{
	"name":"dgi02048",
	"children":[
	{
		"name":"CRISPR-Cas system",
		"children":[
		{
			"name":"Universal Cas proteins",
			"children":[
			{
				"name":"Desgi_0548 CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Desgi_0811 CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Desgi_4163 CRISPR-associated endonuclease Cas1\tK15342 cas1; CRISP-associated protein Cas1"
			},
			{
				"name":"Desgi_0549 CRISPR-associated endoribonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Desgi_0812 CRISPR-associated endoribonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			},
			{
				"name":"Desgi_4162 CRISPR-associated endoribonuclease Cas2\tK09951 cas2; CRISPR-associated protein Cas2"
			}
			]
		},
		{
			"name":"Type I CRISPR-Cas system",
			"children":[
			{
				"name":"Type I signiture cas proteins",
				"children":[
				{
					"name":"Desgi_0546 CRISPR-associated helicase Cas3\/CRISPR-associated endonuclease Cas3-HD\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"Desgi_0809 CRISPR-associated helicase Cas3\/CRISPR-associated endonuclease Cas3-HD\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				},
				{
					"name":"Desgi_4168 CRISPR-associated helicase Cas3\/CRISPR-associated endonuclease Cas3-HD\tK07012 cas3; CRISPR-associated endonuclease\/helicase Cas3 [EC:3.1.-.- 5.6.2.4]"
				}
				]
			},
			{
				"name":"Subtype I-A factors",
				"children":[
				{
					"name":"Desgi_0547 RecB family exonuclease\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0810 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_4164 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0542 CRISPR associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_0803 CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-B factors",
				"children":[
				{
					"name":"Desgi_0543 hypothetical protein\tK19114 csh1; CRISPR-associated protein Csh1"
				},
				{
					"name":"Desgi_0806 CRISPR-associated protein, TM1802 family\tK19114 csh1; CRISPR-associated protein Csh1"
				},
				{
					"name":"Desgi_0544 uncharacterized protein predicted to be involved in DNA repair\tK19115 csh2; CRISPR-associated protein Csh2"
				},
				{
					"name":"Desgi_0807 CRISPR-associated protein Cas7\/Csh2, subtype I-B\/HMARI\tK19115 csh2; CRISPR-associated protein Csh2"
				},
				{
					"name":"Desgi_0547 RecB family exonuclease\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0810 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_4164 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0545 CRISPR-associated protein Cas5, subtype I-B\/HMARI\tK19116 cas5h; CRISPR-associated protein Cas5h"
				},
				{
					"name":"Desgi_0808 CRISPR-associated protein Cas5, subtype I-B\/HMARI\tK19116 cas5h; CRISPR-associated protein Cas5h"
				}
				]
			},
			{
				"name":"Subtype I-C factors",
				"children":[
				{
					"name":"Desgi_4166 CRISPR-associated protein Cas8c\/Csd1, subtype I-C\/DVULG\tK19117 csd1; CRISPR-associated protein Csd1"
				},
				{
					"name":"Desgi_4165 CRISPR-associated protein Cas7\/Csd2, subtype I-C\/DVULG\tK19118 csd2; CRISPR-associated protein Csd2"
				},
				{
					"name":"Desgi_0547 RecB family exonuclease\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0810 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_4164 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_4167 CRISPR-associated protein Cas5, subtype I-C\/DVULG\tK19119 cas5d; CRISPR-associated protein Cas5d"
				}
				]
			},
			{
				"name":"Subtype I-D factors",
				"children":[
				{
					"name":"Desgi_0547 RecB family exonuclease\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0810 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_4164 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0542 CRISPR associated protein Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_0803 CRISPR-associated endoribonuclease Cas6\tK19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]"
				}
				]
			},
			{
				"name":"Subtype I-E factors"
			},
			{
				"name":"Subtype I-F factors"
			},
			{
				"name":"Subtype I-U factors"
			}
			]
		},
		{
			"name":"Type II CRISPR-Cas system",
			"children":[
			{
				"name":"Type II signiture cas proteins"
			},
			{
				"name":"Subtype II-A factors"
			},
			{
				"name":"Subtype II-B factors",
				"children":[
				{
					"name":"Desgi_0547 RecB family exonuclease\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_0810 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				},
				{
					"name":"Desgi_4164 CRISPR-associated protein Cas4\tK07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]"
				}
				]
			}
			]
		},
		{
			"name":"Type III CRISPR-Cas system",
			"children":[
			{
				"name":"Type III signiture cas proteins"
			},
			{
				"name":"Subtype III-A factors"
			},
			{
				"name":"Subtype III-B factors"
			},
			{
				"name":"Subtype III-U factors"
			}
			]
		}
		]
	},
	{
		"name":"Restriction and modification system (R-M system)",
		"children":[
		{
			"name":"Type I R-M system",
			"children":[
			{
				"name":"Desgi_0238 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Desgi_0260 helicase, type I site-specific restriction-modification system restriction subunit\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Desgi_1004 type I site-specific deoxyribonuclease, HsdR family\tK01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]"
			},
			{
				"name":"Desgi_0237 restriction endonuclease S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Desgi_0262 restriction endonuclease S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Desgi_1006 restriction endonuclease S subunit\tK01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]"
			},
			{
				"name":"Desgi_0236 type I restriction system adenine methylase HsdM\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Desgi_0261 type I restriction-modification system methyltransferase subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			},
			{
				"name":"Desgi_1008 type I restriction-modification system methyltransferase subunit\tK03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type II R-M system",
			"children":[
			{
				"name":"Restriction endonucleases"
			},
			{
				"name":"DNA methyltransferases",
				"children":[
				{
					"name":"Desgi_3483 site-specific DNA methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"Desgi_3579 site-specific DNA methylase\tK06223 dam; DNA adenine methylase [EC:2.1.1.72]"
				},
				{
					"name":"Desgi_3515 DNA-methyltransferase Dcm\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				},
				{
					"name":"Desgi_3556 site-specific DNA methylase\tK00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]"
				}
				]
			}
			]
		},
		{
			"name":"Type III R-M system",
			"children":[
			{
				"name":"Desgi_1483 restriction endonuclease\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"Desgi_4229 restriction endonuclease\tK01156 res; type III restriction enzyme [EC:3.1.21.5]"
			},
			{
				"name":"Desgi_1482 adenine specific DNA methylase Mod\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			},
			{
				"name":"Desgi_4230 adenine specific DNA methylase Mod\tK07316 mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]"
			}
			]
		},
		{
			"name":"Type IV R-M system",
			"children":[
			{
				"name":"Desgi_1730 putative restriction endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"Desgi_4393 restriction endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			},
			{
				"name":"Desgi_4519 restriction endonuclease\tK07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]"
			}
			]
		}
		]
	},
	{
		"name":"Toxin-antitoxin system (TA system)",
		"children":[
		{
			"name":"Type I TA system",
			"children":[
			{
				"name":"Hok-Sok"
			},
			{
				"name":"SymE-SymR"
			},
			{
				"name":"Ldr-Rdl"
			},
			{
				"name":"TisB-IstR"
			},
			{
				"name":"Ibs-Sib"
			},
			{
				"name":"ShoB-OhsC"
			},
			{
				"name":"RalR-RalA"
			}
			]
		},
		{
			"name":"Type II TA system",
			"children":[
			{
				"name":"MazF-MazE",
				"children":[
				{
					"name":"Desgi_0424 growth inhibitor\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_2358 growth inhibitor\tK07171 mazF; mRNA interferase MazF [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_0425 growth regulator\tK07172 mazE; antitoxin MazE"
				},
				{
					"name":"Desgi_2359 putative transcriptional regulator with CopG\/Arc\/MetJ DNA-binding domain and metal-binding domain\tK07723 ndoAI; CopG family transcriptional regulator \/ antitoxin EndoAI"
				}
				]
			},
			{
				"name":"ChpB-ChpS"
			},
			{
				"name":"YhaV-PrlF"
			},
			{
				"name":"RelE\/StbE-RelB\/StbD",
				"children":[
				{
					"name":"Desgi_0172 hypothetical protein\tK06218 relE; mRNA interferase RelE\/StbE"
				},
				{
					"name":"Desgi_3871 addiction module toxin, RelE\/StbE family\tK06218 relE; mRNA interferase RelE\/StbE"
				}
				]
			},
			{
				"name":"YafQ-dinJ",
				"children":[
				{
					"name":"Desgi_1210 addiction module toxin component, YafQ family\/addiction module toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_2266 addiction module toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_4394 addiction module toxin component, YafQ family\/addiction module toxin, RelE\/StbE family\tK19157 yafQ; mRNA interferase YafQ [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_0831 addiction module antitoxin, RelB\/DinJ family\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"Desgi_1209 addiction module antitoxin, RelB\/DinJ family\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"Desgi_2265 addiction module antitoxin, RelB\/DinJ family\tK07473 dinJ; DNA-damage-inducible protein J"
				},
				{
					"name":"Desgi_4395 addiction module antitoxin, RelB\/DinJ family\tK07473 dinJ; DNA-damage-inducible protein J"
				}
				]
			},
			{
				"name":"YoeB-YefM",
				"children":[
				{
					"name":"Desgi_4572 toxin-antitoxin system, toxin component, Txe\/YoeB family\tK19158 yoeB; toxin YoeB [EC:3.1.-.-]"
				},
				{
					"name":"Desgi_4573 antitoxin of toxin-antitoxin stability system\tK19159 yefM; antitoxin YefM"
				}
				]
			},
			{
				"name":"HipA-HipB"
			},
			{
				"name":"HicA-HicB",
				"children":[
				{
					"name":"Desgi_0872 hypothetical protein\tK18843 hicB; antitoxin HicB"
				}
				]
			},
			{
				"name":"YafO-YafN"
			},
			{
				"name":"PspC-PspB"
			},
			{
				"name":"CcdB-CcdA"
			},
			{
				"name":"ParE-ParD"
			},
			{
				"name":"Doc-Phd",
				"children":[
				{
					"name":"Desgi_3189 death-on-curing family protein\tK07341 doc; death on curing protein"
				}
				]
			},
			{
				"name":"HigB-HigA"
			},
			{
				"name":"MqsR-MqsA"
			},
			{
				"name":"VapC-VapB"
			},
			{
				"name":"PezT-PezA"
			},
			{
				"name":"YobL-YobK"
			},
			{
				"name":"YokI-YokJ"
			},
			{
				"name":"YqcG-YqcF"
			},
			{
				"name":"YxiD-YxxD"
			},
			{
				"name":"FitB-FitA"
			},
			{
				"name":"BC_0920-BC_0921"
			},
			{
				"name":"SpoIISA-SpoIISB"
			},
			{
				"name":"Tse6-Tsi6"
			},
			{
				"name":"Type II TA system related factors",
				"children":[
				{
					"name":"Desgi_3639 cell division protein FtsZ\tK03531 ftsZ; cell division protein FtsZ"
				},
				{
					"name":"Desgi_3304 cell shape determining protein, MreB\/Mrl family\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				},
				{
					"name":"Desgi_4581 cell shape determining protein, MreB\/Mrl family\tK03569 mreB; rod shape-determining protein MreB and related proteins"
				}
				]
			}
			]
		},
		{
			"name":"Type III TA system",
			"children":[
			{
				"name":"AbiQ system"
			}
			]
		},
		{
			"name":"Type IV TA system",
			"children":[
			{
				"name":"YeeV-YeeU"
			},
			{
				"name":"CptA-CptB"
			},
			{
				"name":"AbiEii-AbiEi"
			}
			]
		},
		{
			"name":"Type V TA system",
			"children":[
			{
				"name":"GhoT-GhoS"
			},
			{
				"name":"Other GhoT\/OrtT toxin family protein"
			}
			]
		},
		{
			"name":"Type VI TA system",
			"children":[
			{
				"name":"SocB-SocA"
			}
			]
		},
		{
			"name":"Type VII TA system",
			"children":[
			{
				"name":"Hha-TomB"
			},
			{
				"name":"TglT-TakA"
			},
			{
				"name":"HepT-MntA",
				"children":[
				{
					"name":"Desgi_0416 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"Desgi_2751 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"Desgi_3242 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"Desgi_4626 hypothetical protein\tK28186 hepT; HepT family RNase toxin"
				},
				{
					"name":"Desgi_0415 putative nucleotidyltransferase\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"Desgi_2249 hypothetical protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"Desgi_2752 nucleotidyltransferase family protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"Desgi_3243 hypothetical protein\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				},
				{
					"name":"Desgi_4625 putative nucleotidyltransferase\tK28187 mntA; MntA family adenylyltransferase antitoxin"
				}
				]
			}
			]
		},
		{
			"name":"Type VIII TA system",
			"children":[
			{
				"name":"SdsR-RyeA"
			}
			]
		}
		]
	},
	{
		"name":"DNA phosphothiolation system",
		"children":[
		{
			"name":"Sulfur modification proteins",
			"children":[
			{
				"name":"Desgi_2685 cysteine desulfurase NifS\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			},
			{
				"name":"Desgi_4304 cysteine desulfurase family protein\tK04487 iscS; cysteine desulfurase [EC:2.8.1.7]"
			}
			]
		},
		{
			"name":"DNA phosphorothioation-dependent restriction proteins"
		}
		]
	}
	]
}