{
	"name":"dfs02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"HGD76_00850 cas1d; type I-D CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"HGD76_00855 cas2; CRISPR-associated endonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"HGD76_00795 cas3; type I-D CRISPR-associated helicase Cas3'\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"HGD76_00845 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"HGD76_00840 cas6; CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"HGD76_00845 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"HGD76_00845 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"HGD76_00830 cas5d; type I-D CRISPR-associated protein Cas5\/Csc1\tK19120 csc1; CRISPR-associated protein Csc1"
				},
				{
					"name":"HGD76_00825 cas7d; type I-D CRISPR-associated protein Cas7\/Csc2\tK19121 csc2; CRISPR-associated protein Csc2"
				},
				{
					"name":"HGD76_00815 cas10d; type I-D CRISPR-associated protein Cas10d\/Csc3\tK19122 csc3; CRISPR-associated protein Csc3"
				},
				{
					"name":"HGD76_00845 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"HGD76_00840 cas6; CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"HGD76_00845 cas4; CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"HGD76_16940 DEAD\/DEAH box helicase family protein\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"HGD76_02150 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"HGD76_08715 hypothetical protein\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"HGD76_16950 restriction endonuclease subunit S\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"HGD76_15330 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"HGD76_16945 SAM-dependent DNA methyltransferase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"HGD76_21945 N-6 DNA methylase\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"HGD76_04775 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"HGD76_10530 DNA adenine methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"HGD76_16240 site-specific DNA-methyltransferase\tK07319 yhdJ; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
				},
				{
					"name":"HGD76_02210 dcm; DNA (cytosine-5-)-methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_03225 dcm; DNA (cytosine-5-)-methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_03235 dcm; DNA (cytosine-5-)-methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_04310 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_06800 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_09955 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_11990 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_12030 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_12245 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"HGD76_21475 DNA cytosine methyltransferase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system"
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"HGD76_14590 HNH endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"HGD76_19785 AAA domain-containing protein\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"HGD76_22175 AAA domain-containing protein\tK07452 mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]"
			},
			{
				"name":"HGD76_22180 restriction endonuclease\tK19147 mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"HGD76_00130 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_02165 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_05115 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_05585 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_08560 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_10225 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_12855 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_18615 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_19680 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_22355 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_24615 type II toxin-antitoxin system PemK\/MazF family toxin\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_05590 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"HGD76_08555 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"HGD76_24610 CopG family transcriptional regulator\tK26989 mazE9; antitoxin MazE9"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF",
				"children":[
				{
					"name":"HGD76_22630 type II toxin-antitoxin system YhaV family toxin\tK19155 yhaV; toxin YhaV [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_23520 hypothetical protein\tK19156 prlF; antitoxin PrlF"
				}
				]
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"HGD76_02230 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"HGD76_09555 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"HGD76_12875 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"HGD76_15590 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"HGD76_21280 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"HGD76_21425 type II toxin-antitoxin system RelE\/ParE family toxin\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"HGD76_21275 type II toxin-antitoxin system Phd\/YefM family antitoxin\tK28297 relB_F; antitoxin RelB\/F"
				},
				{
					"name":"HGD76_21420 type II toxin-antitoxin system Phd\/YefM family antitoxin\tK28297 relB_F; antitoxin RelB\/F"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"HGD76_00320 type II toxin-antitoxin system YafQ family toxin\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_18360 type II toxin-antitoxin system mRNA interferase toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"HGD76_01880 Txe\/YoeB family addiction module toxin\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_15285 Txe\/YoeB family addiction module toxin\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_01875 type II toxin-antitoxin system prevent-host-death family antitoxin\tK19159 yefM; antitoxin YefM"
				},
				{
					"name":"HGD76_09855 type II toxin-antitoxin system Phd\/YefM family antitoxin\tK19159 yefM; antitoxin YefM"
				},
				{
					"name":"HGD76_15290 prevent-host-death protein\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"HGD76_19580 type II toxin-antitoxin system HicB family antitoxin\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD",
				"children":[
				{
					"name":"HGD76_12045 type II toxin-antitoxin system RelE\/ParE family toxin\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"HGD76_18220 type II toxin-antitoxin system RelE\/ParE family toxin\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"HGD76_21575 type II toxin-antitoxin system RelE\/ParE family toxin\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"HGD76_23640 type II toxin-antitoxin system RelE\/ParE family toxin\tK19092 parE1_3_4; toxin ParE1\/3\/4"
				},
				{
					"name":"HGD76_08175 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"HGD76_12050 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"HGD76_12130 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"HGD76_18225 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"HGD76_21215 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				},
				{
					"name":"HGD76_23635 type II toxin-antitoxin system ParD family antitoxin\tK07746 parD1_3_4; antitoxin ParD1\/3\/4"
				}
				]
			},
			{
				"name":"Doc-Phd"
			},
			{
				"name":"HigB-HigA",
				"children":[
				{
					"name":"HGD76_14055 type II toxin-antitoxin system HigB family toxin\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_17040 type II toxin-antitoxin system HigB family toxin\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_21140 type II toxin-antitoxin system HigB family toxin\tK19166 higB; mRNA interferase HigB [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_08035 type II toxin-antitoxin system RelE\/ParE family toxin\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"HGD76_12115 Killer protein\tK07334 higB-1; toxin HigB-1"
				},
				{
					"name":"HGD76_02240 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_02350 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_03320 ImmA\/IrrE family metallo-endopeptidase\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_14060 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_17035 transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_19345 hypothetical protein\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_19515 transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_21135 transcriptional regulator\tK18831 higA; HTH-type transcriptional regulator \/ antitoxin HigA"
				},
				{
					"name":"HGD76_08030 HigA family addiction module antidote protein\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"HGD76_12020 HigA family addiction module antidote protein\tK21498 higA-1; antitoxin HigA-1"
				},
				{
					"name":"HGD76_12120 HigA family addiction module antidote protein\tK21498 higA-1; antitoxin HigA-1"
				}
				]
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB",
				"children":[
				{
					"name":"HGD76_17015 type II toxin-antitoxin system VapC family toxin\tK18828 mvpA; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_17010 AbrB\/MazE\/SpoVT family DNA-binding domain-containing protein\tK18829 mvpT; antitoxin VapB"
				},
				{
					"name":"HGD76_17160 hypothetical protein\tK28280 vapB22; antitoxin VapB22"
				},
				{
					"name":"HGD76_11945 PIN domain-containing protein\tK28282 vapC26; ribonuclease VapC26 [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_18880 PIN domain-containing protein\tK28282 vapC26; ribonuclease VapC26 [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_01125 type II toxin-antitoxin system VapC family toxin\tK19686 vapC28S; ribonuclease VapC28\/30\/34\/36\/42 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA",
				"children":[
				{
					"name":"HGD76_16115 type II toxin-antitoxin system VapC family toxin\tK07062 fitB; toxin FitB [EC:3.1.-.-]"
				},
				{
					"name":"HGD76_16110 plasmid stability protein\tK21495 fitA; antitoxin FitA"
				}
				]
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"HGD76_17395 ftsZ; cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"HGD76_06905 rod shape-determining protein\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"HGD76_05410 glutamate--tRNA ligase\tK01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"HGD76_00810 DUF86 domain-containing protein\tK28186 hepT; HepT family RNase toxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"HGD76_02085 nifS; cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"HGD76_08275 IscS subfamily cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"HGD76_09465 cysteine desulfurase\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"HGD76_13190 dndC; DNA phosphorothioation system sulfurtransferase DndC\tK19170 dndC; DNA sulfur modification protein DndC"
			},
			{
				"name":"HGD76_13185 dndD; DNA sulfur modification protein DndD\tK19171 dndD; DNA sulfur modification protein DndD"
			},
			{
				"name":"HGD76_13220 AAA family ATPase\tK19171 dndD; DNA sulfur modification protein DndD"
			},
			{
				"name":"HGD76_13170 dndE; DNA sulfur modification protein DndE\tK19172 dndE; DNA sulfur modification protein DndE"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}