{
	"name":"dso01008",
	"children":[
	{
		"name":"Polyketide synthase (PKS)",
		"children":[
		{
			"name":"Modular type I PKS",
			"children":[
			{
				"name":"cis-AT PKS",
				"children":[
				{
					"name":"Erythronolide PKS"
				},
				{
					"name":"Oleandomycin synthase"
				},
				{
					"name":"Pikromycin PKS"
				},
				{
					"name":"Avermectin PKS"
				},
				{
					"name":"Tylactone synthase"
				},
				{
					"name":"Protomycinolide IV synthase"
				},
				{
					"name":"Niddamycin PKS"
				},
				{
					"name":"Rapamycin PKS"
				},
				{
					"name":"Immunomycin PKS"
				},
				{
					"name":"Ansamitocin PKS"
				},
				{
					"name":"Rifamycin PKS"
				},
				{
					"name":"Polyene macrolide PKS"
				},
				{
					"name":"Pimaricinolide synthase"
				},
				{
					"name":"Candicidin PKS"
				},
				{
					"name":"Soraphen PKS"
				},
				{
					"name":"Stigmatellin PKS"
				},
				{
					"name":"Mycolactone PKS"
				},
				{
					"name":"Coelimycin PKS"
				},
				{
					"name":"Aureothin PKS"
				},
				{
					"name":"Spectinabilin PKS"
				},
				{
					"name":"Phthiocerol \/ Phenolphthiocerol PKS"
				}
				]
			},
			{
				"name":"trans-AT PKS",
				"children":[
				{
					"name":"Bacillanene hybrid PKS-NRPS",
					"children":[
					{
						"name":"A4U42_06390 2-nitropropane dioxygenase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"A4U42_16090 PfaD family protein\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					}
					]
				},
				{
					"name":"Macrolactin PKS",
					"children":[
					{
						"name":"A4U42_06390 2-nitropropane dioxygenase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"A4U42_16090 PfaD family protein\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					}
					]
				},
				{
					"name":"Difficidin PKS",
					"children":[
					{
						"name":"A4U42_06390 2-nitropropane dioxygenase\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					},
					{
						"name":"A4U42_16090 PfaD family protein\tK15329 pksE; trans-AT polyketide synthase, acyltransferase and oxidoreductase domains"
					}
					]
				},
				{
					"name":"Rhizoxin hybrid PKS-NRPS"
				},
				{
					"name":"Albicidin synthase, hybrid PKS-NRPS"
				}
				]
			}
			]
		},
		{
			"name":"Iterative type I PKS",
			"children":[
			{
				"name":"Fungal nonreducing PKS (NR-PKS)"
			},
			{
				"name":"Fungal partially reducing PKS (PR-PKS)"
			},
			{
				"name":"Fungal highly reducing PKS (HR-PKS)"
			},
			{
				"name":"Fungal hybrid type",
				"children":[
				{
					"name":"Zearalenone synthase"
				}
				]
			},
			{
				"name":"Bacterial type"
			}
			]
		},
		{
			"name":"Type II PKS",
			"children":[
			{
				"name":"C9-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Spore pigment PKS"
				}
				]
			},
			{
				"name":"C7-C14 cyclized polyketide type",
				"children":[
				{
					"name":"Octaketide PKS"
				},
				{
					"name":"Nonaketide PKS"
				},
				{
					"name":"Decaketide PKS"
				}
				]
			}
			]
		},
		{
			"name":"Type III PKS",
			"children":[
			{
				"name":"Plant type"
			},
			{
				"name":"Fungal type"
			},
			{
				"name":"Bacterial type"
			}
			]
		},
		{
			"name":"PKS-NRPS hybrid",
			"children":[
			{
				"name":"Bacterial type (modular)",
				"children":[
				{
					"name":"Myxalamid hybrid PKS-NRPS"
				},
				{
					"name":"Coronatine hybrid PKS-NRPS"
				},
				{
					"name":"Microcystin synthetase"
				},
				{
					"name":"Epothilone synthetase"
				},
				{
					"name":"Bleomycin synthetase"
				},
				{
					"name":"Colibactin synthetase"
				},
				{
					"name":"Myxothiazol hybrid PKS-NRPS"
				}
				]
			},
			{
				"name":"Fungal type (trans-ER, iterative)",
				"children":[
				{
					"name":"Aspyridone synthetase"
				}
				]
			},
			{
				"name":"Fungal type (iterative)"
			}
			]
		}
		]
	},
	{
		"name":"Nonribosomal peptide synthetase (NRPS)",
		"children":[
		{
			"name":"Linear NRPS",
			"children":[
			{
				"name":"Emericellamide synthetase"
			},
			{
				"name":"Cyanopeptolin synthetase"
			},
			{
				"name":"ACV synthetase"
			},
			{
				"name":"Bacitracin synthetase"
			},
			{
				"name":"Viomycin synthetase"
			},
			{
				"name":"Pristinamycin I synthetase"
			},
			{
				"name":"Tyrocidine synthetase"
			},
			{
				"name":"Surfactin family lipopeptide synthetase"
			},
			{
				"name":"Iturin family lipopeptide synthetase"
			},
			{
				"name":"Fengycin family lipopeptide synthetase"
			},
			{
				"name":"Arthrofactin type cyclic lipopeptide synthetase"
			},
			{
				"name":"Vancomycin synthetase"
			},
			{
				"name":"Nocardicin synthetase",
				"children":[
				{
					"name":"A4U42_02235 antibiotic synthesis protein MbtH\tK05375 mbtH; MbtH protein"
				}
				]
			},
			{
				"name":"Bialaphos synthetase"
			},
			{
				"name":"L-2-amino-4-methoxy-trans-3-butenoic acid synthetase"
			},
			{
				"name":"Anabaenopeptin synthetase"
			},
			{
				"name":"Linear gramicidin synthetase"
			}
			]
		},
		{
			"name":"Iterative NRPS",
			"children":[
			{
				"name":"Enterobactin synthetase",
				"children":[
				{
					"name":"A4U42_02260 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"A4U42_06375 hypothetical protein\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]"
				},
				{
					"name":"A4U42_11610 4'-phosphopantetheinyl transferase\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]"
				},
				{
					"name":"A4U42_16055 hypothetical protein\tK02362 entD; enterobactin synthetase component D \/ holo-[acyl-carrier protein] synthase [EC:6.3.2.14 2.7.8.7]"
				},
				{
					"name":"A4U42_02255 entE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Bacillibactin synthetase",
				"children":[
				{
					"name":"A4U42_02260 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"A4U42_02255 entE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Gramicidin synthetase"
			}
			]
		},
		{
			"name":"Nonlinear NRPS",
			"children":[
			{
				"name":"Yersiniabactin synthetase"
			},
			{
				"name":"Pyochelin synthetase"
			},
			{
				"name":"Mycobactin synthetase"
			},
			{
				"name":"Vibriobactin synthetase",
				"children":[
				{
					"name":"A4U42_02260 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"A4U42_02255 entE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				}
				]
			},
			{
				"name":"Myxochelin synthetase",
				"children":[
				{
					"name":"A4U42_02255 entE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"A4U42_02260 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				}
				]
			},
			{
				"name":"Petrobacin synthetase"
			},
			{
				"name":"Syringomycin synthetase"
			},
			{
				"name":"Vanchrobactin synthetase",
				"children":[
				{
					"name":"A4U42_02260 isochorismatase\tK01252 entB; bifunctional isochorismate lyase \/ aryl carrier protein [EC:3.3.2.1 6.3.2.14]"
				},
				{
					"name":"A4U42_02255 entE; 2,3-dihydroxybenzoate-AMP ligase\tK02363 entE; 2,3-dihydroxybenzoate---[aryl-carrier protein] ligase [EC:6.3.2.14 6.2.1.71]"
				},
				{
					"name":"A4U42_02230 non-ribosomal peptide synthetase\tK24101 vabF; L-arginine---[L-arginyl-carrier protein] ligase [EC:6.2.1.63]"
				}
				]
			},
			{
				"name":"Isonitrile lipopeptide synthase"
			}
			]
		}
		]
	},
	{
		"name":"Polyketide tailoring proteins",
		"children":[
		{
			"name":"Hydrolase"
		},
		{
			"name":"Ketoreductase"
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Methylase"
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Halogenase"
		},
		{
			"name":"beta-Branched incorporating proteins",
			"children":[
			{
				"name":"A4U42_06455 poly(3-hydroxyalkanoate) depolymerase\tK00646 pksF; malonyl-[acp] decarboxylase [EC:4.1.1.124]"
			},
			{
				"name":"A4U42_06450 acyl carrier protein\tK15337 acpK; polyketide biosynthesis acyl carrier protein"
			},
			{
				"name":"A4U42_06460 3-hydroxy-3-methylglutaryl-ACP synthase\tK15311 pksG; 3-carboxymethyl-3-hydroxy-acyl-[acp] synthase [EC:2.3.3.22]"
			},
			{
				"name":"A4U42_06465 enoyl-CoA hydratase\tK15312 pksH; 3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase [EC:4.2.1.181]"
			},
			{
				"name":"A4U42_06470 enoyl-CoA hydratase\tK15313 pksI; 4-carboxy-3-alkylbut-2-enoyl-[acp] decarboxylase [EC:4.1.1.125]"
			}
			]
		},
		{
			"name":"Others"
		}
		]
	},
	{
		"name":"Nonribosomal peptide tailoring proteins",
		"children":[
		{
			"name":"Reductase"
		},
		{
			"name":"Thioesterase"
		},
		{
			"name":"Oxygenase"
		},
		{
			"name":"Glycosyltransferase"
		},
		{
			"name":"Aminotransferase"
		},
		{
			"name":"Others",
			"children":[
			{
				"name":"A4U42_16440 aspartate racemase\tK01779 racD; aspartate racemase [EC:5.1.1.13]"
			},
			{
				"name":"A4U42_16650 aspartate racemase\tK01779 racD; aspartate racemase [EC:5.1.1.13]"
			}
			]
		}
		]
	}
	]
}