB_G0272362 gtf2h2; TFIIH subunit\tK03142 TFIIH2; transcription initiation factor TFIIH subunit 2"
					},
					{
						"name":"DDB_G0275517 gtf2h3; general transcription factor IIH, polypeptide 3\tK03143 TFIIH3; transcription initiation factor TFIIH subunit 3"
					},
					{
						"name":"DDB_G0293228 gtf2h4; TFIIH subunit\tK03144 TFIIH4; transcription initiation factor TFIIH subunit 4"
					},
					{
						"name":"DDB_G0269906 gtf2h5; transcription initiation factor IIH5\tK10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit"
					},
					{
						"name":"DDB_G0285417 cdk7; CDK family protein kinase\tK02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]"
					},
					{
						"name":"DDB_G0268668 cycH; hypothetical protein\tK06634 CCNH; cyclin H"
					},
					{
						"name":"DDB_G0289079 mnat1; CDK-activating kinase assembly factor MAT1\tK10842 MNAT1; CDK-activating kinase assembly factor MAT1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"DDB_G0289513 rfa1; OB fold-containing protein, nucleic acid binding\tK07466 RFA1; replication factor A1"
					}
					]
				},
				{
					"name":"Other NER factors",
					"children":[
					{
						"name":"DDB_G0267682 ercc1; DNA excision repair protein 1\tK10849 ERCC1; DNA excision repair protein ERCC-1"
					},
					{
						"name":"DDB_G0284419 ercc4; DNA excision repair protein 4\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
					},
					{
						"name":"DDB_G0274493 lig1; DNA ligase I\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					},
					{
						"name":"DDB_G0288217 mms19; hypothetical protein\tK15075 MET18; DNA repair\/transcription protein MET18\/MMS19"
					},
					{
						"name":"DDB_G0269728 ciao1; WD40 repeat-containing protein\tK24730 CIAO1; cytosolic iron-sulfur protein assembly protein CIAO1"
					},
					{
						"name":"DDB_G0283801 fam96B; DUF59 family protein\tK26403 CIAO2; cytosolic iron-sulfur assembly component 2"
					},
					{
						"name":"DDB_G0284903 culC; cullin C\tK03869 CUL3; cullin 3"
					},
					{
						"name":"DDB_G0284201 hypothetical protein\tK03872 ELOC; elongin-C"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"DDB_G0275809 msh2; DNA mismatch repair protein\tK08735 MSH2; DNA mismatch repair protein MSH2"
					},
					{
						"name":"DDB_G0281683 msh3; DNA mismatch repair protein\tK08736 MSH3; DNA mismatch repair protein MSH3"
					},
					{
						"name":"DDB_G0268614 msh6; DNA mismatch repair protein\tK08737 MSH6; DNA mismatch repair protein MSH6"
					}
					]
				},
				{
					"name":"MutL homologs",
					"children":[
					{
						"name":"DDB_G0287393 mlh1; MutL DNA mismatch repair protein\tK08734 MLH1; DNA mismatch repair protein MLH1"
					},
					{
						"name":"DDB_G0283981 pms1; MutL DNA mismatch repair protein\tK10858 PMS2; DNA mismatch repair protein PMS2"
					},
					{
						"name":"DDB_G0283883 mlh3; MutL DNA mismatch repair protein\tK08739 MLH3; DNA mismatch repair protein MLH3"
					}
					]
				},
				{
					"name":"DNA polymerase delta complex",
					"children":[
					{
						"name":"DDB_G0285381 polD1; DNA polymerase delta catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
					},
					{
						"name":"DDB_G0281641 polD2; DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"DDB_G0289513 rfa1; OB fold-containing protein, nucleic acid binding\tK07466 RFA1; replication factor A1"
					}
					]
				},
				{
					"name":"RFC (replication factor C)",
					"children":[
					{
						"name":"DDB_G0285961 rfc1; replication factor C subunit\tK10754 RFC1; replication factor C subunit 1"
					},
					{
						"name":"DDB_G0286027 rfc4; replication factor C subunit\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"DDB_G0291868 rfc2; replication factor C subunit\tK10755 RFC2_4; replication factor C subunit 2\/4"
					},
					{
						"name":"DDB_G0282235 rfc5; replication factor C subunit\tK10756 RFC3_5; replication factor C subunit 3\/5"
					},
					{
						"name":"DDB_G0293702 rfc3; replication factor C subunit\tK10756 RFC3_5; replication factor C subunit 3\/5"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"DDB_G0287607 pcna; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
					},
					{
						"name":"DDB_G0291570 exo1; 5'3'-exonuclease N- and I-domain-containing protein\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
					},
					{
						"name":"DDB_G0274493 lig1; DNA ligase I\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex",
					"children":[
					{
						"name":"DDB_G0293546 mre11; 3'-5' exonuclease\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"DDB_G0292786 rad50; DNA recombination\/repair protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex",
					"children":[
					{
						"name":"DDB_G0286621 BRIP1; DEAD\/DEAH box helicase\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					},
					{
						"name":"DDB_G0279167 cut5; BRCT domain-containing protein\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
					}
					]
				},
				{
					"name":"BRCA1-C complex",
					"children":[
					{
						"name":"DDB_G0293546 mre11; 3'-5' exonuclease\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"DDB_G0292786 rad50; DNA recombination\/repair protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"BRCA complex",
					"children":[
					{
						"name":"DDB_G0293414 hypothetical protein\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"DDB_G0273139 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"DDB_G0273611 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
					}
					]
				},
				{
					"name":"RecA family proteins",
					"children":[
					{
						"name":"DDB_G0273139 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"DDB_G0273611 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"DDB_G0284507 hypothetical protein\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"DDB_G0285287 hypothetical protein\tK10871 RAD51L3; RAD51-like protein 3"
					},
					{
						"name":"DDB_G0290297 xrcc2; AAA ATPase domain-containing protein\tK10879 XRCC2; DNA-repair protein XRCC2"
					}
					]
				},
				{
					"name":"Rad52 family proteins",
					"children":[
					{
						"name":"DDB_G0269406 hypothetical protein\tK10873 RAD52; DNA repair and recombination protein RAD52"
					},
					{
						"name":"DDB_G0287069 hypothetical protein\tK10873 RAD52; DNA repair and recombination protein RAD52"
					}
					]
				},
				{
					"name":"Rad54 family proteins",
					"children":[
					{
						"name":"DDB_G0282997 rad54; CHR group protein\tK10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]"
					},
					{
						"name":"DDB_G0285117 rad54b; CHR group protein\tK10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]"
					}
					]
				},
				{
					"name":"RecQ family DNA helicases",
					"children":[
					{
						"name":"DDB_G0272384 ATP-dependent DNA helicase RecQ family protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"DDB_G0292130 blm; ATP-dependent DNA helicase RecQ family protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"DDB_G0272384 ATP-dependent DNA helicase RecQ family protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"DDB_G0292130 blm; ATP-dependent DNA helicase RecQ family protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"DDB_G0275257 top3; DNA topoisomerase III\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"DDB_G0284153 hypothetical protein\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"RPA (replication factor A)",
					"children":[
					{
						"name":"DDB_G0289513 rfa1; OB fold-containing protein, nucleic acid binding\tK07466 RFA1; replication factor A1"
					}
					]
				},
				{
					"name":"Protein phosphatase 4",
					"children":[
					{
						"name":"DDB_G0272116 ppp4C; protein phosphatase 4 catalytic subunit\tK15423 PPP4C; serine\/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"DDB_G0281483 ppr1; protein phosphatase 4 regulatory subunit 1\tK15424 PPP4R1; serine\/threonine-protein phosphatase 4 regulatory subunit 1"
					},
					{
						"name":"DDB_G0272668 ppr2; protein phosphatase 4 regulatory subunit 2\tK15425 PPP4R2; serine\/threonine-protein phosphatase 4 regulatory subunit 2"
					},
					{
						"name":"DDB_G0289067 smkA; EVH1 domain-containing protein\tK17491 SMEK; protein phosphatase 4 regulatory subunit 3"
					}
					]
				},
				{
					"name":"AP-5 complex",
					"children":[
					{
						"name":"DDB_G0282421 hypothetical protein\tK19022 AP5B1; AP-5 complex subunit beta-1"
					},
					{
						"name":"DDB_G0285113 hypothetical protein\tK19023 AP5M1; AP-5 complex subunit mu-1"
					},
					{
						"name":"DDB_G0270428 hypothetical protein\tK19024 AP5S1; AP-5 complex subunit sigma-1"
					},
					{
						"name":"DDB_G0293988 hypothetical protein\tK19025 AP5Z1; AP-5 complex subunit zeta-1"
					}
					]
				},
				{
					"name":"SMC5-SMC6 complex",
					"children":[
					{
						"name":"DDB_G0290919 smc5; AAA ATPase domain-containing protein\tK22803 SMC5; structural maintenance of chromosomes protein 5"
					},
					{
						"name":"DDB_G0288993 smc6; AAA ATPase domain-containing protein\tK22804 SMC6; structural maintenance of chromosomes protein 6"
					},
					{
						"name":"DDB_G0279231 hypothetical protein\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
					},
					{
						"name":"DDB_G0289341 hypothetical protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
					},
					{
						"name":"DDB_G0281991 hypothetical protein\tK22825 NSMCE4; non-structural maintenance of chromosomes element 4"
					}
					]
				},
				{
					"name":"Other HR factors",
					"children":[
					{
						"name":"DDB_G0278079 exdl2A; 3'-5' exonuclease domain-containing protein\tK20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]"
					},
					{
						"name":"DDB_G0276519 mus81; crossover junction endonuclease\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"DDB_G0284175 hypothetical protein\tK08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]"
					},
					{
						"name":"DDB_G0287633 DSS1\/SEM1 family protein\tK10881 SHFM1; 26 proteasome complex subunit DSS1"
					},
					{
						"name":"DDB_G0268328 hypothetical protein\tK19026 SPG11; spatacsin"
					},
					{
						"name":"DDB_G0276689 hypothetical protein\tK19027 ZFYVE26; zinc finger FYVE domain-containing protein 26"
					},
					{
						"name":"DDB_G0283075 NuA4 histone H4 acetyltransferase complex subunit\tK11339 MORF4L1; mortality factor 4-like protein 1"
					},
					{
						"name":"DDB_G0272484 HD phosphohydrolase domain-containing protein\tK22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]"
					},
					{
						"name":"DDB_G0268334 hypothetical protein\tK22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]"
					},
					{
						"name":"DDB_G0268092 hypothetical protein\tK25770 ZSWIM7; zinc finger SWIM domain-containing protein 7"
					},
					{
						"name":"DDB_G0283009 mcm8; MCM family protein\tK10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]"
					},
					{
						"name":"DDB_G0286035 mcm9; MCM family protein\tK10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex",
					"children":[
					{
						"name":"DDB_G0286069 ku70; ATP-dependent DNA helicase\tK10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1"
					},
					{
						"name":"DDB_G0286303 ku80; ATP-dependent DNA helicase\tK10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2"
					},
					{
						"name":"DDB_G0281167 dnapkcs; DNA-dependent protein kinase subunit\tK06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]"
					}
					]
				},
				{
					"name":"MRX complex",
					"children":[
					{
						"name":"DDB_G0293546 mre11; 3'-5' exonuclease\tK10865 MRE11; double-strand break repair protein MRE11"
					},
					{
						"name":"DDB_G0292786 rad50; DNA recombination\/repair protein\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
					}
					]
				},
				{
					"name":"DNA Ligase 4 complex",
					"children":[
					{
						"name":"DDB_G0292760 lig4; BRCT domain-containing protein\tK10777 LIG4; DNA ligase 4 [EC:6.5.1.1]"
					}
					]
				},
				{
					"name":"X-family DNA polymerases",
					"children":[
					{
						"name":"DDB_G0284713 polB; DNA polymerase X family protein\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					},
					{
						"name":"DDB_G0284739 gxcFF; IQ calmodulin-binding domain-containing protein\tK02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]"
					}
					]
				},
				{
					"name":"Other NHEJ factors",
					"children":[
					{
						"name":"DDB_G0272839 histidine triad family protein\tK10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]"
					},
					{
						"name":"DDB_G0277185 hypothetical protein\tK23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1"
					}
					]
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex",
					"children":[
					{
						"name":"DDB_G0292744 hypothetical protein\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
					},
					{
						"name":"DDB_G0274841 hypothetical protein\tK10896 FANCM; fanconi anemia group M protein"
					}
					]
				},
				{
					"name":"FA core complex binding factors",
					"children":[
					{
						"name":"DDB_G0291199 hypothetical protein\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
					}
					]
				},
				{
					"name":"Bloom's syndrome complex (BTR)",
					"children":[
					{
						"name":"DDB_G0272384 ATP-dependent DNA helicase RecQ family protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"DDB_G0292130 blm; ATP-dependent DNA helicase RecQ family protein\tK10901 BLM; bloom syndrome protein [EC:5.6.2.4]"
					},
					{
						"name":"DDB_G0275257 top3; DNA topoisomerase III\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
					},
					{
						"name":"DDB_G0284153 hypothetical protein\tK10990 RMI1; RecQ-mediated genome instability protein 1"
					}
					]
				},
				{
					"name":"FANCD2-I complex",
					"children":[
					{
						"name":"DDB_G0268216 hypothetical protein\tK10891 FANCD2; fanconi anemia group D2 protein"
					},
					{
						"name":"DDB_G0293476 hypothetical protein\tK10895 FANCI; fanconi anemia group I protein"
					}
					]
				},
				{
					"name":"Downstream FA components",
					"children":[
					{
						"name":"DDB_G0293414 hypothetical protein\tK08775 BRCA2; breast cancer 2 susceptibility protein"
					},
					{
						"name":"DDB_G0286621 BRIP1; DEAD\/DEAH box helicase\tK15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]"
					}
					]
				},
				{
					"name":"Other FA pathway factors",
					"children":[
					{
						"name":"DDB_G0267916 mtmr15; myotubularin related protein 15\tK15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]"
					},
					{
						"name":"DDB_G0273139 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"DDB_G0273611 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
					},
					{
						"name":"DDB_G0284507 hypothetical protein\tK10870 RAD51L2; RAD51-like protein 2"
					},
					{
						"name":"DDB_G0288215 hypothetical protein\tK11137 TELO2; telomere length regulation protein"
					},
					{
						"name":"DDB_G0277533 WD40 repeat-containing protein\tK15361 WDR48; WD repeat-containing protein 48"
					}
					]
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6",
					"children":[
					{
						"name":"DDB_G0272118 ppp6C; protein phosphatase 6 catalytic subunit\tK15498 PPP6C; serine\/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]"
					},
					{
						"name":"DDB_G0268044 hypothetical protein\tK15501 PPP6R3; serine\/threonine-protein phosphatase 6 regulatory subunit 3"
					}
					]
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others",
					"children":[
					{
						"name":"DDB_G0283495 hypothetical protein\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases",
				"children":[
				{
					"name":"DDB_G0287149 UMUC-like DNA-repair protein\tK03511 POLK; DNA polymerase kappa [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"B-family DNA polymerases",
				"children":[
				{
					"name":"DDB_G0271608 polZ; DNA polymerase zeta catalytic subunit\tK02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group",
				"children":[
				{
					"name":"DDB_G0275787 rad6; ubiquitin-conjugating enzyme E2\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
				},
				{
					"name":"DDB_G0292596 ube2v; hypothetical protein\tK10704 UBE2V; ubiquitin-conjugating enzyme E2 variant"
				},
				{
					"name":"DDB_G0277267 ube2n; hypothetical protein\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
				}
				]
			},
			{
				"name":"Other TLS factors",
				"children":[
				{
					"name":"DDB_G0287607 pcna; proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"DDB_G0288129 hypothetical protein\tK26957 GCNA; germ cell nuclear acidic protein"
				}
				]
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex",
				"children":[
				{
					"name":"DDB_G0274525 rad9; component of 9-1-1 complex\tK10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]"
				},
				{
					"name":"DDB_G0285353 hus1; checkpoint clamp complex protein\tK10903 HUS1; HUS1 checkpoint protein"
				},
				{
					"name":"DDB_G0269378 rad1; checkpoint clamp complex protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"HRAD17(Rad24)-RFC complex",
				"children":[
				{
					"name":"DDB_G0292504 rad17; hypothetical protein\tK06662 HRAD17; cell cycle checkpoint protein"
				},
				{
					"name":"DDB_G0286027 rfc4; replication factor C subunit\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"DDB_G0291868 rfc2; replication factor C subunit\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"DDB_G0282235 rfc5; replication factor C subunit\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"DDB_G0293702 rfc3; replication factor C subunit\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex",
				"children":[
				{
					"name":"DDB_G0269378 rad1; checkpoint clamp complex protein\tK02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]"
				}
				]
			},
			{
				"name":"FPC (fork protection complex)",
				"children":[
				{
					"name":"DDB_G0287103 timeless family protein\tK10997 TIMELESS; replication fork protection complex subunit TIMELESS\/Tof1\/Swi1"
				}
				]
			},
			{
				"name":"Triple T complex",
				"children":[
				{
					"name":"DDB_G0288215 hypothetical protein\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"DDB_G0278121 hypothetical protein\tK20403 TTI1; TELO2-interacting protein 1"
				}
				]
			},
			{
				"name":"BAG6-UBL4A-GET4 complex",
				"children":[
				{
					"name":"DDB_G0281815 DUF410 family protein\tK23387 GET4; golgi to ER traffic protein 4"
				}
				]
			},
			{
				"name":"SOSS complex",
				"children":[
				{
					"name":"DDB_G0268706 ints3; integrator complex subunit 3\tK13140 INTS3; integrator complex subunit 3 (SOSS complex subunit A)"
				},
				{
					"name":"DDB_G0279223 OB fold-containing protein, nucleic acid binding\tK28889 NABP; SOSS complex subunit B"
				}
				]
			},
			{
				"name":"Other check point factors",
				"children":[
				{
					"name":"DDB_G0291380 atr1; ATR subfamily protein kinase\tK06640 ATR; serine\/threonine-protein kinase ATR [EC:2.7.11.1]"
				},
				{
					"name":"DDB_G0281567 fhkC; FHA domain-containing protein\tK06641 CHEK2; serine\/threonine-protein kinase CHEK2 [EC:2.7.11.1]"
				},
				{
					"name":"DDB_G0269138 fttB; hypothetical protein\tK06630 YWHAE; 14-3-3 protein epsilon"
				},
				{
					"name":"DDB_G0277539 WEE1 family protein kinase\tK06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]"
				},
				{
					"name":"DDB_G0275241 nek3; NEK family protein kinase\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"DDB_G0289277 nek4; NEK family protein kinase\tK08857 NEK1_4_5; serine\/threonine-protein kinase Nek1\/4\/5 [EC:2.7.11.1]"
				},
				{
					"name":"DDB_G0284347 vps4; AAA ATPase domain-containing protein\tK12196 VPS4; vacuolar protein-sorting-associated protein 4"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases",
				"children":[
				{
					"name":"DDB_G0271272 DNA polymerase V family protein\tK02331 POL5; DNA polymerase phi [EC:2.7.7.7]"
				},
				{
					"name":"DDB_G0269072 hypothetical protein\tK22761 PRIMPOL; DNA-directed primase\/polymerase protein [EC:2.7.7.102 2.7.7.7]"
				},
				{
					"name":"DDB_G0276361 hypothetical protein\tK22761 PRIMPOL; DNA-directed primase\/polymerase protein [EC:2.7.7.102 2.7.7.7]"
				}
				]
			},
			{
				"name":"Nucleases",
				"children":[
				{
					"name":"DDB_G0277755 dclre1; DNA repair metallo-beta-lactamase domain-containing protein\tK15340 DCLRE1A; DNA cross-link repair 1A protein"
				},
				{
					"name":"DDB_G0273165 endonuclease V\tK21813 ENDOV; endonuclease V [EC:3.1.26.-]"
				}
				]
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex",
				"children":[
				{
					"name":"DDB_G0276803 prp19; WD40 repeat-containing protein\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0279311 cdc5l; myb domain-containing protein\tK12860 CDC5L; pre-mRNA-splicing factor CDC5\/CEF1"
				},
				{
					"name":"DDB_G0282763 spf27; spliceosome-associated protein\tK12861 BCAS2; pre-mRNA-splicing factor SPF27"
				},
				{
					"name":"DDB_G0279507 plrg1; WD40 repeat-containing protein\tK12862 PLRG1; pleiotropic regulator 1"
				}
				]
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"DDB_G0293374 dut; dUTP diphosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				},
				{
					"name":"DDB_G0284071 rnrA; ribonucleoside-diphosphate reductase\tK10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]"
				},
				{
					"name":"DDB_G0272616 rnrB-1; ribonucleoside-diphosphate reductase\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				},
				{
					"name":"DDB_G0274021 rnrB-2; ribonucleoside-diphosphate reductase\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				},
				{
					"name":"DDB_G0291764 ribonucleotide reductase-related\tK10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair",
				"children":[
				{
					"name":"DDB_G0275095 mgmt; 6-O-methylguanine-DNA methyltransferase\tK00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]"
				}
				]
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"DDB_G0277877 uglA; uracil glycosylase\tK03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"DDB_G0270764 MYH; A\/G-specific adenine DNA glycosylase\tK03575 mutY; A\/G-specific adenine glycosylase [EC:3.2.2.31]"
					},
					{
						"name":"DDB_G0271050 magA; DNA-3-methyladenine glycosylase I\tK01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]"
					},
					{
						"name":"DDB_G0277247 apnB; hypothetical protein\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"DNA polymerase I",
					"children":[
					{
						"name":"DDB_G0267464 polA; 3'-5' exonuclease domain-containing protein\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"DDB_G0267464 polA; 3'-5' exonuclease domain-containing protein\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)"
					},
					{
						"name":"TRCF (transcription-repair coupling factor)"
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"Molecular matchmaker"
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"DNA ligase"
				},
				{
					"name":"Other MMR factors"
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins"
				},
				{
					"name":"RecFOR pathway proteins"
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway"
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase"
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"DDB_G0293374 dut; dUTP diphosphatase\tK01520 dut; dUTP diphosphatase [EC:3.6.1.23]"
				}
				]
			},
			{
				"name":"Others"
			}
			]
		}
		]
	}
	]
}