{
	"name":"dfr03032",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"pre-RC (pre-replication complex)",
				"children":[
				{
					"name":"124492680 origin recognition complex subunit 1\tK02603 ORC1; origin recognition complex subunit 1"
				},
				{
					"name":"124494298 Orc2; origin recognition complex subunit 2\tK02604 ORC2; origin recognition complex subunit 2"
				},
				{
					"name":"124491037 uncharacterized protein LOC124491037\tK02605 ORC3; origin recognition complex subunit 3"
				},
				{
					"name":"124493572 Orc4; origin recognition complex subunit 4 isoform X2\tK02606 ORC4; origin recognition complex subunit 4"
				},
				{
					"name":"124498645 origin recognition complex subunit 5\tK02607 ORC5; origin recognition complex subunit 5"
				},
				{
					"name":"124494527 dup; LOW QUALITY PROTEIN: chromatin licensing and DNA replication factor double parked\tK10727 CDT1; chromatin licensing and DNA replication factor 1"
				},
				{
					"name":"124496588 cell division control protein 6 homolog\tK02213 CDC6; cell division control protein 6"
				},
				{
					"name":"124494070 Mcm2; DNA replication licensing factor Mcm2\tK02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]"
				},
				{
					"name":"124490574 Mcm3; minichromosome maintenance 3\tK02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]"
				},
				{
					"name":"124498482 DNA replication licensing factor mcm5-A\tK02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]"
				},
				{
					"name":"124495435 Mcm6; minichromosome maintenance 6\tK02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]"
				},
				{
					"name":"124492828 Mcm7; minichromosome maintenance 7\tK02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]"
				}
				]
			},
			{
				"name":"CDK (cyclin dependent kinase)",
				"children":[
				{
					"name":"124494333 G2\/mitotic-specific cyclin-A-like isoform X2\tK06627 CCNA; cyclin-A"
				},
				{
					"name":"124492462 G1\/S-specific cyclin-E1\tK06626 CCNE; G1\/S-specific cyclin-E1"
				}
				]
			},
			{
				"name":"DDK (Dbf-4 dependent kinase)",
				"children":[
				{
					"name":"124492583 cell division cycle 7-related protein kinase\tK02214 CDC7; cell division control protein 7 [EC:2.7.11.1]"
				}
				]
			},
			{
				"name":"GINS complex",
				"children":[
				{
					"name":"124494775 DNA replication complex GINS protein PSF1\tK10732 GINS1; GINS complex subunit 1"
				},
				{
					"name":"124495928 Psf2; DNA replication complex GINS protein PSF2-like protein\tK10733 GINS2; GINS complex subunit 2"
				},
				{
					"name":"124492784 Psf3; DNA replication complex GINS protein Psf3\tK10734 GINS3; GINS complex subunit 3"
				},
				{
					"name":"124492742 Sld5; DNA replication complex GINS protein Sld5\tK10735 GINS4; GINS complex subunit 4"
				}
				]
			},
			{
				"name":"Other initiation factors",
				"children":[
				{
					"name":"124491449 uncharacterized protein LOC124491449\tK10728 TOPBP1; topoisomerase (DNA) II binding protein 1"
				},
				{
					"name":"124499002 RecQ4; recQ4 helicase\tK10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]"
				},
				{
					"name":"124492130 Cdc45; cell division cycle protein 45\tK06628 CDC45; cell division control protein 45"
				},
				{
					"name":"124494789 protein MCM10 homolog\tK10736 MCM10; minichromosome maintenance protein 10"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"DNA polymerase alpha \/ primase complex",
				"children":[
				{
					"name":"124489909 PolA1; DNA polymerase alpha catalytic subunit isoform X2\tK02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]"
				},
				{
					"name":"124491827 PolA2; DNA polymerase alpha subunit B\tK02321 POLA2; DNA polymerase alpha subunit B"
				},
				{
					"name":"124497026 Prim1; DNA primase small subunit\tK02684 PRI1; DNA primase small subunit [EC:2.7.7.102]"
				},
				{
					"name":"124493397 Prim2; DNA primase subunit 2\tK02685 PRI2; DNA primase large subunit"
				}
				]
			},
			{
				"name":"DNA polymerase epsilon complex",
				"children":[
				{
					"name":"124500038 PolE2; DNA polymerase epsilon subunit 2\tK02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]"
				},
				{
					"name":"124493497 DNA polymerase epsilon subunit 3\tK02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]"
				}
				]
			},
			{
				"name":"DNA polymerase delta complex",
				"children":[
				{
					"name":"124490598 PolD1; DNA polymerase delta 1, catalytic subunit\tK02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]"
				},
				{
					"name":"124495537 PolD2; DNA polymerase delta subunit 2\tK02328 POLD2; DNA polymerase delta subunit 2"
				}
				]
			},
			{
				"name":"DNA polymerase gamma complex (mitochondrial)",
				"children":[
				{
					"name":"124499490 PolG1; DNA polymerase gamma, catalytic subunit tam\tK02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]"
				},
				{
					"name":"124496209 PolG2; DNA polymerase subunit gamma-2, mitochondrial\tK02333 POLG2; DNA polymerase gamma 2"
				}
				]
			},
			{
				"name":"RPA (replication protein A)",
				"children":[
				{
					"name":"124499323 replication protein A 70 kDa DNA-binding subunit\tK07466 RFA1; replication factor A1"
				},
				{
					"name":"124490393 replication protein A 32 kDa subunit\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"124500046 replication protein A 32 kDa subunit-B isoform X1\tK10739 RFA2; replication factor A2"
				},
				{
					"name":"142597576 replication protein A 32 kDa subunit-like\tK10739 RFA2; replication factor A2"
				}
				]
			},
			{
				"name":"RFC (replication factor C)",
				"children":[
				{
					"name":"124498362 Gnf1; germ line transcription factor 1\tK10754 RFC1; replication factor C subunit 1"
				},
				{
					"name":"124494091 LOW QUALITY PROTEIN: replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124496994 RfC4; replication factor C subunit RfC4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124494246 RfC3; replication factor C subunit RfC3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"124499806 RfC38; replication factor C subunit RfC38\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"RNase H",
				"children":[
				{
					"name":"124497590 rnh1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"124499452 ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
				},
				{
					"name":"124490813 ribonuclease H2 subunit A\tK10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]"
				},
				{
					"name":"124493159 ribonuclease H2 subunit B\tK10744 RNASEH2B; ribonuclease H2 subunit B"
				}
				]
			},
			{
				"name":"Other elongation factors",
				"children":[
				{
					"name":"124497215 proliferating cell nuclear antigen\tK04802 PCNA; proliferating cell nuclear antigen"
				},
				{
					"name":"124496545 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase\/nuclease DNA2-like\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
				},
				{
					"name":"124491295 Fen1; flap structure-specific endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
				},
				{
					"name":"124500034 tos; exonuclease tos\tK10746 EXO1; exonuclease 1 [EC:3.1.-.-]"
				},
				{
					"name":"124496173 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"DNA methylation enzymes",
				"children":[
				{
					"name":"124498664 DNA (cytosine-5)-methyltransferase 1 isoform X2\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			},
			{
				"name":"Prevention of re-replication factors",
				"children":[
				{
					"name":"124497910 CycB; cyclin B\tK21770 CCNB2; G2\/mitotic-specific cyclin-B2"
				},
				{
					"name":"124498166 CycB3; cyclin B3\tK21771 CCNB3; G2\/mitotic-specific cyclin-B3"
				},
				{
					"name":"124496701 Cdk1; cyclin-dependent kinase 1\tK02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]"
				}
				]
			},
			{
				"name":"Telomere proteins",
				"children":[
				{
					"name":"Shelterin complex",
					"children":[
					{
						"name":"124493146 uncharacterized protein LOC124493146\tK11109 POT1; protection of telomeres protein 1"
					}
					]
				},
				{
					"name":"TERB1-TERB2-MAJIN complex"
				},
				{
					"name":"CST complex (animals)"
				},
				{
					"name":"CST complex (yeast)"
				},
				{
					"name":"RIF proteins"
				},
				{
					"name":"SIR proteins"
				}
				]
			},
			{
				"name":"Telomerase complex (animals)",
				"children":[
				{
					"name":"124499290 telomerase-binding protein EST1A\tK11124 SMG6; protein SMG6 [EC:3.1.-.-]"
				},
				{
					"name":"124494213 uncharacterized protein LOC124494213\tK11125 SMG5; protein SMG5"
				},
				{
					"name":"124492687 telomerase reverse transcriptase-like\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Dyskerin complex",
					"children":[
					{
						"name":"124495265 H\/ACA ribonucleoprotein complex subunit 1\tK11128 GAR1; H\/ACA ribonucleoprotein complex subunit 1"
					},
					{
						"name":"124493124 NHP2; NHP2 ribonucleoprotein\tK11129 NHP2; H\/ACA ribonucleoprotein complex subunit 2"
					},
					{
						"name":"124493144 Nop10; nop10 ribonucleoprotein\tK11130 NOP10; H\/ACA ribonucleoprotein complex subunit 3"
					},
					{
						"name":"124494702 Nop60B; dyskerin pseudouridine synthase 1 Nop60B\tK11131 DKC1; H\/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]"
					}
					]
				}
				]
			},
			{
				"name":"Telomerase complex (fungi)",
				"children":[
				{
					"name":"124492687 telomerase reverse transcriptase-like\tK11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]"
				},
				{
					"name":"Sm core complex",
					"children":[
					{
						"name":"124491544 SmB; small ribonucleoprotein particle protein SmB\tK11086 SNRPB; small nuclear ribonucleoprotein B and B'"
					},
					{
						"name":"124494393 SmD1; small ribonucleoprotein particle protein SmD1\tK11087 SNRPD1; small nuclear ribonucleoprotein D1"
					},
					{
						"name":"124493203 SmD2; small ribonucleoprotein particle protein SmD2\tK11096 SNRPD2; small nuclear ribonucleoprotein D2"
					},
					{
						"name":"124497274 SmD3; small ribonucleoprotein particle protein SmD3\tK11088 SNRPD3; small nuclear ribonucleoprotein D3"
					},
					{
						"name":"124490782 SmF; small ribonucleoprotein particle protein SmF\tK11098 SNRPF; small nuclear ribonucleoprotein F"
					},
					{
						"name":"124496258 small nuclear ribonucleoprotein G\tK11099 SNRPG; small nuclear ribonucleoprotein G"
					}
					]
				}
				]
			},
			{
				"name":"ELG1-RFC complex",
				"children":[
				{
					"name":"124494091 LOW QUALITY PROTEIN: replication factor C subunit 4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124496994 RfC4; replication factor C subunit RfC4\tK10755 RFC2_4; replication factor C subunit 2\/4"
				},
				{
					"name":"124494246 RfC3; replication factor C subunit RfC3\tK10756 RFC3_5; replication factor C subunit 3\/5"
				},
				{
					"name":"124499806 RfC38; replication factor C subunit RfC38\tK10756 RFC3_5; replication factor C subunit 3\/5"
				}
				]
			},
			{
				"name":"MRN complex",
				"children":[
				{
					"name":"124494941 double-strand break repair protein MRE11\tK10865 MRE11; double-strand break repair protein MRE11"
				},
				{
					"name":"124499634 rad50; DNA repair protein rad50\tK10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]"
				}
				]
			},
			{
				"name":"Other termination factors",
				"children":[
				{
					"name":"124494132 mei-9; DNA repair endonuclease XPF mei-9\tK10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]"
				},
				{
					"name":"124490269 Parp1; poly-(ADP-ribose) polymerase\tK24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]"
				},
				{
					"name":"124497023 Tnks; tankyrase\tK10799 TNKS; tankyrase [EC:2.4.2.30]"
				},
				{
					"name":"124495665 PIN2\/TERF1-interacting telomerase inhibitor 1\tK11135 PINX1; Pin2-interacting protein X1"
				},
				{
					"name":"124497298 Rtel1; LOW QUALITY PROTEIN: regulator of telomere elongation helicase 1\tK11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]"
				},
				{
					"name":"124493140 telomere length regulation protein TEL2 homolog isoform X1\tK11137 TELO2; telomere length regulation protein"
				},
				{
					"name":"124493111 uncharacterized protein LOC124493111\tK01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]"
				},
				{
					"name":"124492535 ATP-dependent DNA helicase PIF1 isoform X1\tK15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]"
				},
				{
					"name":"124495858 Pur-alpha; purine-rich binding protein-alpha isoform X3\tK21772 PURA; transcriptional activator protein Pur-alpha"
				},
				{
					"name":"124499079 splicing regulator SDE2 isoform X1\tK25059 SDE2; replication stress response regulator SDE2"
				},
				{
					"name":"124499534 replication termination factor 2\tK25186 RTF2; replication termination factor 2"
				}
				]
			}
			]
		},
		{
			"name":"DNA Topoisomerases",
			"children":[
			{
				"name":"124496942 DNA topoisomerase 2-alpha\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"124499553 DNA topoisomerase 2-alpha-like isoform X1\tK03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]"
			},
			{
				"name":"124496543 Top3alpha; topoisomerase 3-alpha isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			},
			{
				"name":"124497614 Top3beta; DNA topoisomerase 3-beta isoform X1\tK03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]"
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"DNA Replication Initiation Factors",
			"children":[
			{
				"name":"Initiation factors (bacterial)",
				"children":[
				{
					"name":"124490975 single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"124490986 single-stranded DNA-binding protein, mitochondrial\tK03111 ssb; single-strand DNA-binding protein"
				}
				]
			},
			{
				"name":"Initiation factors (archaeal)"
			}
			]
		},
		{
			"name":"DNA Replication Elongation Factors",
			"children":[
			{
				"name":"Elongation factors (bacterial)",
				"children":[
				{
					"name":"DNA polymerase III holoenzyme"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"124497590 rnh1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"124499452 ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"Other elongation factors"
				}
				]
			},
			{
				"name":"Elongation factors (archaeal)",
				"children":[
				{
					"name":"B-family DNA polymerases"
				},
				{
					"name":"D-family DNA polymerases"
				},
				{
					"name":"RNase H",
					"children":[
					{
						"name":"124497590 rnh1; ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					},
					{
						"name":"124499452 ribonuclease H1\tK03469 rnhA; ribonuclease HI [EC:3.1.26.4]"
					}
					]
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other elongation factors",
					"children":[
					{
						"name":"124496545 LOW QUALITY PROTEIN: DNA replication ATP-dependent helicase\/nuclease DNA2-like\tK10742 DNA2; DNA replication ATP-dependent helicase\/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]"
					},
					{
						"name":"124491295 Fen1; flap structure-specific endonuclease 1\tK04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]"
					},
					{
						"name":"124496173 DNA ligase 1\tK10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DNA Replication Termination Factors",
			"children":[
			{
				"name":"Terminus site-binding protein"
			},
			{
				"name":"DNA methylation enzymes"
			},
			{
				"name":"Prevention of re-replication factors"
			}
			]
		},
		{
			"name":"DNA Topoisomerases"
		}
		]
	}
	]
}