{
	"name":"ddi04121",
	"children":[
	{
		"name":"Ubiquitins and ubiquitin-like proteins",
		"children":[
		{
			"name":"Ubiquitins",
			"children":[
			{
				"name":"DDB_G0269458 ubqJ; hypothetical protein\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"DDB_G0279721 ubqH; hypothetical protein\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"DDB_G0282295 ubqA; hypothetical protein\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"DDB_G0282369 ubqG; hypothetical protein\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"DDB_G0286907 ubqD; hypothetical protein\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"DDB_G0289449 ubqF; hypothetical protein\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"DDB_G0291928 ubqI; hypothetical protein\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"DDB_G0280755 ubqB; ubiquitin\/ribosomal protein L40 fusion protein\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"DDB_G0276765 ubqC; ubiquitin\/ribosomal protein S27a fusion protein\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			}
			]
		},
		{
			"name":"Ubiquitin-like proteins (UBLs)",
			"children":[
			{
				"name":"DDB_G0278711 nedd8; ubiquitin-like protein Nedd8\tK12158 NEDD8; ubiquitin-like protein Nedd8"
			},
			{
				"name":"DDB_G0273191 rps30-1; 40S ribosomal protein S30\tK02983 RP-S30e; small subunit ribosomal protein S30e"
			},
			{
				"name":"DDB_G0273743 rps30-2; 40S ribosomal protein S30\tK02983 RP-S30e; small subunit ribosomal protein S30e"
			},
			{
				"name":"DDB_G0286191 atg8; autophagy protein 8\tK08341 GABARAP; GABA(A) receptor-associated protein"
			},
			{
				"name":"DDB_G0290491 MAP1-LC3 domain-containing protein\tK08341 GABARAP; GABA(A) receptor-associated protein"
			},
			{
				"name":"DDB_G0282929 atg12; autophagy protein 12\tK08336 ATG12; ubiquitin-like protein ATG12"
			},
			{
				"name":"DDB_G0283737 hypothetical protein\tK12161 URM1; ubiquitin related modifier 1"
			},
			{
				"name":"DDB_G0295709 ufm1; ubiquitin-like Ufm1 family protein\tK12162 UFM1; ubiquitin-fold modifier 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-activating enzymes (E1)",
		"children":[
		{
			"name":"Ubiquitin activating enzyme",
			"children":[
			{
				"name":"DDB_G0270272 uae1; ubiquitin activating enzyme E1\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			}
			]
		},
		{
			"name":"UBL-activating enzymes",
			"children":[
			{
				"name":"DDB_G0279641 sae1; sumo-activating enzyme subunit 1\tK10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]"
			},
			{
				"name":"DDB_G0286919 uba2; sumo-activating enzyme subunit 2\tK10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]"
			},
			{
				"name":"DDB_G0283891 ube1c; NEDD8-activating enzyme E1 catalytic subunit\tK10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]"
			},
			{
				"name":"DDB_G0287965 nae1; NEDD8-activating enzyme E1 regulatory subunit\tK04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit"
			},
			{
				"name":"DDB_G0267980 mocs3; molybdenum cofactor synthesis 3\tK11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]"
			},
			{
				"name":"DDB_G0293306 uba5; E1-like enzyme family protein\tK12164 UBA5; ubiquitin-like modifier-activating enzyme 5"
			},
			{
				"name":"DDB_G0277047 hypothetical protein\tK10699 UBE1L2; ubiquitin-activating enzyme E1-like protein 2 [EC:6.2.1.45]"
			},
			{
				"name":"DDB_G0271096 atg7; E1-like enzyme family protein\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-conjugating enzymes (E2)",
		"children":[
		{
			"name":"Ubiquitin-conjugating enzymes",
			"children":[
			{
				"name":"DDB_G0275787 rad6; ubiquitin-conjugating enzyme E2\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0278775 ube2c; ubiquitin-conjugating enzyme E2\tK06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0290547 hypothetical protein\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0281833 hypothetical protein\tK20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0271726 hypothetical protein\tK10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0280347 ubiquitin-conjugating enzyme E2\tK04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0280091 hypothetical protein\tK10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0281369 hypothetical protein\tK10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0286511 hypothetical protein\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0294380 hypothetical protein\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0277267 ube2n; hypothetical protein\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0290629 hypothetical protein\tK10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]"
			},
			{
				"name":"DDB_G0284009 ubcC; ubiquitin-conjugating enzyme E2\tK02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0289021 ube2s; ubiquitin-conjugating enzyme E2 S\tK10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0291199 hypothetical protein\tK13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]"
			},
			{
				"name":"DDB_G0268938 ube2w; ubiquitin-conjugating enzyme E2W\tK10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]"
			},
			{
				"name":"DDB_G0274313 pex4; peroxin 4\tK10689 PEX4; peroxin-4 [EC:2.3.2.23]"
			}
			]
		},
		{
			"name":"UBL-conjugating enzymes",
			"children":[
			{
				"name":"DDB_G0287153 hypothetical protein\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"DDB_G0287693 ubc9; hypothetical protein\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"DDB_G0281725 ube2m; NEDD8-conjugating enzyme\tK10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]"
			},
			{
				"name":"DDB_G0277319 atg3; autophagy protein 3\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
			},
			{
				"name":"DDB_G0268840 atg10; autophagy protein 10\tK17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10"
			},
			{
				"name":"DDB_G0289037 ufc1; ubiquitin-like post-translational modifier\tK12165 UFC1; ufm1-conjugating enzyme 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin ligases (E3)",
		"children":[
		{
			"name":"HECT type E3",
			"children":[
			{
				"name":"DDB_G0290179 ube3a; ubiquitin-protein ligase E3A\tK10587 UBE3A; ubiquitin-protein ligase E3 A [EC:2.3.2.26]"
			},
			{
				"name":"DDB_G0291612 hypothetical protein\tK20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]"
			},
			{
				"name":"DDB_G0287221 armadillo repeat-containing protein\tK10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]"
			},
			{
				"name":"DDB_G0285063 hypothetical protein\tK10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]"
			},
			{
				"name":"HECT type E3 associated proteins"
			}
			]
		},
		{
			"name":"U-box type E3",
			"children":[
			{
				"name":"DDB_G0292264 nosA; U box domain-containing protein\tK10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]"
			},
			{
				"name":"DDB_G0284323 ppil2; Ubox domain-containing protein\tK10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]"
			},
			{
				"name":"DDB_G0276803 prp19; WD40 repeat-containing protein\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
			},
			{
				"name":"DDB_G0279003 hypothetical protein\tK10624 RBBP6; E3 ubiquitin-protein ligase RBBP6 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"Single Ring-finger type E3",
			"children":[
			{
				"name":"BRE1 proteins",
				"children":[
				{
					"name":"DDB_G0274241 bre1; RING zinc finger-containing protein\tK10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"CBL proteins"
			},
			{
				"name":"SINA (Seven in absentia) proteins"
			},
			{
				"name":"Ligand of Numb proteins"
			},
			{
				"name":"March proteins",
				"children":[
				{
					"name":"DDB_G0285705 RING zinc finger-containing protein\tK10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"MDM2\/MDM4 proteins"
			},
			{
				"name":"NFX1 proteins",
				"children":[
				{
					"name":"DDB_G0293590 NF-X1-type zinc finger-containing protein\tK12236 NFX1; transcriptional repressor NF-X1"
				}
				]
			},
			{
				"name":"Pellino proteins"
			},
			{
				"name":"Peripheral membrane proteins",
				"children":[
				{
					"name":"DDB_G0282693 pex10; RING zinc finger-containing protein\tK13346 PEX10; peroxin-10 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0285523 pex12; RING zinc finger-containing protein\tK13345 PEX12; peroxin-12"
				},
				{
					"name":"DDB_G0272234 pex2; RING zinc finger-containing protein\tK06664 PEX2; peroxin-2 [EC:2.3.2.27 2.3.2.36]"
				}
				]
			},
			{
				"name":"RBR proteins",
				"children":[
				{
					"name":"DDB_G0286961 rbrA; C3HC4-type zinc finger-containing protein\tK11968 ARIH1; ariadne-1 [EC:2.3.2.31]"
				},
				{
					"name":"DDB_G0270130 hypothetical protein\tK11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]"
				},
				{
					"name":"DDB_G0275171 hypothetical protein\tK11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"TRAF proteins",
				"children":[
				{
					"name":"DDB_G0268444 TRAF-type zinc finger-containing protein\tK09849 TRAF5; TNF receptor-associated factor 5"
				},
				{
					"name":"DDB_G0286735 hypothetical protein\tK10646 TRAF7; E3 ubiquitin-protein ligase TRAF7 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"TRIM\/RBCC proteins"
			},
			{
				"name":"UBR box proteins",
				"children":[
				{
					"name":"DDB_G0292128 hypothetical protein\tK10626 UBR2; E3 ubiquitin-protein ligase UBR2 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0288473 hypothetical protein\tK11978 UBR3; E3 ubiquitin-protein ligase UBR3 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0283893 hypothetical protein\tK10691 UBR4; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0292022 ubr7; ubiquitin protein ligase E3 component n-recognin 7\tK11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"ATL proteins"
			},
			{
				"name":"Other single Ring-finger type E3",
				"children":[
				{
					"name":"DDB_G0279345 amfr; hypothetical protein\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				},
				{
					"name":"DDB_G0270200 hypothetical protein\tK10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0269498 hypothetical protein\tK10639 CCNB1IP1; E3 ubiquitin-protein ligase CCNP1IP1 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0279263 hypothetical protein\tK10644 CHFR; E3 ubiquitin-protein ligase CHFR [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0275005 RING zinc finger-containing protein\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0292744 hypothetical protein\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0274875 rnf160; RING zinc finger-containing protein\tK22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0281657 hypothetical protein\tK15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0281595 hypothetical protein\tK10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0288453 hypothetical protein\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0285333 hypothetical protein\tK10666 RNF5_185; E3 ubiquitin-protein ligase RNF5\/185 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0280089 hypothetical protein\tK11982 RNF115_126; E3 ubiquitin-protein ligase RNF115\/126 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0278979 hypothetical protein\tK15698 RNF121_175; RING finger protein 121\/175"
				},
				{
					"name":"DDB_G0273451 AAA+ ATPase, core domain-containing protein\tK22754 RNF213; E3 ubiquitin-protein ligase RNF213 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0267718 hypothetical protein\tK28516 RNFT2; E3 ubiquitin-protein ligase RNFT2"
				},
				{
					"name":"DDB_G0281621 SART-1 family protein\tK11984 SART1; U4\/U6.U5 tri-snRNP-associated protein 1"
				},
				{
					"name":"DDB_G0287171 C3HC4-type zinc finger-containing protein\tK15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]"
				},
				{
					"name":"DDB_G0287847 hypothetical protein\tK10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0281183 RING zinc finger-containing protein\tK10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0275581 hypothetical protein\tK22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0278501 hypothetical protein\tK23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Atypical E3",
			"children":[
			{
				"name":"DDB_G0279231 hypothetical protein\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"UBL E3 ligases",
			"children":[
			{
				"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
			},
			{
				"name":"DDB_G0281183 RING zinc finger-containing protein\tK10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]"
			},
			{
				"name":"DDB_G0289341 hypothetical protein\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
			},
			{
				"name":"DDB_G0283667 hypothetical protein\tK22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]"
			},
			{
				"name":"DDB_G0290025 hypothetical protein\tK17822 DCUN1D1_2; DCN1-like protein 1\/2"
			},
			{
				"name":"DDB_G0284369 DUF298 family protein\tK17824 DCUN1D4_5; DCN1-like protein 4\/5"
			}
			]
		},
		{
			"name":"Multi subunit type E3",
			"children":[
			{
				"name":"SCF complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"DDB_G0267384 culB; cullin B\tK03347 CUL1; cullin 1"
					},
					{
						"name":"DDB_G0278991 culE; cullin E\tK03347 CUL1; cullin 1"
					},
					{
						"name":"DDB_G0291972 culA; cullin A\tK03347 CUL1; cullin 1"
					}
					]
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"DDB_G0269230 fpaA; cytosolic glycoprotein FP21\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"DDB_G0273251 fpaB-1; cytosolic glycoprotein FP21\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"DDB_G0273615 fpaB-2; cytosolic glycoprotein FP21\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (F-box)",
					"children":[
					{
						"name":"DDB_G0269442 hypothetical protein\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"DDB_G0286129 hypothetical protein\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"DDB_G0292834 WD40 repeat-containing protein\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"DDB_G0268536 hypothetical protein\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"DDB_G0282285 ApaG domain-containing protein\tK10290 FBXO3; F-box protein 3"
					}
					]
				}
				]
			},
			{
				"name":"Cul2 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"DDB_G0284201 hypothetical protein\tK03872 ELOC; elongin-C"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul3 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"DDB_G0284903 culC; cullin C\tK03869 CUL3; cullin 3"
					}
					]
				},
				{
					"name":"Adoptor and target recognizing subunit (BTB)",
					"children":[
					{
						"name":"DDB_G0291330 kctd9; BTB\/POZ domain-containing protein\tK21919 KCTD9; BTB\/POZ domain-containing protein KCTD9"
					}
					]
				}
				]
			},
			{
				"name":"Cul4 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"DDB_G0292794 culD; hypothetical protein\tK10609 CUL4; cullin 4"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"DDB_G0286013 repE; UV-damaged DNA binding protein1\tK10610 DDB1; DNA damage-binding protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (DCAF)",
					"children":[
					{
						"name":"DDB_G0276481 ercc8; DNA excision repair protein 8\tK10570 ERCC8; DNA excision repair protein ERCC-8"
					},
					{
						"name":"DDB_G0288453 hypothetical protein\tK10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]"
					},
					{
						"name":"DDB_G0288597 hypothetical protein\tK11799 DCAF4; DDB1- and CUL4-associated factor 4"
					},
					{
						"name":"DDB_G0269686 WD40 repeat-containing protein\tK11795 DCAF6; DDB1- and CUL4-associated factor 6"
					},
					{
						"name":"DDB_G0275925 wdr68; WD40 repeat-containing protein\tK11805 DCAF7; DDB1- and CUL4-associated factor 7"
					},
					{
						"name":"DDB_G0291832 wdr23; WD40 repeat-containing protein\tK11801 DCAF11; DDB1- and CUL4-associated factor 11"
					},
					{
						"name":"DDB_G0276815 hypothetical protein\tK11806 DCAF13; DDB1- and CUL4-associated factor 13"
					},
					{
						"name":"DDB_G0285837 BRWD group protein\tK11798 BRWD1_3; bromodomain and WD repeat domain containing protein 1\/3"
					},
					{
						"name":"DDB_G0288313 hypothetical protein\tK22382 WDR26; WD repeat-containing protein 26"
					},
					{
						"name":"DDB_G0283495 hypothetical protein\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			},
			{
				"name":"Cul5 complex",
				"children":[
				{
					"name":"Ring finger protein"
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"DDB_G0284201 hypothetical protein\tK03872 ELOC; elongin-C"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul7 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"DDB_G0269230 fpaA; cytosolic glycoprotein FP21\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"DDB_G0273251 fpaB-1; cytosolic glycoprotein FP21\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"DDB_G0273615 fpaB-2; cytosolic glycoprotein FP21\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul8 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein"
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul9 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0287629 rbx1; hypothetical protein\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				}
				]
			},
			{
				"name":"APC\/C",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"DDB_G0286909 anapc11; anaphase promoting complex subunit 11\tK03358 APC11; anaphase-promoting complex subunit 11"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"DDB_G0276377 anapc2; anaphase promoting complex subunit 2\tK03349 APC2; anaphase-promoting complex subunit 2"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"DDB_G0285601 cdc20; WD40 repeat-containing protein\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"DDB_G0287259 cdh1; WD40 repeat-containing protein\tK03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex"
					}
					]
				},
				{
					"name":"Other subunits",
					"children":[
					{
						"name":"DDB_G0285349 anapc1; anaphase promoting complex subunit 1\tK03348 APC1; anaphase-promoting complex subunit 1"
					},
					{
						"name":"DDB_G0288223 anapc3; anaphase promoting complex subunit 3\tK03350 APC3; anaphase-promoting complex subunit 3"
					},
					{
						"name":"DDB_G0285223 anapc4; anaphase promoting complex subunit 4\tK03351 APC4; anaphase-promoting complex subunit 4"
					},
					{
						"name":"DDB_G0280113 anapc5; anaphase promoting complex subunit 5\tK03352 APC5; anaphase-promoting complex subunit 5"
					},
					{
						"name":"DDB_G0286233 anapc6; TPR repeat-containing protein\tK03353 APC6; anaphase-promoting complex subunit 6"
					},
					{
						"name":"DDB_G0292470 anapc7; anaphase promoting complex subunit 7\tK03354 APC7; anaphase-promoting complex subunit 7"
					},
					{
						"name":"DDB_G0272775 anapc8; anaphase promoting complex subunit 8\tK03355 APC8; anaphase-promoting complex subunit 8"
					},
					{
						"name":"DDB_G0268992 anapc10; anaphase promoting complex subunit 10\tK03357 APC10; anaphase-promoting complex subunit 10"
					},
					{
						"name":"DDB_G0293230 cdc26; subunit of anaphase promoting complex\tK03359 APC12; anaphase-promoting complex subunit 12"
					},
					{
						"name":"DDB_G0278049 hypothetical protein\tK12456 APC13; anaphase-promoting complex subunit 13"
					}
					]
				}
				]
			},
			{
				"name":"BRCC complex",
				"children":[
				{
					"name":"DDB_G0293414 hypothetical protein\tK08775 BRCA2; breast cancer 2 susceptibility protein"
				},
				{
					"name":"DDB_G0273139 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
				},
				{
					"name":"DDB_G0273611 hypothetical protein\tK04482 RAD51; DNA repair protein RAD51"
				}
				]
			},
			{
				"name":"KPC complex"
			},
			{
				"name":"LUBAC complex"
			},
			{
				"name":"CTLH complex",
				"children":[
				{
					"name":"DDB_G0274829 hypothetical protein\tK23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]"
				},
				{
					"name":"DDB_G0292780 hypothetical protein\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				},
				{
					"name":"DDB_G0270626 armc8; armadillo repeat-containing protein\tK23336 ARMC8; armadillo repeat-containing protein 8"
				},
				{
					"name":"DDB_G0284463 maea; CT11-RanBPM domain-containing protein\tK18624 MAEA; macrophage erythroblast attacher"
				},
				{
					"name":"DDB_G0284149 hypothetical protein\tK23335 GID4; glucose-induced degradation protein 4"
				},
				{
					"name":"DDB_G0279265 UPF0559 protein\tK23338 GID8; glucose-induced degradation protein 8"
				},
				{
					"name":"DDB_G0288313 hypothetical protein\tK22382 WDR26; WD repeat-containing protein 26"
				}
				]
			},
			{
				"name":"ERAD complex",
				"children":[
				{
					"name":"DDB_G0279345 amfr; hypothetical protein\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				}
				]
			},
			{
				"name":"LMBR1L-GP78-UBAC2 complex",
				"children":[
				{
					"name":"DDB_G0279345 amfr; hypothetical protein\tK10636 AMFR; E3 ubiquitin-protein ligase AMFR [EC:2.3.2.36]"
				}
				]
			},
			{
				"name":"STUB1-CHIC2  complex"
			},
			{
				"name":"SLX5-SLX8 complex"
			},
			{
				"name":"Multi subunit type E3 associated proteins",
				"children":[
				{
					"name":"DDB_G0274167 cand1; HEAT repeat-containing protein\tK17263 CAND1; cullin-associated NEDD8-dissociated protein 1"
				},
				{
					"name":"DDB_G0292074 commd1; COMM domain-containing protein 1\tK22557 COMMD1; COMM domain containing 1"
				},
				{
					"name":"DDB_G0284879 commd2; COMM domain-containing protein 2\tK22558 COMMD2; COMM domain containing 2"
				},
				{
					"name":"DDB_G0283795 commd3; COMM domain-containing protein 3\tK22559 COMMD3; COMM domain containing 3"
				},
				{
					"name":"DDB_G0277089 commd4; COMM domain-containing protein 4\tK22560 COMMD4; COMM domain containing 4"
				},
				{
					"name":"DDB_G0274791 commd5; COMM domain-containing protein 5\tK22561 COMMD5; COMM domain containing 5"
				},
				{
					"name":"DDB_G0286077 commd6; COMM domain-containing protein 6\tK22562 COMMD6; COMM domain containing 6"
				},
				{
					"name":"DDB_G0275055 commd7; COMM domain-containing protein 7\tK22563 COMMD7; COMM domain containing 7"
				},
				{
					"name":"DDB_G0292688 commd8; COMM domain-containing protein 8\tK22564 COMMD8; COMM domain containing 8"
				},
				{
					"name":"DDB_G0275249 commd10; COMM domain-containing protein 10\tK22566 COMMD10; COMM domain containing 10"
				},
				{
					"name":"DDB_G0285813 hypothetical protein\tK23343 CCDC22; coiled-coil domain-containing protein 22"
				},
				{
					"name":"DDB_G0269994 hypothetical protein\tK23344 DDRGK1; DDRGK domain-containing protein 1"
				},
				{
					"name":"DDB_G0269608 hypothetical protein\tK23345 GLMN; glomulin"
				},
				{
					"name":"DDB_G0270358 UAS domain-containing protein\tK24350 UBXN7; UBX domain-containing protein 7"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Deubiquitinating enzyme (DUB)",
		"children":[
		{
			"name":"Ubiquitin-specific proteases (UBPs)",
			"children":[
			{
				"name":"UCH",
				"children":[
				{
					"name":"DDB_G0282007 uch1; peptidase C12 family protein\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0285527 uch2; peptidase C12 family protein\tK05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"UBP\/USP",
				"children":[
				{
					"name":"DDB_G0284381 peptidase C19 family protein\tK11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4\/11 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0293770 peptidase C19 family protein\tK11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4\/11 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0291239 ubpA; UBP-type zinc finger-containing protein\tK11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5\/13 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0276443 usp7; peptidase C19 family protein\tK11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0275021 ubpB; deubiquinating enzyme\tK11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0290453 usp12; peptidase C19 family protein\tK11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12\/46 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0271264 usp14; peptidase C19 family protein\tK11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0271798 UBP-type zinc finger-containing protein\tK11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22\/27\/51 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0275415 peptidase C19 family protein\tK11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0271348 peptidase C19 family protein\tK11854 USP35_38; ubiquitin carboxyl-terminal hydrolase 35\/38 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0274827 peptidase C19 family protein\tK11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36\/42 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0289611 usp40; peptidase C19 family protein\tK11869 USP40; ubiquitin carboxyl-terminal hydrolase 40 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"OTU",
				"children":[
				{
					"name":"DDB_G0267906 OTU domain containin protein\tK13717 OTUD3; OTU domain-containing protein 3 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0285907 OTU domain containin protein\tK12655 OTUD5; OTU domain-containing protein 5 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0279375 OTU domain containin protein\tK18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MJD",
				"children":[
				{
					"name":"DDB_G0269646 hypothetical protein\tK15235 JOSD; josephin [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MINDY",
				"children":[
				{
					"name":"DDB_G0269770 fam63A; DUF544 family protein\tK01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1\/2 [EC:3.4.19.12]"
				},
				{
					"name":"DDB_G0281445 fam63B; DUF544 family protein\tK01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1\/2 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"JAMM",
				"children":[
				{
					"name":"DDB_G0272566 psmD14; 26S proteasome non-ATPase regulatory subunit 14\tK03030 PSMD14; 26S proteasome regulatory subunit N11"
				},
				{
					"name":"DDB_G0284037 DG1039; MPN\/PAD-1 domain-containing protein\tK11866 STAMBP; STAM-binding protein [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"PPPDE",
				"children":[
				{
					"name":"DDB_G0282041 hypothetical protein\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"ZUFSP"
			},
			{
				"name":"BRISC complex"
			}
			]
		},
		{
			"name":"UBL-specific proteases (ULPs)",
			"children":[
			{
				"name":"DDB_G0292290 hypothetical protein\tK08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]"
			},
			{
				"name":"DDB_G0289557 hypothetical protein\tK08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]"
			},
			{
				"name":"DDB_G0293508 hypothetical protein\tK08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]"
			},
			{
				"name":"DDB_G0278795 senp8; sentrin-specific protease 8\tK08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]"
			},
			{
				"name":"DDB_G0282007 uch1; peptidase C12 family protein\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
			},
			{
				"name":"DDB_G0292886 hypothetical protein\tK22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]"
			},
			{
				"name":"COP9 signalosome (CSN) complex",
				"children":[
				{
					"name":"DDB_G0283587 CSN1; COP9 signalosome complex subunit 1\tK12175 GPS1; COP9 signalosome complex subunit 1"
				},
				{
					"name":"DDB_G0289361 CSN2; COP9 signalosome complex subunit 2\tK12176 COPS2; COP9 signalosome complex subunit 2"
				},
				{
					"name":"DDB_G0291848 CSN3; COP9 signalosome complex subunit 3\tK12177 COPS3; COP9 signalosome complex subunit 3"
				},
				{
					"name":"DDB_G0293844 CSN4; COP9 signalosome complex subunit 4\tK12178 COPS4; COP9 signalosome complex subunit 4"
				},
				{
					"name":"DDB_G0284597 CSN5; COP9 signalosome complex subunit 5\tK09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]"
				},
				{
					"name":"DDB_G0293180 CSN6; COP9 signalosome complex subunit 6\tK12179 COPS6; COP9 signalosome complex subunit 6"
				},
				{
					"name":"DDB_G0271282 CSN7; COP9 signalosome complex subunit 7\tK12180 COPS7; COP9 signalosome complex subunit 7"
				},
				{
					"name":"DDB_G0275471 CSN8; COP9 signalosome complex subunit 8\tK12181 COPS8; COP9 signalosome complex subunit 8"
				}
				]
			}
			]
		}
		]
	}
	]
}