{
	"name":"dse04121",
	"children":[
	{
		"name":"Ubiquitins and ubiquitin-like proteins",
		"children":[
		{
			"name":"Ubiquitins",
			"children":[
			{
				"name":"6610676 polyubiquitin isoform X1\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"6612291 LOW QUALITY PROTEIN: polyubiquitin-C\tK08770 UBB_C; ubiquitin B\/C"
			},
			{
				"name":"6613322 ubiquitin-60S ribosomal protein L40\tK02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e"
			},
			{
				"name":"6611992 ubiquitin-40S ribosomal protein S27a\tK02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae"
			}
			]
		},
		{
			"name":"Ubiquitin-like proteins (UBLs)",
			"children":[
			{
				"name":"6614608 NEDD8\tK12158 NEDD8; ubiquitin-like protein Nedd8"
			},
			{
				"name":"6619202 uncharacterized protein LOC6619202\tK02983 RP-S30e; small subunit ribosomal protein S30e"
			},
			{
				"name":"6611478 small ubiquitin-related modifier 3\tK12160 SUMO; small ubiquitin-related modifier"
			},
			{
				"name":"6617583 gamma-aminobutyric acid receptor-associated protein\tK08341 GABARAP; GABA(A) receptor-associated protein"
			},
			{
				"name":"6605402 autophagy protein 12-like\tK08336 ATG12; ubiquitin-like protein ATG12"
			},
			{
				"name":"6611178 ubiquitin-related modifier 1 homolog\tK12161 URM1; ubiquitin related modifier 1"
			},
			{
				"name":"116800417 ubiquitin-fold modifier 1\tK12162 UFM1; ubiquitin-fold modifier 1"
			},
			{
				"name":"6619992 mastermind-like domain-containing protein 1\tK28515 UBL3; membrane-anchored ubiquitin-fold protein"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-activating enzymes (E1)",
		"children":[
		{
			"name":"Ubiquitin activating enzyme",
			"children":[
			{
				"name":"6608390 ubiquitin-like modifier-activating enzyme 1\tK03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]"
			}
			]
		},
		{
			"name":"UBL-activating enzymes",
			"children":[
			{
				"name":"6606662 SUMO-activating enzyme subunit 1\tK10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]"
			},
			{
				"name":"6604820 SUMO-activating enzyme subunit 2\tK10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]"
			},
			{
				"name":"6609061 nedd8-activating enzyme E1 catalytic subunit\tK10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]"
			},
			{
				"name":"6605224 nedd8-activating enzyme E1 regulatory subunit\tK04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit"
			},
			{
				"name":"6611714 adenylyltransferase and sulfurtransferase MOCS3\tK11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]"
			},
			{
				"name":"6619868 ubiquitin-like modifier-activating enzyme 5\tK12164 UBA5; ubiquitin-like modifier-activating enzyme 5"
			},
			{
				"name":"6609822 ubiquitin-like modifier-activating enzyme ATG7\tK08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin-conjugating enzymes (E2)",
		"children":[
		{
			"name":"Ubiquitin-conjugating enzymes",
			"children":[
			{
				"name":"6613888 ubiquitin-conjugating enzyme E2-17 kDa\tK10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]"
			},
			{
				"name":"6605452 ubiquitin-conjugating enzyme E2 C\tK06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]"
			},
			{
				"name":"6606359 ubiquitin-conjugating enzyme E2-17 kDa\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"6610651 uncharacterized protein LOC6610651\tK06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]"
			},
			{
				"name":"6612060 ubiquitin-conjugating enzyme E2-24 kDa\tK20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]"
			},
			{
				"name":"6617368 ubiquitin-conjugating enzyme E2-24 kDa\tK20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]"
			},
			{
				"name":"6618549 ubiquitin-conjugating enzyme E2-17 kDa isoform X1\tK20217 UBE2E; ubiquitin-conjugating enzyme E2 E [EC:2.3.2.23]"
			},
			{
				"name":"6606487 ubiquitin-conjugating enzyme E2 G1\tK10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]"
			},
			{
				"name":"6620431 ubiquitin-conjugating enzyme E2 G1\tK10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]"
			},
			{
				"name":"6617957 ubiquitin-conjugating enzyme E2 G2\tK04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]"
			},
			{
				"name":"6620162 ubiquitin-conjugating enzyme E2 H\tK10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]"
			},
			{
				"name":"6620992 ubiquitin-conjugating enzyme E2 4\tK10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]"
			},
			{
				"name":"6616741 ubiquitin-conjugating enzyme E2 J2\tK04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]"
			},
			{
				"name":"6605084 ubiquitin-conjugating enzyme E2-22 kDa\tK04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]"
			},
			{
				"name":"6609696 ubiquitin-conjugating enzyme E2 L3\tK04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]"
			},
			{
				"name":"6610845 ubiquitin-conjugating enzyme E2 L5\tK04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]"
			},
			{
				"name":"6614264 ubiquitin-conjugating enzyme E2-18 kDa\tK04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]"
			},
			{
				"name":"6615190 ubiquitin-conjugating enzyme E2 L3\tK04552 UBE2L3; ubiquitin-conjugating enzyme E2 L3 [EC:2.3.2.23]"
			},
			{
				"name":"6611285 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
			},
			{
				"name":"6618481 ubiquitin-conjugating enzyme E2 N\tK10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]"
			},
			{
				"name":"6607603 (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O isoform X1\tK10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]"
			},
			{
				"name":"6611505 ubiquitin-conjugating enzyme E2Q-like protein CG4502\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"6616131 ubiquitin-conjugating enzyme E2 Q2 isoform X1\tK10582 UBE2Q; ubiquitin-conjugating enzyme E2 Q [EC:2.3.2.23]"
			},
			{
				"name":"6605799 ubiquitin-conjugating enzyme E2 R2 isoform X1\tK02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]"
			},
			{
				"name":"6618109 ubiquitin-conjugating enzyme E2 S\tK10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]"
			},
			{
				"name":"6608553 ubiquitin-conjugating enzyme E2 W isoform X2\tK10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]"
			},
			{
				"name":"6621674 baculoviral IAP repeat-containing protein 6 isoform X1\tK10586 BIRC6; baculoviral IAP repeat-containing protein 6 (apollon) [EC:2.3.2.23]"
			}
			]
		},
		{
			"name":"UBL-conjugating enzymes",
			"children":[
			{
				"name":"6617264 SUMO-conjugating enzyme UBC9-B\tK10577 UBE2I; ubiquitin-conjugating enzyme E2 I"
			},
			{
				"name":"6604834 nedd8-conjugating enzyme UbcE2M\tK10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]"
			},
			{
				"name":"6618343 ubiquitin-like-conjugating enzyme ATG3\tK08343 ATG3; ubiquitin-like-conjugating enzyme ATG3"
			},
			{
				"name":"6608069 ubiquitin-like-conjugating enzyme ATG10\tK17888 ATG10L; ubiquitin-like-conjugating enzyme ATG10"
			},
			{
				"name":"6609357 ubiquitin-fold modifier-conjugating enzyme 1\tK12165 UFC1; ufm1-conjugating enzyme 1"
			}
			]
		}
		]
	},
	{
		"name":"Ubiquitin ligases (E3)",
		"children":[
		{
			"name":"HECT type E3",
			"children":[
			{
				"name":"6605248 ubiquitin-protein ligase E3A\tK10587 UBE3A; ubiquitin-protein ligase E3 A [EC:2.3.2.26]"
			},
			{
				"name":"6604972 ubiquitin-protein ligase E3B isoform X2\tK10588 UBE3B; ubiquitin-protein ligase E3 B [EC:2.3.2.26]"
			},
			{
				"name":"6613046 ubiquitin-protein ligase E3C\tK10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]"
			},
			{
				"name":"6614925 uncharacterized protein LOC6614925\tK20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]"
			},
			{
				"name":"6609640 E3 ubiquitin-protein ligase Smurf1\tK04678 SMURF; E3 ubiquitin ligase SMURF1\/2 [EC:2.3.2.26]"
			},
			{
				"name":"6617446 E3 ubiquitin-protein ligase Su(dx)\tK05633 WWP1; NEDD4-like E3 ubiquitin-protein ligase WWP1 [EC:2.3.2.26]"
			},
			{
				"name":"6613867 E3 ubiquitin-protein ligase TRIP12 isoform X9\tK10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]"
			},
			{
				"name":"6606100 E3 ubiquitin-protein ligase Nedd-4 isoform X2\tK10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]"
			},
			{
				"name":"6619958 E3 ubiquitin-protein ligase HUWE1 isoform X1\tK10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]"
			},
			{
				"name":"6617443 apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1\tK22370 AREL1; apoptosis-resistant E3 ubiquitin protein ligase 1 [EC:2.3.2.26]"
			},
			{
				"name":"6607060 E3 ubiquitin-protein ligase hyd\tK10593 EDD1; E3 ubiquitin-protein ligase EDD1 [EC:2.3.2.26]"
			},
			{
				"name":"6611996 uncharacterized protein LOC6611996\tK22371 G2H3; G2\/M phase-specific E3 ubiquitin-protein ligase [EC:2.3.2.26]"
			},
			{
				"name":"6615120 probable E3 ubiquitin-protein ligase HERC2\tK10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]"
			},
			{
				"name":"6610300 probable E3 ubiquitin-protein ligase HERC4 isoform X2\tK10615 HERC4; E3 ubiquitin-protein ligase HERC4 [EC:2.3.2.26]"
			},
			{
				"name":"6617473 E3 ubiquitin-protein ligase HECW2 isoform X1\tK12168 HECW2; E3 ubiquitin-protein ligase HECW2 [EC:2.3.2.26]"
			},
			{
				"name":"6611951 E3 ubiquitin-protein ligase Ufd4\tK12231 HECTD1; E3 ubiquitin-protein ligase HECTD1 [EC:2.3.2.26]"
			},
			{
				"name":"HECT type E3 associated proteins",
				"children":[
				{
					"name":"6606112 NEDD4 family-interacting protein 1-like\tK25839 NDFIP; NEDD4 family-interacting protein"
				},
				{
					"name":"6617995 UPF0472 protein C16orf72 homolog\tK27699 HAPSTR1; HUWE1-associated protein modifying stress responses 1"
				}
				]
			}
			]
		},
		{
			"name":"U-box type E3",
			"children":[
			{
				"name":"6611418 ubiquitin conjugation factor E4 A\tK10596 UBE4A; ubiquitin conjugation factor E4 A [EC:2.3.2.27]"
			},
			{
				"name":"6617789 ubiquitin conjugation factor E4 B\tK10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]"
			},
			{
				"name":"6612005 E3 ubiquitin-protein ligase CHIP\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
			},
			{
				"name":"6609425 RING-type E3 ubiquitin-protein ligase PPIL2 isoform X2\tK10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]"
			},
			{
				"name":"6609799 pre-mRNA-processing factor 19\tK10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]"
			},
			{
				"name":"6613020 E3 ubiquitin-protein ligase RBBP6\tK10624 RBBP6; E3 ubiquitin-protein ligase RBBP6 [EC:2.3.2.27]"
			},
			{
				"name":"6612862 RING finger protein 37\tK10600 UBOX5; U-box domain-containing protein 5 [EC:2.3.2.27]"
			}
			]
		},
		{
			"name":"Single Ring-finger type E3",
			"children":[
			{
				"name":"BRE1 proteins",
				"children":[
				{
					"name":"6610919 E3 ubiquitin-protein ligase Bre1\tK10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"CBL proteins",
				"children":[
				{
					"name":"116801240 E3 ubiquitin-protein ligase CBL-B-B\tK04707 CBL; E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"SINA (Seven in absentia) proteins",
				"children":[
				{
					"name":"6606021 E3 ubiquitin-protein ligase sina\tK04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]"
				},
				{
					"name":"6606022 probable E3 ubiquitin-protein ligase sinah\tK04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Ligand of Numb proteins",
				"children":[
				{
					"name":"6619477 slo-interacting protein 1\tK15682 PDZRN3_4; ligand of Numb protein X 3\/4 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"March proteins",
				"children":[
				{
					"name":"6605019 uncharacterized protein LOC6605019\tK10656 MARCH1_8; E3 ubiquitin-protein ligase MARCH1\/8 [EC:2.3.2.27]"
				},
				{
					"name":"6610121 uncharacterized protein LOC6610121 isoform X2\tK10657 MARCH2_3; E3 ubiquitin-protein ligase MARCH2\/3 [EC:2.3.2.27]"
				},
				{
					"name":"6612590 E3 ubiquitin-protein ligase MARCH5\tK10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]"
				},
				{
					"name":"6613821 E3 ubiquitin-protein ligase MARCH5 isoform X1\tK10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]"
				},
				{
					"name":"6617157 E3 ubiquitin-protein ligase MARCH5\tK10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]"
				},
				{
					"name":"6620182 E3 ubiquitin-protein ligase MARCH5\tK10660 MARCH5; E3 ubiquitin-protein ligase MARCH5 [EC:2.3.2.27]"
				},
				{
					"name":"6610477 E3 ubiquitin-protein ligase MARCH6\tK10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"MDM2\/MDM4 proteins"
			},
			{
				"name":"NFX1 proteins",
				"children":[
				{
					"name":"6611336 protein shuttle craft isoform X1\tK12236 NFX1; transcriptional repressor NF-X1"
				},
				{
					"name":"6610751 NF-X1-type zinc finger protein NFXL1\tK15683 NFXL1; NF-X1-type zinc finger protein NFXL1"
				}
				]
			},
			{
				"name":"Pellino proteins",
				"children":[
				{
					"name":"6607637 protein pellino\tK11964 PELI; pellino [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"Peripheral membrane proteins",
				"children":[
				{
					"name":"6610344 peroxisome biogenesis factor 10\tK13346 PEX10; peroxin-10 [EC:2.3.2.27]"
				},
				{
					"name":"6617300 peroxisome assembly protein 12\tK13345 PEX12; peroxin-12"
				},
				{
					"name":"6604862 peroxisome biogenesis factor 2\tK06664 PEX2; peroxin-2 [EC:2.3.2.27 2.3.2.36]"
				}
				]
			},
			{
				"name":"RBR proteins",
				"children":[
				{
					"name":"6616405 E3 ubiquitin-protein ligase parkin\tK04556 PARK2; parkin [EC:2.3.2.31]"
				},
				{
					"name":"6614829 potential E3 ubiquitin-protein ligase ariadne-1\tK11968 ARIH1; ariadne-1 [EC:2.3.2.31]"
				},
				{
					"name":"6615502 potential E3 ubiquitin-protein ligase ariadne-2\tK11969 ARIH2; ariadne-2 [EC:2.3.2.31]"
				},
				{
					"name":"6611441 uncharacterized protein LOC6611441 isoform X1\tK11974 RNF31; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]"
				},
				{
					"name":"6608921 uncharacterized protein LOC6608921\tK20804 RNF34; E3 ubiquitin-protein ligase RNF34 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"TRAF proteins",
				"children":[
				{
					"name":"6620179 TNF receptor-associated factor 6\tK03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"TRIM\/RBCC proteins",
				"children":[
				{
					"name":"6614657 brain tumor protein\tK11997 TRIM2_3; tripartite motif-containing protein 2\/3"
				},
				{
					"name":"6612028 E3 ubiquitin-protein ligase TRIM9 isoform X1\tK10649 TRIM9_67; tripartite motif-containing protein 9\/67"
				},
				{
					"name":"6619243 transcription intermediary factor 1-alpha isoform X2\tK08883 TRIM33; tripartite motif-containing protein 33 [EC:2.3.2.27]"
				},
				{
					"name":"6611633 tripartite motif-containing protein 45 isoform X1\tK12021 TRIM45; tripartite motif-containing protein 45"
				},
				{
					"name":"6608003 protein wech\tK12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"UBR box proteins",
				"children":[
				{
					"name":"6618020 E3 ubiquitin-protein ligase UBR1\tK10626 UBR2; E3 ubiquitin-protein ligase UBR2 [EC:2.3.2.27]"
				},
				{
					"name":"6620263 E3 ubiquitin-protein ligase Ubr3 isoform X1\tK11978 UBR3; E3 ubiquitin-protein ligase UBR3 [EC:2.3.2.27]"
				},
				{
					"name":"6611612 protein purity of essence\tK10691 UBR4; E3 ubiquitin-protein ligase UBR4 [EC:2.3.2.27]"
				},
				{
					"name":"6614477 putative E3 ubiquitin-protein ligase UBR7\tK11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]"
				}
				]
			},
			{
				"name":"ATL proteins"
			},
			{
				"name":"Other single Ring-finger type E3",
				"children":[
				{
					"name":"6609342 death-associated inhibitor of apoptosis 2\tK16060 BIRC2_3; baculoviral IAP repeat-containing protein 2\/3"
				},
				{
					"name":"6605862 death-associated inhibitor of apoptosis 1\tK16061 BIRC7_8; baculoviral IAP repeat-containing protein 7\/8"
				},
				{
					"name":"6619099 BRCA1-associated protein\tK10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]"
				},
				{
					"name":"6614722 E3 ubiquitin-protein ligase Hakai\tK15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]"
				},
				{
					"name":"116800373 uncharacterized protein LOC116800373 isoform X1\tK10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]"
				},
				{
					"name":"6605546 protein sneaky\tK22375 DCST1; E3 ubiquitin-protein ligase DCST1 [EC:2.3.2.27]"
				},
				{
					"name":"6612259 protein deltex\tK06058 DTX; deltex [EC:2.3.2.27]"
				},
				{
					"name":"6607003 E3 ubiquitin-protein ligase FANCL\tK10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]"
				},
				{
					"name":"6607168 E3 ubiquitin-protein ligase Kcmf1\tK22376 KCMF1; E3 ubiquitin-protein ligase KCMF1 [EC:2.3.2.27]"
				},
				{
					"name":"6619363 E3 ubiquitin-protein ligase listerin\tK22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]"
				},
				{
					"name":"6619478 uncharacterized protein LOC6619478 isoform X2\tK15686 MEX3; RNA-binding protein MEX3 [EC:2.3.2.27]"
				},
				{
					"name":"6605856 E3 ubiquitin-protein ligase mind-bomb\tK10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]"
				},
				{
					"name":"6614632 E3 ubiquitin-protein ligase MIB2 isoform X1\tK10645 MIB; E3 ubiquitin-protein ligase mind-bomb [EC:2.3.2.27]"
				},
				{
					"name":"6616461 probable E3 ubiquitin-protein ligase makorin-1\tK15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]"
				},
				{
					"name":"6619551 probable E3 ubiquitin-protein ligase makorin-1\tK15687 MKRN; E3 ubiquitin-protein ligase makorin [EC:2.3.2.27]"
				},
				{
					"name":"6610695 mitochondrial E3 ubiquitin protein ligase 1\tK15688 MUL1; E3 ubiquitin-protein ligase MUL1 [EC:2.3.2.27]"
				},
				{
					"name":"6619582 E3 ubiquitin-protein ligase highwire\tK10693 MYCBP2; RCR-type E3 ubiquitin transferase [EC:2.3.2.33]"
				},
				{
					"name":"6607164 protein neuralized isoform X2\tK01931 NEUR; protein neuralized [EC:2.3.2.27]"
				},
				{
					"name":"6613628 RING finger and CHY zinc finger domain-containing protein 1\tK10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"6605952 roquin-1 isoform X1\tK15690 RC3H; RING finger and CCCH-type zinc finger domain-containing protein"
				},
				{
					"name":"6606008 E3 ubiquitin-protein ligase RFWD3\tK15691 RFWD3; E3 ubiquitin-protein ligase RFWD3 [EC:2.3.2.27]"
				},
				{
					"name":"6618701 E3 ubiquitin-protein ligase RING1\tK10695 RNF1_2; E3 ubiquitin-protein ligase RNF1\/2 [EC:2.3.2.27]"
				},
				{
					"name":"6614036 E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp2 isoform X1\tK22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]"
				},
				{
					"name":"6614519 LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase RNF4\tK22651 RNF4; E3 ubiquitin-protein ligase RNF4 [EC:2.3.2.27]"
				},
				{
					"name":"6619982 E3 ubiquitin-protein ligase RNF185\tK10666 RNF5_185; E3 ubiquitin-protein ligase RNF5\/185 [EC:2.3.2.27]"
				},
				{
					"name":"6610343 RING finger protein 10\tK26979 RNF10; E3 ubiquitin-protein ligase RNF10 [EC:2.3.2.27]"
				},
				{
					"name":"6619453 RING finger protein 11 isoform X1\tK11980 RNF11; E3 ubiquitin-protein ligase RNF11"
				},
				{
					"name":"6614111 E3 ubiquitin-protein ligase RNF13\tK15692 RNF13; E3 ubiquitin-protein ligase RNF13 [EC:2.3.2.27]"
				},
				{
					"name":"6609063 E3 ubiquitin-protein ligase RNF25 isoform X2\tK10640 RNF25; E3 ubiquitin-protein ligase RNF25 [EC:2.3.2.27]"
				},
				{
					"name":"6618182 uncharacterized protein LOC6618182\tK15693 RNF26; E3 ubiquitin-protein ligase RNF26 [EC:2.3.2.27]"
				},
				{
					"name":"6607097 uncharacterized protein DDB_G0283357 isoform X3\tK19041 RNF38_44; E3 ubiquitin-protein ligase RNF38\/44 [EC:2.3.2.27]"
				},
				{
					"name":"6605839 E3 ubiquitin-protein ligase NRDP1\tK11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]"
				},
				{
					"name":"6617902 E3 ubiquitin-protein ligase NRDP1\tK11981 RNF41; E3 ubiquitin-protein ligase NRDP1 [EC:2.3.2.27]"
				},
				{
					"name":"6606775 uncharacterized protein LOC6606775\tK10635 RNF111; E3 ubiquitin-protein ligase Arkadia [EC:2.3.2.27]"
				},
				{
					"name":"6607170 E3 ubiquitin-protein ligase Iruka\tK11982 RNF115_126; E3 ubiquitin-protein ligase RNF115\/126 [EC:2.3.2.27]"
				},
				{
					"name":"6614790 RING finger protein 121\tK15698 RNF121_175; RING finger protein 121\/175"
				},
				{
					"name":"6606317 E3 ubiquitin-protein ligase RNF123\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"6612698 protein TRC8 homolog isoform X1\tK15703 RNF139; E3 ubiquitin-protein ligase RNF139 [EC:2.3.2.27]"
				},
				{
					"name":"6619383 E3 ubiquitin-protein ligase rnf146 isoform X2\tK15700 RNF146; E3 ubiquitin-protein ligase RNF146 [EC:2.3.2.27]"
				},
				{
					"name":"116802111 E3 ubiquitin-protein ligase MGRN1\tK25192 RNF157; E3 ubiquitin-protein ligase RNF157 [EC:2.3.2.27]"
				},
				{
					"name":"6613748 E3 ubiquitin-protein ligase RNF181 homolog isoform X3\tK22378 RNF181; E3 ubiquitin-protein ligase RNF181 [EC:2.3.2.27]"
				},
				{
					"name":"6607485 E3 ubiquitin-protein ligase Rnf220\tK25174 RNF220; E3 ubiquitin-protein ligase RNF220 [EC:2.3.2.27]"
				},
				{
					"name":"6607679 E3 ubiquitin-protein ligase RNFT1\tK28516 RNFT2; E3 ubiquitin-protein ligase RNFT2"
				},
				{
					"name":"6617684 U4\/U6.U5 tri-snRNP-associated protein 1 isoform X1\tK11984 SART1; U4\/U6.U5 tri-snRNP-associated protein 1"
				},
				{
					"name":"6610995 E3 ubiquitin-protein ligase SHPRH isoform X1\tK15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]"
				},
				{
					"name":"6609630 E3 ubiquitin-protein ligase SH3RF1\tK12171 SH3RF; E3 ubiquitin-protein ligase SH3RF [EC:2.3.2.27]"
				},
				{
					"name":"6619529 E3 ubiquitin-protein ligase HRD1\tK10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]"
				},
				{
					"name":"6613819 E3 ubiquitin-protein ligase TM129 isoform X1\tK22380 TMEM129; E3 ubiquitin-protein ligase TM129 [EC:2.3.2.27]"
				},
				{
					"name":"116800457 E3 ubiquitin-protein ligase Topors\tK10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]"
				},
				{
					"name":"6609752 E3 ubiquitin-protein ligase TRAIP\tK11985 TRAIP; TRAF-interacting protein [EC:2.3.2.27]"
				},
				{
					"name":"6618832 E3 ubiquitin-protein ligase ZNF598\tK22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]"
				},
				{
					"name":"6612197 E3 ubiquitin-protein ligase znrf2\tK10694 ZNRF1_2; E3 ubiquitin-protein ligase ZNRF1\/2 [EC:2.3.2.27]"
				}
				]
			}
			]
		},
		{
			"name":"Atypical E3",
			"children":[
			{
				"name":"6611424 non-structural maintenance of chromosomes element 1 homolog\tK22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]"
			},
			{
				"name":"6618571 probable E3 ubiquitin-protein ligase IRF2BPL isoform X2\tK22383 IRF2BP; interferon regulatory factor 2-binding protein"
			}
			]
		},
		{
			"name":"UBL E3 ligases",
			"children":[
			{
				"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
			},
			{
				"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
			},
			{
				"name":"116800457 E3 ubiquitin-protein ligase Topors\tK10631 TOPORS; E3 ubiquitin-protein ligase Topors [EC:2.3.2.27]"
			},
			{
				"name":"6619688 E3 SUMO-protein ligase RanBP2\tK12172 RANBP2; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]"
			},
			{
				"name":"6608301 E3 SUMO-protein ligase PIAS1 isoform X5\tK04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]"
			},
			{
				"name":"6606093 E3 SUMO-protein ligase NSE2\tK22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]"
			},
			{
				"name":"116802159 RING finger protein narya\tK25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]"
			},
			{
				"name":"6616190 RING finger protein vilya\tK25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]"
			},
			{
				"name":"6621235 RING finger protein nenya\tK25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]"
			},
			{
				"name":"116800975 zinc finger BED domain-containing protein 1-like\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"116801232 zinc finger BED domain-containing protein 1-like isoform X1\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"6611194 uncharacterized protein LOC6611194\tK24637 ZBED1; zinc finger BED domain-containing protein 1 (E3 SUMO-protein ligase ZBED1) [EC:2.3.2.-]"
			},
			{
				"name":"6614189 E3 UFM1-protein ligase 1 homolog\tK22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]"
			},
			{
				"name":"6605793 DCN1-like protein isoform X1\tK17822 DCUN1D1_2; DCN1-like protein 1\/2"
			},
			{
				"name":"6608922 DCN1-like protein 3\tK17823 DCUN1D3; DCN1-like protein 3"
			},
			{
				"name":"6616271 DCN1-like protein 5 isoform X1\tK17824 DCUN1D4_5; DCN1-like protein 4\/5"
			}
			]
		},
		{
			"name":"Multi subunit type E3",
			"children":[
			{
				"name":"SCF complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					},
					{
						"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"6605519 cullin-1\tK03347 CUL1; cullin 1"
					},
					{
						"name":"6608075 cullin homolog 1\tK03347 CUL1; cullin 1"
					}
					]
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"116800333 E3 ubiquitin ligase complex SCF subunit sconC\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"116801228 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6608758 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6615063 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6615714 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6615888 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (F-box)",
					"children":[
					{
						"name":"6620053 beta-TrCP\tK03362 FBXW1_11; F-box and WD-40 domain protein 1\/11"
					},
					{
						"name":"6616293 F-box\/WD repeat-containing protein 4\tK10262 FBXW4; F-box and WD-40 domain protein 4"
					},
					{
						"name":"6613580 F-box\/WD repeat-containing protein 5\tK10263 FBXW5; F-box and WD-40 domain protein 5"
					},
					{
						"name":"6610749 F-box\/WD repeat-containing protein 7\tK10260 FBXW7; F-box and WD-40 domain protein 7"
					},
					{
						"name":"6613812 S-phase kinase-associated protein 2\tK03875 SKP2; F-box and leucine-rich repeat protein 1 (S-phase kinase-associated protein 2)"
					},
					{
						"name":"6608691 F-box\/LRR-repeat protein 20 isoform X1\tK10268 FBXL2_20; F-box and leucine-rich repeat protein 2\/20"
					},
					{
						"name":"6618517 F-box\/LRR-repeat protein 4\tK10270 FBXL4; F-box and leucine-rich repeat protein 4"
					},
					{
						"name":"6608630 F-box\/LRR-repeat protein 6\tK10272 FBXL6; F-box and leucine-rich repeat protein 6"
					},
					{
						"name":"6606189 F-box\/LRR-repeat protein 7\tK10273 FBXL7; F-box and leucine-rich repeat protein 7"
					},
					{
						"name":"6606443 uncharacterized protein LOC6606443\tK10275 FBXL9; F-box and leucine-rich repeat protein 9"
					},
					{
						"name":"6608239 F-box\/LRR-repeat protein 2\tK10275 FBXL9; F-box and leucine-rich repeat protein 9"
					},
					{
						"name":"6607159 jmjC domain-containing histone demethylation protein 1\tK10276 FBXL10_11; F-box and leucine-rich repeat protein 10\/11 [EC:1.14.11.27]"
					},
					{
						"name":"6615579 F-box\/LRR-repeat protein 14\tK10280 FBXL14; F-box and leucine-rich repeat protein 14"
					},
					{
						"name":"6613404 F-box\/LRR-repeat protein 15 isoform X1\tK10281 FBXL15; F-box and leucine-rich repeat protein 15"
					},
					{
						"name":"6605312 F-box\/LRR-repeat protein 16\tK10282 FBXL16; F-box and leucine-rich repeat protein 16"
					},
					{
						"name":"116800174 F-box only protein 9-like\tK10295 FBXO9; F-box protein 9"
					},
					{
						"name":"6606653 F-box only protein 9\tK10295 FBXO9; F-box protein 9"
					},
					{
						"name":"6607027 F-box only protein 11\tK10297 FBXO11; F-box protein 11"
					},
					{
						"name":"6613856 uncharacterized protein LOC6613856 isoform X1\tK06084 LMO7; F-box protein 20"
					},
					{
						"name":"6605321 F-box only protein 32\tK10305 FBXO25_32; F-box protein 25\/32"
					},
					{
						"name":"6605044 F-box only protein 28\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"6608465 uncharacterized protein LOC6608465\tK10306 FBXO28; F-box protein 28"
					},
					{
						"name":"6604980 F-box only protein 33\tK10310 FBXO33; F-box protein 33"
					},
					{
						"name":"6621650 F-box only protein 39\tK10314 FBXO39; F-box protein 39"
					},
					{
						"name":"6615491 F-box only protein 42\tK10317 FBXO42; F-box protein 42"
					},
					{
						"name":"6608965 F-box\/SPRY domain-containing protein 1\tK10319 FBXO45; F-box protein 45"
					}
					]
				}
				]
			},
			{
				"name":"Cul2 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					},
					{
						"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"6619305 cullin-2\tK03870 CUL2; cullin 2"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"6609945 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"6619251 elongin-B\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"6608627 protein Vhl\tK03871 VHL; von Hippel-Lindau disease tumor supressor"
					},
					{
						"name":"6612021 uncharacterized protein LOC6612021\tK10348 LRR1; LRR-repeat protein 1"
					},
					{
						"name":"6606326 protein fem-1 homolog CG6966\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"6616780 protein fem-1 homolog A\tK25805 FEM1A_C; protein fem-1 homolog A\/C"
					},
					{
						"name":"6610115 protein fem-1 homolog B isoform X1\tK10349 FEM1B; protein fem-1 homolog B"
					},
					{
						"name":"6612254 amyloid protein-binding protein 2\tK25806 APPBP2; amyloid protein-binding protein 2"
					},
					{
						"name":"6619833 kelch domain-containing protein 3\tK25808 KLHDC3; kelch domain-containing protein 3"
					},
					{
						"name":"6609797 kelch domain-containing protein 10 homolog\tK25809 KLHDC10; kelch domain-containing protein 10"
					},
					{
						"name":"6610333 protein zer-1 homolog isoform X1\tK10350 ZYG11; Zyg-11 protein"
					},
					{
						"name":"6614927 zinc finger SWIM domain-containing protein 8 isoform X1\tK25207 ZSWIM8; zinc finger SWIM domain-containing protein 8"
					}
					]
				}
				]
			},
			{
				"name":"Cul3 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					},
					{
						"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"6611346 cullin-3-A isoform X1\tK03869 CUL3; cullin 3"
					}
					]
				},
				{
					"name":"Adoptor and target recognizing subunit (BTB)",
					"children":[
					{
						"name":"6620448 kelch-like protein 5 isoform X1\tK10442 KLHL1_4_5; kelch-like protein 1\/4\/5"
					},
					{
						"name":"6614529 ring canal kelch protein\tK10443 KLHL2_3; kelch-like protein 2\/3"
					},
					{
						"name":"6609861 kelch-like protein 17\tK10454 KLHL17; kelch-like protein 17 (actinfilin)"
					},
					{
						"name":"6606740 kelch-like protein 18 isoform X1\tK10455 KLHL18; kelch-like protein 18"
					},
					{
						"name":"6616797 kelch-like ECH-associated protein 1B isoform X1\tK10456 KLHL19; kelch-like protein 19"
					},
					{
						"name":"6605830 kelch-like protein diablo isoform X2\tK10457 KLHL20; kelch-like protein 20"
					},
					{
						"name":"6617819 actin-binding protein IPP\tK13956 IPP; actin-binding protein IPP"
					},
					{
						"name":"6616766 BTB\/POZ domain-containing protein 6 isoform X2\tK10478 BTBD3_6; BTB\/POZ domain-containing protein 3\/6"
					},
					{
						"name":"6619998 BTB\/POZ domain-containing protein 7\tK10479 BTBD7; BTB\/POZ domain-containing protein 7"
					},
					{
						"name":"6617585 BTB\/POZ domain-containing protein 9\tK10481 BTBD9; BTB\/POZ domain-containing protein 9"
					},
					{
						"name":"6608226 protein germ cell-less\tK10485 BTBD13; BTB\/POZ domain-containing protein 13 (germ cell-less protein-like 1)"
					},
					{
						"name":"6616487 ankyrin repeat and BTB\/POZ domain-containing protein 2 isoform X1\tK10521 ABTB2; ankyrin repeat and BTB\/POZ domain-containing protein 2"
					},
					{
						"name":"6616290 rho-related BTB domain-containing protein 1\tK07868 RHOBTB1_2; Rho-related BTB domain-containing protein 1\/2"
					},
					{
						"name":"6620406 BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3\tK15074 BACURD; BTB\/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein"
					},
					{
						"name":"6615397 BTB\/POZ domain-containing protein kctd15-like isoform X2\tK21754 KCTD1_15; BTB\/POZ domain-containing protein KCTD1\/15"
					},
					{
						"name":"6616003 BTB\/POZ domain-containing protein KCTD5\tK21914 KCTD2_5_17; BTB\/POZ domain-containing protein KCTD2\/5\/17"
					},
					{
						"name":"6607029 BTB\/POZ domain-containing protein KCTD3\tK21915 KCTD3; BTB\/POZ domain-containing protein KCTD3"
					},
					{
						"name":"6619196 BTB\/POZ domain-containing protein KCTD12\tK21918 KCTD8_12_16; BTB\/POZ domain-containing protein KCTD8\/12\/16"
					},
					{
						"name":"6613823 BTB\/POZ domain-containing protein KCTD9\tK21919 KCTD9; BTB\/POZ domain-containing protein KCTD9"
					},
					{
						"name":"6606454 protein roadkill isoform X2\tK10523 SPOP; speckle-type POZ protein"
					},
					{
						"name":"6615917 leucine-zipper-like transcriptional regulator 1 homolog\tK23330 LZTR1; leucine-zipper-like transcriptional regulator 1"
					}
					]
				}
				]
			},
			{
				"name":"Cul4 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					},
					{
						"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"6608114 cullin-4A\tK10609 CUL4; cullin 4"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"6606575 DNA damage-binding protein 1\tK10610 DDB1; DNA damage-binding protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit (DCAF)",
					"children":[
					{
						"name":"6612091 DET1 homolog isoform X1\tK10571 DET1; de-etiolated-1"
					},
					{
						"name":"6617855 DET1- and DDB1-associated protein 1\tK11792 DDA1; DET1- and DDB1-associated protein 1"
					},
					{
						"name":"6607004 protein cereblon homolog\tK11793 CRBN; cereblon"
					},
					{
						"name":"6615406 protein mahjong\tK11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]"
					},
					{
						"name":"6615759 protein lethal(2)denticleless\tK11790 DTL; denticleless"
					},
					{
						"name":"6619536 DDB1- and CUL4-associated factor 5\tK11800 DCAF5; DDB1- and CUL4-associated factor 5"
					},
					{
						"name":"6620333 DDB1- and CUL4-associated factor 7\tK11805 DCAF7; DDB1- and CUL4-associated factor 7"
					},
					{
						"name":"6610394 DDB1- and CUL4-associated factor 8 isoform X1\tK11804 DCAF8; DDB1- and CUL4-associated factor 8"
					},
					{
						"name":"6609743 WD and tetratricopeptide repeats protein 1\tK11807 WDTC1; WD and tetratricopeptide repeats protein 1"
					},
					{
						"name":"6612612 DDB1- and CUL4-associated factor 10 homolog\tK11802 DCAF10; DDB1- and CUL4-associated factor 10"
					},
					{
						"name":"6610099 DDB1- and CUL4-associated factor 11\tK11801 DCAF11; DDB1- and CUL4-associated factor 11"
					},
					{
						"name":"6606738 DDB1- and CUL4-associated factor 12\tK11803 DCAF12; DDB1- and CUL4-associated factor 12"
					},
					{
						"name":"6605774 DDB1- and CUL4-associated factor 13\tK11806 DCAF13; DDB1- and CUL4-associated factor 13"
					},
					{
						"name":"6606953 uncharacterized protein LOC6606953\tK11791 DCAF15; DDB1- and CUL4-associated factor 15"
					},
					{
						"name":"6607726 bromodomain and WD repeat-containing protein 3 isoform X1\tK11798 BRWD1_3; bromodomain and WD repeat domain containing protein 1\/3"
					},
					{
						"name":"6616459 WD repeat-containing protein 26 homolog\tK22382 WDR26; WD repeat-containing protein 26"
					},
					{
						"name":"6615773 gastrulation defective protein 1 homolog\tK24752 WDR70; WD repeat-containing protein 70"
					}
					]
				}
				]
			},
			{
				"name":"Cul5 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6608695 RING-box protein 2\tK10611 RBX2; RING-box protein 2"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"6612648 cullin-5\tK10612 CUL5; cullin 5"
					}
					]
				},
				{
					"name":"Adoptor protein",
					"children":[
					{
						"name":"6609945 elongin-C\tK03872 ELOC; elongin-C"
					},
					{
						"name":"6619251 elongin-B\tK03873 ELOB; elongin-B"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"6614530 pneumococcal serine-rich repeat protein\tK04698 SOCS5; suppressor of cytokine signaling 5"
					},
					{
						"name":"6608120 uncharacterized protein LOC6608120\tK04699 SOCS6_7; suppressor of cytokine signaling 6\/7"
					},
					{
						"name":"6614783 uncharacterized protein LOC6614783\tK04699 SOCS6_7; suppressor of cytokine signaling 6\/7"
					},
					{
						"name":"6612951 uncharacterized protein LOC6612951 isoform X1\tK10339 ASB17; ankyrin repeat and SOCS box protein 17"
					},
					{
						"name":"6620141 protein gustavus isoform X3\tK10343 SPSB1_4; SPRY domain-containing SOCS box protein 1\/4"
					},
					{
						"name":"6605843 SPRY domain-containing SOCS box protein 3\tK10345 SPSB3; SPRY domain-containing SOCS box protein 3"
					},
					{
						"name":"6613432 SPRY domain-containing SOCS box protein 3\tK10345 SPSB3; SPRY domain-containing SOCS box protein 3"
					},
					{
						"name":"6618559 ras-related protein Rab-40C isoform X2\tK07928 RAB40; Ras-related protein Rab-40"
					}
					]
				}
				]
			},
			{
				"name":"Cul7 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					},
					{
						"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein",
					"children":[
					{
						"name":"116800333 E3 ubiquitin ligase complex SCF subunit sconC\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"116801228 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6608758 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6615063 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6615714 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					},
					{
						"name":"6615888 S-phase kinase-associated protein 1\tK03094 SKP1; S-phase kinase-associated protein 1"
					}
					]
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul8 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					},
					{
						"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				},
				{
					"name":"Adaptor protein"
				},
				{
					"name":"Target recognizing subunit"
				}
				]
			},
			{
				"name":"Cul9 complex",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6610179 RING-box protein 1B\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					},
					{
						"name":"6615886 RING-box protein 1A\tK03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]"
					}
					]
				},
				{
					"name":"Cullin"
				}
				]
			},
			{
				"name":"APC\/C",
				"children":[
				{
					"name":"Ring finger protein",
					"children":[
					{
						"name":"6611718 anaphase-promoting complex subunit 11\tK03358 APC11; anaphase-promoting complex subunit 11"
					}
					]
				},
				{
					"name":"Cullin",
					"children":[
					{
						"name":"6615823 anaphase-promoting complex subunit 2\tK03349 APC2; anaphase-promoting complex subunit 2"
					}
					]
				},
				{
					"name":"Target recognizing subunit",
					"children":[
					{
						"name":"6613687 cell division cycle protein 20 homolog\tK03363 CDC20; cell division cycle 20, cofactor of APC complex"
					},
					{
						"name":"116800673 fizzy-related protein homolog\tK03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex"
					},
					{
						"name":"6612477 fizzy-related protein homolog\tK03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex"
					}
					]
				},
				{
					"name":"Other subunits",
					"children":[
					{
						"name":"6620482 anaphase-promoting complex subunit 1\tK03348 APC1; anaphase-promoting complex subunit 1"
					},
					{
						"name":"6611115 cell division cycle protein 27 homolog\tK03350 APC3; anaphase-promoting complex subunit 3"
					},
					{
						"name":"6619758 anaphase-promoting complex subunit 4 isoform X1\tK03351 APC4; anaphase-promoting complex subunit 4"
					},
					{
						"name":"6610678 anaphase-promoting complex subunit 5\tK03352 APC5; anaphase-promoting complex subunit 5"
					},
					{
						"name":"6607558 cell division cycle protein 16 homolog\tK03353 APC6; anaphase-promoting complex subunit 6"
					},
					{
						"name":"6612252 anaphase-promoting complex subunit 7\tK03354 APC7; anaphase-promoting complex subunit 7"
					},
					{
						"name":"6618153 cell division cycle protein 23 homolog\tK03355 APC8; anaphase-promoting complex subunit 8"
					},
					{
						"name":"6609616 anaphase-promoting complex subunit 10\tK03357 APC10; anaphase-promoting complex subunit 10"
					},
					{
						"name":"6609693 anaphase-promoting complex subunit 13\tK12456 APC13; anaphase-promoting complex subunit 13"
					},
					{
						"name":"6607897 anaphase-promoting complex subunit 15A\tK25228 APC15; anaphase-promoting complex subunit 15"
					}
					]
				}
				]
			},
			{
				"name":"BRCC complex",
				"children":[
				{
					"name":"6612812 DNA repair protein Rad51 homolog\tK04482 RAD51; DNA repair protein RAD51"
				}
				]
			},
			{
				"name":"KPC complex",
				"children":[
				{
					"name":"6606317 E3 ubiquitin-protein ligase RNF123\tK12169 KPC1; Kip1 ubiquitination-promoting complex protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"6609983 ubiquitin-associated domain-containing protein 1 isoform X2\tK12174 KPC2; Kip1 ubiquitination-promoting complex protein 2"
				}
				]
			},
			{
				"name":"LUBAC complex",
				"children":[
				{
					"name":"6611441 uncharacterized protein LOC6611441 isoform X1\tK11974 RNF31; E3 ubiquitin-protein ligase RNF31 [EC:2.3.2.31]"
				}
				]
			},
			{
				"name":"CTLH complex",
				"children":[
				{
					"name":"6615286 E3 ubiquitin-protein ligase RMND5A\tK23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]"
				},
				{
					"name":"6608514 ran-binding proteins 9\/10 homolog isoform X2\tK23334 RANBP9_10; Ran-binding protein 9\/10"
				},
				{
					"name":"6608875 muskelin\tK23337 MKLN1; muskelin"
				},
				{
					"name":"6619621 E3 ubiquitin-protein transferase MAEA\tK18624 MAEA; macrophage erythroblast attacher"
				},
				{
					"name":"6614890 glucose-induced degradation protein 8-B homolog\tK23338 GID8; glucose-induced degradation protein 8"
				},
				{
					"name":"6618673 protein yippee\tK23339 YPEL5; protein yippee-like 5"
				},
				{
					"name":"6616459 WD repeat-containing protein 26 homolog\tK22382 WDR26; WD repeat-containing protein 26"
				}
				]
			},
			{
				"name":"ERAD complex"
			},
			{
				"name":"LMBR1L-GP78-UBAC2 complex",
				"children":[
				{
					"name":"6607803 protein Lilipod isoform X1\tK25215 LMBR1L; protein LMBR1L"
				}
				]
			},
			{
				"name":"STUB1-CHIC2  complex",
				"children":[
				{
					"name":"6612005 E3 ubiquitin-protein ligase CHIP\tK09561 STUB1; STIP1 homology and U-box containing protein 1 [EC:2.3.2.27]"
				},
				{
					"name":"6617168 cysteine-rich hydrophobic domain-containing protein 2\tK28185 CHIC2; cysteine-rich hydrophobic domain-containing protein 2"
				}
				]
			},
			{
				"name":"SLX5-SLX8 complex"
			},
			{
				"name":"Multi subunit type E3 associated proteins",
				"children":[
				{
					"name":"6611975 cullin-associated NEDD8-dissociated protein 1\tK17263 CAND1; cullin-associated NEDD8-dissociated protein 1"
				},
				{
					"name":"6616639 COMM domain-containing protein 2\tK22558 COMMD2; COMM domain containing 2"
				},
				{
					"name":"6619784 COMM domain-containing protein 3\tK22559 COMMD3; COMM domain containing 3"
				},
				{
					"name":"6605671 COMM domain-containing protein 4\tK22560 COMMD4; COMM domain containing 4"
				},
				{
					"name":"6611990 COMM domain-containing protein 5\tK22561 COMMD5; COMM domain containing 5"
				},
				{
					"name":"116803538 uncharacterized protein LOC116803538\tK22564 COMMD8; COMM domain containing 8"
				},
				{
					"name":"6619894 COMM domain-containing protein 10 isoform X1\tK22566 COMMD10; COMM domain containing 10"
				},
				{
					"name":"6606024 coiled-coil domain-containing protein 22 homolog\tK23343 CCDC22; coiled-coil domain-containing protein 22"
				},
				{
					"name":"6620039 DDRGK domain-containing protein 1\tK23344 DDRGK1; DDRGK domain-containing protein 1"
				},
				{
					"name":"6608043 uncharacterized protein LOC6608043\tK23345 GLMN; glomulin"
				},
				{
					"name":"6613419 UBX domain-containing protein 7\tK24350 UBXN7; UBX domain-containing protein 7"
				},
				{
					"name":"6609957 parkin coregulated gene protein homolog isoform X1\tK26163 PACRG; parkin coregulated gene protein"
				},
				{
					"name":"6608105 protein lingerer isoform X1\tK26545 UBAP2; ubiquitin-associated protein 2"
				},
				{
					"name":"6609673 SH3 domain-containing protein Dlish\tK26546 Dlish; SH3 domain-containing protein Dlish"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Deubiquitinating enzyme (DUB)",
		"children":[
		{
			"name":"Ubiquitin-specific proteases (UBPs)",
			"children":[
			{
				"name":"UCH",
				"children":[
				{
					"name":"6609392 ubiquitin carboxyl-terminal hydrolase calypso\tK08588 BAP1; ubiquitin carboxyl-terminal hydrolase BAP1 [EC:3.4.19.12]"
				},
				{
					"name":"6613053 ubiquitin carboxyl-terminal hydrolase\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
				},
				{
					"name":"6605042 ubiquitin carboxyl-terminal hydrolase isozyme L5\tK05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]"
				},
				{
					"name":"6620320 ubiquitin carboxyl-terminal hydrolase isozyme L5\tK05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"UBP\/USP",
				"children":[
				{
					"name":"6611953 ubiquitin carboxyl-terminal hydrolase CYLD\tK08601 CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]"
				},
				{
					"name":"6612679 ubiquitin carboxyl-terminal hydrolase 1\tK11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]"
				},
				{
					"name":"6620334 ubiquitin carboxyl-terminal hydrolase Usp2 isoform X1\tK11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]"
				},
				{
					"name":"6610566 ubiquitin carboxyl-terminal hydrolase 5\tK11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5\/13 [EC:3.4.19.12]"
				},
				{
					"name":"6619414 ubiquitin carboxyl-terminal hydrolase 32 isoform X2\tK11837 USP6_32; ubiquitin carboxyl-terminal hydrolase 6\/32 [EC:3.4.19.12]"
				},
				{
					"name":"6620313 ubiquitin carboxyl-terminal hydrolase 7 isoform X1\tK11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]"
				},
				{
					"name":"6620048 ubiquitin carboxyl-terminal hydrolase 8 isoform X1\tK11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]"
				},
				{
					"name":"6619531 probable ubiquitin carboxyl-terminal hydrolase FAF isoform X1\tK11840 USP9_24; ubiquitin carboxyl-terminal hydrolase 9\/24 [EC:3.4.19.12]"
				},
				{
					"name":"6610244 trithorax group protein osa\tK11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]"
				},
				{
					"name":"6607502 ubiquitin carboxyl-terminal hydrolase 12A\tK11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12\/46 [EC:3.4.19.12]"
				},
				{
					"name":"6611960 ubiquitin carboxyl-terminal hydrolase 14\tK11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]"
				},
				{
					"name":"6612408 ubiquitin carboxyl-terminal hydrolase 45 isoform X1\tK11844 USP16_45; ubiquitin carboxyl-terminal hydrolase 16\/45 [EC:3.4.19.12]"
				},
				{
					"name":"6609113 ubiquitin carboxyl-terminal hydrolase 20\tK11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20\/33 [EC:3.4.19.12]"
				},
				{
					"name":"6618325 ubiquitin carboxyl-terminal hydrolase nonstop\tK11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22\/27\/51 [EC:3.4.19.12]"
				},
				{
					"name":"6612341 ubiquitin carboxyl-terminal hydrolase 30 homolog\tK11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]"
				},
				{
					"name":"6618869 ubiquitin carboxyl-terminal hydrolase 43 isoform X1\tK11852 USP31; ubiquitin carboxyl-terminal hydrolase 31 [EC:3.4.19.12]"
				},
				{
					"name":"6607778 ubiquitin carboxyl-terminal hydrolase puf isoform X1\tK11853 USP34; ubiquitin carboxyl-terminal hydrolase 34 [EC:3.4.19.12]"
				},
				{
					"name":"6608846 ubiquitin carboxyl-terminal hydrolase 35\tK11854 USP35_38; ubiquitin carboxyl-terminal hydrolase 35\/38 [EC:3.4.19.12]"
				},
				{
					"name":"6610913 ubiquitin carboxyl-terminal hydrolase 36\tK11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36\/42 [EC:3.4.19.12]"
				},
				{
					"name":"6610904 ubiquitin carboxyl-terminal hydrolase 47 isoform X1\tK11857 USP47; ubiquitin carboxyl-terminal hydrolase 47 [EC:3.4.19.12]"
				},
				{
					"name":"6612562 uncharacterized protein LOC6612562 isoform X3\tK27920 USP54; ubiquitin carboxyl-terminal hydrolase 54 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"OTU",
				"children":[
				{
					"name":"6611957 ubiquitin thioesterase otubain-like\tK09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]"
				},
				{
					"name":"6605301 OTU domain-containing protein 5-B\tK12655 OTUD5; OTU domain-containing protein 5 [EC:3.4.19.12]"
				},
				{
					"name":"116801099 deubiquitinase OTUD6B\tK18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]"
				},
				{
					"name":"6607062 ubiquitin thioesterase trabid\tK11862 ZRANB1; ubiquitin thioesterase ZRANB1 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MJD",
				"children":[
				{
					"name":"6612296 josephin-like protein\tK15235 JOSD; josephin [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"MINDY",
				"children":[
				{
					"name":"6605243 inactive ubiquitin carboxyl-terminal hydrolase MINDY-4B\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				},
				{
					"name":"6614929 ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog\tK22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3\/4 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"JAMM",
				"children":[
				{
					"name":"6612129 MPN domain-containing protein CG4751\tK24173 MPND; MPN domain-containing protein"
				},
				{
					"name":"6613442 26S proteasome non-ATPase regulatory subunit 14\tK03030 PSMD14; 26S proteasome regulatory subunit N11"
				},
				{
					"name":"6612868 STAM-binding protein-like A\tK11866 STAMBP; STAM-binding protein [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"PPPDE",
				"children":[
				{
					"name":"6608562 deubiquitinase DESI2\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				},
				{
					"name":"6615002 LOW QUALITY PROTEIN: deubiquitinase DESI2\tK22763 DESI2; deubiquitinase DESI2 [EC:3.4.19.12]"
				}
				]
			},
			{
				"name":"ZUFSP"
			},
			{
				"name":"BRISC complex"
			}
			]
		},
		{
			"name":"UBL-specific proteases (ULPs)",
			"children":[
			{
				"name":"116800984 sentrin-specific protease 2\tK08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]"
			},
			{
				"name":"6614964 uncharacterized protein LOC6614964\tK08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]"
			},
			{
				"name":"116803240 uncharacterized protein LOC116803240\tK08596 SENP7; sentrin-specific protease 7 [EC:3.4.22.68]"
			},
			{
				"name":"6608813 sentrin-specific protease 8\tK08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]"
			},
			{
				"name":"6615193 sentrin-specific protease 8 isoform X1\tK08597 SENP8; sentrin-specific protease 8 [EC:3.4.22.68]"
			},
			{
				"name":"6613053 ubiquitin carboxyl-terminal hydrolase\tK05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]"
			},
			{
				"name":"6607479 uncharacterized protein LOC6607479\tK22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]"
			},
			{
				"name":"COP9 signalosome (CSN) complex",
				"children":[
				{
					"name":"6611303 COP9 signalosome complex subunit 1b\tK12175 GPS1; COP9 signalosome complex subunit 1"
				},
				{
					"name":"6618364 COP9 signalosome complex subunit 1b\tK12175 GPS1; COP9 signalosome complex subunit 1"
				},
				{
					"name":"6611774 COP9 signalosome complex subunit 2\tK12176 COPS2; COP9 signalosome complex subunit 2"
				},
				{
					"name":"6616369 COP9 signalosome complex subunit 3\tK12177 COPS3; COP9 signalosome complex subunit 3"
				},
				{
					"name":"6608095 COP9 signalosome complex subunit 4\tK12178 COPS4; COP9 signalosome complex subunit 4"
				},
				{
					"name":"6616874 COP9 signalosome complex subunit 5 isoform X1\tK09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]"
				},
				{
					"name":"6607455 COP9 signalosome complex subunit 6\tK12179 COPS6; COP9 signalosome complex subunit 6"
				},
				{
					"name":"6608171 COP9 signalosome complex subunit 7\tK12180 COPS7; COP9 signalosome complex subunit 7"
				},
				{
					"name":"6611667 COP9 signalosome complex subunit 8\tK12181 COPS8; COP9 signalosome complex subunit 8"
				},
				{
					"name":"6608964 COP9 signalosome complex subunit 9 homolog\tK28062 COPS9; COP9 signalosome complex subunit 9"
				}
				]
			}
			]
		}
		]
	}
	]
}