{
	"name":"dte03400",
	"children":[
	{
		"name":"Eukaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair"
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"Dester_0409 DNA-(apurinic or apyrimidinic site) lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases"
				},
				{
					"name":"Long Patch-BER factors",
					"children":[
					{
						"name":"DNA polymerase delta complex"
					},
					{
						"name":"DNA polymerase epsilon complex"
					}
					]
				},
				{
					"name":"Short Patch-BER factors"
				},
				{
					"name":"Other BER factors"
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"XPC-HR23B-CETN2 complex"
					},
					{
						"name":"Cul4-DDB2 complex"
					},
					{
						"name":"NER4 complex"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase II complex"
					},
					{
						"name":"Cul4-CSA complex"
					},
					{
						"name":"Other TCR factor"
					}
					]
				},
				{
					"name":"TFIIH complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Other NER factors"
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors"
				},
				{
					"name":"MutL homologs"
				},
				{
					"name":"DNA polymerase delta complex"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"RFC (replication factor C)"
				},
				{
					"name":"Other MMR factors"
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"MRN(MRX) complex"
				},
				{
					"name":"BRCA1-core complex"
				},
				{
					"name":"BRCA1-A complex"
				},
				{
					"name":"BRCA1-B complex"
				},
				{
					"name":"BRCA1-C complex"
				},
				{
					"name":"BRCA complex"
				},
				{
					"name":"RecA family proteins"
				},
				{
					"name":"Rad52 family proteins"
				},
				{
					"name":"Rad54 family proteins"
				},
				{
					"name":"RecQ family DNA helicases"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"RPA (replication factor A)"
				},
				{
					"name":"Protein phosphatase 4"
				},
				{
					"name":"AP-5 complex"
				},
				{
					"name":"SMC5-SMC6 complex"
				},
				{
					"name":"Other HR factors"
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"DNA-PK complex"
				},
				{
					"name":"MRX complex"
				},
				{
					"name":"DNA Ligase 4 complex"
				},
				{
					"name":"X-family DNA polymerases"
				},
				{
					"name":"Other NHEJ factors"
				}
				]
			},
			{
				"name":"FA (Fanconi anemia) pathway",
				"children":[
				{
					"name":"FA core complex"
				},
				{
					"name":"FA core complex binding factors"
				},
				{
					"name":"Bloom's syndrome complex (BTR)"
				},
				{
					"name":"FANCD2-I complex"
				},
				{
					"name":"Downstream FA components"
				},
				{
					"name":"Other FA pathway factors"
				}
				]
			},
			{
				"name":"Other DSBR factors",
				"children":[
				{
					"name":"Protein phosphatase 6"
				},
				{
					"name":"Ubiquitin ligases"
				},
				{
					"name":"Others"
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"B-family DNA polymerases"
			},
			{
				"name":"A-family DNA polymerase"
			},
			{
				"name":"Rad6 epistasis group"
			},
			{
				"name":"Other TLS factors"
			}
			]
		},
		{
			"name":"Check point factors",
			"children":[
			{
				"name":"Rad9-Hus1-Rad1 complex"
			},
			{
				"name":"HRAD17(Rad24)-RFC complex"
			},
			{
				"name":"Rad17-Mec3-Ddc1 complex"
			},
			{
				"name":"FPC (fork protection complex)"
			},
			{
				"name":"Triple T complex"
			},
			{
				"name":"BAG6-UBL4A-GET4 complex"
			},
			{
				"name":"SOSS complex"
			},
			{
				"name":"Other check point factors"
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerases"
			},
			{
				"name":"Nucleases"
			},
			{
				"name":"Helicases"
			},
			{
				"name":"PSO4 complex"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"Dester_1460 NUDIX hydrolase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				}
				]
			}
			]
		}
		]
	},
	{
		"name":"Prokaryotic type",
		"children":[
		{
			"name":"SSBR (single strand breaks repair)",
			"children":[
			{
				"name":"Direct repair"
			},
			{
				"name":"BER (base exicision repair)",
				"children":[
				{
					"name":"DNA glycosylases",
					"children":[
					{
						"name":"Dester_0440 phage SPO1 DNA polymerase-related protein\tK21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]"
					},
					{
						"name":"Dester_0409 DNA-(apurinic or apyrimidinic site) lyase\tK10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]"
					}
					]
				},
				{
					"name":"AP endonucleases",
					"children":[
					{
						"name":"Dester_1431 endonuclease 4\tK01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]"
					},
					{
						"name":"Dester_1088 Endonuclease V\tK05982 nfi; deoxyribonuclease V [EC:3.1.21.7]"
					}
					]
				},
				{
					"name":"RecJ"
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"Dester_0863 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"DNA polymerase I",
					"children":[
					{
						"name":"Dester_0345 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					}
					]
				}
				]
			},
			{
				"name":"NER (nucleotide excision repair)",
				"children":[
				{
					"name":"GGR (global genome repair) factors",
					"children":[
					{
						"name":"Dester_1260 UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A"
					},
					{
						"name":"Dester_0680 UvrABC system protein B\tK03702 uvrB; excinuclease ABC subunit B"
					},
					{
						"name":"Dester_0781 UvrABC system protein C\tK03703 uvrC; excinuclease ABC subunit C"
					},
					{
						"name":"Dester_0097 UvrD\/REP helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"Dester_1522 UvrD\/REP helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"Dester_0345 DNA polymerase I\tK02335 polA; DNA polymerase I [EC:2.7.7.7]"
					},
					{
						"name":"Dester_0863 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"TCR (transcription coupled repair) factors",
					"children":[
					{
						"name":"DNA-directed RNA polymerase complex (RNAP)",
						"children":[
						{
							"name":"Dester_0152 DNA-directed RNA polymerase subunit beta\tK03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]"
						},
						{
							"name":"Dester_0151 DNA-directed RNA polymerase subunit beta'\tK03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]"
						},
						{
							"name":"Dester_0222 DNA-directed RNA polymerase subunit alpha\tK03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]"
						},
						{
							"name":"Dester_0177 DNA-directed RNA polymerase subunit omega\tK03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]"
						}
						]
					},
					{
						"name":"TRCF (transcription-repair coupling factor)",
						"children":[
						{
							"name":"Dester_0988 transcription-repair coupling factor\tK03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]"
						}
						]
					}
					]
				}
				]
			},
			{
				"name":"MMR (mismatch excision repair)",
				"children":[
				{
					"name":"Mismatch and loop recognition factors",
					"children":[
					{
						"name":"Dester_1003 DNA mismatch repair protein mutS\tK03555 mutS; DNA mismatch repair protein MutS"
					},
					{
						"name":"Dester_0795 MutS2 protein\tK07456 mutS2; DNA mismatch repair protein MutS2"
					}
					]
				},
				{
					"name":"Molecular matchmaker",
					"children":[
					{
						"name":"Dester_1142 ATP-binding region ATPase domain protein\tK03572 mutL; DNA mismatch repair protein MutL"
					}
					]
				},
				{
					"name":"Strand discrimination factor"
				},
				{
					"name":"DNA exonucleases"
				},
				{
					"name":"DNA polymerase III holoenzyme",
					"children":[
					{
						"name":"Dester_1146 DNA polymerase III, alpha subunit\tK02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]"
					},
					{
						"name":"Dester_0003 DNA polymerase III, beta subunit\tK02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]"
					},
					{
						"name":"Dester_1527 DNA polymerase III delta\tK02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]"
					},
					{
						"name":"Dester_0955 DNA polymerase III, delta prime subunit\tK02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]"
					},
					{
						"name":"Dester_0521 DNA polymerase III, subunits gamma and tau\tK02343 dnaX; DNA polymerase III subunit gamma\/tau [EC:2.7.7.7]"
					}
					]
				},
				{
					"name":"DNA ligase",
					"children":[
					{
						"name":"Dester_0863 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
					}
					]
				},
				{
					"name":"Other MMR factors",
					"children":[
					{
						"name":"Dester_0097 UvrD\/REP helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"Dester_1522 UvrD\/REP helicase\tK03657 uvrD; ATP-dependent DNA helicase UvrD\/PcrA [EC:5.6.2.4]"
					},
					{
						"name":"Dester_0998 single-strand binding protein\tK03111 ssb; single-strand DNA-binding protein"
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"DSBR (double strand breaks repair)",
			"children":[
			{
				"name":"HR (homologous recombination)",
				"children":[
				{
					"name":"RecBC pathway proteins",
					"children":[
					{
						"name":"Dester_1469 Protein recA\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"Dester_1336 Holliday junction ATP-dependent DNA helicase ruvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"Dester_1337 Holliday junction ATP-dependent DNA helicase ruvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					},
					{
						"name":"Dester_0919 endodeoxyribonuclease RusA\tK01160 rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.21.10]"
					},
					{
						"name":"Dester_1435 primosomal protein N'\tK04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]"
					},
					{
						"name":"Dester_0671 SMC domain protein\tK03546 sbcC; DNA repair protein SbcC\/Rad50"
					},
					{
						"name":"Dester_0334 metallophosphoesterase\tK03547 sbcD; DNA repair protein SbcD\/Mre11"
					}
					]
				},
				{
					"name":"RecFOR pathway proteins",
					"children":[
					{
						"name":"Dester_1469 Protein recA\tK03553 recA; recombination protein RecA"
					},
					{
						"name":"Dester_1345 DNA repair protein RadA\tK04485 radA; DNA repair protein RadA\/Sms"
					},
					{
						"name":"Dester_1274 ATP-dependent DNA helicase RecG\tK03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]"
					},
					{
						"name":"Dester_0715 DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
					},
					{
						"name":"Dester_1074 Recombination protein recR\tK06187 recR; recombination protein RecR"
					},
					{
						"name":"Dester_1211 DNA repair protein RecN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
					},
					{
						"name":"Dester_1336 Holliday junction ATP-dependent DNA helicase ruvA\tK03550 ruvA; holliday junction DNA helicase RuvA"
					},
					{
						"name":"Dester_1337 Holliday junction ATP-dependent DNA helicase ruvB\tK03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]"
					}
					]
				},
				{
					"name":"AddAB pathway proteins"
				},
				{
					"name":"Other HR factor"
				},
				{
					"name":"Archaeal homologous recombinant proteins",
					"children":[
					{
						"name":"Dester_0671 SMC domain protein\tK03546 sbcC; DNA repair protein SbcC\/Rad50"
					},
					{
						"name":"Dester_0334 metallophosphoesterase\tK03547 sbcD; DNA repair protein SbcD\/Mre11"
					},
					{
						"name":"Dester_0149 HerA-ATP synthase, barrel domain\tK06915 herA; DNA double-strand break repair helicase HerA and related ATPase"
					}
					]
				}
				]
			},
			{
				"name":"NHEJ (non-homologous end-joining)",
				"children":[
				{
					"name":"Two-component NHEJ DNA repair complex"
				},
				{
					"name":"SHIIR (short-homology-independent illegitimate recombination)",
					"children":[
					{
						"name":"Facilitator",
						"children":[
						{
							"name":"Dester_1161 DNA gyrase, A subunit\tK02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]"
						},
						{
							"name":"Dester_0243 DNA gyrase, B subunit\tK02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]"
						},
						{
							"name":"Dester_0958 DNA topoisomerase I\tK03168 topA; DNA topoisomerase I [EC:5.6.2.1]"
						}
						]
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"Dester_0018 histone family protein DNA-binding protein\tK03530 hupB; DNA-binding protein HU-beta"
						}
						]
					}
					]
				},
				{
					"name":"SHDIR (short-homology-dependent illegitimate recombination)",
					"children":[
					{
						"name":"RecET pathway",
						"children":[
						{
							"name":"Dester_0715 DNA repair protein RecO\tK03584 recO; DNA repair protein RecO (recombination protein O)"
						},
						{
							"name":"Dester_1074 Recombination protein recR\tK06187 recR; recombination protein RecR"
						},
						{
							"name":"Dester_0863 DNA ligase\tK01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]"
						}
						]
					},
					{
						"name":"Facilitator"
					},
					{
						"name":"Supressor",
						"children":[
						{
							"name":"Dester_1260 UvrABC system protein A\tK03701 uvrA; excinuclease ABC subunit A"
						},
						{
							"name":"Dester_0680 UvrABC system protein B\tK03702 uvrB; excinuclease ABC subunit B"
						}
						]
					}
					]
				}
				]
			}
			]
		},
		{
			"name":"TLS (translesion DNA synthesis) factors",
			"children":[
			{
				"name":"Y-family DNA polymerases"
			},
			{
				"name":"Other SOS response factors",
				"children":[
				{
					"name":"Dester_1469 Protein recA\tK03553 recA; recombination protein RecA"
				},
				{
					"name":"Dester_1211 DNA repair protein RecN\tK03631 recN; DNA repair protein RecN (Recombination protein N)"
				},
				{
					"name":"Dester_0998 single-strand binding protein\tK03111 ssb; single-strand DNA-binding protein"
				},
				{
					"name":"Dester_1471 regulatory protein RecX\tK03565 recX; regulatory protein"
				}
				]
			}
			]
		},
		{
			"name":"Other factors with a suspected DNA repair function",
			"children":[
			{
				"name":"DNA polymerase",
				"children":[
				{
					"name":"Dester_0537 PHP domain protein\tK02347 polX; DNA polymerase (family X)"
				}
				]
			},
			{
				"name":"DNA helicases"
			},
			{
				"name":"Modulation of nucleotide pools",
				"children":[
				{
					"name":"Dester_1460 NUDIX hydrolase\tK03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]"
				},
				{
					"name":"Dester_0256 ribonucleoside-diphosphate reductase, alpha subunit\tK00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]"
				},
				{
					"name":"Dester_0257 ribonucleotide reductase\tK00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]"
				}
				]
			},
			{
				"name":"Others",
				"children":[
				{
					"name":"Dester_0932 phosphoesterase RecJ domain protein\tK06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]"
				}
				]
			}
			]
		}
		]
	}
	]
}